Clinical trials: Hypoperfusion, open to volunteers
Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction
CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State
The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60…
- Conditions
- Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction, Postoperative Delirium, EEG With Periodic Abnormalities
- Trial name
- CERBERUS (NCT06133842)
- Testing
- Intra-op EEG and CO data collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Critical Illness, Diabetes Mellitus
Central Venous vs Arterial Blood Gas and CO2 Gap in Critically Ill Patients With and Without Diabetes
Frequent monitoring of acid-base status, ventilation, and tissue oxygenation is essential for managing critically ill patients in the intensive care unit (ICU).
- Conditions
- Critical Illness, Diabetes Mellitus, Acid-Base Imbalance, Tissue Hypoperfusion
- Trial name
- NCT07799727
- Volunteers
- 100 people
- Sponsor
- Assiut University
Velocity-time Integral Measurement, Critically Ill Patients
Reliability of Minimally Trained Operator's Velocity-Time Integral Measurement Guided by Artificial Intelligence VTI
Stroke volume is a major determinant of tissue perfusion and therefore a key parameter to monitor in patients with hemodynamic instability and hypoperfusion.
- Conditions
- Velocity-time Integral Measurement, Critically Ill Patients, Tissue Hypoperfusion
- Trial name
- MiniTrainedVTI (NCT06486467)
- Testing
- Fluid challenge (cristalloids) OR passive leg raising
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Hypoperfusion
Early Methylene Blue in the Microhemodynamics of Septic Patients
The aim of the study is to evaluate the viability and feasibility of its protocol in order to conduct a larger clinical trial to assess whether methylene blue can improve patient-centered clinical outcomes such as mortality or…
- Trial name
- NCT07264543
- Testing
- Methylene blue infusion
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva
Microcirculatory Dysfunction, Tissue Hypoperfusion
Submental Tissue Oxygenation and Arterial Lactate in Major Surgery
During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects.
- Conditions
- Microcirculatory Dysfunction, Tissue Hypoperfusion, Microcirculatory Status, Microvascular Circulation
- Trial name
- NCT07399275
- Testing
- No intervention. This is a prospective observational study. Near-infrared spectroscopy measurements are performed for monitoring purposes only and do not influence clinical management.
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Cerebral Hypoperfusion, Hypotension
The Effect of Controlled Hypotension
Controlled hypotension is currently used in spinal surgery to reduce bleeding at the surgical site, improve the surgeon's visibility, and decrease intraoperative blood loss.
- Trial name
- NIRS (NCT06928870)
- Testing
- MAP 55-65 mmHg, MAP 66-75 mmHg
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Microvascular Disease, Microvascular Complications
Test of Reproducibility of [15O]H20-PET Assessment of Brain Perfusion
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Diabetes Mellitus Type 2, Cerebral Hypoperfusion
- Trial name
- SVAT (NCT06624267)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Microvascular Disease, Microvascular Complications
Comparison of Differencens in VO2-max, Perfusion of the Heart and Brain and Cognitive Performance Between Patients with Type 2 Diabetes and Healthy Age Matched Controls.
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Dementia, Diabetes Mellitus Type 2
- Trial name
- SVAT (NCT06628297)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg