Clinical trials: Hypovolemia
Hypovolemia
Central Venous and Abdominal Pressures and the Inferior Vena Cava
The elliptic shape of inferior vena cava (IVC) sections, while hindering the ultrasound measurement of IVC diameter, may provide a useful tool to estimate central venous pressure (CVP).
- Trial name
- NCT01840670
- Testing
- Rapid fluid load test
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Catholic University of the Sacred Heart
Acute Kidney Injury
A Study to Support the Development of the Enhanced Fluid Assessment Tool for Patients With Acute Kidney Injury
Acute Kidney Injury (AKI) is the sudden and recent reduction in kidney function. This can be detected by measuring a rise in blood creatinine level or from a reduction in urine.
- Trial name
- NCT05538351
- Testing
- Body Composition Monitor (BCM)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Hertfordshire
Hypotension
Focussed Echocardiography to Detect Preoperative Hypovolemia and Left Ventricular Dysfunction as a Predictor of Post-Induction Hypotension
This is an observational study to evaluate the role of a Bed side Focus assessed Transthoracic Echocardiography (FATE) in identifying the patients at a potential risk of developing hypotension secondary to general anesthesia…
- Trial name
- NCT02944266
- Testing
- Pre operative Focus assessed Transthoracic echocardiographic assessment.
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hypovolemia
Study on Prediction of Fluid Responsiveness Using an Abdominal Compression-induced Change of Blood Pressure in Children
The purpose of this study is to evaluate predictability of an abdominal compression-induced change of blood pressure for fluid responsiveness in children.
- Trial name
- NCT02471534
- Testing
- abdominal compression
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Shock, Hypovolemia
IVC Ultrasound Versus Central Venous Pressure for Early Detection of Hypovolemia in Shock Patients
This study aims to compare ultrasound-guided inferior vena cava (IVC) assessment with central venous pressure (CVP) monitoring for the detection of hypovolemia in shock patients in the emergency department.
- Conditions
- Shock, Hypovolemia, Circulatory Failure
- Trial name
- NCT07206732
- Testing
- Ultrasound-Guided Inferior Vena Cava Assessment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Hypovolemia, Somatic Pain
Influence of Variations of Systemic Venous Return on Analgesia Nociception Index (ANI) During General Anaesthesia
The purpose of this study is to determine whether the value of analgesia nociception index (ANI) is influenced by variations of systemic venous return (cardiac preload) under general anaesthesia.
- Trial name
- NCT02193412
- Testing
- noxious stimulus, change in operating table slope: head-down tilt position, change in operating table slope: head-up tilt position
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Shock, Cardiogenic, Shock Hypovolemic
Clinical Validation of Algorithms for Mean Systemic Filling Pressure and Automated Cardiac Output
Prospective combined clinical validation of an algorithmic calculated mean systemic filling pressure (Pms-Nav) with the gold standard for Pms (Pms calculated from venous return curves during inspiratory hold procedures with…
- Conditions
- Shock, Cardiogenic, Shock Hypovolemic, Hypovolemia, Cardiac Failure
- Trial name
- PP3D (NCT04202432)
- Testing
- Mean systemic filling pressure
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Hypovolemia, Hyperoxia
Supplemental Oxygen in Hypovolemia
Supplemental oxygen is frequently administered in acutely and critically ill patients, specifically, it is often administered in trauma patients to avoid arterial hypoxemia and tissue hypoxia.
- Trial name
- NCT05150418
- Testing
- Oxygen gas, Air
- Where
- Norway
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Hypovolemia
Comparison of Two Gelatine Solutions
The aim of volume replacement is to compensate a reduction in the intravascular volume e.g. during surgery and to counteract hypovolemia in order to maintain hemodynamics and vital functions.
- Trial name
- NCT01515397
- Testing
- Gelofusine balanced, Gelofusine 4%
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- B. Braun Melsungen AG
Hypovolemia, Fluid Overload
Prediction of the Effect of Fluid Administration Using Arterial Pressure and Ventilator Data During Abdominal Surgery
It is well known, that patients with circulatory impairment sometimes, but not always, benefit from intravenous fluids. Predicting if a fluid administration will improve circulation is therefore of substantial clinical interest.
- Trial name
- NCT04298931
- Testing
- Series of ventilator settings
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- University of Aarhus
Hypovolemia
Cerebral Oximetry in Lower Body Negative Pressure
The study aims to describe hemodynamic effects of lower body negative pressure (LBNP). 1. If and how changes in cerebral oxygen saturation (StO2) measured by near infrared spectroscopy (NIRS) relate to changes in blood flow in…
- Trial name
- NCT03009305
- Testing
- Lower body negative pressure, Continuous positive airway pressure, Positive expiratory pressure
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Hypovolemic
Corrected Flow Time in the Carotid Artery as a Predictor of Fluid Responsiveness in Mechanically Ventilated Patients With Low Tidal Volume in the Intensive Care Unit
The purpose of this study is to evaluate predictability of carotid corrected flow time for fluid responsiveness in mechanically ventilated patients with low tidal volume in the intensive care unit.
- Trial name
- NCT04139031
- Testing
- Ultrasonographic measurement of corrected flow time in carotid artery
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Yonsei University
Hypovolemia, Hypotension
Dynamic Parameters in Evaluation of Fluid Responsiveness
Intravenous infusion of fluids in patients after surgery is a very important part of treatment. However, administering too much or too little fluid can lengthen the stay in the intensive care unit or even harm the patient.
- Conditions
- Hypovolemia, Hypotension, Surgery
- Trial name
- NCT04283851
- Testing
- testing functional haemodynamic parameters for preload assessment
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Fluid Therapy
Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients
The aim of the FLUID Trial is to conduct a pragmatic, multi-centre, open label randomized cluster cross-over trial (RCT) to determine whether fluid administration with 0.9% saline as compared to Ringer's lactate decreases death…
- Trial name
- FLUID (NCT04512950)
- Testing
- Ringer's lactate, 0.9% saline
- Where
- 7 sites in Canada
- Volunteers
- 43,626 people
- Sponsor
- Ottawa Hospital Research Institute
Shock, Hypovolemia
RApid Fluid Volume EXpansion in Patients in Shock After the Initial Phase of Resuscitation.
Rapid volume expansion using repeated intravenous fluid boluses is a very common intervention performed in the intensive care unit (ICU) in the early days of resuscitation of patients with shock.
- Trial name
- RAVEXO (NCT02645851)
- Testing
- fluid bolus, PiCCO system (Pulsion, Germany), Vascular pressure transducers (Edwards Life Science, USA)
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Sepsis, Fluid Overload
Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients
Accurate assessment of fluid responsiveness (FRes) is central to guiding fluid management in septic and critically ill patients.
- Conditions
- Sepsis, Fluid Overload, Hypovolemia
- Trial name
- FRESEDICU (NCT02679625)
- Testing
- Ultrasound and NICOM
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Septic Shock, Hypovolemia
Assessment of Fluid Responsiveness in Septic Shock Patients, Can End-tidal co2 Measurement Help?
Fluid therapy is important in patients with sepsis and septic shock. There are many invasive and non-invasive methods to assess fluid responsiveness in patients.
- Conditions
- Septic Shock, Hypovolemia, Sepsis
- Trial name
- NCT05557461
- Testing
- End-tifdal co2, systolic, diastolic blood pressure, ppv values and vci distensibility
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bozyaka Training and Research Hospital
Scoliosis, Spinal Fusion
Is Pleth Variability Index (PVI) a Surrogate for Pulse Pressure Variations (PPV) in Pediatric Spine Fusion (SF) Surgery?
Spine fusion is an involved procedure during which patients are at risk for significant intra-operative blood loss.This study will compare 2 ways of determining fluid status and response to fluid administration.
- Trial name
- NCT00994656
- Testing
- Masimo multi-wavelength pulse co-oximeter
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Children's Hospital of Philadelphia
Hypovolaemia Due to Acute Blood Loss
Safety and Efficacy of 6% Hydroxyethyl Starch (HES) Solution Versus an Electrolyte Solution in Patients Undergoing Elective Abdominal Surgery
The aim of the study is to investigate the safety of a 6% HES (Hydroxyethyl Starch) solution (Volulyte 6%) versus an electrolyte solution (Ionolyte) in patients undergoing elective abdominal surgery.
- Trial name
- PHOENICS (NCT03278548)
- Testing
- Volulyte 6%, Ionolyte
- Where
- 61 sites in Austria, Belgium and 8 more
- Volunteers
- 2,289 people
- Sponsor
- Fresenius Kabi
Perioperative/Postoperative Complications, Hypovolemia
Goal-directed Therapy in High-risk Surgery
There is growing evidence that the risk of postoperative complications can be decreased by optimizing the amount and type of infusion fluids given during surgery, steered by goal-directed therapy based on flow-related hemodynamic…
- Conditions
- Perioperative/Postoperative Complications, Hypovolemia, Hypoxia
- Trial name
- NCT01681238
- Testing
- Protocol group 2, Protocol group 1
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangzhou First People's Hospital