Clinical trials: Hypothermia Treatment
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced
Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest.
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
- Trial name
- NCT05376267
- Testing
- Therapeutic Hypothermia
- Where
- 65 sites in United States, Australia and 3 more
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Neonatal Encephalopathy
Enteral Feeding and Splanchnic NIRS Values in Infants With Neonatal Encephalopathy (NE)
The research team plans to administer trophic enteral feeds to infants with Neonatal Encephalopathy that are undergoing therapeutic hypothermia.
- Trial name
- NCT05471336
- Testing
- Enteral Feeding
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Hypothermia
Hypothermia in the Trauma Patient - When do Trauma Patients Get Cold?
The purpose of this study is to analyze changes in core body- and skin temperature during pre-hospital and early in-hospital treatment of multi-traumatized patients.
- Trial name
- NCT01006837
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Non-environmental Hypothermia, Cardiac Arrest
Trial of Different Hypothermia Temperatures in Patients Recovered From Out-of-hospital Cardiac Arrest
Mild therapeutic hypothermia in the temperature range of 32º - 34ºC. improves survival in patients recovered from a ventricular fibrillation cardiac arrest.
- Trial name
- NCT01155622
- Testing
- Endovascular Cooling
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Hospital Universitario La Paz
Acute Ischemic Stroke
Hypothermia in Acute Stroke With Thrombolysis Imaging Evaluation of Revascularization
The primary objective of this Phase 2 HASTIER study, as an ancillary study to ICTuS 2, is to compare key imaging measurements for serial changes in recanalization and reperfusion between hypothermia and normothermia treatment…
- Trial name
- HASTIER (NCT01778855)
- Testing
- IV t-PA and normothermia, IV-tPA and hypothermia
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of California, Los Angeles
Cardiac Arrest, Hypothermia
NSE Ancillary Study of The Therapeutic Hypothermia After Nonshockable Cardiac Arrest Trial.
Cardiac arrest is at present a major cause of mortality as well as a cause of disability for the surviving victims.In Europe, every year counts as 300,000 cardiac arrests responsible for 250,000 deaths.
- Conditions
- Cardiac Arrest, Hypothermia, Critical Care
- Trial name
- NSE-HYPERION (NCT02722473)
- Testing
- NSE dosage "hypothermia arm", NSE dosage "normothermia arm"
- Where
- 14 sites in France
- Volunteers
- 106 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Severe Brain Injury
Study of PbiO2 Variation by Body Temperature and Capnia in Severe Head Trauma Patients Treated With Targeted Temperature Control
Serious head trauma is a common and pathology and responsible of high morbidity and mortality. The major challenge, from the very first hours, is to limit cerebral ischemia by controlling secondary brain injury factors.
- Trial name
- TODAY (NCT04109430)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic
Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy
Hypoxic-ischemic encephalopathy (HIE) is a serious condition in newborns caused by lack of oxygen and blood flow around the time of birth.
- Trial name
- SiSTEM-NEO (NCT07018739)
- Testing
- Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Caesarean Section
Maternal Hypothermia After Caesarean Section - Implications for Postoperative Recovery
The aim of the study is to assess patient reported outcomes after caesarean section using self report questionnaire.
- Trial name
- NCT07244354
- Testing
- Self report questionnaire
- Where
- Norway
- Volunteers
- 700 people
- Sponsor
- Oslo University Hospital
Prediction by the Synek Score of Poor Neurological Outcome in Postanoxic Comatose Patients Treated With Induced Hypothermia
Synek Score to Predict Poor Neurological Outcome Post Resuscitated Cardiac Arrest
Resuscitated cardiac arrest (CA) is a frequent cause of admission in intensive care unit (ICU). Neurological state of postanoxic comatose patients can evolve either towards the absence of awakening or towards a more or less…
- Trial name
- NCT03737747
- Testing
- induced hypothermia
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hypothermia.
CAERvest® - A Novel Endothermic Hypothermic Device for Core Body Cooling. Safety and Efficacy Testing.
Cooling the whole body to 32-34 degrees Centigrade from the normal of around 37 degrees Centigrade for 24 hours has been shown to be an effective way of reducing damage to brain function after return of spontaneous circulation…
- Trial name
- NCT02030236
- Testing
- Cooling
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bodychillz Ltd
Effect of Reflexology, Hypoxic-Ischemic Encephalopathy, Neonatal
Foot Reflexology in Neonates With Hypoxic-Ischemic Encephalopathy
This randomized controlled trial aims to evaluate the effect of foot reflexology on comfort levels and physiological parameters in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia.
- Conditions
- Effect of Reflexology, Hypoxic-Ischemic Encephalopathy, Neonatal, Foot Reflexology, Therapeutic Hypothermia
- Trial name
- NCT07549789
- Testing
- Foot reflexology, Standard care
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Istanbul Nisantasi University
Acute Kidney Injury, Hypothermia
Hypothermia Risk With Continuous Renal Replacement Therapy
The present study aims at testing if the TherMax blood warmer is more accurate and reliable in reaching and maintaining chosen target temperature during continuous renal replacement therapy as compared to the Prismaflo IIS blood…
- Trial name
- HR-CRRT (NCT03973814)
- Testing
- Thermax Blood Warmer
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Hypothermia Due to Cold Environment
Prehospital Use of Forced Air Warming
Forced air warming may be a feasible strategy for prehospital rewarming of patients with accidental hypothermia. This pilot study will explore the feasibility of this technique which has not been studied outside of hospital.
- Trial name
- NCT07450092
- Testing
- Forced air warming
- Where
- Norway
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Necrotizing Enterocolitis
Therapeutic Controlled Hypothermia in the Treatment of Neonates With Severe Necrotizing Enterocolitis
Hypothesis: Controlled hypothermia to 33.5C for 48 hours reduces the severity of critical illness in neonates with severe necrotizing enterocolitis.
- Trial name
- CoolNEC (NCT01330576)
- Testing
- cooling blanket/mattress, Standard treatment of care at normothermia
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Hypoxic Encephalopathy, Birth Asphyxia
Passive Cooling Versus Blanket-Roll III on The Myocardial Function of Asphyxiated Neonates
Studying the effect of passive versus Blanket roll III modality of therapeutic hypothermia (TH)on myocardial function of asphyxiated neonates through using tissue Doppler (TD).
- Conditions
- Hypoxic Encephalopathy, Birth Asphyxia, Neonatal Encephalopathy, Hypothermia, Newborn
- Trial name
- NCT05652738
- Testing
- Passive cooling application, cooling using Blanket roll III
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Cardiac Arrest
Multicenter Registry Study With Therapeutic Hypothermia After Cardiac Arrest in Japan
Recently, early defibrillation and cardiopulmonary resuscitation (CPR) for sudden onset of cardiac arrest are advancing, however, survival rate is still very low in the world.
- Trial name
- J-PULSE-HYPO (NCT00901134)
- Where
- 14 sites in Japan
- Volunteers
- 452 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Cardiac Arrest, Acute Coronary Syndrome
Mild Therapeutic Hypothermia for Patients With Acute Coronary Syndrome and Cardiac Arrest Treated With PCI
Mild Therapeutic Hypothermia for Patients with Acute Coronary Syndrome and Cardiac Arrest Treated with Percutaneous Coronary Intervention (UNICORN) study is designed to determine whether mild therapeutic hypothermia (MTH) applied…
- Trial name
- UNICORN (NCT02611934)
- Testing
- Mild Therapeutic Hypothermia (MHT)
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Jacek Kubica