Clinical trials: IBD
Ulcerative Colitis
Lactobacillus Acidophilus and Bifidobacterium Animalis Subsp. Lactis, Maintenance Treatment in Ulcerative Colitis
The purpose of this study is to determine whether the lactic acid bacteria " Lactobacillus acidophilus (LA5) and Bifidobacterium animalis subsp. lactis (BB12)" is effective as maintenance treatment in ulcerative colitis.
- Trial name
- NCT00268164
- Testing
- lactobacilus acidophilus & bifidobacterium animalis/lactis
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Hvidovre University Hospital
Polyp of Large Intestine, Colorectal Neoplasms
Perioperative Hemodynamic Optimization Using the Photoplethysmography in Colorectal Surgery
The purpose of this study is to determine whether hemodynamic optimization with photoplethysmography (ClearSight, Edwards Lifesciences, Irvine, CA) during colorectal surgery could decrease the incidence of perioperative…
- Conditions
- Polyp of Large Intestine, Colorectal Neoplasms, Crohn Disease
- Trial name
- PANEX3 (NCT02343601)
- Testing
- Photoplethysmography
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Caen
Crohn Disease, Colitis, Ulcerative
A Study to Evaluate Disease Control, Treatment Patterns, Burden of Disease and Quality of Life in Participants With Moderate to Severe Inflammatory Bowel Disease (IBD)
The purpose of this study is to evaluate the percentage of moderate to severe IBD participants with active disease at Day 1.
- Conditions
- Crohn Disease, Colitis, Ulcerative, Inflammatory Bowel Disease
- Trial name
- RISE AR (NCT03488030)
- Where
- 7 sites in Argentina
- Volunteers
- 246 people
- Sponsor
- Takeda
Irritable Bowel Syndrome Constipation Predominant
Effects of ROSE-010 on GI Transit in Constipation Predominant Irritable Bowel Syndrome (C-IBS) Patients
This trial will study the effects of an investigational (not FDA approved) medication, ROSE-010, on the movement of food through the stomach, small intestine and colon in females with constipation predominant irritable bowel…
- Trial name
- NCT01056107
- Testing
- ROSE-010
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Mayo Clinic
Radiation Exposure to Operator, Endovascular Aortic Repair
Exoskeleton vs. Standard Lead Apron in EVAR Procedures
The goal of this clinical trial is to learn whether an exoskeleton-supported radiation protection system can reduce radiation exposure and musculoskeletal strain in vascular surgeons during endovascular aortic repair procedures…
- Conditions
- Radiation Exposure to Operator, Endovascular Aortic Repair, Musculoskeletal Strain, Occupational Radiation Exposure
- Trial name
- PROTECT-EVAR (NCT07528144)
- Testing
- Exoskeleton-supported radiation protection system, Standard lead apron
- Where
- Poland
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Samodzielny Publiczny Szpital Kliniczny nr 2 PUM
Irritable Bowel Syndrome-IBS
Evaluate the Safety of Linaclotide in IBS-C Patients in China
This is a Multi-center, single arm, observational study to evaluate the safety of linaclotide in IBS-C patients in China. Enrolls approximately 3,000 Chinese patients from 30 participating sites around China and followed up for…
- Trial name
- Liberty (NCT04462900)
- Where
- 29 sites in China
- Volunteers
- 3,028 people
- Sponsor
- AstraZeneca
Crohn's Disease
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
The purpose of this study is to evaluate the clinical efficacy (GALAXI 1), clinical and endoscopic efficacy (GALAXI 2 and GALAXI 3) and safety of guselkumab in participants with Crohn's disease.
- Trial name
- GALAXI (NCT03466411)
- Testing
- Guselkumab Dose 1, Guselkumab Dose 2, Guselkumab Dose 3
- Where
- 579 sites in United States, Australia and 41 more
- Volunteers
- 1,409 people
- Sponsor
- Janssen Research & Development, LLC
Ulcerative Colitis (UC)
Alpha-0261 Tablets for Moderate-to-Severe Ulcerative Colitis
The purpose of this protocol is to evaluate the safety and efficacy of Alpha-0261 in participants with moderately to severely active ulcerative colitis.
- Trial name
- NCT07744646
- Testing
- Alpha-0261
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Crohn's Disease
Study to Evaluate Efficacy and Safety of Two Drug Regimens in Subjects With Moderate to Severe Crohn's Disease
This study will evaluate higher versus standard adalimumab dosing regimens for induction and maintenance therapy in subjects with moderately to severely active Crohn's Disease and evidence of mucosal ulceration.
