Clinical trials: IBD (Inflammatory Bowel Disease)
HELICOBACTER PYLORI INFECTIONS, Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Prevalence of Helicobacter Pylori on Patients With Chronic Inflammatory Bowel Disease (IBD) at the CHU of Guadeloupe
Clinical and experimental data suggest that dysbiosis may play a pivotal role in the pathogenesis of intestinal bowel disease (IBD).
- Trial name
- HP-MICI (NCT07292454)
- Testing
- Biopsies
- Where
- Guadeloupe
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Crohn Disease in Remission, Crohn Disease
Lengthening Adalimumab Dosing Interval in Quiescent Crohn's Disease Patients
Crohn's disease is a chronic inflammatory bowel disease. This disease can be treated with, among other things, biologicals such as adalimumab.
- Trial name
- LADI (NCT03172377)
- Testing
- Lengthening adalimumab dosing interval
- Where
- 22 sites in Netherlands
- Volunteers
- 174 people
- Sponsor
- Radboud University Medical Center
Ulcerative Colitis, Dietary Modification
Evaluating the Combined Effect of Vedolizumab and Semi-Vegetarian Diet on Ulcerative Colitis.
Research of fecal microflora and dysbiosis status in ulcerative colitis (UC) has shown its influential role on the disease pathogenesis.
- Trial name
- NCT03309865
- Testing
- semi-vegetarian diet, Vedolizumab Injection
- Where
- United States
- Sponsor
- Mayo Clinic
Crohn Disease, Ultrasound
Validation and Interobserver Reliability of a Simple Ultrasound Score for Crohn's Disease
Crohn's disease (CD) is a chronic inflammatory disease in the gastrointestinal (GI) tract. It is characterized by an alternating course between remission and relapse, which necessitates subsequent adjustments in medical therapy.
- Trial name
- NCT03481751
- Testing
- Diagnostic test: Ultrasound
- Where
- 3 sites in Norway
- Volunteers
- 124 people
- Sponsor
- Haukeland University Hospital
Crohn Disease
Treatment of Crohn's Complex Perianal Fistulas With Tissue Transplantation by Local Injection of Micro-fragmented Autologous Adipose Tissue.
multicentre randomized controlled prospective study aimed at evaluating the efficacy of the infiltration of microfractured adipose tissue in the healing of perianal fistulas not-responding to treatment with biologics, in order to…
- Trial name
- ATTIC (NCT05594862)
- Testing
- Lipogems
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Lipogems International spa
Inflammatory Bowel Disease
Analysis of Birth Outcomes of Swedish, Danish and Finnish Women Exposed to Remicade With Inflammatory Bowel Disease, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Psoriasis
The purpose of this study is collection and analysis of information pertaining to pregnancy outcomes in women exposed to infliximab during pregnancy, relative to the background risk in similar but non-biologic exposed patients…
- Trial name
- NCT00658827
- Testing
- No intervention
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Janssen Biotech, Inc.
Infections, Pneumococcal, Bowel Diseases, Inflammatory
Anti-pneumococcal Vaccine Strategy in Patients Treated With Immunosuppressants or Biotherapies for CIBD
This is a multicenter, prospective, randomized, open study comparing two anti-pneumococcal vaccination strategies in patients with Chronic Inflammatory Bowel Disease (CIBD) treated by immunosuppressants and/or biotherapies.
- Trial name
- PneumoMICI (NCT02255227)
- Testing
- Prevenar 13, Pneumo 23
- Where
- 8 sites in France
- Volunteers
- 104 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ulcerative Colitis
ChAracterizing the Remission Status in Patients With Ulcerative Colitis Treated by 5-ASA
For the last years the aim of the management of ulcerative colitis (UC) has become more ambitious including not only clinical remission but also the achievement of biological remission, endoscopic and histological healing, which…
- Trial name
- CARUC-ASA (NCT05992142)
- Testing
- 5-ASA
- Where
- 16 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW
Crohn Disease
An Efficacy and Safety Study of Anti-TNF Monoclonal Antibody in Patients With Fistulizing Crohn's Disease
The purpose of this study is to evaluate the effectiveness and safety of anti-TNF chimeric monoclonal antibody (cA2) compared to placebo in the treatment of patients with fistulizing Crohn's disease.
- Trial name
- NCT00269841
- Testing
- Infliximab 10 mg/kg, Infliximab 5 mg/kg
- Volunteers
- 94 people
- Sponsor
- Centocor, Inc.
Ulcerative Colitis
Study to Evaluate the Efficacy and Safety of Tilpisertib in Adults With Moderately to Severely Active Ulcerative Colitis
The primary objective of this study is to demonstrate the efficacy of tilpisertib (formerly GS-4875) compared with placebo control in achieving clinical remission per modified Mayo Clinic Score (MCS) in adults with moderately to…
- Trial name
- Falcon (NCT04130919)
- Testing
- Tilpisertib
- Where
- 49 sites in United States, Australia and 7 more
- Volunteers
- 19 people
- Sponsor
- Gilead Sciences
Crohn Disease
The Effects of Parenteral ω-3 Polyunsaturated Fatty Acid on Postoperative Complications of Patients With Crohn's Disease
This study is intended to investigate the safety and efficacy of ω-3 polyunsaturated fatty acid-based parenteral nutrition (PN) for patients with Crohn's disease.
- Trial name
- ω3CD (NCT03901937)
- Testing
- ω-3 polyunsaturated fatty acid, Intestinal surgery for Crohn's Disease
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Sir Run Run Shaw Hospital
Ulcerative Colitis
Multi-Strain Probiotics Supplementation With Standard Care in Mild to Moderate Ulcerative Colitis
Probiotics are one of the adjunctive treatments that have been extensively explored for Ulcerative colitis (UC) disease management.
- Trial name
- NCT06595719
- Testing
- Multi-Strain Probiotics
- Where
- Malaysia
- Volunteers
- 124 people
- Sponsor
- National University of Malaysia
Mb Crohn, Ulcerative Colitis (UC)
Uneven Nutrition and Life Style as IBD Triggers in Adolescents and Adults
The aims of the study are 1. to determine the effect on dysbiosis, permeability and inflammatory activity after administration of a Mediterranean like diet (a Nordic equivalent, "Nordiet"), 2.
- Trial name
- UNITA (NCT07389161)
- Testing
- Nordiet
- Where
- Sweden
- Volunteers
- 160 people
- Sponsor
- Region Skane
Inflammatory Bowel Disease
Stavanger IBD Study - Cross Sectional
In this cross sectional and longitudinal study, patients with inflammatory bowel disease on biological treatment with infliximab or adalimumab will be included.
- Trial name
- SUSI-CS (NCT02134054)
- Where
- Norway
- Volunteers
- 210 people
- Sponsor
- Helse Stavanger HF
Inflammatory Bowel Diseases, Psychosocial Impairment
Evaluation of Quality of Life and Psychosocial Status in Children With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic condition that affects the psychosocial status and physical activities of children and their parents in many ways.
- Trial name
- NCT06270277
- Testing
- Pediatric Quality of Life Inventory (PedsQL), Strengths and Difficulties Questionnaire (SDQ)
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Ulcerative Colitis
A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis
The purpose of this study is to evaluate the efficacy and safety of mirikizumab as maintenance therapy in participants who completed as clinical responders in the prior 12-week induction study LUCENT-1 (NCT03518086).
- Trial name
- LUCENT 2 (NCT03524092)
- Testing
- Mirikizumab SC, Mirikizumab IV
- Where
- 385 sites in United States, Argentina and 32 more
- Volunteers
- 1,328 people
- Sponsor
- Eli Lilly and Company
Inflammatory Bowel Diseases, Pain
Reactive vs. Proactive Pain Control in IBD
The investigators will compare two physician behaviors for managing pain in patients with IBD: proactive vs. reactive. Both the proactive and reactive behavior/strategies are standard of care at the institution in which the study…
- Conditions
- Inflammatory Bowel Diseases, Pain, Opioid Use, Crohn Disease
- Trial name
- PAIN-Sparing (NCT03798405)
- Testing
- Proactive Analgesic Inpatient Narcotic-Sparing
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Cedars-Sinai Medical Center
Ulcerative Colitis
The Promotion Plan of Moxibustion on Ulcerate Colitis
To evaluate the efficacy of Moxibustion in the treatment of Ulcerative Colitis, thus the scientific foundation for rational use of Moxibustion in clinical usage, in order to find admission of the Acupuncture and Moxibustion and…
- Trial name
- NCT03232528
- Testing
- Herb-partitioned moxibustion
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Crohns Disease, Bile Acid Malabsorption
Colesevelam for the Treatment of Bile Acid Malabsorption in Patients With Crohn's Disease
The purpose of this study is to assess the efficacy of cholestagel to reduce the frequency of soft and liquid stools per day in patients with CD in clinical remission with symptoms of BAM and to assess the improvement in stool…
- Trial name
- COBAM (NCT01203254)
- Testing
- Colesevelam
- Where
- 6 sites in Germany
- Volunteers
- 34 people
- Sponsor
- Florian Beigel
Ulcerative Colitis
Phosphatidylcholine (LT-02) vs. Placebo vs. Mesalamine for Maintenance of Remission in Ulcerative Colitis (PROTECT-2)
The purpose of this study is to prove the superiority of a 48-weeks treatment with 3.2 g/day delayed-release phosphatidylcholine (LT-02) versus placebo for the maintenance of remission in patients with ulcerative colitis (UC)
- Trial name
- PROTECT-2 (NCT02280629)
- Testing
- LT-02, Mesalamine
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Dr. Falk Pharma GmbH
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