Clinical trials: Implant Therapy
Cartilage Lesion to the Femoral Condyle
Study to Evaluate the Safety and Performance of Treatment of Articular Cartilage Lesions Located on the Femoral Condyle With gelrinC
This is a single arm, open label multi-center study to determine safety and the performance of the treatment of cartilage lesions located on the femoral condyle with GelrinC.
- Trial name
- NCT00989794
- Testing
- GelrinC
- Volunteers
- 56 people
- Sponsor
- Regentis Biomaterials
Patellofemoral Osteoarthritis
Treatment of Patellofemoral Osteoarthritis With Engineered Cartilage.
The purpose of this investigator-initiated study is to assess the efficacy of treating patellofemoral osteoarthritis with an Advanced Therapy Medicinal Product (ATMP), autologous nasal chondrocyte tissue engineered cartilage…
- Trial name
- NCT06163573
- Testing
- N-TEC, Platelet rich plasma
- Where
- 9 sites in Croatia, Germany and 1 more
- Volunteers
- 75 people
- Sponsor
- University Hospital, Basel, Switzerland
Malocclusion, Class II Division 1 Malocclusion
The Efficacy of Tow Mechanics for Total-maxillary-arch-distalization
Patients with class II division 1 malocclusion who have increased overjet will be treated in this study. The efficacy of one-jaw and tow-jaw mechanics for mini-implants anchored total-maxillary-arch-distalization in the treatment…
- Trial name
- NCT04814173
- Testing
- One-jaw mechanic total maxillary arch distalization, Two-jaw mechanic total maxillary arch distalization, en-mass retraction
- Where
- Syria
- Volunteers
- 48 people
- Sponsor
- Hama University
Diabetic Macular Edema (DME)
Early Combined Use of Dexamethasone Intravitreal Implant and Anti-VEGF in the Treatment of DME.
The goal of this clinical trial is to learn if the efficacy of dexamethasone implant combined with anti-VEGF superior to anti-VEGF monotherapy in the treatment of DME in Chinese patients.
- Trial name
- NCT06846073
- Testing
- The combination of intravitreal anti-VEGF and dexamethasone implants injections.
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Heart Failure
Deutsches Device Qualitätsregister
It is the aim of this register to document the development of therapies by implantation of Cardioverter/Defibrillators (ICDs) and/or Cardiac Resynchronization therapy (CRT)-Systems.
- Trial name
- NCT01173783
- Where
- 7 sites in Germany
- Volunteers
- 4,008 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Vascular Access Devices, Central Venous Catheter
Safety and Efficacy of Midline and PICC
The purpose of this study is to assess the non-inferiority for safety and efficacy of using Midline in comparison with PICC for intravenous therapy that do not require a central catheter.
- Trial name
- MidLine_PICC (NCT03502980)
- Testing
- Bard PowerPICC, Bard PowerMidline catheter
- Where
- Canada
- Volunteers
- 293 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Acute Anterior Myocardial Infarction
Effects of Intensive Statin Treatment on Left Ventricular Function
First acute anterior myocardial infarction in patients with primary PCI preoperative and postoperative 30 days intensive dose atorvastatin statin therapy compared with conventional -dose therapy , patients can improve left…
- Trial name
- NCT01936103
- Testing
- standard group, intensive group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenyang Northern Hospital
Aortic Dissection Type B
Hybrid Treatment of Type B Aortic Dissection
Authors hypothesize that thoracoabdominal aortic repair combined with bare metal stent implantation is superior over standard thoracoabdominal aortic repair.
- Trial name
- NCT02726841
- Testing
- Open thoracoabdominal aortic repair + abdominal stenting, Classic thoracoabdominal aortic repair
- Volunteers
- 160 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Tennis Elbow, Lateral Epicondylitis
Efficacy Bioinductive Implant for Tennis Elbow (Lateral Epicondylitis)
The investigators are testing the efficacy of a new, FDA-approved bioinductive patch in lateral epicondylitis (tennis elbow) patients.
- Trial name
- NCT03718637
- Testing
- Smith & Nephew Bioinductive Implant, Lateral Epicondylectomy, Ultrasound Imaging
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Symptomatic Aortic Stenosis
Platelet REACtivity According to TICagrelor Dose After Transcatheter AorticValve Implantation
The narrowing of the aortic valve, which prevents blood from reaching the entire body correctly is a common disease in our environment.
- Trial name
- REACTIC-TAVI (NCT04331145)
- Testing
- Ticagrelor 60mg
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Andres Iñiguez Romo
Periprosthetic Infection
"Debridement PhagE AnTibiotics for PJI"
Total joint replacement (TJR) has revolutionized care provided for patients suffering from disabling joint pain. Unfortunately, periprosthetic joint infection (PJI) remains a devastating complication and the leading cause of…
- Trial name
- DePHEAT-PJI (NCT07698002)
- Testing
- The investigational product specifically targeting P. aeruginosa (DP-QB-PSA-005) and that targeting S. aureus (DP-QB-STA-005), each formed of a mixture of 5 bacteriophages.
