Clinical trials: Imaging
Metabolic Syndrome
Early Vascular Wall Changes by Magnetic Resonance Imaging (MRI) in Metabolic Syndrome Versus Metabolically Normal Pre-Menopausal Women: A Pilot Study
The purpose of this study is to compare the vascular permeability of blood vessel walls (of the carotid artery) in pre-menopausal women who have metabolic syndrome (syndrome of having at least 3/5 following features- increased…
- Trial name
- NCT01068535
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy Adult Participants, Synaptic Plasticity
Effects of Adolescent Synaptic Pruning
The study will use a PET-based measure of brain cell (neuron) connections (synapses) in young adults who have also obtained an MRI, to assess how the loss of brain cell connections (synaptic pruning) is captured by MRI-based…
- Trial name
- SPA PET (NCT07569718)
- Testing
- PET Imaging Scan using [11C]UCB-J
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beatriz Luna
Cognitive Change, Atrophy Brain
Physiologic Volume and Atrophy of Brain and Spinal Cord Measured by Magnetic Resonance Imaging
Spinal cord (SC) involvement is prevalent in multiple sclerosis (MS) and contributes importantly to disease progression. To be able reliably evaluate spinal cord volume and its changes in MS patients we need to understand…
- Conditions
- Cognitive Change, Atrophy Brain, Atrophy; Spinal Cord, Multiple Sclerosis
- Trial name
- NCT03706118
- Testing
- Magnetic resonance imaging
- Where
- Czechia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Dana Horakova
Obesity, NAFLD
Low-Calorie Diet in People With Prediabetes/Metabolic Syndrome
Significant weight reduction, achieved by low-calorie diet (LCD), will mobilise ectopic fat (visceral and particularly liver fat), improving insulin sensitivity and other metabolic syndrome components, with secondary beneficial…
- Conditions
- Obesity, NAFLD, Fatty Liver, Pre Diabetes
- Trial name
- CALIBRATE (NCT04786418)
- Testing
- Standard of care, Low-calorie diet
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Floaters, Vitreous Opacities
Imaging of Vitreous Opacities in Human Eyes
Vitreous opacities (VOs), commonly known as floaters, are dark spots that appear in, and may float across your vision. Presently, there is a lack of available data in the literature regarding VOs.
- Trial name
- NCT06097897
- Testing
- SVO-ID
- Where
- Panama
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- PulseMedica
Anorexia Nervosa, Bulimia Nervosa
Study on the Mechanism of Eating Disorder
Eating disorders (EDs) are severe chronic psychiatric disorders with a not fully understood etiopathogenesis. Previous studies have revealed some biological mechanisms of EDs.
- Trial name
- NCT05862389
- Where
- China
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Peking University
Multiple Sclerosis
The Effect of Sildenafil Citrate (Viagra® (Registered Trademark)) on Brain Blood Flow in Multiple Sclerosis Patients
This study will determine whether sildenafil citrate, commonly known as Viagra, can cause increased blood flow to the brain in a wide range of multiple sclerosis (MS) patients, including women.
- Trial name
- NCT00094068
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Mindfulness, Stress
Scrutinizing and Promoting Mindfulness Via New Technologies
The overall goal of the outlined study is to scrutinize and to promote mindfulness via new technologies using a combination of smartphone-based assessment and micro-interventions, fMRI and real-time fMRI-neurofeedback.
- Conditions
- Mindfulness, Stress, Mood, Working Memory
- Trial name
- NCT03148678
- Testing
- Mindfulness, Contingent RT-fMRI-NF, Mind Wandering
- Where
- 2 sites in South Korea, Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Parkinson's Disease
Assessing Cholinergic Innervation in Parkinson's Disease Using the PET Imaging Marker [18F]Fluoroethoxybenzovesamicol
Although PD is considered predominantly as a motor disease caused by loss of dopaminergic neurons, multiple studies indicate that cholinergic dysfunction already starts in early PD and is crucial for the development of dementia…
- Trial name
- NCT02952391
- Testing
- [18F] FEOBV PET scan
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Sickle Cell Disease, Pain
Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0
The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupuncture analgesia in patients with sickle cell disease.
- Conditions
- Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing
- Trial name
- NCT06725550
- Testing
- needling acupuncture, laser acupuncture
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Education
Online Regional Anesthesia Resources - Are They Effective?
Anatomical-based ultrasound imaging has been one of the most rapidly advancing innovations in the field of regional anesthesia in recent years.
- Trial name
- NCT05290974
- Testing
- Self exploring of available online material on supraclavicular brachial plexus block, Conventional in-person teaching on supraclavicular brachial plexus block
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Low Back Pain, Multifidus
Effects of Isolated Lumbar Extension Resistance Training Alone and in Combination with General Exercise and Manual Therapy
This study examines effects of machine-based isolated lumbar extension resistance exercise (ILEX) on paraspinal muscle morphology and function, as well as pain intensity, disability and quality of life in patients with chronic…
- Conditions
- Low Back Pain, Multifidus, Exercise Therapy, Diagnostic Imaging
- Trial name
- NCT06890052
- Testing
- Targeted exercise program, Targeted exercise as part of an integrative therapy program
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Wuerzburg
Head and Neck Cancer
Oxygen Enhanced MRI Measurement in Head and Neck Cancer: Validation and Efficacy of Response.
This is a prospective pilot study to investigate the potential clinical value of oxygen-enhanced magnetic resonance (OE-MRI) biomarkers in head and neck radiotherapy.
- Trial name
- NCT03646747
- Testing
- MRI scan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sally Falk
Chronic Non-Specific Low Back Pain, Cognitive Decline
The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults
Chronic non-specific low back pain (CNSLBP) is a prevalent condition among older adult and has been associated with an increased risk of executive function impairment.
- Conditions
- Chronic Non-Specific Low Back Pain, Cognitive Decline, Cross-Sectional Study, Older Adults
- Trial name
- NCT06704425
- Testing
- For observational studies, participants are not assigned an intervention as part of the study.
- Where
- 3 sites in Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Oocyte Competence
Modulation Contrast Microscopy Imaging for Oocyte Quality Assessment
The present study aims to describe novel non-invasive parameters related to the competence of female reproductive cells (oocytes).
- Trial name
- NCT03683290
- Testing
- Image acquisition and analysis
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Center for Reproductive an Genetic Health
Myocardial Infarction, Myocardial Ischemia
18F-fluorocholine PET-MR Imaging of Coronary Plaque Vulnerability
This study is designed as a prospective observational feasibility study. The investigators will study whether vulnerable plaques on OCT (fibrous cap ≤ 70 μm) show a locally increased uptake of 18F-choline on PET-MRI compared to…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Atherosclerosis, Coronary Artery Disease
- Trial name
- NCT03252990
- Testing
- PET-MRI, Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Essential Untreated Hypertension, Healthy Volunteers
Comparison of Ultrafast Echo With Echotracking
The aim is to compare a new technique for assessing mechanical properties of large arteries: the Ultrafast echo with the reference technique, the echotracking.
- Trial name
- NCT01743352
- Where
- France
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Alzheimer's Disease
Multi-modal Neuroimaging in Alzheimer's Disease IMAP+
Alzheimer's disease (AD) is a major public health problem due to its socio-economic weight. An early diagnosis of AD is urgently needed as it would constitute a determinant breakthrough from a social, financial and research…
- Trial name
- IMAP+ (NCT01638949)
- Testing
- Memory assessment, Circulating biomarkers measure, ApoE4
- Where
- 7 sites in France
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cervical Spondylosis With Myelopathy
DTI of the Brain and Cervical Spine: Evaluation in Normal Subjects and Patients With Cervical Spondylotic Myelopathy
More than half of the middle-aged population has radiologic evidence of cervical spondylosis (Irvine 1965) and a subset of this population develops cervical spondylotic myelopathy (CSM), a condition in which the spinal cord is…
- Trial name
- NCT01868958
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Emory University
Genetic Disease, Inherited Disease
Adaptive Optics Retinal Imaging in Inherited and Acquired Retinal Disorders
This is a Prospective Observational study. The aim of the study is to understand the underlying photoreceptor, retinal pigment epithelium or retinal vascular aberrations in inherited and acquired retinal disorders.
- Trial name
- NCT05386134
- Testing
- Adaptive Optics Retinal Camera
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
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