Clinical trials: Hypotension
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Hypotension of Hemodialysis
Early Warning of Intradialytic Hypotension in Hemodialysis Patients
In this study, the investigators will monitor patients undergoing hemodialysis treatment with a non-invasive wearable PPG-based device.
- Trial name
- NCT04680039
- Testing
- Continuous monitoring
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Biobeat Technologies Ltd.
Hypertension, Hypotension
A Novel Non-interfering Arterial Blood Pressure Monitoring Device
The primary purpose of this investigation is to validate the performance and safety of the Investigational Device (ID) against a validated and legally cleared device for measuring Blood Pressure (BP).
- Conditions
- Hypertension, Hypotension, Healthy
- Trial name
- NCT01954446
- Testing
- 3M, ContiPressTM, Mobil-O-Graph
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sense A/S
Cardiopulmonary Bypass Surgery
HPI (Hypotension Prediction Index) Care Trial
A prospective single-center randomized controlled trial to determine if guided hemodynamic management with the Acumen HPI technology in the OR and ICU can reduce the mean duration of hypotension in cardiac surgery patients…
- Trial name
- NCT05083403
- Testing
- AcumenTM HPI Software Feature, Non-protocolized Standard of Care
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Edwards Lifesciences
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Hypotension
NOX-100 for Preventing Hypotension During Hemodialysis
This study is designed to evaluate the safety, tolerability and efficacy profile of NOX-100 to reduce intradialytic hypotension (IDH) in patients undergoing chronic hemodialysis (HD).
- Trial name
- NCT01672008
- Testing
- NOX-100
- Where
- 6 sites in Taiwan
- Volunteers
- 62 people
- Sponsor
- Medinox, Inc.
Sepsis-Induced Hypotension
A Study of REGN7544 for the Treatment in Adult Patients With Sepsis-Induced Hypotension
This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on adult patients (18 to 85 years) hospitalized due to a serious infection (called "sepsis") and receiving…
- Trial name
- ESTELLA (NCT06608901)
- Testing
- REGN7544, PB
- Where
- 29 sites in United States, France
- Volunteers
- 76 people
- Sponsor
- Regeneron Pharmaceuticals
Hypertension
Evaluation of Potential for Orthostatic Hypotension in Elderly Hypertensives
This is a multi-center, double-blind, randomized, placebo-controlled, 2-session crossover study to evaluate the incidence of orthostatic hypotension in elderly hypertensive subjects following co-administration of carvedilol CR…
- Trial name
- NCT00508365
- Testing
- Carvedilol CR capsules, Lisinopril
- Where
- 20 sites in United States
- Volunteers
- 62 people
- Sponsor
- GlaxoSmithKline
Multiple System Atrophy
A Biomarker Study of ATH434 in Participants With MSA
This study will assess the safety and efficacy of ATH434 in participants with a clinical diagnosis of Multiple System Atrophy
- Trial name
- NCT05864365
- Testing
- ATH434
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Alterity Therapeutics
Hypertension
Magneto-rheology to Lower Blood Pressure
Heart attacks and strokes are the leading causes of death in US. High blood viscosity and turbulence in blood flow are the key for cardiovascular diseases.
- Trial name
- NCT03783117
- Testing
- Magnetic field treatment
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cardiovascular Therapy LLC
Hypotension, Geriatric Patients
Preoperative Ultrasonographic Evaluation of Caval Aorta Diameter Index
General anesthesia is frequently used in daily clinical practice. Elderly patients often require a higher level of care than younger patients during the perioperative period, with higher health care costs.
- Conditions
- Hypotension, Geriatric Patients, Anesthesia
- Trial name
- NCT06155461
- Testing
- Preoperative Ultrasonographic Evaluation of Caval Aorta Diameter Index
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Egymedicalpedia
Hypotension
Efficacy of Voluven® for the Prevention of Hypotension During Spinal Anesthesia for Cesarean Section
The aim of the study is to evaluate the efficacy of Voluven® in the prevention of maternal hypotension in women undergoing spinal anesthesia for cesarean section
- Trial name
- CAESAR (NCT00694343)
- Testing
- HES 130/0.4 (6%) in sodium chloride (solution for infusion), Ringer's Lactate solution
- Where
- 14 sites in France
- Volunteers
- 167 people
- Sponsor
- Fresenius Kabi
Orthostatic Hypotension
Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension
The purpose of this study is to determine whether midodrine works against the symptoms of orthostatic hypotension caused by being on a tilt table.
- Trial name
- NCT01518946
- Testing
- Midodrine HCl
- Where
- 13 sites in United States
- Volunteers
- 24 people
- Sponsor
- Shire
Neurogenic Orthostatic Hypotension
Efficacy and Tolerance of Flucortac in Patients With Orthostatic Neurogenic Hypotension
To evaluate the efficacy of a 4-week fludrocortisone (FLU) treatment on systolic blood pressure depression after 5 minutes of active orthostatism in patients with neurogenic orthostatic hypotension (HON) symptomatic, despite…
- Trial name
- NCT04128137
- Testing
- Fludrocortisone
- Where
- France
- Volunteers
- 90 people
- Sponsor
- H.A.C. PHARMA
Hypotension
Cafedrin/Theodrenalin (Akrinor®) Versus Ephedrine for Treatment of Hypotension in the Peri-operative Phase in Inpatient Setting
This is a national, multicentre, prospective, open, two-arm, non-interventional study with hospitalized patients, who are treated routinely with cafedrine/theodrenaline or ephedrine after occurrence of perioperative hypotension…
- Trial name
- NCT02893241
- Testing
- Cafedrine/theodrenaline, Ephedrine
- Where
- 75 sites in Germany
- Volunteers
- 2,013 people
- Sponsor
- Ratiopharm GmbH
Atrial Fibrillation With Rapid Ventricular Response, Hypotension
Pre-diltiazem, Calcium Versus Placebo for Atrial Fibrillation With Rapid Ventricular Response
The goal of this randomized double blind controlled trial is to learn about the effects of calcium when it is given prior to diltiazem for patients with atrial fibrillation ( a type of irregular heart beat) who have rapid…
- Trial name
- NCT05691959
- Testing
- Calcium
- Volunteers
- 378 people
- Sponsor
- Ascension Health
Primary Immune Deficiency Disorder
A Study About Low Blood Pressure in Patients With Primary Immunodeficiency Disease Treated With Immune Globulin Products
This is a safety study to evaluate the risk of low blood pressure in subjects with Primary Immune Deficiency disorder (PID) treated with Bivigam™ or another commercial product under real world conditions.
- Trial name
- NCT03037359
- Testing
- Bivigam, Other
- Where
- 17 sites in United States
- Volunteers
- 200 people
- Sponsor
- ADMA Biologics, Inc.
Hypertension
Clinical Validation of the Tiba Medical Ambulo 2400 ABPM According to the ISO 80601-2-30 Standard in Adults, Adolescents, and Children
Clinical validation of the Tiba Medical Ambulo 2400 ambulatory blood pressure monitoring system according to the accuracy guidelines of the ISO 80601-2-30 Standard in Adults, Adolescents, and Children.
- Trial name
- NCT00944983
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Tiba Medical, Inc.
Symptomatic Neurogenic Orthostatic Hypotension, Parkinson's Disease
A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy
Evaluate the clinical efficacy and safety of droxidopa versus placebo over a 17 week (maximum) treatment period in patients with symptomatic NOH.
- Conditions
- Symptomatic Neurogenic Orthostatic Hypotension, Parkinson's Disease, Multiple Systems Atrophy, Pure Autonomic Failure
- Trial name
- NCT01927055
- Testing
- Droxidopa
- Where
- 3 sites in United States
- Volunteers
- 61 people
- Sponsor
- Chelsea Therapeutics
Hypotension, Orthostatic
Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension
The purpose of this clinical study is to evaluate the clinical effect of midodrine hydrochloride (ProAmatine®) compared to placebo in patients with orthostatic hypotension by measuring the time to onset of near syncopal symptoms…
- Trial name
- NCT00555880
- Testing
- Midodrine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 24 people
- Sponsor
- Shire