Clinical trials: Immune Suppression
Schizophrenia and Related Disorders, Immune Suppression
The Norwegian Prednisolone in Early Psychosis Study
Objective: The primary objective of this trial is to investigate whether prednisolone improves symptom severity as compared to placebo when given in addition to antipsychotic medication to patients with early-stage psychotic…
- Conditions
- Schizophrenia and Related Disorders, Immune Suppression, Psychosis, Cognitive Change
- Trial name
- NorPEPS (NCT03340909)
- Testing
- Prednisolone
- Where
- 3 sites in Norway
- Volunteers
- 12 people
- Sponsor
- Haukeland University Hospital
Anesthesia Complication, Immune Suppression
Depth of Anesthesia and Proteomics
The primary aim of the study is to compare cellular activity of T-cells, NK-cells and monocytes after anesthesia. Phagocytosis and cellular lysis activity of neutrophils and monocytes are analyzed by flow cytometry.
- Trial name
- NCT05380778
- Testing
- Deep anesthesia, Shallow anesthesia
- Volunteers
- 18 people
- Sponsor
- Heidelberg University
Pneumoperitoneum, Neuromuscular Blockade
The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Innate Immune Homeostasis.
Substudy of the RECOVER trial (a randomised controlled trial comparing the effect of low pressure pneumoperitoneum with deep neuromuscular block versus normal pressure pneumoperitoneum with moderate neuromuscular block during…
- Conditions
- Pneumoperitoneum, Neuromuscular Blockade, Surgery, Immune Suppression
- Trial name
- RECOVER-PLUS (NCT03572413)
- Testing
- Low pressure pneumoperitoneum, Rocuronium bromide
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Immune System Suppression
Effect of Intrathecal Morphine, Dexmedetomidine or Both in Combination to Bupivacaine on Immunity
this work aims to investigate the effect of intrathecal administration of Morphine, Dexmedetomidine or both in combination on cellular immunity and cytokine production in patients undergoing major abdominal cancer surgeries.
- Trial name
- NCT03024957
- Testing
- Morphine Sulfate, Dexmedetomidine, Bupivacaine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Oxidative Stress, Muscle Strength
The Short Term Effects of Oceanix Supplementation on Recovery
The purpose of this study will be to examine the effects of Oceanix supplementation on isometric mid-thigh pull force kinetics and salivary immunoglobulin A (indice of immune function) following a one-week intense resistance…
- Conditions
- Oxidative Stress, Muscle Strength, Resistance Training, Muscle Damage
- Trial name
- NCT04315077
- Testing
- Oceanix®, Resistance Training
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Immune Suppression
The Immune Modulation of Bilateral Paravertebral Block and Propofol in Spine Surgery.
General anesthesia has an important effect on inflammatory cytokines. Inhalational agents as isoflurane and sevoflurane attenuate immune function expressed by neutrophil chemoattractant-1 as well as inflammatory enzyme and also…
- Trial name
- NCT03437213
- Testing
- Total intravenous anesthesia group, Total intravenous plus block group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alaa Mazy Mazy
Fasting, Immune Suppression
Effects of Fasting Strategies on Postoperative Recovery and Long-term Prognosis in Patients With Colorectal Cancer
In 2018, colorectal cancer is the third most common malignant tumor in terms of morbidity and second mortality in the world. Surgical resection is still the main treatment for colorectal cancer.With the introduction of the ERAS…
- Conditions
- Fasting, Immune Suppression, Complication of Surgical Procedure, Colorectal Cancer
- Trial name
- NCT04345978
- Testing
- Fasting hours
- Where
- 7 sites in China
- Volunteers
- 2,400 people
- Sponsor
- Fudan University
Immune Suppression, Immune Deficiency
Coronavirus Infection in Primary or Secondary Immunosuppressed Children and Adults.
A weekly questionnaire is sent to patients and parents of patients who are vulnerable for infections. Possible symptoms of COVID19 are asked for and use of healthcare services and testing for COVID19.
- Conditions
- Immune Suppression, Immune Deficiency, Infection, COVID
- Trial name
- ImmunoCOVID (NCT04382508)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Liver Dysfunction, Immune Suppression
Optimizing HBV Management During Anti-CD20 Antibodies
Hepatitis B virus (HBV) reactivation is common during anti-CD20 containing chemotherapy, even in HBsAg-negative patients with only prior HBV exposure.
- Conditions
- Liver Dysfunction, Immune Suppression, Hepatitis B
- Trial name
- NCT03155984
- Testing
- Anti-CD20 antibody
- Where
- Hong Kong
- Volunteers
- 83 people
- Sponsor
- The University of Hong Kong
Inflammatory Response, Metabolic Disturbance
Blueberries, Bananas, Exercise Recovery
The PURPOSE of this study is to investigate the combined influence of 2-weeks blueberry ingestion and banana ingestion (during exercise) on performance and in mitigating metabolic perturbation, immune dysfunction, and increase in…
- Conditions
- Inflammatory Response, Metabolic Disturbance, Immune Suppression
- Trial name
- NCT03445234
- Testing
- Blueberry, banana, No banana
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Sepsis, Sleep Deprivation
the Relationship of the Use of Eye Masks and Outcomes of Patients With Sepsis in Intensive Care Unit
The aim of the study is to investigate the relationship of nocturnal use of eye masks and immune function, cerebral function and outcomes of patients with sepsis.
- Conditions
- Sepsis, Sleep Deprivation, Immune Suppression
- Trial name
- NCT02304224
- Testing
- eye masks
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital