Clinical trials: Hypertension, open to volunteers
Primary Hypertension
The Safety and Efficacy of Carotid Body Modulation Therapy in Hypertensive Patients by External Ultrasonic Micro-bubble
The investigators intend to find a noninvasive method for CB modulation therapy and find a simple and convenient indicator for assessing CB activity.
- Trial name
- NCT06116357
- Testing
- External Ultrasonic Micro-bubble
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jing Huang
Coronary Microvascular Dysfunction, Resistant Hypertension
Impact of Renal Denervation in Patients With Coronary Microvascular Dysfunction: Study Design and Rationale
Long-standing hypertension may cause an impairment in microvascular coronary circulation which is involved in many different cardiac conditions.
- Conditions
- Coronary Microvascular Dysfunction, Resistant Hypertension, Hypertensive Heart Disease
- Trial name
- IMPRESSION (NCT05994729)
- Testing
- Invasive Physiological Assessment of Coronary Circulation
- Volunteers
- 87 people
- Sponsor
- Aurelia Hospital
Obesity
South Danish Obesity Initiative, Screening for Unrecognized Obesity Related Disease
People with BMI >30 kg/m2 will be included in at population-based cohort. Additionally, one control group with BMI 18.5-25 kg/m2 and one control group with BMI 25-30 kg/m2 will be included.
- Trial name
- SDOI (NCT05176132)
- Testing
- Life style intervention (dietician+ physiotherapist), Self management, No intervention
- Where
- Denmark
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Claus Bogh Juhl
Connective Tissue Diseases, Pulmonary Hypertension
Connective Tissue Disease Patients With Pulmonary Hypertension
Adult patients with suspected or confirmed Connective Tissue Disease Patients (CTD)With Pulmonary Hypertension(PH)will be recruited.
- Trial name
- NCT05980728
- Testing
- No Intervention
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pulmonary Hypertension (Diagnosis)
Applying Artificial Intelligence to the 12 Lead ECG for the Diagnosis of Pulmonary Hypertension: an Observational Study
The goal of this observational study is to apply Artificial Intelligence (AI) and machine learning technology to the resting 12-lead electrocardiogram (ECG) and assess whether it can assist doctors in the early diagnosis of…
- Trial name
- NCT05942859
- Testing
- Artificial Intelligence and Machine Learning technology
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Pulmonary Hypertension
Registration Study for Rare Type of Pulmonary Hypertension
The knowledge on the rare type of pulmonary hypertension which can not be explained by left heart disease, respiratory disease or congenital heart disease is very limited.
- Trial name
- NCT03169010
- Testing
- laboratory biomarker analysis, Genetic analysis
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Hypertension
Heart to Heart: BP Control Partners
The goal of this clinical trial is to compare a new model of care that uses cellular-enabled home blood pressure (BP) telemonitoring and combines it with team-based BP control using a pharmacist to help manage BP medications and…
- Trial name
- NCT05809713
- Testing
- Technology-enabled Team Care, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 780 people
- Sponsor
- East Carolina University
Arterial Hypertension
Women Hypertensive and Young-Renal Denervation
Renal denervation is a new method to lower blood pressure (BP) in hypertensive patients by reducing the impact of sympathetic nervous system.
- Trial name
- WHY-RDN (NCT05563337)
- Testing
- Arteriography and renal denervation, Arteriography without renal denervation
- Where
- 6 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Bordeaux
Liver Cirrhosis, Hepatocellular Carcinoma
Relevance of Sarcopenia in Advanced Liver Disease
Patients with established liver cirrhosis, or end-stage liver disease (ESLD), are at high risk of developing liver cancer (hepatic carcinoma; HCC), portal hypertension, and sarcopenia, all which lead to significant morbidity and…
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma, Sarcopenia, Portal Hypertension
- Trial name
- ACCESS-ESLD (NCT05502198)
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Linkoeping University
Left Ventricular Hypertrophy, Hypertension
Response of the Myocardium to Hypertrophic Conditions in the Adult Population
Hypertension and aortic stenosis are the two leading conditions that cause thickening of the heart muscles (left ventricular hypertrophy). Left ventricular hypertrophy is initially adaptive to maintain optimal heart function.
- Conditions
- Left Ventricular Hypertrophy, Hypertension, Myocardial Fibrosis
- Trial name
- NCT02670031
- Testing
- Cardiovascular Magnetic Resonance, Echocardiogram, Electrocardiogram
- Where
- Singapore
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Arterial Hypertension
Fetuin A as a Predictor of Deterioration of Renal Function in Hypertonic Patients
Commonly used parameters (creatinine, estimated glomerular filtration rate, and urine albumin/creatinine ratio) for prediction of decline of renal function are sensitive for advanced kidney impairment.
- Trial name
- NCT05963126
- Testing
- No intervention.
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Ostrava
Pulmonary Hypertension
Pulmonary Hypertension Observational Study
The purpose of this study is to establish the large PH cohort and biological database in China, aiming for precision medicine to optimize diagnosis and treatment choices.
- Trial name
- NCT05958901
- Testing
- pulmonary hypertension
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Hypertension Arterial, Hypokinetic
Etiological DiagnOsis of caRdiac Diseases Based on echoCardiograpHIc Images and Clinical Data.
Research hypothesis - Recent studies have shown that high-dimensional descriptors of the cardiac function can be efficiently exploited to characterize targeted pathologies.
- Conditions
- Hypertension Arterial, Hypokinetic, Cardiomyopathies, Left Ventricular Hypertrophy
- Trial name
- ORCHID (NCT05942729)
- Testing
- Determine the etiology of hypokinetic and hypertrophic heart disease on transthoracic echocardiography data alone
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Hospices Civils de Lyon
Pulmonary Arterial Hypertension, Connective Tissue Diseases
REgistry of Pulmonary Arterial Hypertension Associated With CONNECTIVE Tissue Diseases (RECONNECTIVE)
The RECONNECTIVE Registry is an observational single center study, focused on the subgroup of precapillary pulmonary hypertension related to connective tissue diseases.
- Trial name
- RECONNECTIVE (NCT05665556)
- Where
- Mexico
- Volunteers
- 170 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hypertension
Impact of Advanced Practical Nursing Intervention Versus Usual Care on Hypertension Control
Hypertension is the most frequent chronic pathology in France and in the world. It is one of the main modifiable cardiovascular risk factors.
- Trial name
- iIPA (NCT05917600)
- Testing
- APN intervention
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension, Renovascular
Drug-eluting Balloon for Treatment of Non-atherosclerotic Renal Artery Stenosis--a Multicenter Study
The study will test the efficacy of drug eluting balloon(DEB) for non-atherosclerotic renal artery stenosis. The DEB (paclitaxel eluting balloon) will be used in the intervention group, while the plain old balloon(POB) will be…
- Trial name
- NCT05858190
- Testing
- Parallel Assignment
- Volunteers
- 90 people
- Sponsor
- Peking Union Medical College Hospital
Ocular Hypertension, Primary Open Angle Glaucoma
Nanodropper Use in Primary Open-Angle Glaucoma Patients: A Non-Inferiority Trial
This randomized, single-masked, crossover, non-inferiority trial aims to evaluate the safety and efficacy of Nanodropper-mediated microdrops of ocular hypotensive topical treatments (experimental intervention) compared to…
- Trial name
- NCT05844384
- Testing
- Nanodropper, Regular dropper
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- 59th Medical Wing
Hypertension, Hyperaldosteronaemia
Effect of MRA on Cardiovascular Disease in Patients With Hypertension and Hyperaldosteronemia
Elevated aldosterone causes moderate to severe increase in blood pressure, and leads to various target organ damage including cardiovascular ones.
- Trial name
- EMRACHH (NCT05688579)
- Testing
- Mineralocorticoid Receptor Antagonists(MRAs), Blank control
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Nanfang Li
Atherosclerotic Plaque, Diabetes Mellitus, Type 2
Pakistan Study of Premature Coronary Atherosclerosis in Young Adults
Coronary heart disease (CHD) is a major cause of morbidity, disability, mortality, and health expenditures worldwide. A wealth of studies has demonstrated that people of South Asian ancestry have a higher risk of CHD and…
- Conditions
- Atherosclerotic Plaque, Diabetes Mellitus, Type 2, Hypertension, Stroke
- Trial name
- PAKSEHAT (NCT05156736)
- Where
- Pakistan
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tabba Heart Institute
Hypercholesterolemia, Obesity
The Impact of Using a Smartphone Health Application in the Improvement of Cardiovascular Disease Risk Factors
This study investigates the effectiveness of Mobile health application (mHealth apps) in the improvement of cardiovascular disease risk factors including metabolic and behavioral factors.
- Conditions
- Hypercholesterolemia, Obesity, Diabetes Mellitus, Hypertension
- Trial name
- NCT05798442
- Testing
- smartphone health application (Opulse)
- Volunteers
- 410 people
- Sponsor
- Sultan Qaboos University