Clinical trials: Hypocalcemia
Chronic Hypoparathyroidism
Efficacy of Calcium Citrate Versus Calcium Carbonate for the Management of Chronic Hypoparathyroidism
Hypoparathyroidism is an endocrinopathy characterized by a deficient secretion or action of PTH associated with low calcium level.
- Trial name
- NCT03425747
- Testing
- Calcium Carbonate, Calcium Citrate
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Campus Bio-Medico University
Hypoparathyroidism Postprocedural
Improving Safety in Pediatric Thyroidectomy by PTH Measurements
We implemented a previously reported algorithm based on intra-postoperative PTH measurements with selected cut-off values, both to predict post-thyroidectomy hypoparathyroid hypocalcemia, and to guide postsurgical management.
- Trial name
- NCT04690842
- Testing
- PTH measurements post-thyroidectomy (at 5 and 60 min post thyroid removal)
- Volunteers
- 66 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Hypocalcemia
Hypocalcemia in Infants and Children
Hypocalcemia is defined as reduction in the level of the ionized calcium in the blood to less than 0.95 mmole/ litre. In some cases it is associated with symptoms such as neuromuscular impairment in the form of convulsions…
- Trial name
- NCT03685877
- Volunteers
- 30 people
- Sponsor
- Assiut University
Post-operative Pain
Open Thyroid Surgery With Pillow Versus no Pillow for Better Post-operative Outcomes
Primary: To compare the post-operative pain in patients with neck extension and without neck extension. Secondary: To determine the benefit of neck exposure and peri-operative complications, which include duration of operation…
- Trial name
- NCT01620151
- Testing
- Extended neck with standard support or pillow
- Where
- 2 sites in Hong Kong
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
DiGeorge Anomaly, DiGeorge Syndrome
Thymus Transplantation Dose in DiGeorge #932
One purpose of this study is to determine whether the amount of cultured thymus tissue implanted into DiGeorge anomaly infants has any effect on the immune outcome.
- Conditions
- DiGeorge Anomaly, DiGeorge Syndrome, Complete DiGeorge Anomaly, Complete DiGeorge Syndrome
- Trial name
- NCT00576836
- Testing
- Cultured Thymus Tissue Implantation (CTTI), Cultured Thymus Tissue Implantation with Parathyroid Transplantation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Autosomal Dominant Hypocalcemia
ADH1 and ADH2 Disease Monitoring Study (DMS)
A global, multi-center, Disease Monitoring Study (DMS) in participants with Autosomal Dominant Hypocalcemia Type 1 (ADH1) or Autosomal Dominant Hypocalcemia Type 2 (ADH2) designed to characterize ADH1 and ADH2 disease…
- Trial name
- CLARIFY (NCT05227287)
- Where
- 27 sites in United States, Australia and 11 more
- Volunteers
- 95 people
- Sponsor
- Calcilytix Therapeutics, Inc., a BridgeBio company
Secondary Hyperparathyroidism
Comparison of Total Parathyroidectomy With and Without Autotransplantation
The purpose of this study is to compare short-term and long-term efficacy of total parathyroidectomy with autotransplantation and total parathyroidectomy without autotransplantation for Secondary hyperparathyroidism.
- Trial name
- NCT02536287
- Testing
- total PTX without autotransplantation, total PTX with autotransplantation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- The Second Hospital of Anhui Medical University
Infantile Malignant Osteopetrosis
A Trial to Evaluate Safety and Efficacy of RP-L401-0120 in Subjects With Infantile Malignant Osteopetrosis
The primary objective of this Phase 1 study is to evaluate the therapeutic safety and feasibility of the investigational product (IP), RP-L401.
- Trial name
- NCT04525352
- Testing
- RP-L401
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Hypoparathyroidism, Hypoparathyroidism Postprocedural
Evaluation of iMmune Function in Post-surgical and AuToimmune HYpoparathyroidism (EMPATHY)
This is an observational pilot study for the evaluation of immune function, infectious diseases, psychometric status and quality of life in patients with hypoparathyroidism compared to healthy controls.
- Conditions
- Hypoparathyroidism, Hypoparathyroidism Postprocedural, Hypoparathyroidism Due to Impaired Parathormone Secretion
- Trial name
- EMPATHY (NCT04059380)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Thyroid Nodules, Hypocalcemia
Phase II Pre-operative Vitamin D Supplementation to Prevent Post-thyroidectomy Hypocalcemia
One of the major side effects of surgery to remove the thyroid gland is transient (lasting for a short time) low calcium levels in the blood, or "hypocalcemia." Low calcium levels can cause symptoms such as numbness around the…
- Trial name
- NCT01868750
- Testing
- Calcitriol, Control Pill
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- David Shonka, MD
Healthy
Magnesium Effects in Apheresis
This study will determine whether magnesium replacement during apheresis can decrease side effects that donors commonly experience.
- Trial name
- NCT00040235
- Testing
- magnesium
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hemorrhage, Trauma
Empiric Calcium in Massive Transfusion
Calcium helps blood to clot and thereby stop bleeding. Trauma patients who experience large volume blood loss often require blood transfusions and bleeding is the most common cause of death.
- Conditions
- Hemorrhage, Trauma, Hypocalcemia, Shock, Hemorrhagic
- Trial name
- NCT05953376
- Testing
- Calcium Gluconate
- Sponsor
- University of California, Irvine
Hyperparathyroidism, Secondary
Efficacy and Safety of Etelcalcetide (AMG 416) in the Treatment of Secondary Hyperparathyroidism (SHPT) in Patients With Chronic Kidney Disease on Hemodialysis
This study is designed to assess the efficacy and safety of etelcalcetide compared with placebo in the treatment of SHPT in patients with chronic kidney disease (CKD) receiving hemodialysis.
- Trial name
- NCT01785849
- Testing
- Etelcalcetide
- Where
- 118 sites in United States, Australia and 13 more
- Volunteers
- 508 people
- Sponsor
- Amgen
Parathyroid Allo-transplantation
Parathyroid Allo-transplantation With a New Technique
Parathyroid allo-transplantation (PA-t) is a valuable alternative in the treatment of permanent hypoparathyroidism. However, it is a difficult process that requires a number of trained staff and advanced laboratory equipment…
- Trial name
- NCT02134483
- Testing
- Parathyroid allo-transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 7 people
- Sponsor
- Erhan Aysan
Hypoparathyroidism Postprocedural
Autofluorescence vs Clinical Assessment of Parathyroid Glands During Thyroid Surgery
The purpose of the investigation is to study if the use of Fluobeam®-LX to identify parathyroid glands through autofluorescence during thyroid surgery, may reduce the risk of postoperative hypoparathyroidism, defined as low PTH…
- Trial name
- NCT04509011
- Testing
- Fluobeam® LX
- Where
- 5 sites in Austria, Norway and 2 more
- Volunteers
- 516 people
- Sponsor
- Region Skane
Hypocalcemia After Total Thyroidectomy, Hypocalcemia
A Comparative Analysis of Hypocalcemia Incidence in Patients Undergoing Thyroidectomy: Ligasure vs Conventional Ligation of Vessels by Knot Tying
This study aims to address the existing gap in knowledge by conducting a comprehensive comparison of the incidence of hypocalcemia in patients undergoing thyroidectomy using Ligasure versus conventional ligation of vessels by…
- Trial name
- THYROIDECTOMY (NCT06716632)
- Testing
- Using Ligasure for heamostasis, Use of conventional knot tying technique for heamostasis
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- Gulab Devi Hospital
Hypocalcemia
A Study to Examine the Use of Zemplar to Increase Serum Calcium Levels in ICU Subjects
A study to determine the effect of Zemplar on the regulation of serum calcium levels and the need for administration of elemental calcium in hypocalcemic intensive care patients
- Trial name
- NCT00053378
- Testing
- paricalcitol injection (Zemplar), Effects on calcium regulation, Administration of elemental Ca during hypocalcemic ICU pts.
- Where
- 9 sites in United States
- Volunteers
- 45 people
- Sponsor
- Abbott
Secondary Hyperparathyroidism, Chronic Kidney Disease-Mineral and Bone Disorder
Injection of Teriparatide to Prevent Hypocalcemia After Parathyroidectomy in Dialysis Patients (TeriCa).
This is a pilot randomized controlled trial aimed to evaluate the effect of teriparatide on the clinical course of hypocalcemia after parathyroidectomy for secondary hyperparathyroidism in dialysis-dependent patients.
- Conditions
- Secondary Hyperparathyroidism, Chronic Kidney Disease-Mineral and Bone Disorder, Dialysis, Hypocalcemia
- Trial name
- TeriCa (NCT04750460)
- Testing
- Teriparatide
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Saint Petersburg State University, Russia
Hypocalcemia, Thyroid
Is Correcting Total Serum Calcium Levels Important After Thyroidectomy
This study is designed as a prospective non-randomized longitudinal single- center cohort study to evaluate the importance of correcting total serum calcium levels.
- Conditions
- Hypocalcemia, Thyroid, Parathyroid Dysfunction, Calcium Disorder
- Trial name
- NCT04304573
- Testing
- Total serum calcium blood test
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University Hospital Sestre Milosrdnice
Hyperparathyroidism
Energy Specific Far Infrared Radiation Treatment for Hyperparathyroidism
A study to determine the possibility of using far infrared radiation to treat Hyperparathyroidism.
- Trial name
- NCT00573573
- Testing
- Far Infrared Radiation
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- GAAD Medical Research Institute Inc.