Clinical trials: Hypoglycemia (Diabetic)
Type 2 Diabetes Mellitus With Hypoglycemia, Aging
Prepare for Your Diabetes Care
As adults with type 2 diabetes age, they are increasingly vulnerable to treatment-related hypoglycemia and its related complications (including hospitalization and death).
- Conditions
- Type 2 Diabetes Mellitus With Hypoglycemia, Aging, Patient Activation
- Trial name
- NCT05263310
- Testing
- Prepare for Your Diabetes Care, Usual Care
- Where
- United States
- Volunteers
- 672 people
- Sponsor
- Kaiser Permanente
Type 1 Diabetes, Hypoglycemia
Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing in Children and Young Adolescents
Objective: to gain experience in children and younger adolescents with in-home use of an algorithm that will dose insulin to minimize projected hyperglycemia overnight in addition to suspending the pump if hypoglycemia is…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Hyperglycemia, Artificial Pancreas
- Trial name
- PHM3 (NCT02714972)
- Testing
- Hyperglycemia Minimization Algorithm
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus
Continuous Glucose Monitoring in the Intensive Care Unit
The aim of the proposed clinical trial is to study the use of the Dexcom G7 continuous glucose monitor (CGM) within the intensive care unit (ICU) environment.
- Trial name
- NCT06190808
- Testing
- Dexcom G7 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
Diabetes Mellitus, Type 2
Time in Glucose Hospital Target
Inpatient management of glycemia in people with diabetes has been inadequately studied. Previous randomized trials of intensive insulin therapy in the hospital setting resulted in excessive hypoglycemia.
- Trial name
- TIGHT (NCT05135676)
- Testing
- Blinded CGM, real-time CGM
- Where
- 6 sites in United States
- Volunteers
- 166 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes
Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms
Objective: to gain experience with in-home use of a modified algorithm that will dose insulin to minimize projected hyperglycemia overnight in addition to suspending the pump if hypoglycemia is projected overnight and to obtain…
- Trial name
- PHM2 (NCT02438189)
- Testing
- Predictive Hyperglycemia Minimization Algorithm, Predictive Hypoglycemia Minimization Algorithm
- Where
- 3 sites in United States, Canada
- Volunteers
- 33 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes, Severe Hypoglycemic Unawareness
A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT01897688
- Testing
- Islet Cell Transplant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwestern University
Diabetes Mellitus, Hypoglycemia
Mechanisms of Hypoglycemia Associated Autonomic Failure
Intensive glucose control in type 1 diabetes mellitus (T1DM) is associated with clear health benefits. However, despite development of insulin analogs, pump/multi-dose treatment and continuous glucose monitoring, maintaining…
- Conditions
- Diabetes Mellitus, Hypoglycemia, Autonomic Failure
- Trial name
- NCT00678145
- Testing
- naloxone, fructose, exercise
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Type 1 Diabetes Mellitus, Hypoglycemia
Exercise-Induced Hypoglycemia Prevention in Adults With Type 1 Diabetes Using an Artificial Pancreas
This is a randomized crossover trial with 1:1 randomization to the admission sequence of using the Control AP system (rMPC - Naïve Model Predictive Control) vs.
- Trial name
- NCT03859401
- Testing
- EnMPC (Ensemble Model Predictive Control) AP Controller, rMPC (Naïve Model Predictive Control) AP Controller
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Marc Breton
Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia
Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes
Almost all people who have had type 1 diabetes for 5 years have a defect in secretion of the hormone Glucagon. This hormone is involved in the body's response to low blood glucose (hypoglycaemia).
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT04614168
- Testing
- Stepped hyperinsulinaemic-hypoglycaemic clamp study, Insulin pump, Continuous glucose monitor
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Edinburgh
Diabetes Mellitus, Type 1, Hypoglycemia
Pilot Study of OMEGA-3 and Vitamin D in High-Dose in Type I Diabetic Patients
The investigator propose to test the safety and efficacy of a regimen that combines Omega-3 Fatty Acids and Vitamin D in a design that considers timing and duration of administration in relation to their effects and predicted…
- Conditions
- Diabetes Mellitus, Type 1, Hypoglycemia, Diabetes Mellitus, Diabetes, Autoimmune
- Trial name
- POSEIDON (NCT03406897)
- Testing
- Cholecalciferol, Omega 3 fatty acid
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Rodolfo Alejandro
Diabetes Mellitus, Type 1, Hypoglycemia
Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF)
The overall goal of this study is to develop a new and practical way to prevent the development of Hypoglycemia Associated Autonomic Failure (HAAF), which is unawareness of hypoglycemia (low blood sugar) in individuals with…
- Conditions
- Diabetes Mellitus, Type 1, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT03608163
- Testing
- Naloxone, Diazoxide
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Type 1 Diabetes, Hypoglycemia
Glucagon and Advanced HCL System to Prevent Exercise-Induced Hypoglycaemia in People With Type 1 Diabetes
The primary aim of the study is to evaluate the glucose response to low-dose glucagon (single 150 µg dose) administered immediately before aerobic exercise in individuals with AHCL-treated T1D.
- Trial name
- HYPOAVOID (NCT05379686)
- Testing
- GlucaGen
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes Mellitus, Hypoglycemia
Allogeneic Islet Cells Transplanted Onto the Omentum
Current islet transplantation into the portal vein of the liver has shown the unique ability of islets to stabilize blood glucose levels and prevent severe hypoglycemia in a selected group of subjects with Type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT02213003
- Testing
- Islet transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rodolfo Alejandro
Hypoglycemia, Type 1 Diabetes
A Study to Inv. Safety, Efficacy & PD of Dasiglucagon as Hypoglycemia Rescue Therapy in Children <6 Years With T1D
This research study will investigate whether dasiglucagon as a rescue therapy for participants under 6 years of age works and is safe to use.
- Trial name
- NCT05378672
- Testing
- Dasiglucagon
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Zealand Pharma
Type 1 Diabetes, Hypoglycemia
Pilot Feasibility Study for HypoPals, a Mobile Health Program for Improving Hypoglycemia Management.
A mobile health program "HypoPals", which incorporates data from continuous glucose monitoring systems (CGMs) and sends personalized text messages to help people sharpen their low blood sugar symptom detection skills, and help…
- Trial name
- NCT05916131
- Testing
- Basic Education, Hypoglycemia Symptom Detection Training, Education Plus
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Type 1 Diabetes Mellitus With Hypoglycemia
DailyDose Smart Snack Study for T1D on MDI
This is a single-center, open-label, crossover trial with two arms and two periods (2x2) and one-week washout period. The study is designed to evaluate the efficacy of an AI-based bedtime smart snack intervention in reducing…
- Trial name
- NCT05967260
- Testing
- DailyDose Smart Snack app, Dexcom G6 CGM
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Severe Hypoglycemia
Comparing the Effectiveness of Two Approaches to Preventing Severe Hypoglycemia in Patients With Type 2 Diabetes (PHT2)
Severe hypoglycemia is the most feared complication of medications used to lower blood glucose levels in patients with diabetes.
- Trial name
- PHT2 (NCT04863872)
- Testing
- Proactive Care Management, MyHC-T2D education program
- Where
- United States
- Volunteers
- 259 people
- Sponsor
- Kaiser Permanente
Hyperglycemia, Hypoglycemia
Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients
The investigators intend to conduct a single-center, prospective, randomized comparative trial of patients admitted to the intensive care unit (ICU) who received continuous glucose monitoring (CGM) vs point of care (POC) glucose…
- Conditions
- Hyperglycemia, Hypoglycemia, Critical Illness, Diabetes Mellitus
- Trial name
- NCT05442853
- Testing
- Continuous glucose monitoring, Point of care glucose monitoring
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Malcom Randall VA Medical Center
Type 2 Diabetes Mellitus, Fear of Hypoglycemia
Effects of a Health Intervention on Fear of Hypoglycemia : a Pilot Study
The purpose of this study was to construct a Fear of Hypoglycemia(FoH) intervention program for type 2 diabetic patients based on the Behaviour Change Wheel (BCW) theory and to investigate the feasibility, acceptability, and…
- Conditions
- Type 2 Diabetes Mellitus, Fear of Hypoglycemia, Health Education, Impaired Awareness of Hypoglycemia
- Trial name
- NCT06197360
- Testing
- Based on BCW Theory of Health Education, General diabetes health education
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yangzhou University
Type 1 Diabetes Mellitus, Hypoglycemia
24/7 Closed-loop in Older Subjects With Type 1 Diabetes
The main objective of this open-label, multi-centre, randomised, crossover design study is to determine whether automated day and night closed-loop insulin delivery for 16 weeks under free living conditions is safer and more…
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Arrythmia
- Trial name
- DAN06 (NCT04025762)
- Testing
- Hybrid closed-loop system (CamAPS FX), Sensor augmented pump therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- University of Cambridge