Clinical trials: IVF Poor Responders
Infertility
Dydrogesterone Versus GnRH Antagonist in Poor Responders Undergoing Double Ovarian Stimulation
The aim of this randomized controlled trial is to compare the efficacy and cost-effectiveness of using progestin with GnRH antagonist to prevent premature LH surge in poor responders undergoing double stimulation protocol.
- Trial name
- NCT06212102
- Testing
- Progestin primed ovarian stimulation, GnRH antagonist
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Bedaya Hospital
Fertilization in Vitro
Poor Ovarian Responders Undergoing IVF Using Luteal Ovarian Stimulation Versus Follicular Ovarian Stimulation
The investigators attempted to compare the clinical outcomes and cumulus genes expression in poor ovarian responders undergoing luteal ovarian stimulation or follicular ovarian stimulation in in vitro fertilization cycles.
- Trial name
- NCT03238833
- Testing
- luteal ovarian stimulation, follicular ovarian stimulation
- Where
- Taiwan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility
Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders
This is a prospective, randomized clinical trial to compare the efficiency and safety of mild stimulation and controlled ovarian stimulation protocol on the treatment of POR.
- Trial name
- POR (NCT01926210)
- Testing
- mild stimulation protocol, controlled ovarian stimulation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Huang Rui
Infertility
Cumulative Live Birth After Double Stimulation Protocol Versus Antagonist Protocol for Poor Ovarian Responders
To compare the difference in cumulative live birth rates within one year between double stimulations protocol and two-cycle antagonist protocol in poor ovarian responders.
- Trial name
- NCT05765968
- Testing
- Double Stimulation Protocol, Antagonist Stimulation Protocol
- Where
- China
- Volunteers
- 1,198 people, healthy volunteers welcome
- Sponsor
- Shandong University
Androgen Receptor Gene Overexpression, Normal Responders
Androgen Receptor mRNA Expression is Positively Associated With Live Birth in Women Undergoing IVF Independently of the Type of Ovarian Response
AR is a steroid hormone receptor that regulates various genes' expression and affects cellular proliferation and differentiation.
- Conditions
- Androgen Receptor Gene Overexpression, Normal Responders, Poor Ovarian Response, Bologna Criteria
- Trial name
- NCT03433768
- Testing
- Real time PCR
- Volunteers
- 67 people
- Sponsor
- Aristotle University Of Thessaloniki
Poor Responders Undergoing IVF
The Comparison of Effect of Four Different Treatment Protocols on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization.
The comparison of effect of four different treatment protocols: Antagonist/letrozole protocol, microdose flare-up protocol, Antagonist/clomiphene protocol, Antagonist on IVF outcomes in poor responders undergoing in vitro…
- Trial name
- NCT01948804
- Testing
- GnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG), microdose flare-up protocol (Lucrin; Abbott + Gonal F, Serono), Antagonist/clomiphene protocol (Cetrotide; serono + Klomen, Kocak pharma)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pınar Özcan Cenksoy
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Infertility, Premature Ovarian Failure
Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responders
The purpose of this study is to compare ovulation induction using a flexible GnRH antagonist protocol and flare up GnRH agonist protocol in IVF patients with poor response to ovarian stimulation.
- Trial name
- NCT00417066
- Testing
- Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands), Arvekap 0.1mg (Triptorelin, Ipsen, France)
- Where
- Greece
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Eugonia
Infertility
Oestradiol Pre-treatment in an Ultrashort Flare GnRH Agonist/GnRH Antagonist Protocol in Poor Responders Undergoing IVF
To evaluate the effect of oestradiol pre-treatment in a combined ultrashort flare GnRH agonist /GnRH antagonist protocol
- Trial name
- NCT01798836
- Testing
- Oestradiol pre-treatment and combination of GnRH agonist/antagonist protocol, GnRH agonist or antagonist protocol without oestradiol pre-treatment
- Where
- Greece
- Volunteers
- 17 people
- Sponsor
- National and Kapodistrian University of Athens
Infertility, Female
Growth Hormone Co-treatment Within a GnRH Antagonist Protocol in Patients With Poor Ovarian Response
In this study, the investigators will assess the efficacy of growth hormone co-stimulation to GnRH antagonist regimen in poor responders to COH for IVF.
- Trial name
- NCT03373149
- Testing
- Growth hormone/HPuFSH/GnRH antagonist, HPuFSH/GnRH antagonist
- Where
- Egypt
- Volunteers
- 228 people
- Sponsor
- Riyadh Fertility and Reproductive Health center
Infertility
The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders
The supplementation of Dehydroepiandrosterone (DHEA) has been used in some centers for patients with previous poor ovarian reserve and response in an attempt to improve pregnancy outcomes.
- Trial name
- DHEA (NCT02357472)
- Testing
- dehydroepiandrosterone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Female Infertility Due to Diminished Ovarian Reserve
Antagonist Protocol in Poor Responders
The effect of use of the growth hormone with antagonist protocol on the outcome of the IVF/ICSI cycles in poor responders.
- Trial name
- NCT02195947
- Testing
- Growth Hormone
- Where
- Egypt
- Volunteers
- 141 people
- Sponsor
- Cairo University
Poor Responders in IVF
Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients
Poor ovarian response population of ART are considered the biggest challenge for providers. Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients.
- Trial name
- NCT03560583
- Testing
- Metoclopramide
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Infertility, Poor Responder to IVF Treatment
Study of Dehydroepiandrosterone Treatment for Poor Responders in In Vitro Fertilization Patients
The aim of this study is to show solid evidences of the efficacy of DHEA in improving the success rates of in-vitro fertilization (IVF) patients facing poor ovarian reserve.
- Trial name
- NCT01535872
- Testing
- Dehydroepiandrosterone
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- KK Women's and Children's Hospital
Infertility
Human Chorionic Gonadotropin Supplementation Prior to In-vitro Fertilization Treatment in Poor Responders
In an era of delayed fertility plans, there is increasing need for fertility treatment in older women with poor response. Human chorionic gonadotropin (hCG) supplementation prior to treatment, as a thecal stimulant, may improve…
- Trial name
- NCT01205009
- Testing
- Ovitrelle
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Fertility Disorders
Dual Ovarian Stimulation (DUOSTIM) for Poor Ovarian Responders
During ovarian stimulation, all the follicles grow under the action of FSH, only the selected follicles and with the faster growth are taken.
- Trial name
- NCT03803228
- Testing
- DUOSTIM, Conventional stimuli
- Where
- 4 sites in France
- Volunteers
- 88 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Infertility
Extended Letrozole Regimen Co-treatment With Gonadotropin Releasing Hormone Antagonist Protocol Versus Gonadotropin Releasing Hormone Antagonist Protocol in Poor Responders Undergoing IVF-ET
The object of this study is to evaluate the efficacy of extended letrozole co-treatment with GnRH-antagonist protocol in ovarian stimulation of poor responder patients undergoing IVF-ET.
- Trial name
- NCT04268927
- Testing
- GnRH ant/letrozole, GnRH ant
- Where
- 2 sites in Egypt
- Volunteers
- 106 people
- Sponsor
- Cairo University
Other Complications Associated With Artificial Fertilization
Delayed Start Versus Conventional Antagonist Protocol in Poor Responders Pretreated by Estradiol in Luteal Phase
40 patients attending IVF center during 2013 \&2014 were fulfilling criteria of poor response and they failed to go through OPU as they gave <3 mature follicles on a dose of 300U GN or more.
- Trial name
- NCT02333253
- Testing
- cetrotide
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Infertility
Extended High Dose Letrozole Regimen Versus Short Low Dose Letrozole Regimen as an Adjuvant to GnRH Antagonist Protocol in the Management of Poor Responders Undergoing IVF-ET
The aim of this randomized controlled trial is to compare the efficacy of extended high dose letrozole regimen (5 mg /day for the first 5 days of cycle and 2.5 mg/day for the subsequent 3 days ) with short low dose letrozole…
- Trial name
- NCT01219153
- Testing
- Extended high dose letrozole regimen /GnRH antagonist protocol, Short low dose letrozole regimen /GnRH antagonist protocol
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Cairo University
Infertility
Protocols for Improved in Vitro Fertilization (IVF) Outcomes
Many infertile patients have a decreased chance of becoming pregnant when using in vitro fertilization (IVF). For these patients, many different treatments are available, but none of them have been shown to be better than the…
- Trial name
- NCT00334243
- Testing
- Microflare protocol for IVF, Antagonist protocol for IVF, Demi-halt protocol for IVF
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco