Clinical trials: Immune Function
Migraine, Healthy
Molecular and Functional PET-fMRI Measures of Analgesia in Migraine
The placebo effect is a phenomenon that has experienced major advances of its understanding in the last decade. However, mechanisms of placebo analgesia in chronic pain patients have yet to be compared to healthy subjects.
- Trial name
- NCT01970943
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Systemic Lupus Erythematosus, Muscle Pain
Laser Therapy for Patients With Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that has detrimental effects on connective tissue and other organs.
- Conditions
- Systemic Lupus Erythematosus, Muscle Pain, Chewing Function
- Trial name
- NCT04453215
- Testing
- GaAlAs semiconductor diode laser device
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Dr. Merve Benli
HIV Infections
Perspective Memory and Executive Functions in HIV+ Patients
The primary goal of this observational study is to evaluate prospective memory in HIV+ patients compared to healthy subjects. The secondary goal is to examine the relationship between prospective memory and Hot Cognition…
- Trial name
- (3514) (NCT05752578)
- Testing
- Neuropsychological testing
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Vitamin D Deficiency
Immunologic Action of a Single Dose Cholecalciferol
Vitamin D receptors are expressed in activated different immune cells. It is not known, which immune cell type is targeted by exogenous vitamin D. Here, vitamin D-deficient individuals will receive once 100.000 I.U.
- Trial name
- ViDImmun (NCT01845142)
- Testing
- single administration of 100.000 I.U. vitamin D
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Margitta Worm
Psoriasis
Effect of Chronic Inflammation on Myocardial Perfusion and Function
Background: Heart failure (HF) is a public health burden. Studies have shown a link between inflammation, myocardial dysfunction, and HF.
- Trial name
- NCT04870827
- Testing
- 13N Amonia
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Healthy Volunteers
Effects of Consumption of Orange Juice on Vascular Protection and Immune Function: Clinical Study on the Specific Contribution of Citrus Flavanones
Epidemiological studies have firmly established the health effects of high intakes of fruits and vegetables and in particular in regards to the prevention of cardiovascular diseases.
- Trial name
- FLORIDE (NCT00983086)
- Testing
- Flavanones of orange juice
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Exercised Induced Asthma, Asthma
The Effects of Prebiotics on Gut Bacterial Parameters, Immune Function & Exercise-Induced Airway Inflammation.
The current study aims to explore the role of prebiotic supplementation in adults with and without Asthma/Exercise-Induced Bronchoconstriction (A/EIB).
- Trial name
- NCT02872675
- Testing
- HOST-DM059, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Incomplete Spinal Cord Injury, Transverse Myelitis
Ultrasound Imaging Based Sensing of Human Ankle Motion Intent and Control Strategies for Ankle Assistance
Robotic therapies aim to improve limb function in individuals with neurological injury. Modulation of robotic assistance in many of these therapies is achieved by measuring the extant volitional strength of limb muscles.
- Trial name
- NCT05249595
- Testing
- Surface electromypgraphy-based interface to predict human ankle joint motion intent and use in ankle assistive devices, Ultrasound imaging-based interface to predict human ankle joint motion intent and use in ankle assistive devices, Surface electromypgraphy and ultrasound imaging-based interface to predict human ankle joint motion intent and use in ankle assistive devices
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Microbiome, Immune Function
Comparison Study of Manapol and DaltonMax on Immune Function, Microbiome, and Related Variables in Men and Women
The present study will compare the effect of Manapol to DaltonMax on select measures of health. Currently, both ingredients are sold both as a stand-alone dietary supplement and as an active ingredient within various…
- Trial name
- NCT05510050
- Testing
- Aloe Vera Extract 1, Control, Aloe Vera Extract 2
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Preeclampsia, Hypertension
Cardiac and Immune Cell Function in Preeclampsia
Preeclampsia is a multi-system vascular disease which affects 2-5% of pregnancies. It is also a risk factor for the development of cardiovascular disease later in life and a number of functional and structural cardiac changes…
- Conditions
- Preeclampsia, Hypertension, Pregnancy Induced Hypertension, Pregnancy Related
- Trial name
- NCT04508582
- Testing
- Cardiovascular magnetic resonance, Echocardiography, Blood test
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Hiv, HIV Infections
Personalized Prevention for Couples: A 16-month Digital RCT
This couples-based, digital health intervention project is serostatus neutral and seeks to determine efficacy for: a) use and adherence to evidence-based HIV/STI prevention-care strategies; b) creation and adherence to a tailored…
- Conditions
- Hiv, HIV Infections, Sexually Transmitted Infection, Sexually Transmitted Diseases
- Trial name
- LuvHub (NCT05708014)
- Testing
- Intervention LuvHub, Waitlist Control LuvHub
- Where
- United States
- Volunteers
- 778 people, healthy volunteers welcome
- Sponsor
- Florida International University
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Immune Senescence, Sarcopenia
Effects of PS-IPC Supplementation on Muscle Mass and Functional Outcomes in Older Adults
Sarcopenia, the age-associated loss of skeletal muscle mass and strength, is a frequent precursor to functional impairment, disability, falls, and loss of independence in the elderly.
- Trial name
- PS-IPC (NCT00926250)
- Testing
- Oral PS-IPC supplement
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Atopic Dermatitis (AD), Psoriasis
A Clinical Evaluation of Marula-Derived Ceramide Cream on Skin Barrier Function Enhancement
Previously, the investigators have demonstrated in vitro the excellent efficacy of marula oil-derived ceramide NPs in enhancing skin barrier function.
- Conditions
- Atopic Dermatitis (AD), Psoriasis, Acne Vulgaris, Contact Dermatitis
- Trial name
- NCT07066150
- Testing
- Apply a cream containing 0.05% marula oil-derived ceramide NPs
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Shanghai Chicmax Cosmetic Co., Ltd.
Diabetes Mellitus, Insulin-Dependent, Hypercholesterolemia
Statins in Children With Type 1 Diabetes and Hypercholesterolemia
Children with type1 diabetes (T1DM) have increased risk for cardiovascular disease (CVD) due to chronic increase in the blood sugars and inflammation.
- Trial name
- NCT01236365
- Testing
- Atorvastatin
- Where
- 5 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Healthy, Suboptimal Vitamin C Levels
The Impact of Qualia Vitamin C+ on Individuals With Suboptimal and Adequate Vitamin C Levels
This is a double-blind, placebo-controlled, parallel-group, study evaluating the effect of a Qualia Vitamin C+ formulation on Whole Blood Vitamin C levels in the blood of healthy adults aged 25 years or older that have suboptimal…
- Conditions
- Healthy, Suboptimal Vitamin C Levels, Adequate Vitamin C Levels
- Trial name
- NCT07652346
- Testing
- Qualia Vitamin C+
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Qualia Life Sciences
Diabetes Mellitus, Type 1
Neurocognitive Performance During Hyperglycemia , and Brain Tissue Integrity in Youth With Type 1 Diabetes and in Healthy
Study population : 90 Participants. 60 with T1DM , and 30 healthy controls. T1DM patients will be recruited by research publication in diabetes mellitus forums. Baseline visit: informed consent signing.
- Trial name
- T1DM (NCT02923323)
- Testing
- MRI including DTI , EEG, CGMS, Neurocognitive tests
- Where
- Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Health, Children, Only
Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude
Microbes and the human body maintain a complex relationship of interaction and influence. Different regions, altitudes, and dietary habits have different degrees of influence on the composition of children's intestinal flora.
- Conditions
- Health, Children, Only, Gut Microbiota
- Trial name
- NCT06157346
- Where
- China
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
High-Intensity Parent Intervention Program in Improving Learning and School Functioning in Latino Children With Acute Leukemia or Lymphoblastic Lymphoma
This randomized clinical trial studies how well a high-intensity intervention parenting program works in improving learning and school functioning in Latino children with acute leukemia or lymphoblastic lymphoma.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Lymphoblastic Lymphoma, Acute Leukemia
- Trial name
- NCT03178617
- Testing
- Educational Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 3 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett