Clinical trials: Hypertension, Pulmonary
Pediatric Pulmonary Hypertension
Actigraphy in Pediatric Pulmonary Hypertension
Physical activity is an important factor in understanding how diseases can affect a child. Decreases in physical activity are sometimes the first thing that happens before a child is diagnosed with a disease.
- Trial name
- NCT02909608
- Testing
- No interventions / observations only
- Where
- 2 sites in United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pulmonary Arterial Hypertension
Pharmacokinetic Linearity and Comparative Bioavailability of Treprostinil Diethanolamine
This study will compare the bioavailability and pharmacokinetics of the 0.5 mg, 1 mg and 2.5 mg treprostinil diethanolamine tablet strengths in healthy volunteers.
- Trial name
- NCT01153386
- Testing
- Treprostinil diethanolamine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- United Therapeutics
COVID-19, Long COVID
Using Data From a Multisensor Rapid Health Assessment Device to Predict Decompensation in Long COVID (AIDI)
We are conducting a research study at the VA hospital in Bedford, MA to learn more about how a multisensor rapid health assessment device, MouthLab, can help predict or anticipate future health complications in patients with…
- Trial name
- AIDI (NCT05713266)
- Testing
- MouthLabTM
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Edith Nourse Rogers Memorial Veterans Hospital
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Safety, Tolerability, and PK Parameters of Sodium Nitrite Inhalation Solution in Healthy Subjects
This is a four-part study of the safety, tolerability, and PK profile of sodium nitrite inhalation solution (AIR001) of ascending multiple doses (Part A) and of escalating doses with steady-state sildenafil (Part B) to healthy…
- Trial name
- NCT01409122
- Testing
- 15 mg sodium nitrite inhalation solution, 90 mg sodium nitrite inhalation solution, 45 mg sodium nitrite inhalation solution
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Aires Pharmaceuticals, Inc.
Pulmonary Hypertension
Evaluation of Echocardiographic Indices and Blood Biomarkers in Group 1 Pulmonary Hypertension
To evaluate different echocardiographic indices in diagnosis and follow up of group 1 pulmonary hypertension. To evaluate blood biomarkers (troponin, uric acid and micro RNA) in naïve group 1 pulmonary hypertension.
- Trial name
- NCT04279145
- Testing
- swan ganze catheter /echocardiography
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pulmonary Arterial Hypertension
National Cohort Study of Idiopathic and Heritable Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH), or high blood pressure in the lungs, is a rare condition that can shorten life. Although the cause of this disease is usually unknown, in about 70% of heritable and 15-20% of idiopathic…
- Trial name
- NAIAD (NCT01907295)
- Where
- 8 sites in United Kingdom
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Pulmonary Hypertension
A First-in-Human Study to Assess the Safety and Tolerability of PDNO
This is a first-in-human, single-blind, placebo-controlled, single-centre study designed to assess the safety and tolerability of PDNO in healthy male and female subjects.
- Trial name
- NCT04891354
- Testing
- PDNO
- Where
- Sweden
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Attgeno AB
Pulmonary Arterial Hypertension
Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of Bosentan
the purpose of this study is: To assess the effect of BIA 5 1058 400 mg on the PK of bosentan. To assess the effect of bosentan on the PK of BIA 5 1058
- Trial name
- NCT04991207
- Testing
- BIA 5-1058, bosentan
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Rutgers University Study of the Genetics of Pulmonary Hypertension
The goal of this observational study is to learn more about how genes impact the risk of pulmonary hypertension. Anyone 18 or older living in the US is eligible, and a diagnosis of PH is NOT required.
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH), Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
- Trial name
- RUGCC-PH (NCT07217522)
- Testing
- Saliva sample, Health surveys
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Pulmonary Hypertension, Pulmonary Artery Pressure
Does Sildenafil Increase Exercise Performance in Air Pollution?
The purpose of this study is to examine if the ingestion of a standard dose of sildenafil enhances the athletic performance of competitive athletes when exercising in a high pollutant environment verses a low air pollutant…
- Conditions
- Pulmonary Hypertension, Pulmonary Artery Pressure, Exercise Performance, Air Pollution
- Trial name
- NCT00808912
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Marywood University
Sepsis, Pneumonia
Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project
The purpose of this study is to determine whether an integrated EmONC package (community mobilization, training of community-based health care providers and a maternal and neonatal health pack) reduce perinatal and neonatal…
- Conditions
- Sepsis, Pneumonia, Omphalitis, Birth Asphyxia
- Trial name
- EmONC (NCT01751945)
- Testing
- EmONC package
- Where
- Pakistan
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Hypertension, Pulmonary
Relative Bioavailability Study of Marketed and Lower Dose Ambrisentan in Healthy Adult Participants
This is a single center, open-label, randomized, single-dose, three-period cross-over study in healthy participants. The aim of this study is to provide clinically relevant information on the pharmacokinetic (PK) and safety…
- Trial name
- NCT04095286
- Testing
- AMB new formulation (1 mg), Reference AMB (5 mg)
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction
Effect of Home Rehabilitation on State of Patients With PAH, HFREF and IHD
The aim of the study is to evaluate the influence of physical training and respiratory rehabilitation performed by patients at home on quality of life, symptoms, physical endurance, force of respiratory and skeletal muscles and…
- Conditions
- Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Ischemic Heart Disease
- Trial name
- NCT03780803
- Testing
- home cardiac rehabilitation and respiratory rehabilitation
- Where
- Poland
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Systemic Sclerosis
Effect of Rosuvastatin on Systemic Sclerosis-related Pulmonary Hypertension
Although the aetiology of SSc-PAH remains elusive, vascular dysfunction seems to be the initial event and statins through their vasculoprotective effect might be of value in the treatment armamentarium of PAH related to SSc.
- Trial name
- NCT00984932
- Testing
- Rosuvastatin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Pulmonary Arterial Hypertension, Idiopathic Pulmonary Arterial Hypertension
StratosPHere (Non-interventional Study)
Pulmonary Arterial Hypertension is a progressive disease that has no cure. Patients die young and are limited in their daily activity. Current treatments only treat the symptoms of the disease rather than the underlying cause.
- Conditions
- Pulmonary Arterial Hypertension, Idiopathic Pulmonary Arterial Hypertension, Pulmonary Hypertension, Respiratory Disease
- Trial name
- NCT05767918
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Medication Adherence, Medication Compliance
Connected Healthcare for Individuals Living at Home With Chronic Conditions
Managing and taking medications as prescribed can be a difficult task. This is especially true for older adults living at home with chronic conditions while managing multiple prescribed medications.
- Conditions
- Medication Adherence, Medication Compliance, Medication Nonadherence, Hypertension
- Trial name
- NCT04339296
- Testing
- Spencer
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
Erectile Dysfunction, Pulmonary Arterial Hypertension
Study of the Pharmacokinetics and Safety of TPN171H Tablets in Subjects With Mild ,Moderate Hepatic Insufficiency and Normal Liver Function
The study aims to investigate and compare the effect of TPN171H on subjects with mild and moderate hepatic impairment compared to healthy subjects.
- Trial name
- NCT05185011
- Testing
- TPN171H
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Diabetes Mellitus Type 2
Diastolic Dysfunction and Pulmonary Hypertension in T2DM With Microalbuminuria
This is a cross-sectional observational study comparing echocardiographic markers of left ventricular diastolic function and pulmonary artery systolic pressure among healthy controls and patients with type 2 diabetes mellitus…
- Trial name
- NCT07839208
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Respiratory Insufficiency, Pulmonary Disease, Chronic Obstructive
The Effect of Aromatherapy Massage on Pain, Anxiety and Comfort
Patients in the intensive care unit (ICU) experience physical and psychological discomfort, including pain. Anxiety is a condition frequently encountered in the ICU.
- Conditions
- Respiratory Insufficiency, Pulmonary Disease, Chronic Obstructive, Diabetes Mellitus, Type 2, High Blood Pressure
- Trial name
- NCT06295874
- Testing
- Effect of aromatherapy massage on vital signs, pain, anxiety and comfort level
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Nilgün Erdoğan