Clinical trials: Ileus, open to volunteers
Paralytic Ileus
Effect of Preoperative Intrathecal Dexamethasone Versus Dexmedetomidine on Paralytic Ileus After Major Abdominal Surgery
Postoperative Ileus (POI) is considered as intolerance of oral intake due to disruption of the normal coordinated propulsive motor activity of the gastrointestinal (GI) tract following abdominal or non-abdominal surgery.
- Trial name
- NCT06752317
- Testing
- Dexamethasone, Dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Assiut University
Postoperative Bowel Function, Postoperative Pain
Fentanyl vs. Remifentanil in Laparoscopic Cholecystectomy: Effects on Bowel Function and Pain
Background: Postoperative ileus (POI) is a common complication after abdominal surgery, leading to delayed gastrointestinal recovery, prolonged hospitalization, and increased healthcare costs.
- Trial name
- NCT07182097
- Testing
- Fentanyl 2 µg/kg IV bolus + 1-2 µg/kg/h infusion during anesthesia, Remifentanil 1 µg/kg IV bolus + 0.1-1 µg/kg/min infusion during anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Konya City Hospital
Bowel Sounds, Colorectal Cancer
The Value of Bowel Sounds in Evaluating Postoperative Intestinal Function Recovery in Colorectal Cancer Patients
This study enrolls patients scheduled to undergo curative surgery for colorectal cancer. Bowel sounds will be assessed preoperatively and postoperatively.
- Conditions
- Bowel Sounds, Colorectal Cancer, Intestinal Obstruction, Postoperative Ileus
- Trial name
- BRIEF (NCT07705139)
- Testing
- colorectal surgery
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Zhongnan Hospital
Postoperative Ileus, Delayed Gastrointestinal Motility
Impact of Chewing Gum on Postoperative Gut Motility in Gastrointestinal Surgery Patients
Postoperative ileus (POI) is a frequent complication after abdominal surgery, leading to delayed gastrointestinal motility, prolonged hospital stay, and increased patient discomfort.
- Conditions
- Postoperative Ileus, Delayed Gastrointestinal Motility, Postoperative Gut Dysfunction
- Trial name
- NCT07425249
- Testing
- Chewing Gum
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Khyber Medical University Peshawar
PIPO
Role of ACTG2 Variants in Smooth Muscle Determination and Function in Pediatric Intestinal Pseudo-obstruction.
The primary objective of this study is to describe the transcriptional impact of R178, R257, R40 or A136 variants of the ACTG2 gene on iPS differentiation mechanisms up to organoids derived from PIPO patient samples versus those…
- Trial name
- SMOOTH-PIPO (NCT06687564)
- Testing
- Biopsy
- Where
- 3 sites in France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Grenoble
Pseudo Obstruction
ACTG2/FLNA Testing Yield in Adult Idiopathic Chronic Intestinal Pseudo-Obstruction (CIPO) With Reduced/Absent Distal Esophageal Contractility
To assess the diagnostic yield of Sanger sequencing for ACTG2 and FLNA genes evaluation on blood or saliva sample in patients with idiopathic CIPO in which high-resolution esophageal manometry (HRM) shows reduced (DCI <450…
- Trial name
- CIPO_GEN (NCT07448753)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Marina Coletta
Ileus Postoperative
Effect of Lollipop on Postoperative Gastrointestinal Recovery in Children
Postoperative ileus is common in children. There are various method to prevent postoperative ileus. In this study, the investigators will explore the role of sucking lollipop after operation on the recovery of gastrointestinal…
- Trial name
- NCT06108011
- Testing
- Lollipop
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Postoperative Ileus, Bowel Paralysis
Gastrointestinal Stimulation As a Treatment of Postoperative Ileus Following Extensive Surgery
The goal of this clinical trial is to investigate the effect of gastrointestinal stimulation with a pacemaker on the length of postoperative bowel paralysis in patients undergoing major abdominal surgery due to metastasizing…
- Trial name
- STIMULATE (NCT05752071)
- Testing
- Gastric electrical stimulation
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Colonic Cancer
Abdominal Massage After Colon Surgery for Cancer
Postoperative ileus is a transient gastrointestinal dysmotility following abdominal surgery that leads to bloating, abdominal distention, visceral pain, nausea, vomiting, and delayed passage of flatus and stool.
- Trial name
- MATRAC_Ter (NCT07713472)
- Testing
- ABDOMINAL MASSAGE, Usual physiotherapeutic intervention
- Where
- France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Grenoble
Cesarean Section
Intraperitoneal Saline Irrigation in Cesarean Section
The study evaluates the effect of intraperitoneal saline irrigation before abdominal closure during cesarean section on postoperative infectious morbidity and the incidence of paralytic ileus.
- Trial name
- NCT07730060
- Testing
- Intraperitoneal Saline Irrigation
- Volunteers
- 150 people
- Sponsor
- Assiut University
Ostomy - Ileostomy or Colostomy, Canser
The Effect of Ostomy Care Education Applied With the Teach-Back Method to Ostomy-Opened Individuals on Self-Care Power, Ostomy Adjustment, and Anxiety
The aim of this study is to examine the effect of ostomy care education-delivered to patients who have undergone ostomy surgery using the Teach-back method on patients' self-care ability, ostomy compliance, and anxiety levels.
- Conditions
- Ostomy - Ileostomy or Colostomy, Canser, Ileus, Intestinal Cancer
- Trial name
- NCT07788079
- Testing
- TEACH BACK METHOD
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Saglik Bilimleri Universitesi
Colon Cancer, Splenic Flexure Mobilization
Surgical Outcomes in Splenic Flexure Cancers: A Multicenter Comparison of Segmental vs. Extended Hemicolectomy (SPARROW Study)
SPARROW Study: Surgical Outcomes in Splenic Flexure Cancer Colonic cancers located at the splenic flexure where the transverse colon turns into the descending colon are uncommon and represent less than 10% of all colorectal…
- Conditions
- Colon Cancer, Splenic Flexure Mobilization, Right Hemicolectomy, Left Hemicolectomy
- Trial name
- SPARROW (NCT07289568)
- Testing
- Colectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Acibadem University
Postoperative Ileus
Simple Bed Exercises for Reducing Postoperative Ileus in Colorectal Surgical Patients.
The purpose of this study is to examine the effect of simple bed exercises for reducing postoperative ileus among colorectal surgical patients who have completed colorectal surgery and are experiencing postoperative ileus.
- Trial name
- NCT07014046
- Testing
- Simple bed exercises
- Where
- Hong Kong
- Volunteers
- 76 people
- Sponsor
- The University of Hong Kong
Delay in GI Recovery/Postoperative Ileus (POI)
TU-100 for Accelerating GI Recovery After Major Abdominopelvic Surgery (RC & CAWR)
This Phase 2, multicenter, randomized, double-blind, placebo-controlled master protocol study will evaluate the safety and efficacy of TU-100, adjunctive to an Enhanced Recovery After Surgery (ERAS) pathway, for accelerating…
- Trial name
- NCT07765589
- Testing
- TU-100
- Volunteers
- 240 people
- Sponsor
- Tsumura USA
Postoperative Ileus
Use of Beetroot Juice to Protect Against Postoperative Ileus Following Colorectal Surgery: BEET IT Study
The goal of the BEET IT study is to examine if preoperative intake of beetroot juice can ameliorate gastrointestinal (GI) recovery after colorectal surgery and thereby help to reduce the duration of postoperative ileus (POI) and…
- Trial name
- BEET IT (NCT05133024)
- Testing
- concentrated beetroot juice
- Where
- 6 sites in Belgium
- Volunteers
- 170 people
- Sponsor
- University Hospital, Ghent
Ileus Postoperative, Gastrointestinal Function
Oral Lactulose for Gastrointestinal Recovery After Complex Appendectomy
This is a prospective, triple-blind, placebo-controlled, single-center randomized clinical trial to evaluate the efficacy and safety of early oral lactulose for promoting postoperative gastrointestinal functional recovery in…
- Conditions
- Ileus Postoperative, Gastrointestinal Function, Complicated Appendicitis
- Trial name
- NCT07589465
- Testing
- Lactulose oral solution
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Nanchong Central Hospital
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Incarcerated Hernia, Appendicitis Acute
Prevention of Postoperative Hernias in Emergency Surgery
The aim of this observational study is to understand the risk factors and incidence of postoperative hernias among patients undergoing emergency surgery.
- Conditions
- Incarcerated Hernia, Appendicitis Acute, Cholecystitis, Acute, Ileus
- Trial name
- PROPHECY (NCT06815822)
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Jan Kochanowski University
Postoperative Ileus, Gastrointestinal Dysfunction
Low Pressure Pneumoperitoneum and Postoperative Ileus
The investigators are testing the hypothesis that lower pressure pneumoperitoneum during laparoscopic large bowel surgery protects the bowel from postoperative ileus and bowel dysfunction leading to faster recovery and discharge…
- Trial name
- NCT05344417
- Testing
- Pneumoperitoneum Pressure, Neuromuscular blockade, Pneumoperitoneum insufflation device
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Ohio State University
Acute Abdomen, Ileus
Rectus Sheath Catheters Following Midline Laparotomy
Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC.
- Conditions
- Acute Abdomen, Ileus, Colorectal Carcinoma
- Trial name
- NCT07099924
- Testing
- Ropivacaine 0.2%, Saline 0.9%
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH