Clinical trials: IUD
Pain
A Trial of 2% Lidocaine Gel for Intrauterine Device (IUD) Insertion
The intrauterine device (IUD) is a long-acting, highly effective, reversible contraceptive that may be underutilized due to fear of pain during insertion.
- Trial name
- NCT01292447
- Testing
- 2% lidocaine gel
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Pain
Cervical Lidocaine for Intrauterine Device Insertion Pain
The aim of this study is to evaluate intracervical lidocaine gel as a means to decrease pain associated with intrauterine device (IUD) insertion.
- Trial name
- CLIIP (NCT01411995)
- Testing
- 2% lidocaine gel, Water based lubricant
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Intrauterine Fetal Demise
Misoprostol for Treatment of Fetal Death at 14-28 Weeks of Pregnancy
The purpose of the proposed study is to test - in a randomized, blinded trial - two different doses of the prostaglandin E1 analogue misoprostol administered buccally as a treatment for fetal death at 14 - 28 weeks, inclusive, of…
- Trial name
- NCT00671060
- Testing
- Misoprostol
- Where
- 5 sites in United States, Vietnam
- Volunteers
- 153 people
- Sponsor
- Gynuity Health Projects
Pregnancy
Copper T380 IUD Versus Oral Levonorgestrel for Emergency Contraception vs. Plan B for Emergency Contraception
The purpose of this study is to see if women presenting for emergency contraception (EC) are willing to accept the copper intrauterine device (IUD).
- Trial name
- NCT00669396
- Testing
- Copper T380 IUD, levonorgestrel
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Utah
Perinatal Death, Neonatal Death
Verbal Autopsy of Maternal Deaths, Stillbirths, and Neonatal Deaths in BetterBirth
The purpose of this study is to conduct Verbal Autopsies of deaths ( stillbirths and neonatal deaths together) identified in the BetterBirth trial to identify their potential causes, timing, and social determinants.
- Conditions
- Perinatal Death, Neonatal Death, Stillbirth
- Trial name
- NCT03213509
- Testing
- Interview (Social and Verbal Autopsy)
- Where
- India
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Genital Tract Mucosal Immunity, Genital Tract Microflora
Study of Immune Cell Changes in the Genital Tract 2 Months After Initiation of an IUD for Contraception
This pilot study is being performed to investigate the influence that starting contraception with an IUD has on the local immune cell populations and features, with a particular focus on the cells and cell-surface features that…
- Trial name
- CHIC (NCT01240811)
- Testing
- IUD placement, Levonorgestrel IUD, Copper T380A IUD
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sharon Achilles
Lactation Suppressed
Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Loss
This research study investigates the use of a drug, cabergoline, given immediately after second-trimester abortion or perinatal loss to decrease breast engorgement.
- Trial name
- LISTA (NCT04701333)
- Testing
- Cabergoline 1 MG
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Stanford University
Lactation Suppressed
Cabergoline for Lactation Inhibition After Early Second-Trimester Abortion or Pregnancy Loss
Breast pain following second-trimester abortion is common. Breast engorgement and milk leakage following second-trimester perinatal loss and abortion can cause both physical pain and emotional distress.
- Trial name
- eLISTA (NCT06029673)
- Testing
- Cabergoline 1 MG
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Stanford University
Atypical Endometrial Hyperplasia, Stage I Uterine Corpus Cancer AJCC v7
Levonorgestrel-Releasing Intrauterine System in Treating Patients With Complex Atypical Hyperplasia or Grade I Endometrial Cancer
This phase II trial studies how well levonorgestrel-releasing intrauterine system works in treating patients with complex atypical hyperplasia or grade I endometrial cancer.
- Conditions
- Atypical Endometrial Hyperplasia, Stage I Uterine Corpus Cancer AJCC v7, Stage IA Uterine Corpus Cancer AJCC v7, Stage IB Uterine Corpus Cancer AJCC v7
- Trial name
- NCT00788671
- Testing
- Laboratory Biomarker Analysis, Levonorgestrel-Releasing Intrauterine System, Quality-of-Life Assessment
- Where
- 7 sites in United States
- Volunteers
- 69 people
- Sponsor
- M.D. Anderson Cancer Center
Intrauterine Device Complications, Contraceptive Device Failure
Patient Factors Associated With Fragmentation of Copper Intrauterine Device (IUD) Requiring Hysteroscopic Removal
The purpose of this retrospective chart review was to identify risks factors for patients associated to Cooper IUD fragmentation upon removal resulting in the requirement of a hysteroscopy evaluation.
- Conditions
- Intrauterine Device Complications, Contraceptive Device Failure, IUD Fragmentation, Retained Intrauterine Device
- Trial name
- NCT07351084
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Kansas Medical Center
Pain Due to Intrauterine Contraceptive Device
Pain Control for Intrauterine Device Placement Using Paracervical Block
Intrauterine device (IUD) placement can be painful for patients during and after the procedure. Fear of pain from IUD insertion can be a barrier to obtaining this highly effective long acting reversible contraception.
- Trial name
- NCT02219308
- Testing
- Paracervical Block (PCB)
- Where
- 2 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Contraception
GyneFix-Viz*: A Study of Serosal-Anchor (SA) Distance
The GyneFix-Viz is a frameless copper intrauterine device (IUD) used for contraception. The GyneFix IUD has been marketed in Europe and Asia for about 10 years.
- Trial name
- GF (NCT01979835)
- Testing
- GyneFix Viz
- Where
- Canada
- Volunteers
- 1,030 people, healthy volunteers welcome
- Sponsor
- Wiebe, Ellen, M.D.
Contraception
Immediate Postplacental IUD Insertion
The study will be a randomized clinical trial. Women with less than 10 prenatal visits and/or 2 or more no show visits who desire an Intrauterine Device (IUD) will be considered for enrollment.
- Trial name
- NCT02169869
- Testing
- Mirena, Paragard
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Oregon Health and Science University
Intrauterine Devices, Copper, Metrorrhagia
Tracking IUD Bleeding Experiences: An Evaluation of Bleeding Profiles in New Intrauterine Device Users
This study aims to use validated tools as well as new technology to examine changes in bleeding patterns among women who are initiating the copper T380A IUD.
- Conditions
- Intrauterine Devices, Copper, Metrorrhagia, Menstruation, Menstrual Cycle
- Trial name
- TRIBE (NCT02311478)
- Testing
- T380A Intrauterine Copper Contraceptive
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- University of Utah
Infant, Small for Gestational Age, Infant, Low Birth Weight
KBTH-GIRHL Healthy Birth Weight Study: A Cross-Section
This study was designed and conducted in an effort to establish a comparison group for the Ghana PrenaBelt Trial (NTC02379728). The Ghana PrenaBelt Trial examined the effect, on birth weight, of a belt-like device to help…
- Conditions
- Infant, Small for Gestational Age, Infant, Low Birth Weight, Pregnancy, Sleep
- Trial name
- KBTH-HBWS (NCT03062228)
- Where
- Ghana
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Unplanned Pregnancy
A Pilot Study of Early Postpartum Intrauterine Contraception
This is a prospective clinical trial of ultrasound guided intrauterine contraception insertion 10 minutes - 48 hours after vaginal delivery of single infant.
- Trial name
- ImmPPIUD (NCT00997932)
- Testing
- Levonorgestrel-Releasing Intrauterine Contraceptive System (LNG-IUS), 52 Mg, 5 Year Duration
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Contraception
Safety and Expulsion of Delayed Versus Immediate Postpartum Intrauterine Device Placement
This is randomized controlled trial designed for pregnant women who deliver vaginally at the University of Louisville Hospital and desire to have an intrauterine device (IUD) inserted for postpartum contraception.
- Trial name
- IUD (NCT01598662)
- Testing
- Mirena (levonorgestrel-releasing intrauterine system)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Pain
Intracervical Lidocaine Gel for IUD Insertional Pain
The intrauterine device (IUD) is a form of birth control that is extremely effective and safe, even in women who have not yet had children.
- Trial name
- NCT01214161
- Testing
- 2% lidocaine gel
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Columbia University
Contraception
Naproxen for Pain Control With Intrauterine Device Insertion
The purpose of this study is: 1. To evaluate whether 550 mg of naproxen sodium reduces pain scores with IUD insertion on a 0-10cm visual analogue scale compared to placebo (primary outcome). 2.
- Trial name
- NCT02388191
- Testing
- Naproxen sodium
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Contraception, Unintended Pregnancy
Innovative Model of Patient-Centered ConTraception
This study is testing models of contraceptive care that were developed as part of the Contraceptive CHOICE Project. CHOICE is a prospective cohort study of 9,256 women designed to: 1) promote the use of long-acting reversible…
- Trial name
- IMPACCT (NCT02364037)
- Testing
- CHOICE Project Structured Contraceptive Counseling, Contraceptive Education Session, Cost Support for IUDs and implants
- Where
- 3 sites in United States
- Volunteers
- 1,008 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine