Clinical trials: Hypertrophic Scars
Scars, Keloids
Silicone vs Pirfenidone in the Treatment of Hypertrophic Scars and Keloids
Justification: Keloid scars are a major medical and cosmetic problem, especially in darker skin types that predominate in Mexico. It is estimated that hypertrophic scars affecting from 1.5 to 4.5% of the general population.
- Conditions
- Scars, Keloids, Hypertrophic Scar
- Trial name
- NCT06909812
- Testing
- pirfenidone 8% gel, silicon gel
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Fundación Nacional para la Enseñanza y la Investigación de la Dermatología A.C.
Hypertrophic Scar
Clinical Investigation to Evaluate the Performance of Hyaluronic Acid for the Treatment of Hypertrophic Scars
The study includes two study groups, one involves treatment with auto-cross-linked Hyaluronic acid by intralesional and hypodermic injection, repeated after two weeks (T14), while the control arm provides an equal treatment but…
- Trial name
- NCT04614415
- Testing
- Autocrosslinked Hyaluronic aid
- Where
- 4 sites in Italy
- Volunteers
- 78 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Wrinkle, Acne Scars - Mixed Atrophic and Hypertrophic
Functional Usability and Feasibility Testing of the Profound Matrix™ System
This is a non-randomized, multi-center, open-label clinical trial evaluating the efficacy and clinical feasibility of the Profound Matrix device for electrocoagulation and for treatment of wrinkles and acne scars.
- Trial name
- NCT06192550
- Testing
- Profound Matrix™ System
- Where
- 5 sites in United States, Israel
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
Keloid and Hypertrophic Scars
Polidocanol 1% and Steroid in Keloids and Hypertrophic Scars
we will inject intralesional polidocanol 1% in keloids and hypertrophic scars to decrease vascularity and decrease size of lesion compared to intralesional steroid as standard treatment line
- Trial name
- NCT07606391
- Testing
- Group 1 (polidocanol 1% group):, Group 2 (Triamcinolone acetonide group):, Group 3 (combined Triamcinolone acetonide and polidocanol 1% group):
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Sohag University
Acne Scars - Mixed Atrophic and Hypertrophic, Hyperpigmentation
Efficacy and Tolerability of a Hybrid Fractional Laser for the Treatment of Acne Scars in Patients With Skin of Color
The investigators aim to investigate the efficacy and tolerability of a hybrid non-ablative/ablative laser for acne scarring in skin of color.
- Conditions
- Acne Scars - Mixed Atrophic and Hypertrophic, Hyperpigmentation, Laser-Induced Hyperpigmentation
- Trial name
- NCT05362929
- Testing
- Sciton Halo
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Burns, Hypertrophic Scar
Comparison and Clinical Utility of the Portable Pressure Measuring Device for Garment Pressure Measurement on Hypertrophic Scar by Burn Injury During Compression Therapy
The investigators developed a portable pressure measuring device using silicon piezoresistive pressure sensors. As PicoPress® is the most accurate (i.e., lowest variation and error) manometric sensor for pressure measurement, the…
- Trial name
- NCT04456543
- Testing
- pressure monitoring
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Hangang Sacred Heart Hospital
Hypertrophic Scar
Role of Topical Putrescine (Fibrostat) for Prevention of Hypertrophic Scars in Mammoplasty Patients
Linked to previous Clinical Trial E92:069 in which biochemical effect of 1,4 diaminobutane was studied in human scar harvested at revision surgery after a 12 week application.
- Trial name
- NCT03376620
- Testing
- 1,4-Diaminobutane, 10% Urea cream
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Hypertrophic Scar
Study to Evaluate Efficacy of OLX10010 in Reducing Recurrence of Hypertrophic Scarring After Scar Revision Surgery
Phase 2a, prospective, randomized, double-blind, intra-subject, placebo-controlled, proof of concept study. Approximately twenty subjects will be randomized 1:1 to one of two treatment arms: Arm A: 2.0 mg/cm OLX10010 biweekly…
- Trial name
- NCT04877756
- Testing
- OLX10010
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- Olix Pharmaceuticals, Inc.
Coronary Restenosis, Coronary Stent Occlusion
Restenosis in Coronary Stents And Cutaneous HEaLing
Case control study of patients with and without restenosis to demonstrate the link between in-stent restenosis and an excessive skin healing.
- Conditions
- Coronary Restenosis, Coronary Stent Occlusion, Skin Scarring, Keloid
- Trial name
- RACHEL (NCT04915391)
- Testing
- Skin biopsy and blood sample for inflammation markers, RNA and proteins
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Keloid
Keloid Radiation Registry
Radiation therapy has been, and is being used in treatment of patients with keloid. Radiation is typically used as an adjunct to surgery in order to reduce the recurrence rate of keloid.
- Trial name
- NCT01457079
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Tirgan, Michael H., M.D.
Burn Scar, Hypertrophic Scarring
Remimazolam vs Propofol in Laser Burn Cases
This randomized, single-blind, crossover study compares remimazolam and propofol for monitored anesthetic care during fractional ablative CO₂ laser therapy for burn scars.
- Conditions
- Burn Scar, Hypertrophic Scarring, Procedural Sedation
- Trial name
- NCT07213544
- Testing
- Remimazolam besylate, Propofol
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Medical University of South Carolina
Hypertrophic
A Study of a Novel Silicone Dressing to Minimize Scar Formation
Neodyne has developed an investigational dressing for post-operative incision care. Neodyne is conducting this research to study whether the investigational dressing, called the Neodyne Dressing, can minimize scar formation in a…
- Trial name
- REFINE (NCT01399099)
- Testing
- embrace device
- Where
- 13 sites in United States
- Volunteers
- 67 people
- Sponsor
- Neodyne Biosciences, Inc.
Burns
Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma
Deep skin burn injuries, especially extensive deep burns or/and deep burns extending on the face, hands, feet, genitalia and perineum, remain one of the most challenging therapeutic problems.
- Trial name
- NCT01383187
- Testing
- DE graft and PRP concentrate, DE graft
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava
Keloid
Web Based Investigation of Natural History of Keloid Disorder, an Online Survey
This trial intends to gather very basic clinical information about keloid, its patterns of presentation, family history, ethnic background and correlation with the type of keloid, as well as prior treatment results that patients…
- Trial name
- NCT01423981
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Tirgan, Michael H., M.D.
Keloid, Alopecia Areata
Pain Outcomes Following Intralesional Corticosteroid Injections
Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics.
- Conditions
- Keloid, Alopecia Areata, Acne, Hypertrophic Scar
- Trial name
- NCT03630198
- Testing
- Corticosteroid with lidocaine, Corticosteroid with normal saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Heart Failure
Feasibility Study of Radiofrequency Heating of Cardiac Infarction Scar to Treat Heart Failure
The purpose of this study is to examine the safety and potential effectiveness of a new surgical procedure for treating heart failure.
- Trial name
- RECOVER (NCT00881777)
- Testing
- Radiofrequency heating of the myocardial infarct scar, Coronary Artery Bypass Grafting (CABG) surgery
- Where
- 3 sites in Paraguay, Poland
- Volunteers
- 3 people
- Sponsor
- CoRepair, Inc.
Burns, Hypertrophic Scar
Effect of Elastic Bandage With Tension on the Inflammatory Response of Hypertrophic Scars
Burns can lead to lesions of total thickness, which extend the reticular layer of the dermis requiring a healing process, resulting in aesthetic problems, hypertrophic and functional scars that causes the patient a state of low…
- Trial name
- NCT04643223
- Testing
- kinesio tape with tension, kinesio tape without tension
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Knee Arthropathy, Hip Arthropathy
SMART Dressing for Hypertrophic Scar Treatment Post-Total Knee/Hip Arthroplasty
Pressure therapy (PT) and silicone therapy are recommended as first-line non-invasive treatment for Hypertrophic Scar (HS), yet the effectiveness of the combination of these two treatments through an RCT trial has not been…
- Conditions
- Knee Arthropathy, Hip Arthropathy, Hypertrophic Scar
- Trial name
- NCT03849274
- Testing
- Smart Scar Care Pad=Pressure Garment, Pressure Garment
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Dermatologic Disease
Effect of Vitamin D Injection on Hypertrophic Scars and Keloids
Scars and keloids cause patients severe morbidity and psychological distress. Hypertrophic scars rise above the skin but stay within the scar boundaries, while keloids expand.
- Trial name
- NCT06301178
- Testing
- Cholecalciferol
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Mostafa Bahaa
Cicatrix, Hypertrophic
A Study to Evaluate Safety and PK Profiles of OLX10010 in Healthy Subjects
The Study Drug is an investigational drug which is being developed by OliX Pharmaceuticals Inc., with an aim to help people who develop hypertrophic scars (a type of permanent scar) in the future.
- Trial name
- NCT03569267
- Testing
- OLX10010
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Olix Pharmaceuticals, Inc.