Clinical trials: Hypersensitivity Reactions, open to volunteers
Tooth Discoloration, Tooth Staining
Peroxide Versus Non-Peroxide In-Office Tooth Bleaching
This randomized clinical trial aims to compare the effectiveness of peroxide and non-peroxide in-office tooth bleaching systems.
- Trial name
- BECTS (NCT07818031)
- Testing
- peroxide -based in office tooth bleaching, non-peroxide -based in office tooth bleaching
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Minia University
Atopic Dermatitis
CorEvitas International Adolescent Atopic Dermatitis (AD) Drug Safety and Effectiveness Registry
Prospective observational registry for an adolescent cohort with AD under the care of a dermatology provider. Approximately 1500 subjects and 75 clinical sites in North America and select European countries will be recruited to…
- Trial name
- NCT06238765
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- CorEvitas
Muscle Strength, Healthy
Reference Equations and Normative Data for Isometric Quadriceps and Handgrip Muscles STrength in Southern European Populations - RESTart: a Multicentre Study
This observational study aims to learn about peripheral muscle strength in healthy adults and people with chronic respiratory diseases.
- Conditions
- Muscle Strength, Healthy, Chronic Respiratory Diseases
- Trial name
- RESTart (NCT07628530)
- Where
- Spain
- Volunteers
- 2,815 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Chronic Spontaneous Urticaria (CSU)
A Phase Ib/IIa Study Assessing the Rapid Onset Characteristics of TLL-018 for Moderate-to-Severe CSU With Inadequate Response to Second-Generation H1 Antihistamines
The goal of this clinical trial is to evaluate the rapid onset characteristics of TLL-018 in moderate-to-severe CSU with inadequate response to second-generation H1 antihistamines.
- Trial name
- NCT07665996
- Testing
- TLL-018
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Hangzhou Highlightll Pharmaceutical Co., Ltd
Asthma in Children, Asthma
Improving Quality of Life for Teenagers With Asthma
BACKGROUND: Asthma is a long-term lung condition affecting 1 in 11 children and young people in the UK. Many teenagers have well controlled asthma, but a significant number continue to experience regular symptoms and asthma…
- Trial name
- IMPAQT (NCT06851715)
- Testing
- Clinic consultation focused on asthma self-management
- Where
- 2 sites in United Kingdom
- Volunteers
- 98 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Asthma
The Impact of Medical TV Drama in Improving Literacy on Asthma
Asthma is an important chronic noncommunicable disease that affects children and adults following a complex immune-mediated mechanism involving airway inflammation, bronchial hyperresponsiveness, and transient and intermittent…
- Trial name
- NCT07262918
- Testing
- TELEVISION DRAMA
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cephas Health Research Initiative Inc, Ibadan, Nigeria
Pediatric Asthma
Cohort Multiple Randomized Controlled Trial in Pediatric Asthma
The overarching goal of this study is to optimize pediatric asthma care and to continuously evaluate variations/innovations of the care (including transformation to remote eHealth care).
- Trial name
- CIRCUS (NCT06278662)
- Testing
- video directly observed therapy (vDOT)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Mattienne van der Kamp
Allergy
Study to Assess the Safety and Effectiveness of Beltaven® in Patients With Allergy to Apis Mellifera, Polistes Dominula or Vespula Spp.
Non-interventional Study to Assess the Safety and Effectiveness Profile of a SCIT Therapy With Beltaven® With Apis mellifera, Polistes dominula or Vespula spp. allergic patients
- Trial name
- NCT07309822
- Where
- 13 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Probelte Pharma S.L.U.
Headache Disorders, Secondary, Brain Diseases
Hypersensitivity to Amylin in Post-Traumatic Headache
Pramlintide is a peptide analogue of human amylin which is a vasoactive substance involved in the pathogenesis of headache. This study investigates whether pramlintide induces migraine-like headache in people with persistent…
- Conditions
- Headache Disorders, Secondary, Brain Diseases, Headache Disorders, Nervous System Diseases
- Trial name
- NCT07340775
- Testing
- Amylin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Asthma in Children, Directly Observed Therapy
Project ASTHMA - Aligning With Schools To Help Manage Asthma and Improve Outcomes
Children with asthma from communities that experience health inequities frequently do not receive guideline-based asthma care, and as a result, account for a disproportionate percentage of asthma exacerbations, emergency…
- Trial name
- NCT06539312
- Testing
- APP assessment and management of asthma
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- State University of New York at Buffalo
Sarcoidosis, Pulmonary
Evaluation of the Efficacy and Safety of Compound Betamethasone in Pulmonary Sarcoidosis
The goal of this clinical trial is to learn whether a study drug called Compound Betamethasone (also known as Diprospan) works to treat pulmonary sarcoidosis in people with early-stage disease (stage I or II).
- Trial name
- NCT07668895
- Testing
- Prednisone, Compound betamethasone
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Peking Union Medical College Hospital
Eczema, Atopic Dermatitis
Sodium in the Skin and Atopic Dermatitis
The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above.
- Trial name
- SIS-AD (NCT06998446)
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS)
SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY)
The goal of this observational study is to comprehensively profile six immune-mediated inflammatory diseases, including atopic dermatitis (AD), plaque psoriasis (PSO), hidradenitis suppurativa (HS), cutaneous T-cell lymphoma…
- Conditions
- Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS), Psoriasis (PsO), Atopic Dermatitis (AD)
- Trial name
- SKINERGY (NCT07021495)
- Where
- 8 sites in Netherlands
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Digestive System Surgical Procedures
Study to Evaluate the Efficacy of a Polyamine-deficient Diet for Treating Postoperative Pain After Abdominal Surgery
The aim of this study is to evaluate if a polyamine deficient diet started 7 days prior to a major abdominal surgery (eventration cure and digestive continuity) and followed 7 days post-surgery reduces the area under the curve of…
- Trial name
- POLYAMAL (NCT04219956)
- Testing
- Polyamine Deficient Diet
- Where
- 4 sites in France
- Volunteers
- 278 people
- Sponsor
- Nantes University Hospital
Moderate to Severe Vernal Keratoconjunctivitis
A Study to Compare the Effectiveness and Safety of T1695 Versus Ciclosporin in Participants With Moderate to Severe Vernal Keratoconjunctivitis
The aim of the study is to Compare the Effectiveness and Safety of T1695 Versus Ciclosporin in Participants with Moderate to Severe Vernal Keratoconjunctivitis
- Trial name
- NCT07169695
- Testing
- Slit Lamp Examination, Far Best Corrected Visual Acuity (BCVA), T1695
- Where
- 11 sites in India
- Volunteers
- 120 people
- Sponsor
- Laboratoires Thea
Allergic Rhinitis, Seasonal
A Study of IL4Rα Monoclonal Antibody in Patients With Seasonal Allergic Rhinitis
Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin E after exposure to allergens in atopic individuals.
- Trial name
- NCT07154342
- Testing
- GR1802 injection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Chronic Inflammatory Disease, Angioedema
Deployment o the Multidisciplinary Prospective Cohort Imminent
Immune-mediated inflammatory diseases (IMIDs) most often affect young patients and have high impact on morbidity and mortality with a significant alteration in the quality of life of patients with professional, social and…
- Conditions
- Chronic Inflammatory Disease, Angioedema, Severe Asthma, Lupus
- Trial name
- IMMINeNT (NCT04334031)
- Testing
- Biobanking with genetic analysis, SF-12 questionnaire
- Where
- France
- Volunteers
- 2,200 people
- Sponsor
- University Hospital, Lille
Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis
HLA-B*58:01-Guided Therapy for Gout: Effectiveness, Safety, and Cost-Effectiveness
Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS), are rare but life-threatening complications that…
- Conditions
- Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis, Gout and Hyperuricemia
- Trial name
- HLA-SCREEN (NCT07369622)
- Testing
- HLA-B*58:01 Genotyping, Allopurinol Tablet, Febuxostat
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Haiphong University of Medicine and Pharmacy
Milk Intolerance, Milk Hypersensitivity
Goat vs. Cow Milk Digestive Tolerance
The objective of this study is to assess to what extent goat's milk is better tolerated than cow's milk among individuals who report being intolerant to cow's milk, and, if so, to understand the underlying factors.
- Conditions
- Milk Intolerance, Milk Hypersensitivity, Cow Milk Protein Sensitivity
- Trial name
- DIGIGOAT (NCT07239856)
- Testing
- Cow milk, Goat Milk
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Childhood Asthma With Acute Exacerbation
Azithromycin Treatment of Hospitalized Children With Asthmatic Symptoms
The purpose of this double-blind, randomized, controlled clinical trial is to investigate the effect of a three-day azithromycin treatment versus placebo treatment in children aged 1-5 years who are hospitalized due to…
- Trial name
- COPSACazt (NCT05028153)
- Testing
- Azithromycin Oral Liquid Product
- Where
- Denmark
- Volunteers
- 320 people
- Sponsor
- Copenhagen Studies on Asthma in Childhood
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