Clinical trials: IBD
Inflammatory Bowel Diseases
Inherited Thromophilia and Thrombotic Risks in Inflammatory Bowel Disease During Activity and Remission
Inherited thombopllia and thrombotic risks in inflammatory bowel Disease during activity and remission
- Trial name
- NCT06691451
- Volunteers
- 93 people
- Sponsor
- Asmaa mohammed abdelaal abdelaal
Colitis, Ulcerative
JAK Inhibition in Ulcerative Colitis
The treatment for Ulcerative Colitis (UC) aims to achieve and maintain remission and is usually lifelong and expensive. Current available medications are unable to break the cycle of chronic inflammation, and still a significant…
- Trial name
- NCT05456412
- Testing
- JAK inhibitor treatment
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Crohn's Disease
Mesenchymal Stem Cell Therapy for the Treatment of Severe or Refractory Inflammatory and/or Autoimmune Disorders
This project aims to assess safety and efficacy of allogeneic Mesenchymal stem Cell (MSC) in Crohn's disease refractory or intolerant to conventional therapies.
- Trial name
- NCT01540292
- Testing
- Mesenchymal Stem Cells (MSC)
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University of Liege
Crohn Disease, Inflammatory Bowel Diseases
Stricture Definition and Treatment (STRIDENT) Endoscopic Therapy Study
Two thirds of patients with Crohn's disease require intestinal surgery at some time in their life. Intestinal strictures, that is narrowing of the bowel due to inflammation and scarring, are the most common reason for surgery.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Stricture; Bowel
- Trial name
- STRIDENT (NCT03222011)
- Testing
- Standard (single) endoscopic stricture dilatation, Intensive endoscopic stricture dilatation
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- St Vincent's Hospital Melbourne
Crohn's Disease
Effect of Intravenous (IV) Vedolizumab on Mucosal Healing in Crohn's Disease
The purpose of this study is to evaluate endoscopic remission at Week 26 as assessed by ileocolonoscopy.
- Trial name
- NCT02425111
- Testing
- Vedolizumab
- Where
- 79 sites in United States, Belgium and 6 more
- Volunteers
- 101 people
- Sponsor
- Takeda
Irritable Colon, Irritable Bowel Syndrome (IBS)
Study In Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy
The purpose of this study is to compare the safety and effectiveness of as needed versus fixed dosing of an investigational medication for women with severe diarrhea-predominant Irritable Bowel Syndrome (IBS) who have failed…
- Trial name
- NCT00067457
- Testing
- alosetron
- Where
- 191 sites in United States, Australia
- Volunteers
- 700 people
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome, Irritable Bowel Syndrome - Constipation
Efficacy of Chatbot for Irritable Bowel Syndrome (IBS) Patients
The goal of this clinical trial is to evaluate the efficacy of an automated chatbot system in improving quality of life, reducing depression and anxiety, and decreasing visceral sensitivity in patients with Irritable Bowel…
- Conditions
- Irritable Bowel Syndrome, Irritable Bowel Syndrome - Constipation, Irritable Bowel Syndrome - Diarrhoea, Irritable Bowel Syndrome - Mixed
- Trial name
- IrBiS (NCT06837064)
- Testing
- Chatbot supporting system
- Where
- Russia
- Volunteers
- 54 people
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Crohn Disease
Determination of Ustekinumab Levels in Patients With Crohn's Disease
Observational, prospective, single-center follow-up study carried out with patients from the area of the Virgen de Macarena University Hospital, diagnosed with chronic kidney disease, who started treatment with ustekinumab.
- Trial name
- Ustekinumab (NCT05057832)
- Where
- Spain
- Volunteers
- 95 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
IBD (Inflammatory Bowel Disease), Hemorrhoid
HEmorrhoidAl Disease in Inflammatory Bowel Disease: a Multicenter Prospective Cohort Study
Patients who will undergo surgery for HD after the diagnosis of IBD over a 12-month period will be enrolled across Europe. Primary objective of this study is to determine the safety and effectiveness of surgical treatments for HD…
- Conditions
- IBD (Inflammatory Bowel Disease), Hemorrhoid, Safety, Sugery
- Trial name
- HEAD-IBD-II (NCT06638814)
- Volunteers
- 50 people
- Sponsor
- Treviso Regional Hospital
IBD - Inflammatory Bowel Disease
Monitoring of Patients With Inflammatory Bowel Diseases: the Experience of the Reference Center of the Emilia-Romagna
The study is observational with descriptive purposes, aimed at enhancing and deepening current knowledge and providing a foundation for future studies.
- Trial name
- NCT06721767
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Irritable Bowel Syndrome, Gluten Sensitivity
Reduced Content of Gluten Diet on Patients With Irritable Bowel Syndrome (Pro.Ali.Fun.)
This study aim to manufacture bread and pasta with an reduced content of gluten and to assess the impact of reducing the daily intake of gluten by 50% in irritable bowel syndrome (IBS) patients.
- Trial name
- PROALIFUN (NCT03638544)
- Testing
- Reduced gluten bread and Pasta compared o normal gluten bread and Pasta
- Volunteers
- 20 people
- Sponsor
- University of Bari
Ulcerative Colitis
A Study of Pentasa in Patients With Ulcerative Colitis
Confirmation of safety profile of Pentasa slow release tablets 500 mg in patients with ulcerative colitis (UC).
- Trial name
- NCT01104753
- Where
- 30 sites in Czechia
- Volunteers
- 338 people
- Sponsor
- Ferring Pharmaceuticals
Complex Perianal Fistula
Clinical Trials of Autologous Cultured Adipose-derived Stem Cells (ANTG-ASC) on Complex Fistula
Mesenchymal stem cells derived from adipose tissue are pluripotent to differentiate into myocytes, adipocytes or others. They have an immunosuppressive activity. Complex perianal fistula is difficult to cure and easy to relapse.
- Trial name
- ANTG-ASC-210 (NCT01314092)
- Testing
- Autologous cultured adipose derived stem cells(low dose group), Autologous cultured adipose derived stem cells(high dose group)
- Where
- 6 sites in South Korea
- Volunteers
- 15 people
- Sponsor
- Anterogen Co., Ltd.
Acute Severe Colitis
Prognostic Role of Bowel Ultrasound Scan in Children Affected by Acute Severe Colitis
ASC is a life-threatening medical emergency. The lack of a timely intervention has shown to be associated with a mortality rate higher than 20% in adults, whereas a prompt targeted therapy has displayed a decrease of the…
- Trial name
- NCT06324500
- Where
- 4 sites in Italy, Spain
- Volunteers
- 120 people
- Sponsor
- Meyer Children's Hospital IRCCS
Crohn's Disease
Adalimumab Trough Concentrations in Crohn's Disease: A Pilot Pharmacokinetic Study
Observational pharmacokinetics study of adalimumab in patients with active refractory Crohn's disease who are naïve to TNF antagonist therapy.
- Trial name
- NCT02450513
- Testing
- Adalimumab
- Where
- 2 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
IBD
Single Ascending Dose Study to Assess the Safety, Tolerability, PK and PD Effects in Male Volunteers
This will be a double-blind, randomized, placebo-controlled, single ascending dose, Phase I study in healthy male subjects.
- Trial name
- NCT02914262
- Testing
- AKB-4924
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Aerpio Therapeutics
Ulcerative Colitis (Disorder)
The PODIUM Study - a Three-arm Comparison of Target Therapies After Anti-TNFα in Ulcerative Colitis
The goal of this observational study is to compare the real-life effectiveness and safety of vedolizumab, ustekinumab and JAK inhibitors in patients with UC who had been exposed to at least one anti-TNF-alpha therapy.
- Trial name
- NCT06691061
- Testing
- Vedolizumab, Ustekinumab - Standard Dosage, JAK Inhibitor
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- Humanitas Clinical and Research Center
Crohn's Disease
Vagus Nerve Stimulation in Crohn's Disease
This is an open label interventional study using an implantable vagus nerve stimulation device in patients with Crohn's disease who have active disease despite treatment with a tumor necrosis factor (TNF) antagonist drug.
- Trial name
- NCT02311660
- Testing
- Vagus Nerve Stimulation Device
- Where
- 4 sites in Croatia, Italy and 2 more
- Volunteers
- 15 people
- Sponsor
- SetPoint Medical Corporation
Irritable Bowel Syndrome
Serum Levels of Apelin, Chemerin and Adiponectin Adipokines in Irritable Bowel Syndrome and Healthy Subjects
In this observational case-control study investigators aimed to assess the serum levels of adipokines such as Apelin, Chemerin and adiponectin in patients with irritable bowel syndrome (IBS), and compare it with healthy controls.
- Trial name
- NCT03366389
- Where
- Iran
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Amir Abbasnezhad
Inflammatory Bowel Disease
Association of Functional Changes in the Brain and the Perception of Pain in Patients With Chronic Inflammatory Bowel Diseases (IBD)
In the study the investigators aim to test whether transcranial direct current stimulation (tDCS)-induced pain reduction is in association with functional changes in the brain measured with magnetic resonance imaging (MRI) in…
- Trial name
- NCT02433470
- Testing
- Transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany