Clinical trials: IGRT
Malignant Tumor, Benign Neoplasm
Twenty-five Years of Advanced RadioTherapy at San Raffaele Hospital
This retrospective observational study aims to evaluate the efficacy and toxicity of advanced radiotherapy (ART) techniques, including intensity-modulated radiotherapy (IMRT), image-guided radiotherapy (IGRT), and stereotactic…
- Conditions
- Malignant Tumor, Benign Neoplasm, Parkinson Disease, Trigeminal Neuralgia
- Trial name
- 25-ART-HSR (NCT07894900)
- Testing
- Advanced radiotherapy techniques
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Cervical Cancer
Gynaecologic Organ Segmentation and Motion Tracking Using Ultrasound
This study will establish the feasibility and accuracy of localising and outlining the uterus on ultrasound images using both healthy volunteer and cervical patient cohorts.
- Trial name
- GENIUS (NCT02503917)
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Lymphedema, Musculoskeletal Complications
Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg
RATIONALE: Image-guided radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a lower dose of radiation directly to the tumor may kill more tumor cells and cause less damage to…
- Conditions
- Lymphedema, Musculoskeletal Complications, Radiation Fibrosis, Radiation Toxicity
- Trial name
- NCT00589121
- Testing
- Chemotherapy, Radiation therapy, Surgery
- Where
- 17 sites in United States, Canada
- Volunteers
- 98 people
- Sponsor
- Radiation Therapy Oncology Group
Pancreatic Adenocarcinoma
Radiopaque Hydrogel in Patients Undergoing Radiotherapy for Pancreatic Cancer
The goal of this pilot imaging study is to evaluate the visibility of marking the interface between the pancreas and duodenum with TraceIT Tissue Marker.
- Trial name
- NCT03307564
- Testing
- TraceIT tissue marker injection
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Metastatic Disease
Study Using High-Dose Single Fraction Image-Guided Radiotherapy for Metastatic Lesions to Soft Tissue Masses, Lymph Node, or Bone
The purpose of this research study is to find out what IG-IMRT radiation dose works best for treatment of disease in bone or soft tissues. This protocol will study what dose level may work most effectively.
- Trial name
- NCT00678158
- Testing
- intensity modulated radiation therapy
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Metastatic Prostate Cancer, Prostate Adenocarcinoma
Single Dose Radiotherapy (SDRT) With or Without Adjuvant Systemic Therapy for Oligometastatic Prostate Cancer
The present study aims to optimize the use of systemic therapy relative to local tumor ablation in a prospective randomized clinical trial and to validate the existence and characterize the clinical and pathology phenotype of…
- Trial name
- NCT04031378
- Testing
- Single Dose Radiotherapy (24 Gy) to all detectable lesions, followed by observation, Single Dose Radiotherapy (24 Gy) to all detectable lesions followed by adjuvant systemic therapy for 6 months
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Fundacao Champalimaud
Prostate Cancer
Study of MR-based IGRT for Prostate Cancer
MR (Magnetic Resonance Imaging) - based IGRT (image-guided radiotherapy) for patients with prostate carcinoma.
- Trial name
- M-basePro (NCT02724670)
- Testing
- IGRT
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- University Hospital Tuebingen
Hepatocellular Carcinoma
Trial Comparing PLA to HIGRT (PROVE-HCC)
This phase II, randomized trial compare Quality of Life for patients with Hepatocellular Carcinoma (HCC) who are not surgical candidates or decline surgery and are treated with Percutaneous Local Ablation (PLA) or…
- Trial name
- PROVE-HCC (NCT03402607)
- Testing
- Percutaneous Local Ablation, Hypofractionated Image Guided Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Cancer Cervix
Tomotherapy vs Conventional Radiation for Adjuvant Pelvic RT in Ca Cervix
The study tests Tomtherapy based Image Guided Radiation against conventional radiation techniques for it's ability to reduce long term small bowel toxicity.
- Trial name
- PARCER (NCT01279135)
- Testing
- Conventional Radiation, Tomotherapy based IGRT
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Tata Memorial Hospital
Adenocarcinoma
PRIMER: Development of Daily Online Magnetic Resonance Imaging for Magnetic Resonance Image Guided Radiotherapy
In radiotherapy high-tech scans with x-rays (CT scans) are taken before and during treatment to locate the tumour and ensure the radiation is hitting the target.
- Trial name
- NCT02973828
- Testing
- Imaging
- Where
- United Kingdom
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Stage IV Non-Small Cell Lung Cancer
Radical RADiotherapy and Immunotherapy for Metastatic CAncer of the Lung (RRADICAL)
This phase II trial studies how well radical-dose image guided radiation therapy works in treating patients with non-small cell lung cancer that has spread to other places in the body who are undergoing immunotherapy.
- Trial name
- NCT03176173
- Testing
- Image-guided Radiation Therapy, Immunotherapy (physician's choice for standard of care immunotherapy)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Prostate Cancer
Single-Dose Image-Guided Radiotherapy With Urethral Sparing and DIL Boost for Intermediate-Risk Prostate Cancer (PROSINT II)
This prospective single-arm phase II study evaluates the safety, feasibility, quality-of-life effects, PSA kinetics, imaging response, and clinical outcomes of definitive ultra-high dose single-fraction external beam radiation…
- Trial name
- PROSINT II (NCT04035642)
- Testing
- IGRT-VMAT / SDRT 24 Gy in 1 fraction, Rectal balloon with air filling, Urethral catheter loaded with beacon transponders
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Fundacao Champalimaud
Localized Prostate Cancer, Stereotactic Body Radiotherapy
Is Adaptive SBRT for Prostate vs Image-guided Radiotherapy a True Evolution (ASPIRE)
The ASPIRE study is a Phase III randomized, single-center study designed to evaluate whether adaptive stereotactic body radiotherapy (SBRT) offers superior clinical benefits compared to standard image-guided SBRT for patients…
- Trial name
- ASPIRE (NCT06825091)
- Testing
- SBRT
- Where
- Canada
- Volunteers
- 320 people
- Sponsor
- University Health Network, Toronto
Sarcoma, Ewing's, Rhabdomyosarcoma
Radiation Therapy to Treat Musculoskeletal Tumors
Researchers at St. Jude Children's Research Hospital are looking for more effective ways to deliver radiation therapy to pediatric tumors of the bone and soft tissues.
- Conditions
- Sarcoma, Ewing's, Rhabdomyosarcoma, Soft Tissue Sarcoma, Musculoskeletal Tumors
- Trial name
- NCT00186992
- Testing
- image-guided radiotherapy
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- St. Jude Children's Research Hospital
Brain Metastases, Adult, Cancer Brain
Hypofractionated Brain Radiationcavity
Stereotactic radiosurgery or hypofractionated radiotherapy of the resection cavity after metastasectomy in cancer patients with brain metastases
- Trial name
- NCT03561896
- Testing
- IGRT, SRS
- Where
- 6 sites in Switzerland
- Volunteers
- 56 people
- Sponsor
- Oncology Institute of Southern Switzerland
Non-small Cell Lung Cancer
Phase I Study of Accelerated Hypofractionated Image-Guided Radiation Therapy
The study is designed to determine whether daily image guidance and motion assessment/control will allow treatment of poor performance status patients with stage II-IV NSCLC, who would benefit from local therapy, with an…
- Trial name
- NCT03623334
- Testing
- Image-Guided Radiation Therapy
- Volunteers
- 55 people
- Sponsor
- University of Texas Southwestern Medical Center
Prostate Cancer
Multi-target Tracking in Prostate Radiotherapy Using MLC and KIM
Assessing the feasibility of implementing real-time multi-leaf collimator (MLC) tracking to account for the relative motion of the moving prostate tumour target and the static pelvic nodal target for high-risk prostate cancer…
- Trial name
- KOALA (NCT02588846)
- Testing
- Combined real-time use of 'Multi-Leaf Collimator Adaptation' and 'kV Intrafraction Monitoring'
- Where
- Australia
- Sponsor
- Royal North Shore Hospital
Chimeric Antigen Receptor T-cell Therapy, B Cell Acute Lymphoblastic Leukemia (B-ALL)
Immunoglobulin Replacement Therapy (IgRT) Versus Antibiotic Prophylaxis (PA) in Patients Treated by CD19-targeted Chimeric Antigen Receptor (CAR)T Cells for a B Cell Acute Lymphoblastic Leukemia or a B Cell Lymphoma
B cell (CD19) targeted chimeric antigen receptor modified T Cells (CAR-T) has transformed treatment of relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) or B-cell lymphoma (BCL).
- Conditions
- Chimeric Antigen Receptor T-cell Therapy, B Cell Acute Lymphoblastic Leukemia (B-ALL), B Cell Lymphoma, Antibiotic Prophylaxis
- Trial name
- PREV-CART (NCT07754682)
- Testing
- Immunoglobulin, antibiotic prophylaxis
- Volunteers
- 228 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prostate Cancer, Radiotherapy Side Effect
Ultra Hypofractionnated Radiotherapy With HDR Brachytherapy Boost.
Phase 1-2 study, comparing ultra-hypofractionnated (UH) to a moderately hypofractionnated (MH) radiation therapy, with image guided HDR prostate brachytherapy.
- Conditions
- Prostate Cancer, Radiotherapy Side Effect, Hypofractionation, Brachytherapy
- Trial name
- HYPO-5 (NCT05786742)
- Testing
- grade and compare reported side effects between groups
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Liver Cancer, Hepatocellular Carcinoma (HCC)
Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients
This is a research study to evaluate change in Quality of Life, as defined by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC C-30), from baseline to 1 month post…
- Trial name
- NCT04933435
- Testing
- Quality of life questionnaires
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Duke University