Clinical trials: Hypertension, Resistant to Conventional Therapy
Hypertension, Resistant to Conventional Therapy, Renal Denervation
Renal Denervation in Hypertension
The DENER-HTN study is a, multicenter, prospective, open, randomized, controlled study of the effectiveness and costs of renal denervation in addition to standardized medical treatment compared to medical treatment alone in…
- Trial name
- DENER-HTN (NCT01570777)
- Testing
- renal denervation and optimized medication regimen, optimized medication regimen
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Hypertension, Hypertension, Resistant to Conventional Therapy
Causal Inference Research of Resistant Hypertension Treatment With Chinese Approach in a Cohort Study
The research of clinical effectiveness assessment is to explore the causal relationship between treatment and outcome.Accordingly, based on the effectiveness of tan-yu treatment, the research takes the Resistant Hypertension (RH)…
- Trial name
- NCT01904695
- Testing
- Herbs, Antihypertensive drugs
- Where
- China
- Volunteers
- 192 people
- Sponsor
- China Academy of Chinese Medical Sciences
Hypertension, Resistant to Conventional Therapy
Continued Safety and Performance of the TIVUS System
The TIVUS II is a prospective, multicenter, non-randomized, open-label clinical study of the safety and performance of the TIVUS™ System consisting of three (3) concurrent cohorts: TIVUS™ Severe Resistant HTN Cohort TIVUS™…
- Trial name
- NCT01835535
- Testing
- TIVUS
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- Cardiosonic
Systemic Arterial Hypertension, Hypertension Resistant to Conventional Therapy
Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular Events
Renin-angiotensin-aldosterone system (RAAS) polymorphisms influence 24h arterial pressure fluctuation. Resistant systemic arterial hypertension (RSAH) has an increased risk of end organ damage and unfavourable prognosis, whereas…
- Conditions
- Systemic Arterial Hypertension, Hypertension Resistant to Conventional Therapy, Myocardial Infarction, Stroke
- Trial name
- GENHART (NCT01173029)
- Testing
- Anti-hypertensive drug treatment
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- Universidade Gama Filho
Hypertension, Resistant to Conventional Therapy
Safety and Efficacy Study of Extracorporeal Shockwave Therapy in the Treatment of Patients With Resistant Hypertension
Low intensity shockwaves have been proven in animal and human studies to increase tissue perfusion, promote angiogenesis and tissue regeneration and improve neural function.
- Trial name
- RHT (NCT02042066)
- Testing
- Omnispec model Vascuspec
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Medispec
Hypertension, Resistant to Conventional Therapy
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension.
- Trial name
- NCT06246396
- Testing
- Minocycline Hydrochloride
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Hypertension, Resistant to Conventional Therapy
The Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the Prognosis
Hypertension is still one of the major preventable risk factor for cardiovascular as well as cerebrovascular diseases globally, including ischaemic heart disease, heart failure, and renal impairment.
- Trial name
- doublepres (NCT01703780)
- Where
- 18 sites in China
- Volunteers
- 9,638 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hypertension, Resistant to Conventional Therapy
Renal Sympathetic Denervation and Potential Effects on Glucose Metabolism and Cardiovascular Risk-Factors
The Re-Shape CV-Risk Study is a clinical study where renal adrenergic denervation (RDN) is done in high risk patients with treatment-resistant hypertension.
- Trial name
- Re-Shape (NCT01630928)
- Testing
- Renal sympathetic denervation
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital of North Norway
Hypertension, Resistant to Conventional Therapy
The Use of Ambulatory Blood Pressure Monitors to Assess Angiotensin Converting Enzyme Inhibitors
The purpose of this study is to use ambulatory blood pressure monitors to investigate whether enalapril is superior to lisinopril in managing nocturnal hypertension in patients with resistant hypertension currently treated with…
- Trial name
- NCT02623036
- Testing
- Equivalent dose enalapril, Equivalent dose lisinopril
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Memorial Health University Medical Center
Hypertension, Resistant to Conventional Therapy, Obstructive Sleep Apnea
CPAP Effect on Blood Pressure and Arterial Stiffness in Obstructive Sleep Apnea Patients With Resistant Hypertension
Resistant hypertension is defined as uncontrolled blood pressure (BP ≥ 140/90mmHg) despite the current use of three or more antihypertensive drugs at full doses, including a diuretic.
- Trial name
- POP-ART (NCT02385864)
- Where
- 4 sites in France
- Volunteers
- 166 people
- Sponsor
- University Hospital, Grenoble
Hypertension, Resistant to Conventional Therapy
Optimum Treatment for Drug-Resistant Hypertension
This study was recommended by NICE, as part of its 2006 guidance for the treatment of hypertension, and is urgently required to provide evidence for the treatment recommendations in patients with resistant hypertension.
- Trial name
- PATHWAY2 (NCT02369081)
- Testing
- Spironolactone, Bisoprolol, Doxazosin
- Where
- 16 sites in United Kingdom
- Volunteers
- 348 people
- Sponsor
- University of Cambridge
Hypertension, Resistant to Conventional Therapy, Diabetes Mellitus
Efficacy of Spironolactone in Cameroonian Diabetic Patients With Resistant Hypertension
This is a four-week randomized controlled single blinded trial of subjects presenting with resistant hypertension in a specialized diabetes care unit of Cameroon.
- Trial name
- SPIRY (NCT02426099)
- Testing
- Low dose spironolactone, Routine intensification of antihypertensive treatment
- Where
- Cameroon
- Volunteers
- 17 people
- Sponsor
- Sobngwi Eugene
Hypertension, Resistant to Conventional Therapy
How to Test Success of a Renal Denervation
The study aimed to assess the success of a clinically indicated renal denervation by different tests and correlate the results of the tests with the clinical outcome.
- Trial name
- NCT02559882
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Zurich
Hypertension, Hypertension Resistant to Conventional Therapy
High Prevalence of Secondary Arterial Hypertension (HIPRESH) with Prospective Systematic Screening in a Cohort of Consecutive Hypertensive Patients Referring to Regional Specialized Center
Hypertensive Patients referring to our center will undergo a systematic diagnostic workup aimed at finding the cause(s) of their high blood pressure.
- Conditions
- Hypertension, Hypertension Resistant to Conventional Therapy, Secondary Hypertension to Endocrine Disorders, Secondary Hypertension
- Trial name
- HIPRESH (NCT06664255)
- Volunteers
- 1,400 people
- Sponsor
- University Hospital Padova
Hypertension, Resistant to Conventional Therapy
Full Length Versus Proximal Renal Arteries Ablation
Catheter-based renal sympathetic modification has been documented to be effective option for blood pressure control in patients with resistant hypertension, but the safety is still concerned around worldwide.
- Trial name
- NCT01848275
- Testing
- Thermocool®Rcatheter
- Where
- China
- Volunteers
- 47 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Hypertension, Resistant to Conventional Therapy
Resistant Hypertension and Physical Activity Performed in a Heated Pool
patients with resistant hypertension will be submitted to an exercise protocol in a heated pool for three months
- Trial name
- HAR (NCT01863082)
- Testing
- exercise
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hypertension, Resistant to Conventional Therapy, Atrioventricular Block
Moderato System in Patients With Hypertension
The purpose of this double blind randomized study is the evaluation of the safety and efficacy of the Moderato System. The Moderato implantable pulse generator is indicated for patients who have hypertension and also require a…
- Trial name
- NCT03757377
- Testing
- BackBeat Moderato System, BackBeat Moderato Sytsem
- Where
- 4 sites in Belgium, Lithuania and 1 more
- Volunteers
- 203 people
- Sponsor
- BackBeat Medical Inc
Hypertension, Resistant to Conventional Therapy
Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in China
Recent studies indicate that primary aldosteronism (PA) is a much more common cause of hypertension than had been demonstrated historically.
- Trial name
- NCT01459042
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Hypertension, Resistant to Conventional Therapy
Rapid Renal Sympathetic Denervation for Resistant Hypertension
The Covidien OneShot™ ablation system use is to deliver low-level radio frequency (RF) energy through the wall of the renal artery to denervate the human kidney.
- Trial name
- RAPID (NCT01520506)
- Testing
- Covidien OneShot™ System
- Where
- 14 sites in Belgium, Germany and 4 more
- Volunteers
- 50 people
- Sponsor
- Medtronic Endovascular
Hypertension, Hypertension Resistant to Conventional Therapy
Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis (ANDORRA)
The ANDORRA study is a, multicenter, prospective, open, randomized, controlled blinded endpoint trial (PROBE) comparing two treatment strategies (renal artery stenting + standardized and optimized medical treatment [SOMT] versus…
- Conditions
- Hypertension, Hypertension Resistant to Conventional Therapy, Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) Greater Than or Equal to 60 Percent
- Trial name
- ANDORRA (NCT02539810)
- Testing
- Renal artery Angioplasty plus stenting., Anti hypertensive, statin and antiplatelet medication.
- Where
- 15 sites in France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris