Clinical trials: ICH - Intracerebral Hemorrhage
Acute Stroke, Ischemic Stroke
Rescue Intracranial Stenting in Acute Ischemic Stroke
In acute ischemic stroke caused by intracranial large vessel occlusion, rescue intracranial stenting has been recently a treatment option to achieve recanalization in patients with the failure of mechanical thrombectomy.
- Conditions
- Acute Stroke, Ischemic Stroke, Intracranial Atherosclerosis, Stent Stenosis
- Trial name
- RISIS (NCT04986774)
- Testing
- Rescue intracranial stenting
- Where
- Vietnam
- Volunteers
- 85 people
- Sponsor
- Can Tho Stroke International Services Hospital
Moyamoya Disease
Clinical Safety and Efficacy Evaluation of the Blood-cooling and Stasis-removing Formula as an Adjunct to Atorvastatin in the Treatment of Hemorrhagic Moyamoya Disease.
Moyamoya disease is a relatively rare chronic cerebrovascular disease, and its exact cause is currently unknown. This disease is characterized by the gradual narrowing or even blockage of important blood vessels in the brain (the…
- Trial name
- NCT07894640
- Testing
- Atorvastatin, Blood-cooling and Stasis-clearing Formula
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Colchicine, ICH - Intracerebral Hemorrhage
Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage
Data indicate that patients with intracerebral hemorrhage (ICH) are at high risk for thromboembolic events and disability that is not being sufficiently mitigated by current treatment strategies.
- Conditions
- Colchicine, ICH - Intracerebral Hemorrhage, Stroke, Dependence
- Trial name
- CoVasc-ICH2 (NCT06587737)
- Testing
- Colchicine 0.5 MG
- Volunteers
- 1,125 people
- Sponsor
- Population Health Research Institute
Early Systolic Blood Pressure Control Rate, Hematoma Growth
Analgesia-first Minimal Sedation for Spontaneous Intracerebral Hemorrhage Early Antihypertensive Treatment
This study evaluates safety and efficacy of analgesia-first minimal sedation as an early antihypertensive treatment for spontaneous intracerebral hemorrhage.
- Conditions
- Early Systolic Blood Pressure Control Rate, Hematoma Growth, Blood Pressure Variability, Healthcare Worker Satisfaction
- Trial name
- ASSICHH (NCT03207100)
- Testing
- Analgesia-first minimal sedation, Antihypertensive treatment
- Where
- 17 sites in China
- Volunteers
- 338 people
- Sponsor
- Hong Yang
Intracerebral Hemorrhage
Non-invasive Evaluation of Cerebrovascular Reactivity in Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) remains a significant cause of morbidity and mortality around the globe. The most common etiology of nontraumatic spontaneous ICH is hypertensive arteriopathy (HA), while cerebral…
- Trial name
- NCT03815513
- Testing
- brain MRI
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Intracerebral Hemorrhage, Acute Ischemic Stroke
Cranial Ultrasound for Prehospital ICH Diagnosis
To evaluate the feasibility of Emergency Medical System (EMS)-performed cPOCUS in the field for diagnosis of acute Intracerebral hemorrhage (ICH)
- Trial name
- CUPID_EMS (NCT05492474)
- Testing
- Cranial Point of Care Ultrasound
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Wake Forest University Health Sciences
Intracerebral Hemorrhage
REmifentanil And Dexmedetomidine for EarlY Intensive Blood Pressure Lowering in ICH.
Intracerebral hemorrhage (ICH) remains the most devastating subtype of stroke, with a case fatality rate of approximately 40% at one months post-onset, imposing a particularly heavy medical and economic burden on low- and…
- Trial name
- READY-ICH (NCT07695220)
- Testing
- Remifentanil and Dexmedetomidine, Guideline standard care
- Volunteers
- 1,116 people
- Sponsor
- The Third Affiliated Hospital of Southern Medical University
Cerebrovascular Event, Acute Ischemic Stroke
Prospective Italian Validation of SMS in Patients With Suspected Acute Stroke
The overall objective of the study is to prospectively validate the diagnostic accuracy of the Stroke Mimics Score (SMS). This score is calculated using information collected at the time of the patient's arrival in the Emergency…
- Conditions
- Cerebrovascular Event, Acute Ischemic Stroke, Intracerebral Hemorrhage, TIA (Transient Ischemic Attack)
- Trial name
- PIVA-SMS (NCT07601659)
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Intracerebral Haemorrhage, Intracerebral Hemorrhage
Timing and Outcomes of Recovery After intraCerebral Hemorrhage
The TORCH registry is a prospective, observational cohort study, which will collect detailed, longitudinal data on the clinical characteristics, treatment modalities, and outcomes of patients with ICH.
- Trial name
- TORCH (NCT07166146)
- Testing
- Surgical interventions
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage
Smartphone Enabled Detection of Cognitive Motor Dissociation in the ICU
The purpose of this research study is to evaluate whether a smartphone-enabled EEG (electroencephalography) system can be used to detect Cognitive Motor Dissociation (CMD) in patients with acute neurological injuries who appear…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Cardiac Arrest (CA)
- Trial name
- SMART-CMD (NCT07917728)
- Where
- 9 sites in United States, Brazil and 3 more
- Volunteers
- 240 people
- Sponsor
- Columbia University
Intracerebral Haemorrhage
Efficacy and Safety of Mirabegron in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes without effective pharmacological treatment. Inflammation following ICH contributes to barrier disruption and peri-hematoma edema, leading to deterioration of…
- Trial name
- NCT05369351
- Testing
- Standard treatment+mirabegron, Standard treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Tianjin Medical University General Hospital
Pulmonary Injury After Intracerebral Hemorrhage
Efficacy and Safety of Baricitinib in the Post-intracerebral Hemorrhage Pulmonary Injury
Some patients with intracerebral hemorrhage will develop severe lung injury such as respiratory distress syndrome. Baricitinib has been approved by the FDA for severe pneumonia caused by the coronavirus, and has been used in the…
- Trial name
- BRIGHT (NCT06548802)
- Testing
- Baricitinib
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tianjin Medical University General Hospital
Intracranial Hemorrhage, Hypertensive
Minimally-invasive Surgery Versus Craniotomy in Patients With Supratentorial Hypertensive Intracerebral Hemorrhage
The effectiveness of craniotomy in the treatment of intracerebral hemorrhage remains controversial. Two main types of minimally invasive surgery, endoscopic evacuation and stereotactic aspiration, have been attempted for hematoma…
- Trial name
- MISICH (NCT02811614)
- Testing
- Endoscopic Evacuation, Stereotactic Aspiration, Craniotomy
- Where
- China
- Volunteers
- 733 people
- Sponsor
- Chinese PLA General Hospital
Intracerebral Hemorrhage
Administration of Celecoxib for Treatment of Intracerebral Hemorrhage : A Pilot Study
Primary: Change of volume of perihematomal edema as assessed by brain CT. Secondary: The change of ICH volume between the initial and the follow-up CT scans The neurological status at 90 day using E-GOS and mRS.
- Trial name
- ACE-ICH (NCT00526214)
- Testing
- celecoxib medication
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Cerebrovascular Disorders, Intracranial Hemorrhages
Statins for Treatment of Primary Intracerebral Hemorrhage
The STOP ICH trial is a multicenter, prospective, randomized, open-label, blinded end-point (PROBE) study designed to assess the efficacy and safety of atorvastatin in patients with intracerebral hemorrhage (ICH) presenting…
- Conditions
- Cerebrovascular Disorders, Intracranial Hemorrhages, Intracranial Hemorrhage, Intracerebral Haemorrhage
- Trial name
- STOP ICH (NCT07088250)
- Testing
- Atorvastatin Treatment, Best Medical Treatment
- Where
- 22 sites in China
- Volunteers
- 264 people
- Sponsor
- The Second Hospital of Anhui Medical University
Normobaric Hyperoxia, Intracerebral Hemorrhage
Normobaric Hyperoxia for Intracerebral Hemorrhage
Perihematoma edema (PHE), as the major injury for intracranial hemorrhage (ICH) involves more than the initial tissue damage induced directly by the hematoma.
- Trial name
- NCT04144868
- Testing
- Oxygen storage face masks and nasal catheter, Nasal catheter
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Capital Medical University
Sedation of Cerebrovascular Ventilated Critical Care Patients
Sedation Depth in Neurocritical Care
Background: Sedation of the intensive care unit (ICU) patient is necessary to relieve the patient from pain, anxiety and agitation and to enable mechanical ventilation, diagnostic investigations and invasive procedures.
- Trial name
- MODERNISE (NCT02317497)
- Testing
- Intensive Care Sedation (depth, level), Vasopressors to maintain normal blood pressure values, if needed, Osmotherapeutics to lowr intracranial pressure, if needed
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heidelberg University
Intracerebral Hemorrhage
TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage
TIME-ICH (TrIal of early Minimally Invasive catheter Evacuation with thrombolysis in IntraCerebral Hemorrhage) is a multicenter, randomized, adaptive clinical trial comparing best medical management to early minimally invasive…
- Trial name
- TIME-ICH (NCT07187687)
- Testing
- Early Minimally Invasive Surgery with Thrombolysis (eMIST)
- Where
- 70 sites in China
- Volunteers
- 750 people
- Sponsor
- Xuanwu Hospital, Beijing
Hypothermia, Primary Intracerebral Hemorrhage
Pilot Study of Hypothermia for Intracerebral Hemorrhage in Croatia
In this pilot study the researchers will investigate efficacy of hypothermia in the early stage of treatment patients with primary intracerebral hemorrhage.
- Conditions
- Hypothermia, Primary Intracerebral Hemorrhage, Signs and Symptoms
- Trial name
- NCT01221142
- Testing
- Cincinnati Sub-Zero," Blanketrol III"
- Where
- Croatia
- Volunteers
- 20 people
- Sponsor
- University of Rijeka
Aphasia, Acquired, Aphasia
Aphasia Physical EXercise Study: Randomized Trial
The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia.
- Conditions
- Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia, Non-fluent
- Trial name
- APEX (NCT07281313)
- Testing
- High-intensity physical exercise, Low-intensity physical exercise
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Berkeley