Clinical trials: Immune Dysfunction
Multiple Myeloma
An Open Protocol for the Compassionate Use of Thalidomide
The purpose of this study is to evaluate the use of thalidomide for the treatment of cancer. Patients with many types of cancers will be enrolled because the researchers will also study how the different cancers respond and what…
- Trial name
- NCT00081757
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Arkansas
Recurrent Multiple Myeloma, Refractory Multiple Myeloma
Donor Immune Cells (TGFbi NK Cells) and Isatuximab for the Treatment of Relapsed or Refractory Multiple Myeloma
This phase I trial tests the side effects and best dose of TGFbi natural killer (NK) cells (TiNK) when given together with isatuximab for the treatment of patients with multiple myeloma that has come back after a period of…
- Trial name
- NCT06203912
- Testing
- Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Cyclophosphamide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Elvira Umyarova
Asthma
Pediatric ASTHMA-Educator
This project seeks to develop and pilot test the pediatric ASTHMA-Educator mobile application.
- Trial name
- NCT03520881
- Testing
- Pediatric ASTHMA-Educator mobile application
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Montefiore Medical Center
Multiple Sclerosis, Neurophysiologic Abnormality
Investigation The Effect of Conventional Vs. Individualized tDCS Intensity to Achieve Uniform E-Fields
Background: Replications of studies employing transcranial direct stimulation (tDCS) shows great variations in physiological and behavioral outcomes.
- Trial name
- NCT05962281
- Testing
- Transcranial direct current stimulation (tDCS)
- Volunteers
- 30 people
- Sponsor
- Koen Cuypers
Chronic Lung Disease, HIV Infection
Bronchopulmonary Function in Response to Azithromycin Treatment for Chronic Lung Disease in HIV-infected Children
Chronic pulmonary disease (CLD) is the most common manifestation of HIV/AIDS among children, accounting for more than 50% of HIV-associated mortality.
- Trial name
- BREATHE (NCT02426112)
- Testing
- Azithromycin
- Where
- 2 sites in Malawi, Zimbabwe
- Volunteers
- 347 people
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections, Pregnancy
Combination Treatment With and Without Protease Inhibitors for Women Who Begin Therapy for HIV Infection During Pregnancy
The best anti-HIV treatment regimen for pregnant women is not known. Protease inhibitors (PIs) are often used, but they have side effects that may be harmful for pregnant women.
- Trial name
- NCT00017719
- Testing
- Lamivudine, Lamivudine/Zidovudine, Nelfinavir mesylate
- Where
- 49 sites in United States, Brazil and 2 more
- Volunteers
- 440 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Autoimmune Disease, Autoimmune Hemolytic Anemia
Treatment of Autoimmune Thrombocytopenia (AITP)
Platelets are particles found along with red and white blood cells in the blood that play a role in the process of blood clotting.
- Conditions
- Autoimmune Disease, Autoimmune Hemolytic Anemia, Thrombocytopenia
- Trial name
- NCT00001630
- Testing
- Isolex 300i
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Allergic Rhinitis
Hypothalamic-Pituitary-Adrenal (HPA)-Axis Study in Pediatric Subjects With Perennial Allergic Rhinitis (PAR)
The purpose of this study is to compare the effect of 6 weeks of treatment with beclomethasone dipropionate (BDP) nasal aerosol versus placebo on HPA-axis function, as assessed by 24-hour serum cortisol weighted mean, and to…
- Trial name
- NCT01697956
- Testing
- BDP
- Where
- 6 sites in United States
- Volunteers
- 99 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Multiple Myeloma
A Phase III Trial on the Effect of Elotuzumab in VRD Induction /Consolidation and Lenalidomide Maintenance in Patients With Newly Diagnosed Myeloma
Trial in patients with newly diagnosed myeloma to evaluate the effect of elotuzumab in induction and consolidation therapy with bortezomib/lenalidomide/dexamethasone and in lenalidomide maintenance treatment
- Trial name
- GMMG-HD6 (NCT02495922)
- Testing
- elotuzumab, Lenalidomide, Bortezomib
- Where
- 68 sites in Germany
- Volunteers
- 564 people
- Sponsor
- University of Heidelberg Medical Center
Lung Cancer, Gastro-intestinal Cancer
The SOAR Study: a Study of Geriatric Assessment and Exercise for Older Adults and Their Support Person
Phase 2 randomized controlled study using a waitlist control group. The study also has a single arm pre-post test 12-week chair-based exercise arm for those who have received the geriatric assessment in the older adults with…
- Conditions
- Lung Cancer, Gastro-intestinal Cancer, Genito-Urinary Cancer, Breast Cancer
- Trial name
- SOAR (NCT05509751)
- Testing
- GAM, exercise, health education, online chair-based exercise combined with health education
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Martine Puts
Type 1 Diabetes Mellitus
Evaluation of a Simulation-Based Educational Tool for Personalized Feedback in Insulin Therapy Management
This study combines data collection and simulation-based education, and it will enroll up to 36 adults with T1DM who already have experience with insulin pump therapy and some experience with a continuous glucose monitor (CGM).
- Trial name
- NCT01767831
- Testing
- iBOLUSED
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Chronic Lymphocytic Leukemia
Standard Chemoimmunotherapy (FCR/BR) Versus Rituximab + Venetoclax (RVe) Versus Obinutuzumab (GA101) + Venetoclax (GVe) Versus Obinutuzumab + Ibrutinib + Venetoclax (GIVe) in Fit Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without Del(17p) or TP53 Mutation
The aim of this study is to evaluate if standard chemoimmunotherapy (FCR, BR) in frontline treatment of physically fit CLL patients without del17p or TP 53 mutation can be replaced by combinations of targeted drugs (Venetoclax…
- Trial name
- GAIA (NCT02950051)
- Testing
- Fludarabine, Cyclophosphamide, Rituximab
- Where
- 161 sites in Austria, Belgium and 8 more
- Volunteers
- 926 people
- Sponsor
- German CLL Study Group
Atopic Dermatitis
CLINICAL EFFICACY OF EMOLLIENTS IN ATOPIC DERMATITIS PATIENTS
his was a monocentric, intra-individual study, that was performed in at least 45 valid cases (50% children ≥3 YO; 50% adults). Study duration was 168 days with five (5) visits (D0, D14, D28, D84 and D168) to the research center.
- Trial name
- NCT05783453
- Testing
- Cosmetic study
- Where
- Brazil
- Volunteers
- 63 people
- Sponsor
- Cosmetique Active International
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
Cyclosporine in Combination With Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma Refractory to Carfilzomib and High Expression of PPIA Gene in Myeloma Cells
This phase 1, open-label, single-arm, prospective, single center study will evaluate the safety, tolerability and efficacy of cyclosporine in combination with carfilzomib and dexamethasone in patients with relapsed and refractory…
- Trial name
- NCT04813653
- Testing
- cyclosporine in combination with carfilzomib and dexamethasone
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma
Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma
This phase II trial studies the side effects of an escalated ramp-up of sonrotoclax following initial debulking with zanubrutinib or rituximab in treating patients with chronic lymphocytic leukemia (CLL), small lymphocytic…
- Conditions
- Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Recurrent Chronic Lymphocytic Leukemia, Recurrent Mantle Cell Lymphoma
- Trial name
- NCT06839053
- Testing
- Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Fred Hutchinson Cancer Center
Alcohol Use Disorder, HIV/AIDS
Understanding and Intervening With Heavy Drinking Among Patients With HIV and HCV
Among patients with HIV, especially those also infected with HCV, heavy drinking is associated with significant risks to health.
- Conditions
- Alcohol Use Disorder, HIV/AIDS, Hepatitis C, Binge Drinking
- Trial name
- NCT03652675
- Testing
- Intervention: (Clinician's Guide + HealthCall for HIV/HCV)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- New York State Psychiatric Institute
HIV Infection
Clinical Trial, Open-label, Randomised, in Order to Compare the Quality of Life for Those VIH+ Patients That Start With Monotherapy on LPV/r Tablets Vs. Triple Therapy With a Boosted Protease Inhibitor
The Study will help to compare the Quality of Life for those HIV patients that are on monotherapy with LPV/r Vs. triple therapy with a boosted protease inhibitor
- Trial name
- QoLKAMON (NCT01166477)
- Testing
- Lopinavir and ritonavir, Triple therapy with ritonavir
- Where
- 31 sites in Spain
- Volunteers
- 228 people
- Sponsor
- Sociedad Andaluza de Enfermedades Infecciosas
Multiple Myeloma
UARK 2003-33, Total Therapy III
There have been two previous Total Therapy studies for multiple myeloma (MM) at the Myeloma Institute for Research and Therapy (MIRT): Total Therapy I (from 1989 through 1994) and Total Therapy II (from 1996 to 2004).
- Trial name
- NCT00081939
- Testing
- Velcade, Thalidomide
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- University of Arkansas
Chronic Kidney Disease(CKD), Pediatric ALL
Evaluating the Effectiveness of Respiratory Muscle Training in Pediatric Kidney Transplant Patient
Chronic kidney disease is defined as kidney damage lasting three months or longer and irreversible loss of renal function (glomerular, tubular and endocrine) or a glomerular filtration rate of less than 60 ml/min /1.73 m2 .
- Conditions
- Chronic Kidney Disease(CKD), Pediatric ALL, Pediatric Kidney Transplantation, Respiratory Muscle Training
- Trial name
- NCT06655181
- Testing
- Respiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Atlas University
Bipolar Disorder, Cannabis Use
Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders
This research study evaluates the effects of an FDA-approved medication Gabapentin in individuals with Bipolar Disorder who smoke marijuana.
- Conditions
- Bipolar Disorder, Cannabis Use, Schizoaffective Disorder, Bipolar Type, Bipolar I Disorder
- Trial name
- NCT05064319
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Medical University of South Carolina