Clinical trials: Immune
Asthma, COPD
The Effects of Broccoli Sprout Extract on Obstructive Lung Disease
The purpose of this study is to examine whether broccoli sprout extract can effect lung function measurements in individuals with asthma and COPD.
- Trial name
- NCT00994604
- Testing
- broccoli sprout extract
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Multiple Sclerosis, Gait Disorders, Neurologic
Walking and Thinking - Brain Activity During Complex Walking in People With Multiple Sclerosis
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills.
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Neuro-Degenerative Disease, Aging
- Trial name
- NCT05787704
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 41 people
- Sponsor
- Karolinska Institutet
Severe Malaria
Malaria Treatment With Injectable ArteSunate
The MATIAS study aims to demonstrate through limited scope implementation studies how injectable artesunate may be progressively rolled out nationwide in the Democratic Republic of the Congo as the preferred treatment for severe…
- Trial name
- MATIAS (NCT01828333)
- Testing
- No intervention
- Where
- 9 sites in Democratic Republic of the Congo
- Volunteers
- 350 people
- Sponsor
- Swiss Tropical & Public Health Institute
Tuberculosis, Hiv
Pharmacokinetics of Twice or Once Daily DTG (50mg) in Children With HIV and TB
Stage 1 proposed study will provide evidence to support the use of twice-daily dose 50mg DTG in children (20-35kgs) co-treated with RIF.
- Trial name
- ORCHID (NCT04746547)
- Testing
- Dolutegravir 50 MG, Dolutegravir 10 MG
- Where
- South Africa
- Volunteers
- 20 people
- Sponsor
- University of KwaZulu
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Diffuse Large B-cell Lymphoma
Chidamide Plus R-CHOP in Elderly DLBCL
This is a prospective, single-arm, open-label phase II study of Chidamide in combination with R-CHOP in the treatment of de novo, elderly, high-risk diffuse large B cell lymphoma patients.
- Trial name
- NCT02753647
- Testing
- Rituximab, Cyclophosphamide, Doxorubicin
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Ruijin Hospital
Multiple Sclerosis, MS, Multiple Sclerosis
Transcranial Direct Current Stimulation for Fatigue, Mood, and Cognition in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic, inflammatory and disabling disease of the Cnetral Nervous System characterized by relapsing and / or progressive somatosensory, motor and vestibular clinical manifestations.
- Conditions
- Multiple Sclerosis, MS, Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis (MS) Primary Progressive
- Trial name
- NCT07680738
- Testing
- Transcranial Direct Current Stimulation
- Where
- Mexico
- Volunteers
- 38 people
- Sponsor
- Universidad de Almeria
Lymphoma (Non-Hodgkin's Lymphoma)
A Prospective Clinical Study on Reduced-intensity Radiotherapy for Stage I/II Low-risk Nasal-type NK/T-cell Lymphoma Achieving Complete Remission After Chemotherapy
This study is designed to evaluate the efficacy and safety of reduced-intensity radiotherapy for stage I/II low-risk nasal-type NK/T-cell lymphoma that has achieved complete remission after chemotherapy.
- Trial name
- NCT07628738
- Testing
- reduced-intensity radiotherapy
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Ruijin Hospital
Myocarditis, Immune Checkpoint Inhibitors
Assessment of Myocardial Injury in Patients Treated With Immune Checkpoint Inhibitors
ICI's have become the first-line treatment for patients with various malignancies. Although case studies represent fulminant myocarditis, there is uncertainty in prevalence of subclinical myocardial injury induced by ICI's.
- Conditions
- Myocarditis, Immune Checkpoint Inhibitors, Cardiotoxicity, Myocardial Injury
- Trial name
- MIICI (NCT05349058)
- Testing
- Immune Checkpoint Inhibitors
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Flinders University
Hepatocellular Carcinoma, Colorectal Cancer Liver Metastasis
The Safety, Efficacy, and Immune Response of Multimodal Thermal Therapy in the Treatment of Malignant Liver Tumors
Multimodal thermal therapy (MTT), as an initiative integration of cryotherapy and radiofrequency heating, has been applied to treat various solid tumors.
- Trial name
- NCT07159048
- Testing
- Multimodal Tumor Thermal Therapy System, Radiofrequency Ablation System or Microwave Ablation System
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fudan University
Diabetes, Diabetes Mellitus, Type 1
Efficacy and Safety of Insulin Aspart in Subjects With Type 1 or Type 2 Diabetes
This trial is conducted in Asia. The aim of this trial is to compare the efficacy of postprandial plasma glucose of two treatment regimens in Chinese subjects.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00593255
- Testing
- soluble human insulin, insulin aspart, insulin NPH
- Where
- 5 sites in China
- Volunteers
- 220 people
- Sponsor
- Novo Nordisk A/S
Fasting, Immune Suppression
Effects of Fasting Strategies on Postoperative Recovery and Long-term Prognosis in Patients With Colorectal Cancer
In 2018, colorectal cancer is the third most common malignant tumor in terms of morbidity and second mortality in the world. Surgical resection is still the main treatment for colorectal cancer.With the introduction of the ERAS…
- Conditions
- Fasting, Immune Suppression, Complication of Surgical Procedure, Colorectal Cancer
- Trial name
- NCT04345978
- Testing
- Fasting hours
- Where
- 7 sites in China
- Volunteers
- 2,400 people
- Sponsor
- Fudan University
Nervous System Diseases, Respiratory Tract Diseases
Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU)
Oxygen administration is a common practice in intensive care units, although concern is growing about oxygen toxicity. The aim of the study is to access whether a rigorous maintenance of a state of normal oxygenation in…
- Conditions
- Nervous System Diseases, Respiratory Tract Diseases, Cardiovascular Diseases, Immune System Diseases
- Trial name
- OXYGEN-ICU (NCT01319643)
- Testing
- Oxygen
- Where
- Italy
- Volunteers
- 660 people
- Sponsor
- University of Modena and Reggio Emilia
Rheumatoid Arthritis(RA)
A Study Assessing the Efficacy and Safety of SM03 in Patients With Active Rheumatoid Arthritis Receiving MTX
To demonstrate that SM03 added to methotrexate (MTX) reduce signs and symptoms of rheumatoid arthritis (RA) in Chinese RA participants with an inadequate response to MTX.
- Trial name
- NCT04312815
- Testing
- SM03, MTX
- Where
- China
- Volunteers
- 510 people
- Sponsor
- SinoMab BioScience Ltd
Relapsing-Remitting Multiple Sclerosis
PK and PD Study of Natalizumab in Pediatric Subjects With RRMS
The primary objective of the study is to determine the pharmacokinetic (PK) profile of multiple doses of natalizumab in pediatric subjects with relapsing-remitting multiple sclerosis (RRMS).
- Trial name
- NCT01884935
- Testing
- Natalizumab
- Where
- 5 sites in Italy
- Volunteers
- 13 people
- Sponsor
- Biogen
HIV Infections, Hepatitis C
Liver Transplantation in Patients With Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Coinfection
To show the feasibility of liver transplantation in HCV-HIV coinfected patients. To study the two-year survival after transplantation, the interaction between HCV and HIV after transplantation, the influence of HIV on HCV…
- Trial name
- NCT00158535
- Testing
- liver transplantation
- Where
- France
- Volunteers
- 15 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Type 1 Diabetes
Efficacy and Safety of an Artificial Intelligence Tool for Carbohydrate Counting (Tiabete) in Children and Adults With Type 1 Diabetes Mellitus
IntroductionType 1 Diabetes Mellitus (T1DM) requires lifelong exogenous insulin therapy, along with self-management strategies, such as carbohydrate counting, to appropriately adjust insulin doses in response to meals.
- Trial name
- Tiabete (NCT07150052)
- Testing
- Artifical intelligence in whatsapp
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
B Cell Lymphoma
Novel Autologou CAR-T Therapy for Relapsed/Refractory B Cell Lymphoma
It's a single arm, open label prospective study, in which the safety and efficacy of autologous CAR-T are evaluated in refractory/relapsed B cell lymphoma patients.
- Trial name
- NCT03258047
- Testing
- CAR-T
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Dengue (Virus); Fever, Sandfly, Sickle Cell Disease
Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell Patients
Dengue virus (DENV) belongs to the genus of Flavivirus transmitted by the mosquito Aedes aegypti and is responsible for an infectious disease associated with different forms and severities such as dengue hemorrhagic fever or…
- Trial name
- DREPADENGUE (NCT07000747)
- Where
- Guadeloupe
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Multiple Sclerosis
Calorie Restriction in Multiple Sclerosis Patients
The investigators hypothesize that adipokine (soluble molecules produced by the adipose tissue) levels are altered in MS compared to control subjects.
- Trial name
- NCT02411838
- Testing
- Calorie restriction
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine