Clinical trials: Hypoxic Conditions
Hypoxia
SpO2 Accuracy Validation of Pulse Oximetry Systems During Motion and Non-Motion Conditions
Study to evaluate the %SpO2 accuracy performance of the Nonin Medical pulse oximetry systems.
- Trial name
- NCT02475668
- Testing
- Pulse oximeter
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Nonin Medical, Inc
Hypoxia
High-intensity Interval Training Enhances Mobilization/Functionality of Endothelial Progenitor Cells and Depressed Shedding of Vascular Endothelial Cells Undergoing Hypoxia
Exercise training improves endothelium-dependent vasodilation, whereas hypoxic stress causes vascular endothelial dysfunction. Monocyte- derived endothelial progenitor cells (Mon-EPCs) contribute to vascular repair process by…
- Trial name
- NCT02802462
- Testing
- HIT, MCT
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Anoxic Brain Injury
Safety and Efficacy Assessment of Autologous Bone-marrow Derived Adult Mesenchymal Stem Cell Therapy in Patients With Anoxic(or Hypoxic) Brain Injury Pilot Trial
The purpose of study is to evaluate the safety and efficacy of autologous bone marrow-derived stem cells therapy in patients with anaerobic (hypoxic) brain injury.
- Trial name
- NCT02210624
- Testing
- HYNR-CS inj.
- Where
- South Korea
- Volunteers
- 4 people
- Sponsor
- Hyun Young Kim
Healthy Volunteers
Effects of Ferrous Sulfate on the Pharmacokinetics of AKB-6548
The primary purpose of this study is to assess the single-dose bioavailability of AKB-6548 with ferrous sulfate relative to AKB-6548 in healthy volunteers.
- Trial name
- NCT02327546
- Testing
- AKB-6548, Ferrous Sulfate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Akebia Therapeutics
Pain, Hypoxia
Effects of Static Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent static apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxia, Hypercapnia, Apnea
- Trial name
- NCT06158256
- Testing
- Voluntary apnoea
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Brain Injury Traumatic Severe (Diagnosis), Coma
Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
Phase 1 of the STIMPACT trial is an open label,dose-escalation,safety study of intravenous (IV) methylphenidate (MPH) therapy in patients with disorders of consciousness (DoC) caused by severe brain injuries.
- Conditions
- Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
- Trial name
- STIMPACT (NCT03814356)
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Hypoxemia
CPAP in Liver Transplant
The purpose of this study is to determine the effectiveness of continuous positive airway pressure compared to standard treatment in preventing the need for intubation and mechanical ventilation in patients who develop acute…
- Trial name
- NCT00510770
- Testing
- CPAP application
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Turin, Italy
Severe Acute Respiratory Distress Syndrome, Refractory Hypoxemia
ECMO for Critically Ill Patients With Respiratory Failure and/or Circulatory Failure
Extracorporeal membrane oxygenation (ECMO) had been used to treat refractory hypoxemia associated with acute respiratory distress syndrome (ARDS).
- Trial name
- NCT04031794
- Testing
- Extra Corporeal Membrane Oxygenator (ECMO)
- Where
- Thailand
- Volunteers
- 250 people
- Sponsor
- Mahidol University
Hypertension, Pulmonary
Study of the Effects of Iron on Lung Blood Pressure at High Altitude
Body iron levels may be important in determining how the blood pressure in the lungs changes in response to low oxygen levels. At high altitude, where oxygen levels are low, some patients develop elevated lung blood pressure.
- Trial name
- NCT00960921
- Testing
- Iron sucrose, Normal saline
- Where
- Kyrgyzstan
- Sponsor
- University of Oxford
Pulmonary Disease, Chronic Obstructive, Mitochondrial Alteration
High Intensity Interval Training and Muscle Adaptations During PR
Pulmonary rehabilitation (PR) is a validated treatment in patients with Chronic Obstructive Pulmonary Disease (COPD), improving exercise tolerance, quality of life and dyspnea.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Mitochondrial Alteration, Oxygen Deficiency
- Trial name
- MITOXITRAIN (NCT05858463)
- Testing
- Modality of exercise training
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Pulmonary Hypertension
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
This is a prospective, real world, multicenter, registry of patients with pulmonary hypertension associated with interstitial lung disease (PH-ILD) and interstitial lung disease (ILD).
- Conditions
- Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Pulmonary Hypertension, Interstitial Lung Disease
- Trial name
- NCT06388421
- Testing
- Prospective study assessments
- Where
- 71 sites in United States, Puerto Rico
- Volunteers
- 900 people
- Sponsor
- United Therapeutics
Gestational Diabetes, Pregnancy Complications
Gestational Diabetes Monitoring and Management
The primary goal is to predict the clinical outcomes of mother and baby using blood glucose and other routinely collected clinical data in pregnancy to predict adverse outcomes at birth in women with GDM.
- Conditions
- Gestational Diabetes, Pregnancy Complications, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT06963528
- Where
- United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- University of Oxford
Hypoxia
Effect of Different Positions During Extubation on Incidence of Hypoxemia in the Peri Extubation Period
Pediatric Obstructive Sleep Apnea Syndrome (OSAS) is common, often due to enlarged tonsils/adenoids. Tonsillectomy/adenoidectomy frequently performed under GA with tracheal intubation due to the age of children.
- Trial name
- NCT07231887
- Testing
- positioning during peri-extubation
- Volunteers
- 262 people
- Sponsor
- Assiut University
Hypoxic Ischaemic Encephalopathy (HIE), Asphyxia
BiHiVE2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.
Despite recent advances in the care of mothers and newborn infants, many infants (approximately 20 per 1000 live births) continue to need resuscitation at birth.
- Trial name
- BiHiVE2 (NCT02019147)
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College Cork
Delirium, Confusion
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
To improve the safety of diagnosis and therapy for a set of conditions and undifferentiated symptoms for hospitalized patients, the investigators will employ a set of methods and tools from the disciplines of systems engineering…
- Conditions
- Delirium, Confusion, Mental Status Change, Back Pain
- Trial name
- PSLL2-0 (NCT04393909)
- Testing
- Diagnostic Uncertainty Educational Curriculum, Diagnostic Timeout, Patient Diagnostic (Dx) Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Brigham and Women's Hospital
Hypoxemia, Severe Acute Respiratory Syndrome
Steroid Treatment for Severe Acute Respiratory Infection (STAR) Trial
Multicenter, parallel-group, randomized clinical trial comparing the administration of systemic corticosteroids at a dose equivalent to 40 mg of prednisolone per day for 7 days vs no corticosteroid administration among adults…
- Trial name
- STAR (NCT07199192)
- Testing
- Corticosteroid
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hypoxia
Beetroot Juice as a Potential Ergogenic Aid During Exercise in Hypoxia
The study will aim to describe and evaluate the effect of beetroot juice supplementation upon whole body running exercise at altitude.
- Trial name
- NCT01795534
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bangor University
Hypoxemia, Ards
Effectiveness of Low Volume and Low Pressure in Severe Hypoxemic Patients
The present study set up to answer two questions: (a) "how low tidal volume must be to provide protective ventilatory settings able to minimize the risk of death due to Ventilator-Induced Lung Injury (VILI)?"; (b) "if protection…
- Trial name
- avengARDS (NCT06513299)
- Testing
- low tidal volume, high tidal volume, low driving pressure
- Where
- Italy
- Volunteers
- 4,300 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Intubation Complication
Non-invasive Technology for Early Signal Detection of Hypoxemia With ORI During Intubation
Intubation of patients in the intensive care unit (ICU) carries a risk of potentially severe complications, including cardiac arrest.
- Trial name
- NESOI (NCT03600181)
- Testing
- RAD - 97 pulse co-oximeter
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Nantes University Hospital
Sleep Apnea, Obstructive Sleep Apnea
Prevalence, Phenotypes, Predictors and Prognostic Implication of Obstructive Sleep Apnea in Pulmonary Hypertension
The investigators propose a prospective, observational study to determine the impact of OSA and associated physiological parameters on clinical outcomes in patients with pulmonary hypertension.
- Conditions
- Sleep Apnea, Obstructive Sleep Apnea, Pulmonary Hypertension, Epidemiology
- Trial name
- POSAPH (NCT05595200)
- Testing
- Level III portable sleep study
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group