Clinical trials: Immediate Effect
Asthma
A Study to Investigate the Safety, Tolerability and Effects of AZD8630 in Healthy Subjects and Subjects With Asthma on Inhaled Corticosteroids and Long-acting Beta-agonists
This is a first in human (FIH) clinical study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8630 in healthy adults (Part A) and adult asthma patients on medium to high dose inhaled…
- Trial name
- NCT05110976
- Testing
- AZD8630
- Where
- 29 sites in United States, Germany and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Delayed Onset Muscle Soreness (DOMS), Inflammation
Effects of Immediate and Delayed Repeated Cold Exposure After Physical Exertion
The goal of this clinical trial is to learn if applying cold therapy can reduce swelling, inflammation, and pain after physical activity in adults who experience muscle soreness (Delayed Onset Muscle Soreness, or DOMS).
- Conditions
- Delayed Onset Muscle Soreness (DOMS), Inflammation, Muscle Pain, Muscle Damage
- Trial name
- NCT06813690
- Testing
- Cold Therapy with Axanova Cold Hot Pearls Maxi Pack
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Pharmacokinetics of ASP015K, Food Effect
A Phase I Study to Compare 3 Different Strengths of an Extended Release Formulation of ASP015K to an Immediate Release Formulation of ASP015K
The purpose of this study is to compare the pharmacokinetics (PK) profiles of three different strengths of ASP015K extended release formulation and an immediate release formulation and to evaluate food effect on extended release…
- Conditions
- Pharmacokinetics of ASP015K, Food Effect, Healthy Volunteers
- Trial name
- NCT01686217
- Testing
- ASP015K ER, ASP015K IR
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Chronic Spontaneous Urticaria
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Single and Multiple Doses of HRS-3095 Oral Administration in Healthy Subjects, as Well as the Effect of HRS-3095 on CYP3A4 Metabolic Enzymes
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of HRS-3095 oral administration in healthy subjects.
- Trial name
- NCT07230418
- Testing
- HRS-3095 Tablet
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Chengdu Suncadia Medicine Co., Ltd.
Sports Physical Therapy
Immediate Effect of Dynamic Stretching With and Without Floss Band on Flexibility of Hamstrings in Futsal Players
To compare the immediate effect of dynamic stretching with and without floss band on the hamstring flexibility in futsal players.
- Trial name
- NCT06101602
- Testing
- Dynamic Stretching with Floss Band, Dynamic Stretching without Floss Band
- Where
- Pakistan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Asthma, Healthy
Effects of Salbutamol in Athletes and Implications for Screening and Sports
β2-Agonists, commonly used to treat asthma, have also been used by athletes to enhance performance, leading to their ban by the International Olympic Committee in 1972.
- Conditions
- Asthma, Healthy, Effect of Drug
- Trial name
- NCT07037511
- Testing
- Salbutamol
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Intestinal Obstruction
Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects
The purpose of this study is to describe the effects of methylnaltrexone in preventing loperamide-induced delay of the oro-cecal and whole-gut transit time and measure pharmacokinetics of methylnaltrexone after subcutaneous and…
- Trial name
- LOP-MNTX-2009 (NCT01596777)
- Testing
- Loperamide, Methylnaltrexone 12 mg sc., Methylnaltrexone IR capsule
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Lower Extremity Performance, Ankle Dorsiflexion
Immediate Effects of Ankle Joint Mobilization on Jump Performance in Healthy University Students
The purpose of this randomized controlled study is to investigate the immediate effects of ankle joint mobilization on countermovement jump performance and ankle dorsiflexion range of motion in healthy university students.
- Conditions
- Lower Extremity Performance, Ankle Dorsiflexion, Healthy Volunteers
- Trial name
- NCT07711379
- Testing
- Mobilization with Movement (MWM)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Food Allergy
Integrated Approaches to Food Allergen and Allergy Risk Management
Patients with history of a food allergy to hazelnut, walnut or celeriac will undergo food provocation with a dose of the allergenic food to which 5% of the respective food allergic population (ED05) has been calculated to respond…
- Trial name
- iFAAM (NCT02295397)
- Testing
- food
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
Study of PF 04965842 Effect on MATE1/2K Activity in Healthy Participants
This is a Phase 1, randomized, 2 way crossover, open label study of the effect of PF-04965842 on metformin (a probe for MATE1/2K activity) PK in healthy adult participants.
- Trial name
- NCT03796182
- Testing
- Metformin, PF-04965842
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Asthma, COPD
The Effects of Broccoli Sprout Extract on Obstructive Lung Disease
The purpose of this study is to examine whether broccoli sprout extract can effect lung function measurements in individuals with asthma and COPD.
- Trial name
- NCT00994604
- Testing
- broccoli sprout extract
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Effect of Putty Form Bone Graft in Immediate Implant Placment
Evaluation of Hyaluronic Acid in Addition to Xenograft in Immediate Implant Placement Within Maxillary Esthetic Zone
Study design: The present study will be carried out on twenty patients selected from the department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Mansoura University for replacement of non…
- Trial name
- NCT06783517
- Testing
- cerabone, cerabone®plus
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Hereditary Angioedema (HAE)
Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers
This is a single-dose study to evaluate the pharmacokinetics, safety, and tolerability of icatibant administered to adult Japanese subjects.
- Trial name
- NCT02045264
- Testing
- Icatibant (30 mg)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Shire
Asthma
The Effect of Single Dose Paracetamol on the Lower Airways of Asthmatic and Healthy Children
Asthma is a common inflammatory airway disease. Several researches have demonstrated a possible connection between asthma and exposure to paracetamol.
- Trial name
- NCT01073748
- Testing
- paracetamol
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pectoralis Minor Length
Is There an Immediate Effect on Pectoralis Minor Length After Performing a Prone Scapular Retraction Exercise
The goal of this clinical trial is to test normal participants. The main question it aims to answer is: Do the participant's pectoralis minor muscles change length immediately after performing an exercise that recruits the…
- Trial name
- NCT06346314
- Testing
- Scapular retraction exercise
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Andrews University
Atopic Dermatitis
A Study to Learn If the Study Medicine Called PF-08049820 Changes How the Body Processes the Other Study Medicines Called Oral Contraceptives, Midazolam, and Dabigatran in Healthy Adult Female Participants
The purpose of this study is to see how a medicine called PF-08049820 affects how other medicines move through the body. This information will help plan future studies.
- Trial name
- NCT07190430
- Testing
- PF-08049820, Midazolam, Dabigatran Etexilate
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Asthma, Dietary Intervention
Vegan Diet and Immune-Inflammatory Outcomes in Asthma and Healthy Adults
This randomized controlled study evaluates the effects of a balanced vegan diet compared with a balanced omnivorous diet on inflammatory and immune response markers and clinical asthma parameters in healthy adults and individuals…
- Conditions
- Asthma, Dietary Intervention, Vegan Diet
- Trial name
- VEGASTHMA (NCT07480369)
- Testing
- Omnivorous diet, Vegan diet
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Neck Pain, Headache
Cervical Spine Manipulation Affects on Balance and Proprioception
Cervical spine manipulation (CSM) is utilized by many health care practitioners in the management of patients with neck pain and headache.
- Trial name
- NCT01745705
- Testing
- Cervical Spine Manipulation, Manual Contact
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Asthma
Effect of Flovent Discus vs QVAR vs Pulmicort Flexhaler on Short Term Growth
Children with mild persistent asthma that have asthma symptoms once or twice a week and use a daily controller, while children with mild intermittent asthma rarely have asthma symptoms and do not use a daily controller.
- Trial name
- NCT01520688
- Testing
- Fluticasone, Budesonide, Beclomethasone, Fluticasone, Beclomethasone, Budesonide, Budesonide, Fluticasone, Beclomethasone
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- West Penn Allegheny Health System
Healthy
Effects of Dynamic Cupping on Shoulder Active Range of Motion of Senior Male Handball Athletes
The purpose of this study is to to verify the immediate effects of dynamic cupping on shoulder active range of motion (AROM) of senior male handball athletes.
- Trial name
- NCT06226961
- Testing
- cupping
- Where
- Portugal
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Fernando Pessoa