Clinical trials: Impaired Glucose Tolerance
Impaired Glucose Tolerance, Diabetes
A Lifestyle and Combination Medication Therapy Diabetes Prevention Study
It is now well established that the 21st century will be characterized by a global epidemic of Type 2 diabetes. The principal aim of the CANOE study is to determine whether individuals with the pre-diabetes condition impaired…
- Trial name
- NCT00116922
- Testing
- Avandamet [Rosiglitazone 2mg/Metformin 500mg] BID
- Where
- 2 sites in Canada
- Volunteers
- 207 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Prediabetic State
A Mediterranean Intervention on Prediabetic Children
Prediabetes is a pathological condition where the blood glucose concentration is higher than normal concentrations but lower than those considered in type 2 diabetes mellitus (DM2) diagnosis.
- Trial name
- INTKIDMEDPRED (NCT05424107)
- Testing
- KIDMED
- Where
- Spain
- Volunteers
- 254 people
- Sponsor
- Pilar Aparicio Martinez
PreDiabetes, Diabetes Mellitus, Type 2
Chronotype, Chrononutrition and Glucose Tolerance Among Prediabetic Individuals
Chronotype and chrononutrition, both are emerging research fields in nutritional epidemiology. However, its association with glycemic control in the global population is less clear.
- Trial name
- NCT05163964
- Testing
- Lifestyle Intervention
- Where
- 11 sites in Malaysia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
Metabolic Syndrome, Diabetes
Biomarkers of Metabolic Syndrome and Prediabetes
The purpose of this study is to investigate the feasibility of using salivary biomarkers to screen for complications of metabolic syndrome including prediabetes.
- Conditions
- Metabolic Syndrome, Diabetes, Prediabetes, Hypertension
- Trial name
- NCT01086137
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- West Virginia School of Osteopathic Medicine
Type 2 Diabetes Mellitus, Hypercholesterolemia
Effects of Metformin Hydrochloride (HCl) in Combination With Colesevelam HCl, Compared to Metformin HCl Alone, in Patients With Type 2 Diabetes Mellitus and the Effects of Colesevelam HCl on Lipids and Glucose on Pre-diabetic Patients.
This is a 16-week double-blind, placebo-controlled (for colesevelam hydrochloride (HCl)) study in the type 2 diabetic subjects and pre-diabetic subjects.
- Conditions
- Type 2 Diabetes Mellitus, Hypercholesterolemia, Pre-diabetes
- Trial name
- NCT00570739
- Testing
- Metformin HCl tablets and Colesevelam tablets, Colesevelam
- Where
- 31 sites in United States, Colombia and 2 more
- Volunteers
- 502 people
- Sponsor
- Daiichi Sankyo
High Blood Pressure, Metabolic Syndrome
Comparison of Aliskiren and Amlodipine on Insulin Resistance and Endothelial Dysfunction in Patients With Hypertension and Metabolic Syndrome
The purpose of this study was to determine the effects of Aliskiren on insulin resistance (IR) and endothelial dysfunction (ED) in patients with high blood pressure and metabolic syndrome.
- Conditions
- High Blood Pressure, Metabolic Syndrome, Insulin Resistance, Endothelial Dysfunction
- Trial name
- NCT00417170
- Testing
- Aliskiren, Amlodipine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Novartis Pharmaceuticals
Impaired Glucose Tolerance
Preliminary Safety and Efficacy Study of Extracellular Vesicle Infusion in the Intervention of Age-related Phenotypes With Impaired Glucose Tolerance.
The objective of this exploratory study was to evaluate the initial safety of human mesenchymal stem cell-derived extracellular vesicle infusion in an age-related phenotype with impaired glucose tolerance
- Trial name
- NCT06495437
- Testing
- Intravenous infusion of extracellular vesicle preparation derived from Wharton's jelly mesenchymal stem cells.
- Volunteers
- 20 people
- Sponsor
- BEAUTECH
Type 2 Diabetes
Prevention of Type 2 Diabetes Amongst South Asians With Central Obesity and Prediabetes
The investigators' general goal is to identify approaches to risk stratification and health promotion through lifestyle modification that are acceptable, effective and efficient for prevention of T2D in South Asian communities…
- Trial name
- iHealth-T2D (NCT02949739)
- Testing
- Intensive lifestyle modification
- Where
- United Kingdom
- Volunteers
- 5,244 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Prediabetes (Impaired Fasting Glucose and/or Impaired Glucose Tolerance)
Effect of Rubus Occidentalis Extract on Plasma Glucose Levels in Subject With Prediabetes
The purpose of this study is to determine whether Rubus occidentalis extract could improve fasting or postprandial serum glucose levels, and related metabolic markers among patients with prediabetes (impaired fasting glucose…
- Trial name
- NCT01964703
- Testing
- Rubus occidentalis extract
- Volunteers
- 29 people
- Sponsor
- Korea University Anam Hospital
Diabetes Mellitus, Pre Diabetes
Development and Validation of DM and Pre-DM Risk Prediction Model
Many DM and pre-DM remain undiagnosed. The aim is to develop and validate a risk prediction function to detect DM and pre-DM in Chinese adults aged 18-84 in primary care (PC). The objectives are to: 1.
- Trial name
- NCT04881383
- Testing
- OGTT and HbA1c
- Where
- Hong Kong
- Volunteers
- 1,014 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Type 2 Diabetes, Obesity, Prediabetes
The Influence of Glucose Flux on Fat Synthesis in a Whole Body Calorimeter
The study is carried out to find out the inclusion of high and low glycaemic index foods to daily meals and how they impact 24 hour blood glucose fluctuations and energy regulation.
- Trial name
- NCT02631083
- Testing
- Breakfast, lunch, snack and dinner
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
PreDiabetes
Efficacy of Physical Exercise on Glucose Control in People With Prediabetes (GLYCEX) - Phase II
Aim: To assess the efficacy of different frequencies of physical exercise on glycaemic control in adults with prediabetes. Methods: parallel, randomised, controlled, clinical trial will be carried out, with a total of 90…
- Trial name
- GLYCEX (NCT05658770)
- Testing
- 5 days/ week, 3 days/ week, 2 days/ week
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Insulin Resistance
Effects of Sourdough Fermentation Duration and Acid Development on Postprandial Blood Glucose in Prediabetic Adults
The primary intervention for management of prediabetes is lifestyle changes. Eating healthier and increasing physical activity was found to slow the progression of prediabetes into diabetes, reduce the risk of other diseases like…
- Trial name
- NCT06925451
- Testing
- sourdough bread 24, sourdough bread 48, sourdough bread 72
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Arizona State University
Type 2 Diabetes Mellitus
Insulin Sensitivity and Metabolomics During Oral Administration of Glucose and Graded Intravenous Infusion
Bariatric surgery has been proven to be an effective treatment of type 2 diabetes and it has highlighted to role of the small intestine in glucose homeostasis.
- Trial name
- NCT03223129
- Testing
- Oral glucose tolerance test, Graded intravenous glucose infusion
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Catholic University of the Sacred Heart
PreDiabetes, Dysbiosis
Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components
This study will investigate the gut microbiota-mediated effects of whole wheat consumption on human health in adults with pre-diabetes.
- Conditions
- PreDiabetes, Dysbiosis, Endotoxemia, Inflammation
- Trial name
- NCT05318183
- Testing
- Whole Wheat Bread, White Bread (control)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Ohio State University
Pre-Diabetic
Effect of 1,25-dihydroxyvitamin D3, Treatment on Insulin Secretion and Muscle Strength in Pre-diabetic Persons
The purpose of this research is to study the effects of 1,25(OH)2 D3 (a prescription form of active Vitamin D) on muscle strength and insulin secretion by the pancreas and glucose utilization by skeletal muscle.
- Trial name
- NCT04286529
- Testing
- Calcitriol capsules
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Metabolic Syndrome X, Prediabetic State
Effects of PPAR Ligands on Ectopic Fat Accumulation and Inflammation
The relationship between obesity and insulin resistance is known, however the mechanism(s) associating obesity with insulin resistance is not well understood.
- Trial name
- NCT00470262
- Testing
- Fenofibrate 145mg PO QD, Pioglitazone 45 mg PO QD
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Diabetes Mellitus, Glucose Intolerance
Prevalence of Glucose Intolerance and Risk Factors in Ethiopian Immigrants in Israel; Follow-up Study.
High risk population: Screening for impaired glucose tolerance.
- Trial name
- NCT01402362
- Where
- Israel
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Type 2 Diabetes
Dynamic Responsiveness of Insulin Secretory Parameters To Sitagliptin and Glimeperide Administration in Type 2 DM
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT02443922
- Testing
- Glimepiride, Sitagliptin, Metformin
- Volunteers
- 100 people
- Sponsor
- Foundation for the National Institutes of Health
Overweight and Obesity
The Effect of Epitomee Capsule on Body Weight in Patients With Overweight and Obesity
The effect of Epitomee Capsule on body weight in patients with overweight and obesity with and without Prediabetes
- Trial name
- RESET (NCT04222322)
- Testing
- Epitomee Capsule
- Where
- 9 sites in United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Epitomee medical
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