Clinical trials: Hypoxemia
Hypoxemia
Effect of Different Oxygen Concentrations Before Extubation After General Anesthesia on Hypoxemia After Extubation in Post-anesthesia Care Unit
Before extubation during the anesthesia recovery period, 100% oxygen is routinely inhaled to increase the oxygen reserves, maximizing the time window for anesthesiologists to adjust strategies when they encounter hypoxemia after…
- Trial name
- NCT07293286
- Testing
- 100% oxygen concentration inhaled, 30% oxygen concentration inhaled
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Retinoblastoma
Severe and Transient Hypoxemia During Selective Intra-arterial Chemotherapy for Retinoblastoma in Children: Evaluation of the Right-sided Heart Function.
Children having selective ophthalmic artery chemotherapy for retinoblastoma under general anaesthesia may experience troubles during the procedure.
- Trial name
- NCT03559894
- Testing
- Trans-thoracic echocardiography
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Christian Kern
Hypoxemia
Effects of Acute Intermittent Hypoxia on Brain Function Imaging and Systemic Inflammation
Effects of acute intermittent hypoxia on brain function imaging and systemic inflammation Patients with obstructive sleep apnea (OSAS) may have neurological cognitive impairment. The reason is not clear.
- Trial name
- NCT03453697
- Testing
- acute intermittent hypoxia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
COVID-19
Awake Prone Position for Early Hypoxemia in COVID-19
Prone positioning is a well studied and validated treatment for severe acute respiratory distress syndrome (ARDS), however there are no randomized studies on the use of prone positioning in the non-intubated patient.
- Trial name
- APPEX-19 (NCT04344587)
- Testing
- Self-prone position recommendation, Usual care
- Where
- 13 sites in United States, Spain
- Volunteers
- 305 people
- Sponsor
- Boston University
In the Study the Value of Capnography for Avoiding Complications During Sedation for PEG is Evaluated.
Capnography During Percutaneous Endoscopic Gastrostomy (PEG)
In this randomized controlled trial the utility of capnography gets evaluated. Hypoxemia may occur during sedation with midazolam and propofol.
- Trial name
- PEG (NCT01242358)
- Testing
- Capnography, Standard monitoring
- Where
- 3 sites in Germany
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Hepatopulmonary Syndrome
Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome
The Hepatopulmonary syndrome (HPS) results from intrapulmonary microvascular dilatation that impairs arterial oxygenation in the setting of cirrhosis or portal hypertension.
- Trial name
- NCT00593658
- Testing
- pentoxifylline
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Alabama at Birmingham
COPD Exacerbation, Pneumonia
Comparison of Multiple Oxygenation Targets With Different Oximeters in Chronic Obstructive Pulmonary Disease (COPD) and Non-COPD Patients- Impact on Oxygen Flows
The oximeter is an instrument for monitoring patients receiving oxygen therapy. It displays pulse oxygen saturation (SpO2), which is a reflection of arterial oxygen saturation (SaO2).
- Conditions
- COPD Exacerbation, Pneumonia, Hypoxemia, Respiratory Disease
- Trial name
- NCT05819164
- Testing
- Masimo oximeter, Nellcor oximeter, Nonin oximeter
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Hypoxemia
Recovery Hypoxemia After Sedated Upper Gastrointestinal Endoscopy
Sedation during upper gastrointestinal endoscopy may lead to respiratory events not only during the procedure but also in the early recovery period.
- Trial name
- NCT07445256
- Testing
- Sedated Upper Gastrointestinal Endoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istinye University
Hypoxemic Respiratory Failure, Side Effect
Clinical Relevance of Nicardipine Induced Hypoxemia in the Intensive Care Unit
In the context of postoperative hypertension in the intensive care units, or after resusitation of hypertensive patients, intravenous antihypertensive drugs are often used.
- Conditions
- Hypoxemic Respiratory Failure, Side Effect, Hypertensive Emergency
- Trial name
- ECRHIN-ICU (NCT05155202)
- Testing
- Antihypertensive Agents
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Pain, Hypoxemia
Effects of Walking Apnea At Low Lung Volume on Hypoalgesia
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxemia, Hypercapnia, Apneas
- Trial name
- NCT06638515
- Testing
- Walking apnea at Low Lung Volume, Walking at normal breathing
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Adult Patients, Requiring Intubation
Lung MORphological Modifications Evaluated by Electrical Impedance Tomography During Preoxygenation for the Intubation of Hypoxemic Patients: Comparison of Standard Oxygenation, High Flow Nasal Oxygen Therapy, and NonInvasive Ventilation (MORPHEIT Study, an Ancillary Study of PREONIV Trial)
Prospective, randomized clinical multicentric study, in ICU, during preoxygenation for the intubation of hypoxemic patients. Electrical impedance tomographic evaluation of lung morphology variations according to the…
- Conditions
- Adult Patients, Requiring Intubation, Hypoxemia (Defined by PaO2/FiO2( Fraction of Inspired Oxygen) Below 200), Patient Covered by French Health Care System
- Trial name
- MORPHEIT (NCT03282331)
- Testing
- Standard oxygenation, High flow nasal oxygenation, noninvasive ventilation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Obstructive Pulmonary Disease
Gas Usage for Those With COPD Who Experience Low Oxygen Levels During Activities Only
Several studies have described the use of supplemental oxygen during exertion or activities of daily living (ambulatory oxygen) in study populations that have different characteristics.
- Trial name
- NCT00546299
- Testing
- oxygen
- Volunteers
- 27 people
- Sponsor
- West Park Healthcare Centre
Hypoxemia During EBUS Bronchoscopy
High - Flow Nasal Cannula Versus Conventional Nasal Cannula During Endobronchial Ultrasound Procedure
EBUS bronchoscopy is performed in most centers under local anesthesia and moderate sedation. Both the bronchoscopy itself and the sedation can lead to decreased ventilation and a drop in oxygen saturation in the body.
- Trial name
- NCT06637280
- Testing
- High - flow nasal cannula, Standard nasal cannula
- Where
- 4 sites in Croatia, Greece and 2 more
- Volunteers
- 150 people
- Sponsor
- The University Clinic of Pulmonary and Allergic Diseases Golnik
Pain, Postoperative, Obesity
TC02 Obese Women Using It Morphine vs PCA IV Hydromorphone for Post-Cesarean Analgesia
Cesarean deliveries are the most commonly performed surgery in the United States and account for 32.9% of all births.8,9 The ASA recommends the use of neuraxial opioids of post-cesarean analgesia partly because respiratory…
- Conditions
- Pain, Postoperative, Obesity, Respiratory Insufficiency
- Trial name
- NCT03282669
- Testing
- Intrathecal Morphine, Intravenous hydromorphone
- Sponsor
- Northwestern University
Fever
Timing of Surgery in Pediatric Patients Following Fever Recovery: a Prospective Cohort Study
Objectives: The timing of fever recovery may affect the risk of intra-operative hypoxemia in children undergoing elective surgery after SARS-CoV-2 infection.
- Trial name
- NCT06568809
- Testing
- Time interval between recovery of body temperature and operation
- Where
- China
- Volunteers
- 3,053 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pneumonia, Community-Acquired Infections
Helmet Continuous Positive Airway Pressure Versus Oxygen Venturi in Acute Respiratory Failure in CAP: CAPOVeRSO
The purpose of this study is to compare the efficacy of CPAP application by a helmet and O2 administration by a Venturi mask in terms of gas exchanges improvement in patients with acute respiratory failure due to…
- Conditions
- Pneumonia, Community-Acquired Infections, Respiratory Insufficiency, Acute Lung Injury
- Trial name
- CAPOVeRSO (NCT00603564)
- Testing
- Castar Starmed (CPAP) delivered by a helmet
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- University of Milan
Coronavirus Disease 2019 (COVID-19), Pneumonia
Frespaciguat (MK-5475) in Participants With Hypoxemia Due to COVID-19 Pneumonia (MK-5475-009)
The purpose of this study is to evaluate safety, tolerability, and pharmacodynamics of frespaciguat after administration of multiple doses to participants with COVID-19 pneumonia.
- Conditions
- Coronavirus Disease 2019 (COVID-19), Pneumonia, Hypoxemia
- Trial name
- NCT04425733
- Testing
- Frespaciguat
- Sponsor
- Merck Sharp & Dohme LLC
Postoperative Respiratory Complication
The Effect of Continuous Pulse Oximetry Monitoring and Early Intervention Using Wearable Device on the Incidence of Postoperative Hypoxemia
Vital signs of postoperative patient are monitored intensively in post-anesthesia care unit or intensive care unit, but the frequency of surveillance decreases in typical surgical wards.
- Trial name
- NCT04694599
- Testing
- Low flow oxygen
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Acute Respiratory Tract Infection, Acute Respiratory Insufficiency
An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19
The purpose of the study is to evaluate an effectiveness of the drug Dalargin in combination with Leitragin for the prevention and treatment of severe pulmonary complications symptoms associated with severe and critical…
- Conditions
- Acute Respiratory Tract Infection, Acute Respiratory Insufficiency, Pneumonia, Septic Shock
- Trial name
- NCT04346693
- Testing
- Standard therapy recommended by the Ministry of Health of the Russian Federation., Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin intramuscular injection, Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin inhalation
- Where
- Russia
- Volunteers
- 320 people
- Sponsor
- Burnasyan Federal Medical Biophysical Center
Intubation Complication, Preoxygenation
PreOxygenation for EndoTracheal Intubations
Hypoxemia is a life threatening complication during emergency airway management. Despite advances in technology and training, hypoxemia still occurs in up to a quarter of all intubations placing patients at high risk for damage…
- Conditions
- Intubation Complication, Preoxygenation, Hypoxemia
- Trial name
- POET (NCT03240614)
- Testing
- Non-rebreather oxygen mask, Bag-valve-mask, High Flow Nasal Cannulae
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority