Clinical trials: Impaired Synaptic Plasticity
HIV/AIDS, Cognitive Impairment
A Randomized Pilot Trial Evaluating the Impact of a Yoga Intervention on Cognition in Older Adults Infected With HIV
Approximately 50% of people living with HIV (and as many as 80% over the age of 50) have difficulties with cognitive functions such as memory and thinking that can have a profound negative impact on activities of daily living and…
- Conditions
- HIV/AIDS, Cognitive Impairment, Aging, Mobility Limitation
- Trial name
- NCT03071562
- Testing
- Yoga-mindfulness
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Adria Quigley
Heart Arrest, Out-Of-Hospital, Cognitive Impairment
Brain Outcome After Cardiac Arrest - Intervention
People who suffered a cardiac arrest are often have cognitive impairments. In this study the investigators test the effectiveness of an intervention, combining direct training and metacognitive training, in a single case…
- Trial name
- BROCA-i (NCT05133869)
- Testing
- Metacognitive training + direct training
- Where
- 3 sites in Netherlands
- Volunteers
- 4 people
- Sponsor
- Maastricht University
Stroke, Upper Limb Paresis
Effects of High-Frequency rTMS on Cortical Motor Mapping in Stroke Patients With Severe Upper Limb Impairment (MAP2024SJD)
The goal of this clinical trial is to learn if a single session of high-frequency repetitive transcranial magnetic stimulation (rTMS) can increase cortical motor activity in stroke patients with severe upper limb impairment.
- Trial name
- MAP2024SJD (NCT07787793)
- Testing
- High-frequency repetitive transcranial magnetic stimulation
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Ancor Rebassa Cabrera
Mild Cognitive Impairment (MCI), Cognitive Training
Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial
Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia.
- Trial name
- COGIT-2 (NCT06601933)
- Testing
- Cognitive Training
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Columbia University
Stroke, Cerebrovascular Accident
Combining Armodafinil With Neuro-rehabilitation to Improve Neurological Recovery and Reduce Disability Post-Stroke
Armodafinil is an FDA approved medication with wakefulness-promoting properties. It is a relatively safe agent with interesting neurochemical effects on the catecholamine system, producing an improvement in cognitive function…
- Conditions
- Stroke, Cerebrovascular Accident, Hemiparesis
- Trial name
- NCT01896128
- Testing
- Armodafinil
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Burke Rehabilitation Hospital
Mild Cognitive Impairment, Older Adults at High Risk for MCI
The Impact of 6-months of Resistance Training on Brain and Muscle Health in Older Adults With MCI
The goal of this clinical trial is to learn about the effect of long resistance training intervention on brain and muscle health in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT06252844
- Testing
- Resistance exercise training, Active control
- Where
- 2 sites in Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Aging
Gait Adaptation Study
This pilot study proposes a clinical trial to target treatment of sensorimotor and cognitive deficits in persons with Multiple Sclerosis (pwMS).
- Trial name
- NCT07660601
- Testing
- Gait Adaptation Training, Basic Physical Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Mild Cognitive Impairment
Computerized Memory Enhancing Treatment in MCI
The investigators propose to apply neuroplasticity-based computerized cognitive remediation (nCCR) to improve memory function in patients with Mild Cognitive Impairment (MCI).
- Trial name
- COMET (NCT05332522)
- Testing
- Neuroplasticity-based Computerized Cognitive Remediation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Vanderbilt University Medical Center
Mild Cognitive Impairment, Alzheimer's Disease
Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment
The aging US population threatens to overwhelm our healthcare infrastructure, especially since the rate of Alzheimer's disease (AD) alone is expected to triple in the coming decades.
- Trial name
- NCT02155946
- Testing
- Transcranial direct current stimulation (tDCS) Soterix Medical Inc. tDCS unit
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- VA Office of Research and Development
Brain Injuries, Visually Impaired Persons
Functional Vision in TBI
The objective of this study is to test functional vision outcome measures that reflect the loss in everyday life tasks that require vision and that are sensitive to changes after a course of vision rehabilitation in…
- Trial name
- NCT01214070
- Testing
- Vision Restoration Therapy, NVT Eye Scanning Therapy, Eccentric Viewing Training
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Chronic Stroke Patient, Motor Impairment
Multifocal Theta-Burst Stimulation to Enhance Upper Limb Motor Recovery After Stroke (INSPIRE)
Stroke is one of the leading causes of long-term disability worldwide. Many individuals who survive a stroke continue to experience weakness and reduced control of one arm, even months or years after the event.
- Conditions
- Chronic Stroke Patient, Motor Impairment, Neurorehabilitation, Theta Burst Stimulation
- Trial name
- INSPIRE (NCT07439367)
- Testing
- Active iTBS, Tablet-based upper limb training
- Where
- Switzerland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Spinal Cord Injuries (SCI), Spinal Cord Injury, Chronic
BCI-Assisted SCS-EXS for Gait Optimization
The goal of this clinical trial is to evaluate the safety and technical feasibility of a novel brain-machine interface (BCI)-assisted spinal cord stimulation (SCS) and exoskeleton (EXS) system in patients with spinal cord injury…
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Chronic, Spinal Cord Injury, Spinal Cord Injury Cervical
- Trial name
- BASEGO (NCT06939660)
- Testing
- BCI-SCS-EXS
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Xuanwu Hospital, Beijing
Mild Cognitive Impairment, Memory Disorders
Cognitive Training and Neuroplasticity in Mild Cognitive Impairment
The purpose of this study is to evaluate if systematic cognitive training can improve cognitive performance in participants (55 and older) with memory loss.
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Memory Impairment, Cognitive Impairment
- Trial name
- CogTraining (NCT03205709)
- Testing
- Computerized Cognitive Training, Crossword Puzzles
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- New York State Psychiatric Institute
Chemo-brain, Chemotherapy-Related Cognitive Impairment
nCCR for Chemotherapy Related Cognitive Impairment Randomized Study
The investigators propose to apply neuroplasticity-based computerized cognitive remediation (nCCR) to treat chemotherapy-related cognitive impairment (CRCI).
- Trial name
- NCT05283629
- Testing
- Neuroplasticity-based Computerized Cognitive Remediation, Active Control Condition
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Mild Cognitive Impairment (MCI), Mild Alzheimer's Disease
Sensory-cognitive and Physical Fitness Training in Mild Cognitive Impairment
Age-related cognitive decline is unavoidable. However, recent results of neuroplasticity-based research show that neuroplasticity-based training and physical activity might have the potential to decelerate or even reverse effects…
- Trial name
- NCT01061489
- Testing
- auditory discrimination training, physical movement training
- Where
- 2 sites in Germany
- Volunteers
- 65 people
- Sponsor
- University of Konstanz
Delirium
Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)
Many individuals experience an acute change in thinking and reasoning skills after surgery. This is called post-operative delirium (PD). PD symptoms typically start 1-3 days after surgery.
- Trial name
- NCT02230605
- Testing
- Mini-Mental State Examination, Self-Administered Gerocognitive Examination, Geriatric Depression Scale
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Mild Cognitive Impairment
Multimodal Investigation of Neural Plasticity
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in cognitively intact older adults (healthy controls, HC) and in those with mild cognitive impairment (MCI).
- Trial name
- miniSTIM (NCT06453980)
- Testing
- active tDCS
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Multiple Sclerosis
Home-based EXergames To impRove cognitivE Function in MUltiple Sclerosis
Study design: Phase II, multicenter, randomized, sham-controlled, single-blind, parallel arm, multicenter study to test the hypothesis that home-based exergames is not inferior to home-based cognitive rehabilitation delivered by…
- Trial name
- EXTREMUS (NCT04169750)
- Testing
- Exergames, Adaptive COGNI-TRAcK
- Where
- 4 sites in Italy
- Volunteers
- 135 people
- Sponsor
- San Camillo Hospital, Rome
Spinal Cord Injuries, Cervical Spinal Cord Injury
Neurostimulation for Respiratory Function After Spinal Cord Injury
The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is: Changes in…
- Conditions
- Spinal Cord Injuries, Cervical Spinal Cord Injury, Respiratory Function Impaired
- Trial name
- NCT05756894
- Testing
- Neurostimulation, Repiratory training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab