Clinical trials: Hyperpigmentation
Melasma
Fractional Photothermolysis for Treating Melasma
In several observational studies, non-ablative fractional photothermolysis (FP) has been reported to bridge the gap between efficacy and tolerability in the treatment of melasma.
- Trial name
- NCT01245881
- Testing
- Non-ablative fractional photothermolysis laser, broad-spectrum sunblock (SPF 50+)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- Laserklinik Karlsruhe
Gingival Hyperpigmentation
Gingival Depigmentation With Diode and Er,Cr:YSGG Laser: A Split-mouth Trial
Gingival hyperpigmentation is a common physiological condition caused by excessive melanin deposition in oral mucosa, negatively affecting smile esthetics.
- Trial name
- Laser (NCT07520266)
- Testing
- Er,Cr:YSGG laser, Diode laser
- Where
- 2 sites in Vietnam
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Effect of Drugs, Adverse Effects of Medical Drugs
Comparison of Efficacy of Tranexamic Acid Mesotherapy Versus 0.9% Normal Saline for Melasma
It is a randomized controlled trial in which investigators determine the efficacy of tranexamic acid (TA) by mesotherapy in comparison to normal saline on participants having Melasma.
- Trial name
- NCT04170088
- Testing
- Tranexamic Acid, 0.9% Normal Saline
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Peutz-Jeghers Syndrome
Pilot Study of mTOR Inhibitor Therapy in Peutz-Jeghers Syndrome
Pilot study, Open-label, Phase II study of Everolimus. Objective: To determine if Everolimus can diminish large gastrointestinal polyps in patients with Peutz-Jeghers Syndrome.
- Trial name
- NCT00811590
- Testing
- Everolimus
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Melanosis
Treatment of Melasma With Stabilized Kligman Preparation Associated or Not With Pulsed Dye Laser
Melasma is an acquired disorder of pigmentation that leads to irregular pigmented patches on the face. Treatment is difficult and to date the best treatment option is the combination of hydroquinone, retinoic acid and steroids…
- Trial name
- NCT00863278
- Testing
- pulsed dye laser treatment, Kligman's Trio
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Melasma
Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel
The aim of this pilot study is to conduct a controlled comparison of the efficacy and safety of a combination peel (glycolic acid and salicylic acid) as compared to glycolic acid peel alone in the treatment of melasma.
- Trial name
- NCT02812719
- Testing
- Glycolic acid peel alone, Glycolic and salicylic acid peel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Medical Center
Epidermal Melasma, Facial Hyperpigmentation
Topical Metformin Versus Triple Regimen for Epidermal Melasma
Melasma is a common skin condition that causes dark brown patches, mainly on sun-exposed areas of the face. It is often persistent, may recur after treatment, and can affect a person's quality of life.
- Trial name
- MET-MEL (NCT07779811)
- Testing
- Topical 30% metformin cream, Topical Triple Regimen
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Combined Military Hospital, Pakistan
Melasma
Photoaging Reversing After Picosecond Laser With DLA Assessed by Cellular Resolution OCT in Asian Patient With Melasma
Background Melasma is a commonly acquired hypermelanosis that affects facial sun exposed areas, most commonly in Asians and other darker skin type females. Recent evidence has demonstrated melasma to be a photoaging disorder.
- Trial name
- NCT04602819
- Testing
- PicoSure 755nm picosecond alexandrite laser with diffractive lens, ApolloVue® S100 Image System, Cutometer® dual MPA 580
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- China Medical University Hospital
Melasma
Comparison of Intralesional Tranexamic Acid and Platelets Rich Plasma in the Treatment of Melasma
ABSTRACT Objective: To study the efficacy while comparing Intralesional tranexamic acid Vs Platelets rich plasma (PRP) in treatment of Melasma. Study design: Randomized-controlled trial (RCT).
- Trial name
- NCT05884151
- Testing
- Tranexamic acid, Platelets rich plasma
- Where
- 3 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Combined Military Hospital Abbottabad
Melasma
Effectiveness and Safety of Intradermal Tranexamic Acid Injection as An Adjunctive Treatment for Melasma in Skin Type IV - V
A double-blind, randomized, split-face controlled trial of 34 female patients with melasma was conducted. All subject were randomized to receive either intradermal tranexamic acid or placebo injection on the right or the left…
- Trial name
- NCT05236569
- Testing
- Tranexamic acid injection, Injection Water
- Where
- Indonesia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Melasma, Hyperpigmentation
Evaluation of an Herbal-Based De-Pigmenting System
The purpose of this study is to evaluate the effectiveness and tolerability of an herbal de-pigmenting regimen applied to one side of the face compared with hydroquinone applied to the other side of the face in treating mottled…
- Trial name
- NCT02138539
- Testing
- Herbal depigmenting agent (Epionce), Hydroquinone
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sadick Research Group
Melasma
Efficacy and Safety of Picosecond, Neodymium-doped Yttrium Aluminum Garnet Laser Therapy Using 1,064 nm and 595 nm
This is a prospective, multi-center, split-face, controlled clinical trial that aims to investigate the efficacy and safety of picosecond, neodymium-doped yttrium aluminum garnet laser laser therapy on patients with melasma…
- Trial name
- NCT03040089
- Testing
- PICO+4, Neoquine Cream 2%
- Volunteers
- 40 people
- Sponsor
- CynosureLutronic
Diabetes Mellitus
Adjunctive Metformin Therapy in Double Diabetes
The significance of this project is to investigate the effects of adjunctive metformin therapy in children and adolescents with double diabetes.
- Trial name
- AMTIDD (NCT01334125)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Massachusetts, Worcester
Gingival Hyperpigmentation, Oral Health-Related Quality of Life
MEBO Bio-Dressing on Patient-Reported Outcomes and Tissue Healing Following Rotary Gingival Depigmentation
The purpose of this randomized, single-blind, parallel-group clinical trial is to evaluate the clinical efficacy of Moist Exposed Burn Ointment (MEBO) as a biological topical dressing compared to open secondary healing (no…
- Conditions
- Gingival Hyperpigmentation, Oral Health-Related Quality of Life, Wound Healing
- Trial name
- NCT07876921
- Testing
- MEBO Ointment
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Lentigo
Solar Lentigines Treatment With the Triple Combination Cream
Background Lentigines are usually the first sign of photoaging and may produce a significant impact on patients' quality of life. There is no a treatment of choice for this condition.
- Trial name
- NCT00975312
- Testing
- Triple combination cream, Tretinoin 0.05%
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Li Fraumeni Syndrome, Lynch Syndrome
Inherited Cancer Early Diagnosis (ICED) Study
ICED is a prospective sample collection research study, aiming to develop or validate a blood/urine biomarker which could potentially detect cancers early in individuals at high risk of developing cancers, due to certain germline…
- Conditions
- Li Fraumeni Syndrome, Lynch Syndrome, Hereditary Diffuse Gastric Cancer, Cowden Syndrome
- Trial name
- ICED (NCT06163365)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Freckles
A Novel 532-nm Picosecond Laser for Freckle Treatment in Chinese Patients
The goal of this clinical trial was to learn if a novel laser device works as well and is as safe as an already approved laser device for removing freckles on the face.
- Trial name
- PICO-FRECK-C (NCT07352631)
- Testing
- Nd:YAG Picosecond Laser Therapy Device, Nd:YAG Picosecond Laser Therapy System
- Where
- 2 sites in China
- Volunteers
- 84 people
- Sponsor
- Beijing Hospital
Acanthosis Nigricans
Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans
evaluate and compare the clinical Efficacy \& Safety Of Fractional Carbon Dioxide (Co₂) Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans.
- Trial name
- NCT07760181
- Testing
- Topical metformin
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Melanin Hyperpigmentation
Vitamin C Depigmenattion Versus Conventional Technique
Although physiologic gingival hyperpigmentation is not a pathologic condition, it is considered one of the main esthetic problems in dentistry.
- Trial name
- NCT03719274
- Testing
- vitamin c depigementation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity
Clinical Efficacy and Safety of a Laparoscopic Sleeve Gastrectomy in Obese Patients
This study aim to evaluate the clinical efficacy and safety after laparoscopic sleeve gastrectomy in patients with obesity. 300 patients with obesity and 49 healthy individuals with normal BMI were enrolled.
- Trial name
- NCT04548232
- Testing
- Laparoscopic sleeve gastrectomy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital