Clinical trials: Hypertension in Pregnancy
Renal Artery Stenosis, Hypertension, Renovascular
Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension
The purpose of this trial is to test how well the iCAST™ RX Stent works in patients diagnosed with atherosclerotic renal artery stenosis and whether or not increased blood flow by the stent will help to control blood pressure.
- Trial name
- ARTISAN (NCT01673373)
- Testing
- iCAST™ Rx Stent System
- Where
- 12 sites in United States
- Volunteers
- 68 people
- Sponsor
- Atrium Medical Corporation
Preeclampsia, Preeclampsia Postpartum
Vascular Effects of High-Salt After Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT06749418
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Preeclampsia, Eclampsia
RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil
The perinatal morbidity and mortality rates for Brazil are five to ten-fold higher than those reported for upper income countries.
- Conditions
- Preeclampsia, Eclampsia, HELLP Syndrome, Pregnancy
- Trial name
- NCT00097110
- Testing
- Vitamin C and E
- Where
- Brazil
- Volunteers
- 734 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Sleep Disordered Breathing, Obstructive Sleep Apnea
Sleep Disordered Breathing and Gestational Hypertension
Sleep disordered breathing (SDB) is a common problem in the adult population. By conservative estimates, 4% of the adult female population has SDB.
- Conditions
- Sleep Disordered Breathing, Obstructive Sleep Apnea, Gestational Hypertension, Preeclampsia
- Trial name
- NCT00757718
- Testing
- CPAP, Oral Appliance
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Saskatchewan
Gestational Diabetes
Myo-inositol in Obese Pregnant Women
Myo-Inositol is classified as a member of the vitamin B complex. It is a constituent of living cells and is widespread in many food.
- Trial name
- NCT01047982
- Testing
- myo-inositol, folic acid 400 mcg
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- University of Messina
Proteinuria
High Doses of Candesartan Cilexetil on the Reduction of Proteinuria
The purpose of this study is to assess the effects of high doses of candesartan cilexetil and also to assess which dose (16mg, 64mg, 128mg) is the most optimal for the maximum reduction of proteinuria.
- Trial name
- NCT00242346
- Testing
- candesartan cilexetil
- Where
- 26 sites in Canada
- Volunteers
- 270 people
- Sponsor
- AstraZeneca
Preeclampsia
Daily Aspirin Treatment After Preeclampsia
Women who develop preeclampsia during pregnancy are four times more likely to develop cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT06168461
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Anna Stanhewicz, PhD
Thrombotic Microangiopathies, Hemolytic Uremic Syndrome, Atypical
Complement Prospective Evaluation of Thrombotic Microangiopathy on Endothelium
Thrombotic microangiopathy (TMA) is a severe and life-threatening condition, often affecting the kidneys and brain. It can occur on the background of various clinical conditions.
- Conditions
- Thrombotic Microangiopathies, Hemolytic Uremic Syndrome, Atypical, Hemolytic-Uremic Syndrome
- Trial name
- COMPETE (NCT04745195)
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Maastricht University Medical Center
Preeclampsia
Marinobufagenin as a Target for DIGIBIND in Preeclampsia
Background: Preeclampsia is a combination of high blood pressure and other potentially life-threatening symptoms. Preeclampsia occurs in up to 10% of pregnancies and is a main cause of maternal and fetal death worldwide.
- Trial name
- NCT01328600
- Where
- 3 sites in Russia
- Volunteers
- 144 people
- Sponsor
- National Institute on Aging (NIA)
Hypertension, Chronic Kidney Disease
Efficacy and Safety of the DASH Diet in Adults With Moderate Chronic Kidney Disease: Pilot Study
More than two-thirds of US adults with chronic kidney disease (CKD) have uncontrolled hypertension. Both hypertension and CKD are major independent risk factors for cardiovascular disease, which is the leading cause of death in…
- Trial name
- NCT02059811
- Testing
- DASH Diet, Control Diet
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Duke University
Polycystic Ovary Syndrome, Hypertension
Mechanisms of Hypertension in Women With Polycystic Ovary Syndrome
Women with androgen excess polycystic ovary syndrome (AE-PCOS) leads to hypertension.
- Trial name
- NCT04327934
- Testing
- GnRH antagonist, GnRH antagonist + MethylTESTOSTERone 5 MG
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Neonatal Hypoxia and Asphyxia
Can Shorter Time Intervals Help the Baby Survive the Triad Effect of Maternal Hypertension, Caesarean Section and Spinal Anesthesia?
Patients were classified into two equal groups using the presence or absence of hypertension during pregnancy into: hypertensive group (BP>140/90) and normotensive group (BP≤140/90.
- Trial name
- NCT03461913
- Testing
- Cesarean section
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Preeclampsia, Fetal Growth Restriction
First Trimester Prediction of Preeclampsia and Fetal Growth Restriction
To evaluate the feasibility of screening for preeclampsia and fetal growth restriction between 11-13+6 weeks' gestation utilizing the combination of uterine artery doppler, maternal blood pressure, maternal characteristics…
- Trial name
- NCT02379494
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Fetal Medicine Foundation
Vasomotor Symptoms, Urinary Incontinence
Nurse-led Primary Healthcare Intervention Model in Women's Health Management in Hong Kong
The goal of this randomized clinical trial is to learn if a nurse-led primary healthcare intervention can help improve health management in women adults aged 45 to 64, and to develop an evidence-based primary healthcare model for…
- Conditions
- Vasomotor Symptoms, Urinary Incontinence, Anxiety, Depression - Major Depressive Disorder
- Trial name
- JCDATAZONEWH (NCT06628388)
- Testing
- Nurse-Led Risk-Based 5As Primary Healthcare Model, Minimal Intervention
- Where
- 3 sites in Hong Kong
- Volunteers
- 1,728 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
AKI, CKD
Genetics in the Progression of Nephropathies
This study evaluates the role of genetic in the development and progression of different nephropaties with particular attention to: AKI CKD Hypertension ADPKD CKD-MBD Patients with decompensated heart failure undergoing either…
- Conditions
- AKI, CKD, Ckd-Mbd, CKD (Chronic Kidney Disease) Stage 5D
- Trial name
- NCT06416761
- Testing
- genetic polymorphisms
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Ospedale San Raffaele
Severe Preeclampsia
Risk Prediction Models for Adverse Maternal and Neonatal Outcomes in Preeclampsia
This proposal describes a single centre retrospective cross-sectional study which will address the need to further develop and test statistical risk prediction models for adverse maternal and neonatal outcomes in low-resource…
- Trial name
- NCT04058405
- Testing
- Observational
- Where
- Zimbabwe
- Volunteers
- 549 people
- Sponsor
- Mpilo Central Hospital
Pregnant Women, Preeclampsia
Antioxidant Supplementation in Pregnant Women
The purpose of this study is to investigate the benefit of several micro nutrients of antioxidants (using milk) in a cohort of women with low antioxidant status and the changes in cell-free mRNA.
- Trial name
- ASIP1 (NCT01232205)
- Testing
- micronutrient antioxidant, Control
- Where
- Indonesia
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Showa University
Diabetes Mellitus, Hypertension
The Long-term Spill-over Impact of COVID-19 on Health and Healthcare of People With Non-communicable Diseases
Objectives and aim: To evaluate the long-term spill-over (indirect) effect of Coronavirus disease (COVID-19) on health outcomes and healthcare utilization among people with non-communicable diseases and without COVID-19.
- Conditions
- Diabetes Mellitus, Hypertension, Cancer, Cardiovascular Diseases
- Trial name
- NCT05248412
- Testing
- COVID-19 outbreaks
- Where
- China
- Volunteers
- 250,000 people
- Sponsor
- The University of Hong Kong
Preeclampsia, Intracranial Pressure Increase
Assessment of Optic Nerve Sheath Diameter in Preeclamptic Pregnant Women Using Ultrasonography and Anesthetic Management
Preeclampsia is a serious condition associated with complications such as pulmonary edema, placental abruption, hemolysis, thrombocytopenia, and cardiac, renal, and neurological complications, occurring at a rate of 2.7-8% in…
- Conditions
- Preeclampsia, Intracranial Pressure Increase, Pregnancy; Anesthesia, Adverse Effect, Central Nervous System
- Trial name
- NCT06522295
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Pulmonary Arterial Hypertension, Renal Dysfunction
The Effect of Renal Impairment on the Pharmacokinetics of Oral Treprostinil
This is a single-center, open-label, single-dose evaluation of 1 mg UT-15C SR pharmacokinetics, safety, and tolerability in subjects with normal, mild, moderate and end stage renal disease (ESRD; on dialysis).
- Trial name
- NCT01131845
- Testing
- UT-15C SR (treprostinil diethanolamine)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- United Therapeutics
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