Clinical trials: Immune Responses
Immune System, Innate Inflammatory Response
Evaluation of the Effects of Routine Intake of Fresh vs- Pasteurized Yoghurt on the Immune System in Healthy Adults
In this study, the purpose was to describe and compare the modulator effects on the immune system of the routine ingestion of fresh vs. pasteurized yoghurt.
- Trial name
- YASI-03 (NCT06263686)
- Testing
- Pasteurised yoghurt, Fresh yoghurt, Sterilised yoghurt
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Valladolid
Measurement of Immune Response to Prevenar13, Measurement of Immune Response to Hepatitis A
PCV13 + Hepatitis A Vaccine for Adults
The present study explores whether a simultaneously given hepatitis A vaccine (Epaxal) will have an impact on the immune response to PCV13 (pneumococcal conjugate vaccine; Prevenar13) vaccine in adults.
- Trial name
- PCV13+HepA (NCT01926860)
- Testing
- Prevenar13, Hepatitis A vaccine
- Where
- 2 sites in Finland, Sweden
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Immune Response, Upper Respiratory Tract Infection
Walnut and Immunity Study
The main objective of the study is to determine if eating walnuts enhances immune function, in older free-living men and postmenopausal women with overweight.
- Trial name
- walnutimmune (NCT05915390)
- Testing
- walnuts, Habitual diet
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Immune Response, Cardiometabolic Risk Factors
Effects of Peanuts on Immunity and Cardiometabolic Risk Factors
The aim of the proposed study is two-fold: to determine whether the intake of peanuts (a) enhances immune function and (b) produces a desirable impact on selected cardiometabolic biomarkers and risk factors.
- Trial name
- NCT06159556
- Testing
- Peanut intake
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Immune Response
Study to Evaluate the Ability of Sublingual MV130 to Induce the Expression of Trained Immunity in Peripheral Blood Cells
A mechanistic clinical trial with the aim to evaluate whether MV130 can induce the expression of a particular immune response (trained immunity) in peripheral blood cells.
- Trial name
- NCT05208060
- Testing
- MV130
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Inmunotek S.L.
Solid Tumor, Immune Response
Clinical Study on Intraluminal Injection of FOLactis
This clinical study is a single arm, prospective, single center clinical study on the safety, tolerability, and preliminary efficacy of a novel FOLactis in situ vaccine in the treatment of advanced solid tumors with malignant…
- Conditions
- Solid Tumor, Immune Response, Pleural Effusion, Malignant, Peritoneal Effusion
- Trial name
- NCT06512896
- Testing
- FOLactis
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
COVID19, Vaccination
Spike-specific Cellular Immune Response After COVID-19 Vaccination
Aim of this study is to evaluate whether COVID-19 vaccination induces a persistent cellular immune response. To this aim, blood samples are taken from vaccinated individuals and not immunized subjects as a control group.
- Conditions
- COVID19, Vaccination, Immune Response
- Trial name
- RIS-COV (NCT05102669)
- Testing
- analysis of immunological response, analysis of serum antibodies
- Where
- Italy
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Immune Response, Safety
Immunogenicity and Safety of Concomitant Administration of Bivalent COVID-19 Vaccines With Influenza Vaccines
The goal is to evaluate the immunogenicity and safety of coadministration of a bivalent BA.4/BA.5-adapted COVID-19 booster vaccine, and influenza vaccine among healthy adults during 2022-23 season.
- Trial name
- NCT05970887
- Testing
- bivalent BNT162b2 mRNA original/omicron BA.4-5 vaccine, quadrivalent influenza vaccine
- Where
- South Korea
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Catholic Kwandong University
Immune Response
Evaluation of the Effect of a Soluble Fiber Consumption on Immunity Response
At European level, the European Food Safety Agency has recognized two claims relating to the effects of prebiotics on the gastrointestinal sphere and on the immune system.
- Trial name
- NUTIVAC (NCT05313451)
- Testing
- Soluble fiber
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- CEN Biotech
Inflammatory Response, Metabolic Disturbance
Beet Supplementation, Exercise, Inflammation
This study will determine if ingesting a beet-based supplement with nitrates for 2 weeks moderates exercise-induced inflammation.
- Conditions
- Inflammatory Response, Metabolic Disturbance, Immune Suppression
- Trial name
- NCT05907135
- Testing
- Beet
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Chronic Pain, Central Sensitisation
Childhood Adversity, Inflammatory Reactivity and Persistent Pain
The goal of this observational study is to investigate how adverse experiences during childhood are linked to people experiencing persistent pain and fatigue in adulthood. The questions the investigators aim to answer are: 1.
- Conditions
- Chronic Pain, Central Sensitisation, Immune Response, Adverse Childhood Experiences
- Trial name
- CAIR (NCT06127693)
- Testing
- Tetravalent Influenza Vaccine, High-frequency electrical stimulation
- Where
- South Africa
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Immune Response
LIFEHOUSE: Description of the Tent Bucket -Immune Support
This immune support program will be an extension to the existing LIFEHOUSE program. Essential employees in Gig Harbor, WA; Colonial Heights, VA; Lenexa, KS, and Santa Fe Springs, CA, will be offered complimentary supplementation…
- Trial name
- LIFEHOUSE (NCT04734288)
- Testing
- Vit.D3 5000 IU, Immune Active
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Steatosis of Liver, Sepsis
The Role of Immune Semaphorins in Steatotic Liver Disease and Sepsis
The impact of the complex liver immunological network on sepsis outcome is largely unknown. Steatotic liver disease (SLD) is the most common chronic liver disease with prevalence of 25% in European countries.
- Conditions
- Steatosis of Liver, Sepsis, Immune Response
- Trial name
- SepsisFAT (NCT06021743)
- Testing
- Evaluation of the degree of steatosis, Screening for the components of metabolic syndrome, Measurement of serum semaphorin concentrations
- Where
- Croatia
- Volunteers
- 160 people
- Sponsor
- University Hospital for Infectious Diseases, Croatia
Non-Alcoholic Fatty Liver Disease, Immune Response
The Role of Immune Semaphorins in NAFLD
To goal is to identify semaphorins that are associated with NAFLD and to investigate their relationship with variable degrees of steatosis and fibrosis.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Immune Response, Biomarkers, Liver Fibrosis
- Trial name
- SepsisFAT (NCT04573543)
- Testing
- Evaluation of the degree of fibrosis and steatosis, Screening for the components of metabolic syndrome, Measurement of serum semaphorin concentrations
- Where
- Croatia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital for Infectious Diseases, Croatia
Immune Response
Snack Foods and Their Impact on the Immune Response Following Influenza Vaccination
The purpose of this study is to evaluate the impact of replacing usual snacks with alternative snack foods on the immune response to influenza vaccination in a population of healthy, middle-aged adults.
- Trial name
- NutrImmune (NCT05515263)
- Testing
- Intervention snack, Control snack
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- King's College London
Inflammatory Response, Metabolic Disturbance
Astaxanthin, Exercise Inflammation, Skin Health
Vigorous exercise can stress the body. Consuming special types of diet supplements may help the body recover better from exercise.
- Conditions
- Inflammatory Response, Metabolic Disturbance, Immune Suppression
- Trial name
- NCT05409092
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Immune Response
KLH Challenge to Explore the Human Immune Response
One approach to improve the efficiency of the drug development process is the use of human 'immune challenge' studies. In these studies, healthy volunteers are given small amounts of substances which are foreign to their immune…
- Trial name
- NCT05876195
- Testing
- Keyhole-Limpet Hemocyanin, Saline, Montanide ISA 51 VG
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Liver Transplant; Complications, Infections
Inflammatory and Anti-Inflammatory Gene Expressions in Liver Transplant Patients
In our study, some inflammatory Interleukin-2 , Interleukin-6, Interferon-γ, Tumor Necrosis Factor-α and anti-inflammatory Interleukin-4 and Interleukin-10 cytokine genes expressions and Triggering Receptor Expressed On Myeloid…
- Conditions
- Liver Transplant; Complications, Infections, Gene Amplification, Immune Response
- Trial name
- NCT05852964
- Testing
- Molecular Immunology , gene expressions
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Inonu University
Immune Response
Comparative Analysis of Anti-COVID-19 (Severe Acute Respiratory Syndrome) Humoral and Memory T Cell Responses in Children With Various Degrees of Immunosuppression:
Adaptive immune responses are essential for clearing viral infections and retention of virus specific memory populations is required for long-term immunity.
- Trial name
- PEDIMMCO (NCT04916847)
- Testing
- blood collection
- Where
- France
- Volunteers
- 205 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Safety of 25 ug of ChulaCov19-BNA159 mRNA Vaccine, Tolerability of 25 ug of ChulaCov19-BNA159 mRNA Vaccine
Safety and Immunogenicity of ChulaCov19 BNA159 mRNA Vaccine
This is a phase 1 study that will evaluate the safety and immunogenicity of ChulaCov19 BNA159 mRNA vaccine in healthy adults.
- Conditions
- Safety of 25 ug of ChulaCov19-BNA159 mRNA Vaccine, Tolerability of 25 ug of ChulaCov19-BNA159 mRNA Vaccine, Immune Response of 25 ug of ChulaCov19-BNA159 mRNA Vaccine, Safety of 50 ug of ChulaCov19-BNA159 mRNA Vaccine
- Trial name
- NCT05231369
- Testing
- ChulaCov19 BNA159 mRNA vaccine
- Where
- 2 sites in Thailand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University