Clinical trials: Immunology
Herpes Zoster, Allergy and Immunology
Training the Innate Immune System Against SARS-CoV-2 (COVID-19) Using the Shingrix Vaccine in Nursing Home Residents
The purpose of this study is to measure the effect of the Shingrix vaccine on your immune system and whether that has any effect on the body's ability to fight off other infections such as COVID-19.
- Conditions
- Herpes Zoster, Allergy and Immunology, Corona Virus Infection
- Trial name
- NH-Shingrix (NCT04523246)
- Testing
- SHINGRIX (Zoster Vaccine REcombinant, Adjuvanted), Normal Saline
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Plasmapheresis, Haematology
Plasmapheresis: a Multi-modal Approach
Only very few studies have prospectively looked at the effect of repeated intensive plasma donation. In collaboration with the Rode Kruis Vlaanderen, we have recently found that repeated whole blood donation with a 3-month…
- Conditions
- Plasmapheresis, Haematology, Sport Performance, Body Composition
- Trial name
- NCT05815615
- Testing
- Plasmapheresis
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Aging, Immunology
Peri-operative Inflammaging in the Elderly After Surgery
The population older than 80 years will significantly increase in the near future. Older patients' cognitive and physical status is known to deteriorate after surgery, leading to a high 30-day mortality due to post-operative…
- Conditions
- Aging, Immunology, Postoperative Complications, Surgery
- Trial name
- POPIMAGE (NCT05368896)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University of Bonn
Acute Pancreatitis, Exocrine Pancreatic Insufficiency
Exocrine Pancreatic Insufficiency After Acute Pancreatitis and Pancreatic Enzyme Replacement Therapy
Acute pancreatitis represents an acute inflammatory process of the pancreas, which undergoes local and systemic complications, associated with non-negligible morbidity and mortality, and significant economic and quality of life…
- Conditions
- Acute Pancreatitis, Exocrine Pancreatic Insufficiency, Gut Microbiota, Immunology
- Trial name
- NCT05480241
- Testing
- Pancreatic Enzyme Replacement Therapy
- Where
- Portugal
- Volunteers
- 84 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Helicobacter Pylori, Gut Microbiota
Helicobacter Pylori Eradication Therapy in Portugal
Helicobacter pylori (H. pylori) infection remains a major public health problem, with an estimated prevalence of over 50% worldwide and 60-86% for Portugal. H.
- Conditions
- Helicobacter Pylori, Gut Microbiota, Immunology
- Trial name
- NCT05449028
- Testing
- H. pylori eradication scheme A, H. pylori eradication scheme B, H. pylori eradication scheme C
- Where
- Portugal
- Volunteers
- 230 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Covid19 Immunology
The COVID-19 PUI Reality Check (CPRC) Study
This study compares SARS-CoV-2 immune responses in high pretest probability swab negative hospitalized PUI patients vs. low pretest probability swab negative hospitalized APS (Asymptomatic Persons being Screened) patients to try…
- Trial name
- CPRC (NCT04474288)
- Testing
- SARS-CoV-2 antibody testing
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Bassett Healthcare
Nutrition Immunology
Cranberry Supplementation, Viral Defense, Antibody Response to the Flu Shot
This study will investigate the effect of 8-weeks cranberry supplementation on the antibody response to influenza vaccination and ex-vivo anti-viral activity.
- Trial name
- NCT04597554
- Testing
- Cranberry
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Immunotherapy, Allergy and Immunology
MAPS & ITEC Cohorts: 6-8 Years Follow-up
This study represents the follow-up, age 6-8 years, of children recruited at birth into two cohorts. The first cohort, the Mite Allergen Prevention Study (MAPS) was a double-blind, randomized controlled trial of the use of house…
- Conditions
- Immunotherapy, Allergy and Immunology, Asthma
- Trial name
- NCT03763630
- Testing
- House dust-mite SLIT, Normal saline
- Where
- 2 sites in United Kingdom
- Volunteers
- 263 people
- Sponsor
- University of Southampton
Radiotherapy, Immunology
Evaluation of the Immunological Effects of a Combined Treatment With Radiation and Cyclophosphamide in Metastasized Breast Cancer Patients
In metastasized of locally advanced breast cancer patients, local problems often occur like skin metastases, ulcerations or lymph node metastases.
- Trial name
- NCT02441270
- Testing
- Cyclophosphamide, Stereotactic body radiotherapy
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Allergy and Immunology
An Investigator-initiated, Explorative Trial Evaluating the Effect of SAT-008 in Healthy Adults
The purpose of this exploratory study is to evaluate the efficacy, safety, and feasibility of a novel digital device called SAT-008 in healthy adults.
