Clinical trials: Hypoxemia
Hypoxemia, Desaturation of Blood
Alternate Methodology of Pulse Oximeter Validation
This study will determine if the replacement of the measured arterial blood oxygen saturation with expired (end-tidal) oxygen value is an acceptable method to calculate the accuracy of pulse oximeters.
- Trial name
- NCT03628560
- Testing
- RespirAct Step-Wise Normocapnia desaturation sequence, RespirAct Slope Normocapnia desaturation sequence, RespirAct Step-Wise Hypocapnia desaturation sequence
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Duke University
Acute Hypoxemic Respiratory Failure, Hypoxemia
Evaluation of the FreeO2 System for Oxygen Weaning After Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure (AHRF) is a common condition associated with substantial morbidity, mortality, and healthcare resource utilization.
- Trial name
- EVOLUERA (NCT07794124)
- Testing
- FreeO2 automated oxygen titration system, Standard oxygen weaning
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Acute Respiratory Failure With Hypoxia, Hypoxemia
Conduct of Nasal High Flow Oxygen in Acute Respiratory Failure
Although many studies have investigated the clinical benefits of nasal high flow during acute hypoxemic respiratory failure, there is no data (and even less so recommendations) on how to best conduct this technique, including its…
- Trial name
- DECIPHEROBS (NCT03311087)
- Where
- 10 sites in France
- Volunteers
- 100 people
- Sponsor
- Hôpital Louis Mourier
Hypoxemia, Airway Management
Multifunctional Oropharyngeal Airway and Hypoxemia in Sedated GI Endoscopy: A Multicenter RCT
This multicenter, prospective, randomized controlled trial aims to evaluate whether a novel multifunctional oropharyngeal airway (MOPA) reduces the incidence of hypoxemia in 1,518 adult patients (ASA I-II, aged 18-80 years)…
- Trial name
- NCT07623863
- Testing
- Novel Multifunctional Oropharyngeal Airway
- Volunteers
- 1,518 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Recovery Period, Hypoxemia
Efficacy of Propofol-Ketamine and Sevoflurane in Children Undergoing Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is becoming increasingly important in the diagnosis and follow-up of pediatric diseases. However, successful MRI requires complete and prolonged immobility, which can be challenging for young…
- Conditions
- Recovery Period, Hypoxemia, Patient Safety
- Trial name
- NCT06832683
- Testing
- Sevoflurane, Propofol, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Kocaeli City Hospital
Hypoxemia
Effect of Different Bed Head Angles on Intraoperative Hypoxemia in Patients Undergoing Painless Gastroenteroscopy: A Prospective Randomized Controlled Study
Abstract: Objective: This study aimed to investigate the effect of different bed angles (0° vs. 15°) on the incidence of intraoperative hypoxemia in patients undergoing gastroscopy and colonoscopy.
- Trial name
- NCT07594951
- Testing
- Elevating the head of the bed to 15 degrees
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xiangya Hospital of Central South University
Hypoxemia
The Correlation Between Sleep Quality and Atrial Fibrillation Undergoing High-flow Nasal Cannula Oxygen (HFNC)
The investigators hypothesized that heated humidified high-flow nasal cannula oxygen(HFNC) along with high quality of sleep, in comparison with noninvasive positive pressure ventilation (NIV), could reduce the release of…
- Trial name
- NCT02713737
- Testing
- heated humidified high-flow nasal cannula, noninvasive ventilation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Hypoxemia, Extubation
Postoperative Extubation in Hypoxemic Patients
The objective of this clinical trial is to assess whether early extubation of patients with hypoxemia during the spontaneous breathing trial (SBT) shortens the duration of ventilatory support.
- Conditions
- Hypoxemia, Extubation, Postoperative Respiratory Complication
- Trial name
- EPHYRE (NCT06688487)
- Testing
- early extubation of hypoxemic patients
- Where
- 12 sites in France
- Volunteers
- 152 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Chronic Obstructive Pulmonary Disease (COPD)
Intermittent Hypoxemia, Lung Function Decline, Morbidity, and Mortality in COPD (PROSA Study).
This study aims to analyze if patients with chronic obstructive lung disease who experience a decline of blood oxygen saturation during physical exercise have a disease course different from that of COPD patients who do not…
- Trial name
- PROSA (NCT06265623)
- Testing
- No active intervention, but observational follow-up
- Where
- Germany
- Volunteers
- 148 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
ENT Tumor
Impact of the Experience of Anaesthetists in Changing Ventilation Strategies During Panendoscopy on the Incidence of Intraoperative Hypoxaemia
High Flow Nasal Oxygen Therapy (HFNO) is a new oxygenation tool that is becoming increasingly widespread in perioperative anaesthesia. The benefits of this oxygenation tool are based on different physiological principles.
- Trial name
- NCT05601570
- Where
- France
- Volunteers
- 850 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome)
EFFICACY and SAFETY OF BEVACIZUMAB (ZIRABEV®) IN PATIENTS WITH SEVERE HYPOXEMIC COVID-19
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the most frequent complications of the COVID-19 pandemic.
- Conditions
- Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Virus Diseases, Coronaviridae Infections
- Trial name
- BEVA (NCT04822818)
- Testing
- BEVA+SOC, SOC
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypoxemia
Transcutaneous Auricular Vagus Nerve Stimulation for Reducing Postoperative Hypoxemia
Hypoxemia is a common complication in the post-anesthesia care unit (PACU) and represents one of the most meaningful factors associated with poor patient prognosis. Obese patients have a relatively higher incidence of hypoxemia.
- Trial name
- NCT07827131
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulator
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Nantong University
Type A Aortic Dissection
iNO as Salvage Treatment of Hypoxemia After TAAD Surgery
The purpose of this study was to clarify the possible mechanism of hypoxemia after surgical treatment of type A acute aortic dissection and the possible mechanism of the treatment role of inhaled nitric oxide in refractory…
- Trial name
- NCT04032366
- Testing
- inhaled nitric oxide, PEEP
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Awake Tracheal Intubation, Difficult Airway
High-flow Nasal Cannula Versus Conventional Oxygen During Awake Tracheal Intubation With Difficult Airways
Study Background Airway management is one of the most fundamental and critical technical procedures in anesthesiology, critical care, and emergency medicine.
- Trial name
- NCT07384494
- Testing
- High-Flow Nasal Cannula, Ligh-Flow Nasal Cannula
- Where
- 6 sites in China
- Volunteers
- 336 people
- Sponsor
- Wenxian Li
Community-Acquired Pneumonia, Pediatric Pneumonia
Clinical Predictors of Severity in Pediatric Community-Acquired Pneumonia at Assiut University Children's Hospital
This study aims to identify the clinical factors that predict the severity of community-acquired pneumonia (CAP) in pediatric patients.
- Conditions
- Community-Acquired Pneumonia, Pediatric Pneumonia, Lower Respiratory Tract Infection
- Trial name
- CAP-Severity (NCT07279675)
- Testing
- Assessment of Pneumonia Severity
- Volunteers
- 67 people
- Sponsor
- Assiut University
Covid19
Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Hypoxemia
Of the many treatments proposed for COVID-19, few directly address the severe hypoxia among COVID-19 patients. Interim results from our single-center, non-randomized clinical trial (NCT04332081) suggest that hyperbaric oxygen…
- Trial name
- NCT04619719
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Legacy Health System
Hypoxemia
Pulse Oximetry With Automated Verbal Prompts
This study will evaluate the effectiveness of an automated voice prompting system on post operative hypoxia within the Postoperative Anesthesia Care Unit (PACU).
- Trial name
- NCT02930863
- Testing
- pulse oximetry software, Brief post-PACU stay survey.
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Florida
Precapillary Pulmonary Hypertension, Pulmonary Arterial Hypertension
Evolution of Hypoxic Burden and Sympathetic/Parasympathetic Balance in Patients With Pulmonary Hypertension
Background and Rationale: Sleep-disordered breathing and nocturnal hypoxemia are highly prevalent in patients with precapillary pulmonary hypertension (PH), and current guidelines recommend systematic sleep assessment in this…
- Conditions
- Precapillary Pulmonary Hypertension, Pulmonary Arterial Hypertension, Sleep-disordered Breathing, Nocturnal Hypoxemia
- Trial name
- HRV&PH (NCT07464184)
- Testing
- Standard Clinical and Functional Assessment, Overnight Polysomnography
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Rouen
Respiratory Failure, Hypoxemia
Comparison of Pulse Oximetry (SpO2) With Different Oximeters and Arterial Saturation (SaO2): Oxygap2 Study
The oximeter is used to monitor intensive care patients undergoing oxygen therapy. It indicates pulsed oxygen saturation (SpO2), a reflection of arterial oxygen saturation (SaO2) which enables detection of hypoxemia and…
- Conditions
- Respiratory Failure, Hypoxemia, Hyperoxemia
- Trial name
- Oxygap 2 (NCT06102499)
- Testing
- SpO2 and SaO2 comparison
- Where
- 3 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Laval University
Respiratory Failure, Respiratory Failure With Hypoxia
Preventing Hypoxemia With Manual Ventilation During Endotracheal Intubation (PreVent) Trial
Complications are common during endotracheal intubation of critically ill adults. Manual ventilation between induction and intubation ("bag-valve-mask" ventilation) has been proposed as a means of preventing hypoxemia, the most…
- Conditions
- Respiratory Failure, Respiratory Failure With Hypoxia, Endotracheal Intubation
- Trial name
- PreVent (NCT03026322)
- Testing
- Manual Ventilation, No Manual Ventilation
- Where
- 5 sites in United States
- Volunteers
- 401 people
- Sponsor
- Vanderbilt University Medical Center