- Trial name
- NCT02065570
- Testing
- Adalimumab
- Where
- 143 sites in United States, Austria and 18 more
- Volunteers
- 514 people
- Sponsor
- AbbVie
Inflammatory Bowel Disease (IBD), CD - Crohn's Disease
Prophylactic Dexamethasone Before Infliximab in Moderate-to-Severe IBD
This comparative observational cohort clinical study aims to investigate the necessity of premedication for allergy prevention prior to infliximab injection, and is designed to evaluate whether non-routine administration of…
- Conditions
- Inflammatory Bowel Disease (IBD), CD - Crohn's Disease, UC - Ulcerative Colitis
- Trial name
- PA (NCT07385131)
- Testing
- Dexamethasone (IV)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Crohn Disease, Recurrence
Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease.
The study is looking at the role of the mesentery in disease recurrence for ileocolic Crohn's disease. It is a prospective study that has been designed to perform extended mesenteric excision on patients undergoing their first…
- Conditions
- Crohn Disease, Recurrence, Crohn's Ileocolitis
- Trial name
- NCT04539665
- Testing
- Extended mesenteric resection.
- Where
- 2 sites in Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Montreal General Hospital
Irritable Bowel Syndrome, Bacterial Overgrowth Syndrome
Atrantil for Intestinal Bacterial Overgrowth
Intestinal Bacterial Overgrowth (IBO) is a common functional condition due to excessive amounts of bacteria in the gastrointestinal tract.
- Conditions
- Irritable Bowel Syndrome, Bacterial Overgrowth Syndrome, SIBO
- Trial name
- NCT04755673
- Testing
- Atrantil (Medical Food)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Irritable Bowel Syndrome
Clinical Effectiveness of Enteric Coated(E.C.) Anise-oil on Irritable Bowel Syndrome
Colpermin ® (Peppermint oil) is used in the treatment of Irritable Bowel Syndrome but Peppermint (Mentha x piperita) isn't native in Iran.
- Trial name
- IBS-Anise (NCT02364830)
- Testing
- Anise-oil EC Capsule, Colpermin®
- Where
- 2 sites in Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Crohn's Disease (CD)
Biologics and Paediatric Enteral Nutrition in Crohn's Disease Study
Crohn's disease (CD) is a chronic, incurable condition associated with gut inflammation. Two important treatments currently used to manage CD are special drug injections (biologics) or a liquid-only diet using specialised…
- Trial name
- BIOPIC-Kids (NCT07522528)
- Testing
- enteral nutrition
- Where
- 6 sites in United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Ulcerative Colitis
Safety and Efficacy Study of TLL018 in the Treatment of Ulcerative Colitis
A study to investigate the safety and efficacy of TLL018 compared with placebo in subjects with moderate to severe ulcerative colitis.
- Trial name
- NCT05121402
- Testing
- TLL018
- Where
- United States
- Sponsor
- TLL Pharmaceutical, LLC
Irritable Bowel Syndrome, Dyspepsia
Visible Abdominal Distension
Background. Abdominal distention is produced by an abnormal somatic postural tone. The authors developed an original biofeedback technique.
- Conditions
- Irritable Bowel Syndrome, Dyspepsia, Functional Bloating
- Trial name
- NCT06369753
- Testing
- Biofeedback
- Where
- 7 sites in United States, Canada and 5 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Ulcerative Colitis, Cytomegalovirus Infections
Assessment of CMV-specific ELISPOT Assay for Predicting CMV Colitis in Patient With Ulcerative Colitis
Consequences of latent cytomegalovirus (CMV) infection reactivation on ulcerative colitis flare, as a flare-worsening factor or simple bystander, are debated.
- Conditions
- Ulcerative Colitis, Cytomegalovirus Infections, Disease Exacerbation
- Trial name
- ACE-UC (NCT02439372)
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Asan Medical Center
Crohn's Disease
A Comparative Study of Capsule Endoscopy, Magnetic Resonance Imaging and Computer Tomography Scanning of the Small Bowel in Crohn's Disease
The aim of this study is to evaluate three diagnostic methods for assessing small bowel disease in patients with suspected or known Crohn's disease.
- Trial name
- NCT01019460
- Testing
- Magnetic resonance imaging, computed tomography scanning and capsule endoscopy
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Randomized Controlled Trial of Citizen-targeted Evidence-based Resources
The purpose of this study is to determine whether an online resource developed to aid health consumers in making health decisions and better support them to seek quality evidence before other evidence is effective in the context…
- Trial name
- NCT04693780
- Testing
- Structured guide, List
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- McMaster University
Crohn's Disease, Fistula
Follow-up Study of Autologous Cultured Adipose-derived Stem Cells for the Crohn's Fistula
This is an open follow-up clinical trials to evaluate a sustained efficacy and safety of Adipoplus inj. for 10 months (12 months after final dose injection)after Phase II clinical trial.
- Trial name
- ANTG-ASC-203 (NCT01314079)
- Where
- 3 sites in South Korea
- Volunteers
- 37 people
- Sponsor
- Anterogen Co., Ltd.