Clinical trials: Immune Response
Sepsis
Immunity in Critical Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response to infection, and remains the leading cause of death in critical care medicine worldwide.
- Trial name
- NCT07770347
- Testing
- Individualized anti-infective therapy, Individualized immunomodulatory therapy, Individualized organ function support therapy
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- Beijing Chao Yang Hospital
Smallpox
Safety and Immunogenicity of CJ-50300
The currently available stock of smallpox vaccine would be insufficient in the face of an incident of smallpox attack. Thus, new manufacturing methods for smallpox vaccine is urgently needed because previous manufacturing methods…
- Trial name
- NCT00336635
- Testing
- cell-culture derived smallpox vaccine
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Human Anaplasmosis
Epidemiological, Clinical and Biological Characteristics of Human Anaplasmosis Cases in Alsace
Anaplasmosis is a bacterial infection caused by the intracellular bacterium Anaplasma phagocytophilum and transmitted by ticks. This bacterium is present in approximately 1% of ticks in Alsace.
- Trial name
- ANARETRO (NCT07312474)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Peripheral T Cell Lymphoma
Golidocitinib Versus Placebo as Maintenance Therapy in PTCL Patients With Response (CR/PR) After First-Line Chemotherapy
This is a multicenter, randomized, double-blind, phase III clinical study comprising two arms: a golidocitinib group and a placebo group.
- Trial name
- T-START-M1 (NCT07414758)
- Testing
- golidocitinib
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Follicular Lymphoma, Non-Hodgkin's Lymphoma
Response-Adapted Therapy With Copanlisib and Rituximab in Untreated Follicular Lymphoma
Background: The disease follicular lymphoma (FL) develops when the body makes abnormal B-cells. These cells usually build up in the lymph nodes, but can also affect other parts of the body.
- Conditions
- Follicular Lymphoma, Non-Hodgkin's Lymphoma, NHL
- Trial name
- NCT03789240
- Testing
- Rituximab, Copanlisib, Bone Marrow Aspiration/Biopsy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- National Cancer Institute (NCI)
Rheumatoid Arthritis
TORPEDO Study: A Study on Rapid Effect of Tocilizumab in Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) or Anti-TNF
This study will assess the onset and maintenance of effect of tocilizumab on relief in patients with active moderate or severe rheumatoid arthritis who have had an inadequate response to DMARDs or anti-TNF.
- Trial name
- NCT00977106
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 22 sites in France
- Volunteers
- 103 people
- Sponsor
- Hoffmann-La Roche
Initiation of Oral Contraception (OC), Initiation of Depo-Provera (DMPA)
Modulation of Mucosal and Systemic Immunity by Hormonal Contraceptives
The investigators are conducting a research study to understand how cells responsible for fighting infection (immune cells) are affected by hormonal contraceptive use.
- Conditions
- Initiation of Oral Contraception (OC), Initiation of Depo-Provera (DMPA), Initiation of Mirena (LNG-IUD)
- Trial name
- NCT01750476
- Testing
- Mirena, Oral contraception, Depo-Provera
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Thomas Cherpes, DVM, MD
Irritable Bowel Syndrome
Manipulation of Visceral Sensitivity and Immune System in IBS
Irritable bowel syndrome (IBS) is a common condition. At least 20% of the population suffer from IBS. The symptoms of abdominal pain, diarrhoea, constipation, bloating and difficulty with bowel motions are often disabling.
- Trial name
- NCT00418340
- Testing
- probiotic (bacterial/dietary supplement)
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- London North West Healthcare NHS Trust
Asthma
Inhalation of Corticosteroids in Smoking and Non-smoking Asthmatics.
People with asthma suffer from breathlessness because the small tubes (bronchioles) that carry air in and out of the lungs become inflamed and narrow.
- Trial name
- NCT01400906
- Testing
- 100 micrograms Fluticasone propionate, 500 micrograms Fluticasone propionate, lactose powder
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 36 people
- Sponsor
- GlaxoSmithKline
Multiple Sclerosis, Covid19
Estimating Prevalence of COVID-19 Infection and SARS-CoV-2 Antibodies in MS Patients
This non-interventional, biospecimen collection study is designed to help us better understand whether MS patients have impaired immune defenses to COVID-19 infection.
- Trial name
- NCT04682548
- Where
- United States
- Volunteers
- 920 people
- Sponsor
- NYU Langone Health
COVID-19 Pandemic, SARS-CoV2 Infection
Hacettepe University COVID-19 Vaccinated's Health Cohort- Students of Health Sciences
The first COVID-19 case in Turkey was reported on March 11, 2000. National COVID-19 mass vaccination was initiated on Jan 13, 202, with two doses of CoronaVac (R) inactivated vaccine (of Sinovac), 28 days apart.