- Trial name
- SAT-008 (NCT04916145)
- Testing
- SAT-008
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Allergy and Immunology, Infection Viral
Evaluation of Immune Response in COVID-19 Patients
The aim of the project is to evaluate the immunological features of COVID-19 patients. Patients are recruited without any pharmacological treatments restriction.
- Trial name
- IMMUNOVID (NCT04438629)
- Testing
- COVID-19 treatment
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Immunology, Nephrology
Immune Response to Influenza Vaccine in ESRD Patients
On-line hemodiafiltration (HDF) clears more azotaemic toxins compared to high-flux hemodialysis (HD). The response to vaccination is impaired in dialysis patients.
- Trial name
- NCT04122222
- Testing
- Influenza vaccine
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Kidney Transplantation, Rituximab (RTx)
Impact of Rituximab (RTx) Induction and Living Donation on Immunoregulation and Virus Control in Renal Transplantation
This project comprises immunological and virological analyses within a prospective clinical study of Rituximab (Rtx)-treated blood group incompatible living donor (LD) renal transplant recipients compared to blood group…
- Conditions
- Kidney Transplantation, Rituximab (RTx), Living Donors, Immunology
- Trial name
- NCT01136395
- Testing
- Rituximab, living donor transplantation, deceased donor transplantation
- Where
- Germany
- Volunteers
- 85 people
- Sponsor
- University of Giessen
Breast Cancer, Triple Negative Breast Cancer
Emotions Immunology and Breast Cancer
Pilot study representing a proof of concept regarding the potential for immune system enhancement with psychotherapy, resulting in improved immunological response at lumpectomy or mastectomy in patients undergoing neoadjuvant…
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, Emotions, Immunology
- Trial name
- NCT03609671
- Testing
- Standard of Care + Experimental Individualized Therapy, Control: Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Luz A. Venta, MD
Immunology
ABO Blood Group Antibody Elimination by a Combination of Semiselective Immunoadsorption Therapy and Membrane Filtration
Recipient desensitization protocols were shown to enable successful living donor kidney transplantation across major ABO blood group barriers.
- Trial name
- NCT01698736
- Testing
- Membrane filtration, Semiselective IA
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
IBD, Immunology
Immunological Profiles in Inflammatory Bowel Disease
Inflammatory Bowel Diseases (IBD) is a heterogeneous group of diseases regarding clinical presentation, disease course and treatment response.
- Conditions
- IBD, Immunology, Crohn Disease, Ulcerative Colitis
- Trial name
- ImmunoIBD (NCT03366090)
- Testing
- Biopsies during coloscopy
- Where
- Netherlands
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Hepatitis C, Liver
Study Investigating Immunological Effects of Treatment for Chronic Hepatitis C Patients.
Aim To evaluate the effects of peginterferon and ribavirin therapy on the immune response in chronic HCV genotype 1,2 or 3 patients before, during and after treatment.
- Conditions
- Hepatitis C, Liver, Immunology, Regulation
- Trial name
- CIRES (NCT00422838)
- Testing
- fine-needle aspiration biopsy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Foundation for Liver Research
Allergy and Immunology
Escalating Single Dose Study of Epsi- Gam in Healthy Normal Subjects
This is a single-center, randomized, double-blind, placebo-controlled, single-dose, dose- escalation study in otherwise healthy cat-, dust mite-, or Bermuda grass-allergic male and female subjects.
- Trial name
- NCT02559258
- Where
- Australia
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Tunitas Therapeutics, Inc.
Immunology of Septic Shock
Evaluation of Immunosuppression in Septic Shock: Biomarkers and Pharmacological Restoration (IMMUNOSEPSIS)
Septic syndromes (systemic inflammatory response associated with infection) remain a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units.
- Trial name
- IMMUNOSEPSIS (NCT02803346)
- Testing
- Circulating blood (leukocytes)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Kidney Transplantation, Transplantation Immunology
A Randomized Study to Assess the Safety and Efficacy of Prograf vs Prograf-XL in de Novo Kidney Transplant Recipients
The purpose of this study is to compare the efficacy and safety of Prograf extended release(XL) plus MMF with Prograf plus MMF in de novo kidney transplant recipients.
- Conditions
- Kidney Transplantation, Transplantation Immunology, Host vs Graft Reaction
- Trial name
- NCT00717678
- Testing
- Prograf-XL, Prograf, MMF
- Where
- 5 sites in Taiwan
- Volunteers
- 73 people
- Sponsor
- Astellas Pharma Inc