Clinical trials: Immunometabolism
Systemic Lupus Erythematosus (Sle)
Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
Study Description: Systemic lupus erythematosus (SLE) occurs predominantly in women and is driven by type I interferon dysregulation and neutrophil hyperresponsiveness.
- Trial name
- NCT06032923
- Testing
- Nicotinamide Riboside
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stress, Healthy
The Efficacy of Pasteurised Akkermansia Muciniphila in Healthy Medical Workers
Gut microbiota alterations secondary to chronic stress might serve as a triggering factor towards manifestation of somatic and mental symptoms. The administration of pasteurised A.
- Conditions
- Stress, Healthy, Dietary Supplement
- Trial name
- MENTAkHEALTH (NCT05738746)
- Testing
- Pasteurized Akkermansia muciniphila
- Where
- 2 sites in Poland
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Healthy
Pizza Meal Challenge and Immunometabolism (PIMETA)
High salt intake is a major risk factor for cardiovascular events, including stroke, heart disease and kidney failure. Pizza is a popular salty food.
- Trial name
- PIMETA (NCT04175249)
- Testing
- Pizza meal challenge
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Dietary Intervention, Gut Microbiota
Phenolic Dependent And Independent Effects Of Whole Grain Sorghum On Immunometabolism
Sorghum is a nutrient-dense ancient grain that, when eaten as a whole grain, provides health-beneficial dietary fiber, protein, and phenolics.
- Conditions
- Dietary Intervention, Gut Microbiota, Insulin Sensitivity/Resistance, Obesity & Overweight
- Trial name
- NCT07832071
- Testing
- Whole grain sumac sorghum, Whole grain white sorghum, White rice
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Normobaric Hypoxia, Hypoventilation
Influence of Hypoxic, Normobaric and Hypobaric Training on the Immunometabolism of Post-covid-19 Athletes
COVID-19 has significantly impacted sports globally, with event postponements, training disruptions, and wide-ranging concerns. SARS-CoV-2 infection can result in hyperinflammation and cardiopulmonary changes, with hypoxia as an…
- Conditions
- Normobaric Hypoxia, Hypoventilation, Normoxia
- Trial name
- NCT06128941
- Testing
- Repeated sprint
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
No Condition, Assessment of Healthy Volunteers
Immunometabolism of Exercise
This study aims to examine the effects of acute aerobic exercise and cardiorespiratory fitness on cellular metabolism of CD8+ T cells and regulatory T cells (Tregs) found in the peripheral blood of humans.
- Trial name
- IMEX (NCT07188389)
- Testing
- Acute exercise-moderate intensity, Acute effects-heavy intensity
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Houston
Endoplasmic Reticulum Stress, Viral Infection
Modulate Cellular Stress in the Immune Cells to Reduce Rate of Symptomatic Viral Infection
To determine the efficacy of metformin in reducing the rate of symptomatic YF17D infection, and to elucidate the effects of metformin on YF17D viremia and the downstream adaptive immune response, we hereby propose a randomised…
- Conditions
- Endoplasmic Reticulum Stress, Viral Infection, Yellow Fever
- Trial name
- NCT04267809
- Testing
- Metformin Hydrochloride, Calcium and Vitamin D
- Where
- Singapore
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Obesity, Metabolic Syndrome
Lipoproteins and ImmunoMetabolism
Dietary interventions have been consistently proposed as a part of a comprehensive strategy to lower the incidence and severity of atherosclerosis and cardiovascular diseases (CVD).
- Conditions
- Obesity, Metabolic Syndrome, Metabolism Disorder, Inflammation
- Trial name
- NCT05746013
- Testing
- Lipid Emulsion
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Seville
Fragility
Biological Markers of Functional Effects of Physical Activity in an Elderly Population
Circulating biomarkers are promising tools for the early diagnosis of aging-associated pathologies. Inflammation and immunity are associated with the risk of sarcopenia and frailty in elderly patients.
- Trial name
- BIO-APAS (NCT04080063)
- Testing
- adapted physical activity
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Fasting
The Meta-SHIFT Study: How Metabolic Shift Shapes Human Immunometabolism - a Fasting Trial
During fasting, the body shifts from using carbohydrates to relying more on fat as its main source of energy. This process is known as the 'metabolic shift'.
- Trial name
- Meta-SHIFT (NCT07527208)
- Testing
- Fasting
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cornell University
Fasting, Immune Function
The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults
Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans.
- Conditions
- Fasting, Immune Function, Glucose Tolerance
- Trial name
- FASTEX (NCT06737224)
- Testing
- Fasting + Exercise (FAST+EX): fasting + exercise condition, Fasting only (FAST): Non-exercise fasting condition
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Immunometabolism, Mitochondrial Function, Bioenergetics
Independent and Combined Effects of Short-term Sulforaphane Supplementation and Exercise on Immunometabolism in Healthy Adults
The study consist of 3 interventional periods which will be completed by each consenting participant in a randomized, crossover fashion. The interventional periods will be separated by a minimum 1 week washout period.
- Conditions
- Immunometabolism, Mitochondrial Function, Bioenergetics, Inflammation
- Trial name
- EXSFN (NCT07668596)
- Testing
- Sulforaphane-rich Broccoli Sprout Extract, High Intensity Interval Treadmill Running
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia