Clinical trials: Immune-Inflammatory
Type II Diabetes, Periodontal Disease
Periodontal Treatment Response in Type II Diabetic Patients
Diabetes mellitus affects > 171 million people worldwide, with type II diabetes being the most prevalent, affecting 85-95% of the diabetic population.
- Trial name
- NCT01881074
- Testing
- Triclosan containing toothpaste, Non-triclosan containing toothpaste
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Florida
CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
Subcutaneous Immunoglobulin Therapy Effectiveness Monitoring in CIDP Patients Using Smart Devices
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare autoimmune disease that affects the peripheral nerves. It causes progressive weakness and sensory loss in the arms and legs, which can severely limit daily…
- Trial name
- STEPS (NCT07273903)
- Where
- 2 sites in Germany
- Volunteers
- 35 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Human Immunodeficiency Virus, Immune Reconstitution Inflammatory Syndrome
Pediatric Urgent Start of Highly Active Antiretroviral Treatment (HAART)
Design: Randomized clinical trial involving hospitalized HIV-1 infected children. Children will be randomized to randomized to urgent (<48 hours) versus early antiretroviral therapy (7-14 days). This trial will be unblinded.
- Trial name
- PUSH (NCT02063880)
- Testing
- Urgent ART, Early ART
- Where
- 4 sites in Kenya
- Volunteers
- 183 people
- Sponsor
- University of Washington
CIDP, Chronic Inflammatory Demyelinating Polyneuropathy
Lipoic Acid to Treat Chronic Inflammatory Demyelinating Polyneuropathy
The purpose of the study is to examine if alpha lipoic acid is an effective treatment for chronic inflammatory demyelinating polyneuropathy (CIDP).
- Trial name
- NCT00962429
- Testing
- lipoic acid
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Oregon Health and Science University
Healthy, Sepsis
The Role of the Microbiota in the Systemic Immune Response
The objective of this study is to investigate the role of the gut microbiota in the systemic priming of immune effector cells. Twelve healthy male volunteers, 18-35 years of age, will be treated with broad spectrum antibiotics…
- Trial name
- MISSION-1 (NCT02340182)
- Testing
- Vancomycin, Ciprofloxacin, Metronidazole
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- W.J. Wiersinga, MD, PhD
Rheumatoid Arthritis
Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis
The primary objective of this study is to assess the feasibility of an intensive, remotely-delivered, combined aerobic and resistance training exercise program for patients with Rheumatoid Arthritis (RA) and to collect data to…
- Trial name
- TRAINERa (NCT06841562)
- Testing
- TRAINERa intensive exercise training
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Cryopyrin-Associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome
Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease
This will provided long-term safety and efficacy data for ACZ885 (a fully human anti-interleukin-1β [anti-IL-1β] monoclonal antibody) given as an injection subcutaneously in patients who participated in the CACZ885A2102…
- Conditions
- Cryopyrin-Associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome, Muckle Wells Syndrome, Neonatal Onset Multisystem Inflammatory Disease
- Trial name
- NCT00685373
- Testing
- Canakinumab (ACZ885)
- Where
- 28 sites in United States, Belgium and 7 more
- Volunteers
- 166 people
- Sponsor
- Novartis
Multiple Sclerosis
Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis
Background: Multiple sclerosis (MS) is a disease of the central nervous system (CNS). People who have MS may have lesions that form on parts of the CNS, such as the brain. Some of these lesions may be inflamed for a long time.
- Trial name
- NCT04025554
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Myeloma
Efficacy of NF-kB Inhibition for Reducing Symptoms During Maintenance Therapy in Multiple Myeloma Patients
The goal of this clinical research study is to learn if curcumin can reduce the symptoms reported by patients with multiple myeloma (MM) who receive treatment with lenalidomide.
- Trial name
- NCT01269203
- Testing
- Curcumin
- Sponsor
- M.D. Anderson Cancer Center
Juvenile Idiopathic Arthritis
Assessment of Composite Inflammatory Ratios in Juvenile Idiopathic Arthritis and Their Association With Disease Activity
Juvenile Idiopathic Arthritis (JIA) is a prevalent pediatric rheumatic disorder characterized by persistent inflammation of one or more joints in children and adolescents.
- Trial name
- NCT07083466
- Testing
- complete blood count, serum albumin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Immune Reconstitution Inflammatory Syndrome, HIV
Maraviroc (CCR5) Antagonism to Decrease the Incidence of the Immune Reconstitution Inflammatory Syndrome in HIV-Infected Patients
The purpose of this study is to determine if Maraviroc administration can decrease IRIS incidence in HIV infected patients initiating ARV therapy.
- Conditions
- Immune Reconstitution Inflammatory Syndrome, HIV, HIV Infections
- Trial name
- CADIRIS (NCT00988780)
- Testing
- maraviroc
- Where
- 10 sites in United States, Mexico and 1 more
- Volunteers
- 276 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Severe Sepsis
Alterations of Immunologic Mediators During Severe Sepsis
Severe sepsis induces significant changes in expression of insulin- and toll-like receptors, cytokines, markers of apoptosis, and activation of t- and b-lymphocytes.
- Trial name
- LAVISS_01 (NCT00484146)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Klinikum St. Georg gGmbH
Immune Reconstitution Inflammatory Syndrome, HIV
Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone
Tuberculosis (TB) is the most common opportunistic infection amongst HIV-infected patients starting antiretroviral therapy (ART) in developing countries and thus the most frequent form of immune reconstitution inflammatory…
- Conditions
- Immune Reconstitution Inflammatory Syndrome, HIV, Tuberculosis
- Trial name
- Pred-ART (NCT01924286)
- Testing
- Prednisone
- Where
- South Africa
- Volunteers
- 240 people
- Sponsor
- University of Cape Town
Chronic Inflammatory Demyelinating Polyneuropathy
Study of Efficacy and Safety of Privigen in Subjects With Chronic Inflammatory Demyelinating Polyneuropathy
The objective of this study is to demonstrate the efficacy and safety of Privigen in subjects with CIDP.
- Trial name
- NCT01184846
- Testing
- 10% liquid formulation of human immunoglobulin
- Where
- 22 sites in Belgium, Finland and 3 more
- Volunteers
- 31 people
- Sponsor
- CSL Behring
Ankylosing Spondylitis, Autoimmune Disease
Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors
This study learn how easily patients can use an educational tool that will be created for patients with melanoma and pre-existing autoimmune diseases who receive or will receive immune checkpoint inhibitor drugs.
- Conditions
- Ankylosing Spondylitis, Autoimmune Disease, Crohn Disease, Enteropathic Arthritis
- Trial name
- NCT04751396
- Testing
- Best Practice, Educational Intervention, Interview
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- M.D. Anderson Cancer Center
Rheumatoid Arthritis, Inflammatory Rheumatism
Observational Study in Patients Treated With JAK Inhibitors for Inflammatory Rheumatism (MAJIK)
Janus kinase (JAK) inhibitors are a new class of molecules available to the therapeutic arsenal for chronic inflammatory rheumatic diseases.The tolerance profile of this new class needs to be better defined and its use in real…
- Conditions
- Rheumatoid Arthritis, Inflammatory Rheumatism, Psoriatic Arthritis, Spondyloarthritis
- Trial name
- MAJIK (NCT04602091)
- Testing
- no intervention
- Where
- 60 sites in France
- Volunteers
- 2,300 people
- Sponsor
- Societe Francaise de Rhumatologie
Critical Illness, Infection Complication
A Trial of Enteral Colostrum on Clinical Outcomes in Critically Ill Patients
Enteral administration of immune-modulating nutrients such as glutamine, omega-3 fatty acids, selenium, and antioxidants has been suggested to reduce infections and improve recovery from critical illness.
- Conditions
- Critical Illness, Infection Complication, Multiple Organ Dysfunction Syndrome
- Trial name
- NCT03019250
- Testing
- Colostrum, Maltodextrin
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- National Nutrition and Food Technology Institute
Systemic Lupus Erythematosus, Rheumatoid Arthritis
A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune Diseases
The purpose of this study is to learn about the safety and effects of the study medication called PF-08154225 for the potential treatment of autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus, Rheumatoid Arthritis, Idiopathic Inflammatory Myositis, Systemic Sclerosis
- Trial name
- NCT07782450
- Testing
- PF-08154225
- Volunteers
- 54 people
- Sponsor
- Pfizer
Long COVID
Clinical Trial on a Natural Compound to Improve Chronic Inflammation After SARS-CoV-2 Infection
A controlled, randomized clinical trial is proposed to demonstrate the effectiveness of the experimental product in controlling hepato-pulmonary inflammation and neurovascular encephalic inflammation, which may constitute the…
- Trial name
- NUTRACOVID (NCT07397910)
- Testing
- Experimental Product, Physical exercise, No Physical Exercise
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Inflammatory Arthritis, Spondylarthropathies
Assessing Pain by the painDETECT Questionnaire (PDQ)
Prospective cohort study using drug survival rates to assess the predictive value of the PDQ when used to classify patients into a non-neuropathic pain phenotype group (score <13) or a neuropathic pain phenotype group (score ≥13)
- Conditions
- Inflammatory Arthritis, Spondylarthropathies, Rheumatoid Arthritis, Psoriatic Arthritis
- Trial name
- NCT06402396
- Testing
- bDMARDS
- Volunteers
- 7,056 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg