Clinical trials: Hypertension Complicating Pregnancy
Pre-Eclampsia
Certain Maternal Antibodies in Relation to Doppler in Hypertension With Pregnancy
Relation of certain maternal serum antibodies to Doppler changes will be studied in cases suffering from hypertension with pregnancy.
- Trial name
- NCT03214393
- Testing
- Doppler, serum antibodies
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Preeclampsia
Role of the Maternal Microbiota on the Immune Response and Metabolism During Hypertensive Disorders
Preeclampsia (PE) is a significant cause of maternal and fetal morbidity and mortality, characterized by high blood pressure and proteinuria during pregnancy.
- Trial name
- MATER (NCT06421493)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Clinico Humanitas
Pre Eclampsia
Study of Coagulation Activation Markers and Pre Eclampsia
The primary purpose of the trial is to evaluate coagulation activator markers in patients with pre eclampsia compared to control (normal pregnancy) and to correlate these markers with the severity of the pathology.
- Trial name
- PRESTIGE (NCT01261351)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Lille
Pre-Eclampsia
Implementation of First-trimester Screening and preventiOn of pREeClAmpSia Trial (FORECAST)
This implementation study aims to evaluate the efficacy, acceptability, and safety of first-trimester screening and prevention for preterm-preeclampsia.
- Trial name
- FORECAST (NCT03941886)
- Testing
- Low-dose aspirin in women with high risk of preeclampsia
- Where
- 19 sites in China, Hong Kong and 8 more
- Volunteers
- 42,454 people
- Sponsor
- Chiu Yee Liona Poon
Pre-eclampsia, Pregnancy, High Risk
Placental Growth Factor Assessment of Women With Suspected Pre-eclampsia
The primary aim is to establish the effectiveness of plasma PlGF measurement in reducing maternal morbidity (with assessment of perinatal safety in parallel) in women presenting with suspected pre-eclampsia prior to 37 weeks'…
- Conditions
- Pre-eclampsia, Pregnancy, High Risk, Pregnancy Complications
- Trial name
- PARROT (NCT02881073)
- Testing
- Maternal plasma PlGF quantification
- Where
- 7 sites in Ireland
- Volunteers
- 2,313 people
- Sponsor
- Irish Centre for Fetal and Neonatal Translational Research
HELLP Syndrome
Effectivity of Postpartum Dexamethasone for Women With Class I HELLP Syndrome
Corticotherapy accelerates maternal postpartum recovery in women with class I HELLP syndrome. The benefit of faster and better recovery would be observed in fewer complications, less utilization of blood products and shorter…
- Trial name
- COHELLP (NCT00711841)
- Testing
- dexamethasone
- Where
- Brazil
- Volunteers
- 400 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Pregnancy; Proteinuria, With Hypertension (Severe Pre-eclampsia), Delivery; Proteinuria, With Gestational Hypertension (Pre-eclampsia, Severe)
Impedance Cardiographic (ICG) Assessment of Pregnant Women With Severe Hypertension to Assess Impact of Standard Therapy
The utilization of external cardiohemodynamic patient assessment, applying non-invasive stick-on contact patches to the mother's neck on either side and chest wall on either side, enables the practitioner to have information…
- Conditions
- Pregnancy; Proteinuria, With Hypertension (Severe Pre-eclampsia), Delivery; Proteinuria, With Gestational Hypertension (Pre-eclampsia, Severe), Pregnancy; Hypertension, Gestational Hypertension, With Albuminuria (Severe Pre-eclampsia)
- Trial name
- ICASH (NCT01248169)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Mississippi Medical Center
Infant,Premature, Bronchopulmonary Dysplasia
L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects up to 35% of very low birth weight infants (VLBW < 1500 g).
- Conditions
- Infant,Premature, Bronchopulmonary Dysplasia, Pulmonary Hypertension
- Trial name
- NCT03542812
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Pre-eclampsia, Pregnancy
Vitamin D for Preventing Recurrent Preeclampsia in Pregnant Women
The goal of this clinical trial is to find out whether giving vitamin D to pregnant women who had pre-eclampsia in a previous pregnancy helps prevent the condition from coming back.
- Conditions
- Pre-eclampsia, Pregnancy, Vitamin D
- Trial name
- NCT07288801
- Testing
- Vitamin D
- Where
- Pakistan
- Volunteers
- 146 people
- Sponsor
- Nishtar Medical University
Preeclampsia
A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen
The trial will test the equivalence of a repeat bolus protocol of magnesium sulfate administered by the Springfusor® controlled pump to a continuous intravenous regimen.
- Trial name
- NCT02091401
- Testing
- Springfusor infusion pump, IV administration, Magnesium Sulfate
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Gynuity Health Projects
Hypertension, Renal
Trial on the Safety and Efficacy of MLS-101 in Patients With Uncontrolled Hypertension
A randomized, double-blind, placebo-controlled, dose-ranging, Phase II study to evaluate the safety, efficacy, and tolerability of MLS-101 in Subjects With Uncontrolled Hypertension
- Trial name
- Target-HTN (NCT05001945)
- Testing
- MLS-101 (Part I), MLS-101 (Part II)
- Where
- 44 sites in United States
- Volunteers
- 200 people
- Sponsor
- Mineralys Therapeutics Inc.
Preeclampsia, Gestational Diabetes
The Association Between High Risk Pregnancy and Sleep-disordered Breathing
The aim of the present study is to establish, using polysomnographic criteria and prospective nature, whether sleep apnea in pregnancy is more prevalent in women with high risk pregnancies including preeclampsia, gestational…
- Conditions
- Preeclampsia, Gestational Diabetes, Premature Labor
- Trial name
- NCT01022619
- Where
- 2 sites in Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Chronic Kidney Disease
CRICKET Study, Coronary Calcium Scores in Patients With Chronic Kidney Disease
Patients with Chronic Kidney Disease (CKD) have been shown to have high coronary calcium scores (CAC), but the temporal association between Glomerular Filtration Rate, CVD risk factors and CAC has not been described.
- Trial name
- NCT00142636
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Pre-Eclampsia, Depression
Preeclampsia Research on Vitamin D, Inflammation, & Depression
This study is designed to comprehensively investigate the anti-inflammatory role of vitamin D in reproductive aged women, and its association with preeclampsia and depression.
- Conditions
- Pre-Eclampsia, Depression, Inflammation, Vitamin D Deficiency
- Trial name
- PROVIDE (NCT03018132)
- Testing
- mental health screening, education and referral program
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Diabetes Mellitus and Heart Failure
A Dose Finding Study to Assess the Effect of LIK066 Compared to Placebo or Empagliflozin in Patients With Type 2 Diabetes Mellitus and Heart Failure
This was a dose-finding study to evaluate the efficacy, safety and tolerability of 3 different doses of LIK066 compared to placebo or empagliflozin in T2DM patients with heart failure
- Trial name
- NCT03152552
- Testing
- LIK066, Empagliflozin
- Where
- 106 sites in United States, Argentina and 22 more
- Volunteers
- 125 people
- Sponsor
- Novartis Pharmaceuticals
Medication Adherence, Preeclampsia
Adherence to Universal Aspirin Compared to Screening Indicated Aspirin for Prevention of Preeclampsia
There are data showing that a majority of pregnant women may not be accurately identified as high risk through screening and therefore, not receiving prophylactic low dose aspirin as recommended.
- Trial name
- NCT04797949
- Testing
- Low-dose aspirin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Preeclampsia, Hypertensive Disorders of Pregnancy (HDP)
Clinician Notification to Increase Aspirin Prophylaxis for Preeclampsia Prevention
Preeclampsia is a leading cause of maternal morbidity and mortality. Low-dose aspirin prophylaxis reduces preeclampsia risk among high-risk pregnant individuals but remains underused in routine clinical practice.
- Conditions
- Preeclampsia, Hypertensive Disorders of Pregnancy (HDP), Pregnancy Complications, Aspirin Prophylaxis
- Trial name
- NCT07614893
- Testing
- Clinician notification of elevated preeclampsia risk
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Massachusetts General Hospital
Chronic Kidney Disease, Hypertension
Five, Plus Nuts and Beans for Kidneys
This Five, Plus Nuts and Beans for Kidneys Study is a single center, randomized controlled trial with 2 parallel arms testing the hypothesis that delivery of nutritional advice to adopt a Dietary Approaches to Stop Hypertension…
- Trial name
- NCT03299816
- Testing
- Coaching DASH group (C-DASH), Self-Shopping DASH group (S-DASH)
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Johns Hopkins University
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Pre-Eclampsia
Evaluation of HALP Score in Preeclampsia
Preeclampsia is a serious condition that can occur during pregnancy and can pose problems for both the mother and the baby. It occurs in approximately 2-8% of all pregnancies globally and is caused by issues with blood vessels…
- Trial name
- NCT05816044
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
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