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Patient Adherence
Efficacy Of An Education Plan And Adherence Follow-Up To The Exercise In Patients With Angioplasty And Stent Coronary
Cardiovascular diseases are a leading cause of death worldwide. Some of the risk factors that have been identified are considered as be non-modifiable and modifiable.
- Trial name
- NCT03231631
- Testing
- Education plan and adherence to exercise
- Where
- Colombia
- Volunteers
- 71 people
- Sponsor
- Clínica de Occidente S.A
Degenerative Sacroiliitis, Sacroiliac Joint Disruption
Sacroiliac Joint Fusion With iFuse Implant System (SIFI)
The purpose of this study is to evaluate the use of the iFuse Implant System to treat degenerative sacroiliitis (arthritis of the SI joint) and sacroiliac disruption (abnormal separation or tearing of the sacroiliac joint).
- Trial name
- SIFI (NCT01640353)
- Where
- 26 sites in United States
- Volunteers
- 194 people
- Sponsor
- SI-BONE, Inc.
Breakthrough Bleeding
Treatment of Prolonged Uterine Bleeding of Etonogestrel (ENG)-Releasing Implant
Long-acting reversible contraceptives [LARC; copper-intrauterine devices (IUDs), the levonorgestrel-releasing intrauterine system (LNG-IUS) and subdermal implants] are the most effective reversible contraceptives available.
- Trial name
- NCT04047875
- Testing
- Norethisterone 10mg/day
- Where
- 2 sites in Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Coronary Artery Disease, Coronary Disease
Sirolimus-eluting vs Zotarolimus-eluting Stents for Chronic Total Coronary Occlusions
Primary intracoronary stent placement after successfully crossing chronic total coronary occlusions (CTO) decreases the high restenosis rate at long-term follow-up compared with conventional balloon angioplasty.
- Conditions
- Coronary Artery Disease, Coronary Disease, Coronary Stenosis
- Trial name
- NCT00428454
- Testing
- sirolimus-eluting stent, zotarolimus-eluting stent
- Where
- 5 sites in Belgium, Netherlands
- Volunteers
- 301 people
- Sponsor
- R&D Cardiologie
Coronary Artery Disease
STOPping Versus Continuing Antiplatelet Therapy During Noncardiac Surgery and Procedures After Next Generation Drug-eluting Stent Implantation
Most previous trials support the absolute increase in bleeding risk with perioperative administration of antiplatelet. Furthermore, recent studies demonstrated that perioperative major bleeding may be related to increase…
- Trial name
- NCT03184805
- Testing
- Continuing aspirin, Stopping aspirin
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Yonsei University
Dupuytren Contracture, Dupuytren Disease of Palm and Finger
Treatment of Dupuytren's Disease With Minimal Invasive Surgery and VIVOSORB® Resorbable Implant Device
Dupuytren's disease is a progressive fibroproliferative condition of the hand which progresses in 20% of patients into a serious condition.
- Trial name
- Vivosorb (NCT03741764)
- Testing
- Vivosorb
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- prof. dr. Ilse Degreef
Healing Wound, Alveolar; Wound
Ultrasound for Socket Healing Evaluation
The design is a single blinded, dual comparative study of ultrasound versus micro-CT/LASCA in one study group. Up to a total of 140 subjects registered will be recruited.
- Conditions
- Healing Wound, Alveolar; Wound, Alveolar Bone Loss, Image
- Trial name
- NCT06017193
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetic Macular Edema
Suprachoroidal Sustained-Release OXU-001 Compared to Intravitreal Ozurdex® in the Treatment of Diabetic Macular Edema
The purpose of this clinical trial is to compare safety, tolerability, efficacy, and durability of two dose levels of suprachoroidal sustained-release OXU-001 (dexamethasone microspheres; DEXAspheres®) using the Oxulumis®…
- Trial name
- OXEYE (NCT05697809)
- Testing
- OXU-001, Semi-automated suprachoroidal illuminated microcatheter, Ozurdex® Ophthalmic Intravitreal Implant
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 3 people
- Sponsor
- Oxular Limited
Recurrent Dislocation of Temporomandibular Joint (Disorder)
Evaluation of Using Patient Specific Zirconium Dioxide Implant Versus Patient Specific Titanium Implant in Treatment of Chronic Condylar Dislocation
Alternate hypothesis that treatment of Tempromandibular joint dislocation with Zirconium Dioxide eminoplasty will be more efficient than using titanium onlays in terms of decreasing maximum inter incisal distance and providing…
- Trial name
- NCT05377593
- Testing
- eminoplasty with patient specific Zirconium dioxide onlay implant
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cairo University
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