Clinical trials: Hypertension, Pregnancy-Induced, open to volunteers
Hypertensive Disorders of Pregnancy, Preeclampsia
AtorvaStatin Postpartum and Reduction of Cardiovascular risK
The objective is to conduct a double-blinded randomized controlled trial of atorvastatin vs. placebo among postpartum individuals with hypertensive disorders of pregnancy, to improve cardiovascular risk score postpartum.
- Conditions
- Hypertensive Disorders of Pregnancy, Preeclampsia, Gestational Hypertension
- Trial name
- SPARK (NCT06632379)
- Testing
- Atorvastatin 10 mg
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Ohio State University
Hypertension
Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of Pregnancy
The goal of this clinical trial is to determine if the medication eplerenone yields greater improvements in coronary microvascular function than chlorthalidone in women who experienced hypertension during pregnancy and…
- Trial name
- CARDAMOM (NCT07238400)
- Testing
- Eplerenone 100 mg daily, Chlorthalidone 25 mg daily, Potassium Chloride
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Hypertensive Disorder of Pregnancy, Preeclampsia
MumCare: Mum's Cardiovascular Health for Life
The goal of this randomized clinical trial study is to test the potential benefits of eHealth-assisted follow-up after pregnancy complications that confer and increased risk for premature cardiovascular (CV) disease.
- Conditions
- Hypertensive Disorder of Pregnancy, Preeclampsia, Gestational Hypertension, Gestational Diabetes
- Trial name
- MumCare (NCT05835596)
- Testing
- Access to MumCare app
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- Oslo University Hospital
Hypertensive Disorders of Pregnancy, Chronic Hypertension in Pregnancy
MH-Rx Study (Baby on Board: Check-in on You, Your Medication, & Your Blood Pressure)
This randomized controlled trial will evaluate whether adding Community Health Worker (CHW)/Social Worker (SW)-led support for non-medical health related needs (NMHRN) and clinician-led Medication Therapy Management (MTM) to…
- Conditions
- Hypertensive Disorders of Pregnancy, Chronic Hypertension in Pregnancy, Gestational Hypertension
- Trial name
- NCT07842341
- Testing
- Community Health Worker (CHW)/Social Worker (SW)-led non-medical health related needs (NMHRN) intervention + Clinician-Led Medication Therapy Management (MTM) with remote blood pressure monitoring, Active Comparator (Control group)
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Texas Southern University
Preeclampsia (PE), Hypertension ,Pregnancy
Retinal and Choroidal Microcirculation in Preeclampsia: An OCTA Study
Preeclampsia is a multisystemic and multifactorial disorder that complicates pregnancy and is characterized by new-onset hypertension after the 20th week of gestation accompanied by proteinuria or systemic findings such as renal…
- Conditions
- Preeclampsia (PE), Hypertension ,Pregnancy, Retinal Microvascular Changes, Hypertensive Disorders of Pregnancy
- Trial name
- PE-OCTA (NCT07874191)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Severe Preeclampsia
Role of Postpartum Furosemide in Recovery of Patients With Severe Preeclampsia
This randomized controlled trial will compare oral furosemide with placebo for improving blood pressure control in women with severe preeclampsia after delivery.
- Trial name
- NCT07861685
- Testing
- Furosemide and Potassium
- Where
- Pakistan
- Volunteers
- 434 people
- Sponsor
- Lady Reading Hospital, Pakistan
Preterm Birth Complication, Preterm Birth
Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities
The goal of this clinical trial is to learn if a personalized prenatal support program [(Personalized Toolkit Building a Comprehensive Approach to Resource optimization and Empowerment in Pregnancy \& Beyond, (PTBCARE+)] works to…
- Conditions
- Preterm Birth Complication, Preterm Birth, Preterm Birth Recurrence, Preeclampsia
- Trial name
- PTBCARE+ (NCT06915428)
- Testing
- Care coordination, Electronic massage, support gift #1
- Where
- United States
- Volunteers
- 1,228 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypertensive Disorders of Pregnancy (HDP)
Roy Adaptation Model-Based Prenatal Education in Hypertensive Pregnant Women
This study aims to evaluate the effect of Roy Adaptation Model-based prenatal education on perceived stress and quality of life in pregnant women with hypertensive disorders of pregnancy.
- Trial name
- NCT07820306
- Testing
- Roy Adaptation Model-Based Prenatal Education
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Istanbul University - Cerrahpasa
Hypertensive Disorder of Pregnancy, Pre-Eclampsia
Treatment With Aspirin After Preeclampsia: TAP Trial
The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through…
- Conditions
- Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia
- Trial name
- TAP (NCT06281665)
- Testing
- Low-dose aspirin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Malamo Countouris
Hypertensive Disorders of Pregnancy (HDP), Hypertension, Pregnancy Induced
Community Support and Mobile Apps to Help Black Women Control High Blood Pressure After Pregnancy
The goal of this randomized clinical trial is to evaluate the effectiveness of a collaborative care intervention, consisting of remote blood pressure monitoring and support from community health workers, in improving blood…
- Conditions
- Hypertensive Disorders of Pregnancy (HDP), Hypertension, Pregnancy Induced, Severe Maternal Morbidity, Postpartum Hypertension
- Trial name
- PRIME CARE (NCT07606027)
- Testing
- Collaborative care, Standard of Care (SOC)
- Volunteers
- 404 people
- Sponsor
- University of Nebraska
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Hypertension (HTN), Hypertension ,Pregnancy
REmote Physical ACtivity Intervention for High Blood Pressure Postpartum
The purpose of this intervention is to help new mothers who had elevated blood pressure during pregnancy become more physically active after birth. The investigators will connect data from FitBits to the electronic health record.
- Conditions
- Hypertension (HTN), Hypertension ,Pregnancy, Physical Activity
- Trial name
- REACH BP (NCT07127731)
- Testing
- Patient Portal Messaging, FitBit EHR Linkage
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Hypertension, Pregnancy-Induced, HELLP Syndrome
PROTECT-Africa: Biomarker Validation for Preeclampsia Triage
Preeclampsia is a serious high blood pressure condition that can develop during pregnancy. It is one of the leading causes of death and illness for mothers and babies in Africa.
- Conditions
- Hypertension, Pregnancy-Induced, HELLP Syndrome, Eclampsia, Fetal Growth Retardation
- Trial name
- PROTECT-Africa (NCT07810439)
- Where
- Zimbabwe
- Volunteers
- 1,106 people
- Sponsor
- Africa Clinical Research Network (ACRN)
Preeclampsia, Gestational Hypertension
Exploring the Effect of Discharge Education, Blood Pressure Cuffs, and Postpartum Bracelets to Improve Health Among Newly Diagnosed Gestational Hypertension and Preeclampsia Patients During the Postpartum Period.
This pilot, exploratory qualitative, descriptive study will examine whether standard postpartum discharge education, a free home blood pressure cuff, and an "At-Risk Postpartum" bracelet support self-management among postpartum…
- Conditions
- Preeclampsia, Gestational Hypertension, Postpartum
- Trial name
- NCT07807098
- Testing
- Education, Blood Pressure Cuff, and Visual Cue Bracelet
- Volunteers
- 40 people
- Sponsor
- Memorial Hermann Health System
Gestational Hypertension, Preeclampsia
Vagal Stimulation Therapy and Preeclampsia
Preeclampsia is one of the most common and serious complications of pregnancy, affecting both the mother and baby. It is a condition characterized by high blood pressure and can lead to severe complications, including…
- Trial name
- NCT06953115
- Testing
- Vagal stimulation physiotherapy with trigger point release, Positional Release Therapy
- Where
- 4 sites in Mexico
- Volunteers
- 210 people
- Sponsor
- Fundación Internacional René Mey
Pregnancy-Associated Hypertension, Gestational Hypertension
Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure
High blood pressure during or after pregnancy (such as preeclampsia, gestational hypertension, eclampsia, or Hemolysis, Elevated Liver enzymes, and Low Platelet (HELLP) syndrome) raises a mother's risk of heart disease later in…
- Conditions
- Pregnancy-Associated Hypertension, Gestational Hypertension, Preeclampsia, Eclampsia
- Trial name
- AW2H (NCT07778966)
- Testing
- Alabama Womb to Heart Solution (AW2H) Community Health Worker (CHW) Program, Usual postpartum care with self-measured blood pressure education and home blood pressure monitor
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- University of Alabama at Birmingham
Hypertension in Pregnancy
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
The CHAP2 study is designed to provide preliminary data for a larger multicenter study to assess whether treatment of stage 1 hypertension (HTN) in pregnancy improves maternal and or neonatal outcomes.
- Trial name
- CHAP2 (NCT05989581)
- Testing
- Labetalol or Nifedipine
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Perinatal Death, Hypertension, Pregnancy-Induced
Pregnancy in the Context of Urbanicity and Climate Change. The Overall Aim of the Project is to Co-create, Implement, and Test New Clinical Guidelines in Order to Improve the Quality of Care in Antenatal Clinics in the Context of Urbanisation and Climate Change in Dar es Salaam, Tanzania.
Tanzania's population is growing quickly, and Dar es Salaam is one of the fastest-growing cities in the world. At the same time, the city is increasingly affected by very hot weather, flooding, and air pollution.
- Conditions
- Perinatal Death, Hypertension, Pregnancy-Induced, Abortion, Spontaneous, Stillbirth
- Trial name
- NCT07751432
- Testing
- CC-ANC intervention group.
- Where
- Tanzania
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Preeclampsia, Hypertensive Disorder of Pregnancy
Cardiovascular Protection After Preeclampsia With Enalapril
The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.
- Conditions
- Preeclampsia, Hypertensive Disorder of Pregnancy, Hypertension, Gestational Hypertension
- Trial name
- CAPP-E (NCT07222852)
- Testing
- Enalapril, Standard treatment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Preeclampsia (PE), Hypertension ,Pregnancy
Dipyridamole for Early-Onset Preeclampsia: A Pilot Study of Feasibility, Pharmacokinetics, and Biological Effects
Early-onset preeclampsia (PE), defined as preeclampsia presenting before 34 weeks of gestation, is a severe placental disorder associated with significant maternal and perinatal morbidity.
- Trial name
- NCT07738562
- Testing
- Dipyridamole 75 MG
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Hadassah Medical Organization