- Conditions
- COVID-19 Pandemic, SARS-CoV2 Infection, Immunization; Infection, Health
- Trial name
- HU-CoVaCS (NCT05104385)
- Testing
- Observational, prospective, follow-up of the recipients of CoronaVac (inactivated), Pfizer-Biontech (mRNA) vaccines
- Where
- Turkey (Türkiye)
- Volunteers
- 1,223 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Solid Tumor
A Clinical Study on LM103 Injection for the Treatment of Advanced Solid Tumors
This study is an open exploratory clinical study to evaluate the safety, tolerance, immune response, and initial efficacy of autologous tumor infiltrating lymphocyte LM103 injection in advanced solid tumor patients.
- Trial name
- NCT05971589
- Testing
- LM103
- Volunteers
- 5 people
- Sponsor
- Suzhou BlueHorse Therapeutics Co., Ltd.
Chronic Obstructive Pulmonary Disease
Innate Immune Responses in Chronic Obstructive Pulmonary Disease (COPD) Patients
We hypothesize that ongoing and more severe airway inflammation in COPD may result from the impairment in activation of innate immune response
- Trial name
- NCT00826163
- Testing
- Budesonide
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Mahidol University
HIV Infections, Hepatitis B
Safety of and Immune Response to a Hepatitis B Virus Vaccine Given With a Booster (CpG7909 ODN) in HIV Infected and HIV Uninfected People
The purpose of the study is to determine the safety of and immune response to a hepatitis B virus vaccine series given with a boosting agent, CpG7909 oligodeoxynucleotides (ODN), in HIV infected and HIV uninfected individuals who…
- Trial name
- NCT00100633
- Testing
- CpG7909 oligodeoxynucleotides (ODN), Hepatitis B virus vaccine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumococcal Infection
Systems Biology of PNEUMOVAX®23 and PREVNAR 13®
Vaccination is the most effective way of preventing infectious diseases. Despite the success of vaccines in general, vaccines induce diminished antibody responses and lower protection in the elderly in particular.
- Trial name
- NCT01307449
- Testing
- PNEUMOVAX, Prevnar
- Where
- 2 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Emory University
Pulmonary Disease, Chronic Obstructive, Lung Diseases
Innate and Adaptive Immunity in Individuals Experiencing Chronic Obstructive Pulmonary Disease Exacerbations
The purpose of this study is to determine whether there is a statistical association between the changes from baseline in the levels of two cytokines interleukin (IL)-17A and IL-6 in the sputum of patients with chronic…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Lung Diseases, Lung Diseases, Obstructive
- Trial name
- NCT00281216
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Asthma
Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation
Purpose: The primary objective of this study is to examine the effectiveness of anakinra as a rescue treatment for allergic airway inflammation.
- Trial name
- LateAna (NCT03513458)
- Testing
- Anakinra, Dermatophagoides Farinae
- Sponsor
- University of North Carolina, Chapel Hill
Rheumatoid Arthritis (RA)
Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)
Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function.
- Trial name
- NCT04888585
- Testing
- ABBV-154
- Where
- 220 sites in United States, Australia and 19 more
- Volunteers
- 473 people
- Sponsor
- AbbVie
Pneumonia, Pneumocystis Carinii, HIV Infections
A Double-Blind Group Comparative Study To Evaluate the Long-Term Safety and Effectiveness of Two Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients With Multiple Episodes of PCP
To evaluate and compare the safety, tolerability, and effectiveness of long-term biweekly administration of 1 of 2 doses of aerosol pentamidine when used as a prophylactic agent in patients who have had multiple episodes of AIDS…
- Trial name
- NCT00002055
- Testing
- Pentamidine isethionate
- Where
- 4 sites in United States
- Sponsor
- Fisons
Influenza, Human
VRC 309: A Multi-Center, Open-Label, Randomized Phase I Study of an Investigational Influenza DNA Vaccine Followed by 2009/2010 Seasonal Influenza Trivalent Inactivated Vaccine (TIV) Compared to Two Injections of TIV in Adults 45-70 Years
Background: Vaccines are substances used to try to create resistance or immunity to a disease and to prevent an infection. Investigators are looking into improved ways to give and test the results of different kinds of vaccines.
- Trial name
- NCT00995982
- Testing
- VRC-FLUDNA056-00VP
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)