Clinical trials: Hyperpigmentation
Melasma
LaseMD System for the Treatment of Melasma
This study will evaluate the clinical outcomes associated with use of the LaseMD Laser System for the treatment of melasma.
- Trial name
- NCT03456674
- Testing
- LaseMD System
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- CynosureLutronic
Physiological Gingival Hyperpigmentation
Evaluation of the Efficacy of Blue Laser in the Management of Gingival Hyperpigmentation Using Contact vs. Non-contact Mode
The goal of this clinical trial is to compare clinical and digital color parameter results of gingival depigmentation using blue laser in both contact and non- contact modes in patients with physiological gingival…
- Trial name
- NCT07836894
- Testing
- Gingival depigmentation using blue laser in non-contact mode, Gingival depigmentation using blue laser in contact mode
- Where
- Lebanon
- Volunteers
- 20 people
- Sponsor
- Beirut Arab University
Melasma
A Clinical Observation of 1064-nm Q-Switched Fractional Laser Combined With Oral Tranexamic Acid on Treating of Melasma.
1.Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types.
- Trial name
- NCT03963466
- Testing
- tranexamic acid, 1064-nm Q-Switched fractional laser, 1064-nm Q-Switched laser
- Where
- China
- Volunteers
- 30 people
- Sponsor
- xjpfW
Acne Vulgaris, Post Inflammatory Hyperpigmentation
The Use of Onexton in Moderate Acne Vulgaris for Patients With Skin of Color
This is a single-center, open label pilot study. The study is comprised of 5 study visits; Screening, Baseline, and Weeks 4, 8, and 16.
- Trial name
- NCT03402893
- Testing
- ONEXTON Topical Gel
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Derm Research, PLLC
Melasma, Treatment of Stable Melasma
Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment of Melasma
Melasma is a common pigmentation disorder among young and middle-aged women, characterized by symmetrical brown-black patches on the face.
- Conditions
- Melasma, Treatment of Stable Melasma, Tranexamic Acid, Laurocapram
- Trial name
- NCT07530016
- Testing
- Ligustrazine - tranexamic acid - aloe polysaccharide composite gel
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Melasma
Melanil in the Treatment of Melasma
The purpose of the study is to assess the efficacy of Melanil facial cream in the treatment of melasma. The duration of this double-blind phase 3 clinical trial will be 54 weeks.
- Trial name
- NCT01001624
- Testing
- Melanil facial cream, Hydroquinone 2% cream
- Where
- Cuba
- Volunteers
- 150 people
- Sponsor
- Catalysis SL
Melasma
Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study
1. To evaluate the efficacy and safety of topical resveratrol 1 % gel in treatment of melasma. 2. To compare between the efficacy of topical resveratrol 1 %gel versrs chemical peeling with TCA 20% in melasma.
- Trial name
- NCT07060157
- Testing
- resveratrol 1 % gel, TCA20%
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Assiut University
Melasma
Comparative Study of Dual Yellow Laser Versus Stabilized Kilnman Preparation in the Treatment of Melasma
Recent data highlight the role of vascularity in melasma and a recent study showed the interest to target this vascular component by pulsed dye laser.
- Trial name
- NCT01850186
- Testing
- Dual yellow Laser, Stabilized kilnman trio
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lentigo
The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser
This study will conduct a split-face and -body randomized control trial to compare lidocaine 2.5%/prilocaine 2.5% topical anesthetic (LPTA), lidocaine 7%/tetracaine 7% topical anesthetic (LTTA), and placebo vechicle (PV) on…
- Trial name
- NCT02427724
- Testing
- lidocaine 2.5%/prilocaine 2.5% topical anesthetic, lidocaine 7%/tetracaine 7% topical anesthetic, Q-switched 532nm Laser
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Melasma, Platelet Rich Plasma
Platelet Rich Plasma in Treatment of Melasma
Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. The therapy for melasma has always been challenging and discouraging.
- Trial name
- NCT03308370
- Testing
- Platelet rich plasma
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Assiut University
Benign Pigmented Lesions
Evaluation of Laser Treatment for Benign Pigmented Lesions by Non-invasive, Cellular Resolution Optical Coherence Tomography
In recent years, with the maturity of laser technology, laser therapy is one of the popular options for the treatment of pigment diseases. The absorption spectrum of melanin ranges from 300 to 1,000 nm.
- Trial name
- NCT04861246
- Testing
- Laser, ApolloVue® S100 Image System, VISIA®
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Acanthosis Nigricans, Polycystic Ovary Syndrome
Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome
OBJECTIVES: I. Evaluate insulin resistance in thin and obese hyperandrogenic women with polycystic ovarian disease or hyperandrogenism insulin resistance acanthosis nigricans syndrome and in thin and obese controls, using an…
- Trial name
- NCT00004311
- Testing
- leuprolide acetate, spironolactone
- Sponsor
- National Center for Research Resources (NCRR)
Hyperpigmentation
Efficacy of Ceramic Soft Tissue Trimming Bur Versus Conventional Scalpel Technique in Ginigival Depigmentation Procedure
the investigator compares the clinical outcomes and pain levels after gingival depigmentation by ceramic soft tissue bur vs scalpel surgery
- Trial name
- NCT06031116
- Testing
- depigmentation
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hyperpigmentation, Gingival Hyperpigmentaion
Effectiveness of Omega-3 Poly Unsaturated Fatty Acids on The Treatment of Gingival Hyperpigmentation
This new study compares the effectiveness of scalpel surgery and omega-3 poly unsaturated fatty acid (PUF) injections in treating gingival hyperpigmentation.
- Trial name
- Omega-3 (NCT07067515)
- Testing
- non surgical with PUFA injection, surgical treatment
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Suez Canal University
Healthy
Fractionated 1927-nm Non Ablative Thulium Laser in Treating Post Inflammatory Hyperpigmentation
To study the effect of fractionated 1927-nm non ablative thulium laser in reduction of post inflammatory hyperpigmentation (PIH) using a validated and reproducible model for studying PIH.
- Trial name
- NCT06149780
- Testing
- Patients treated with laser
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Vitiligo
PHNA, Efficacy of Tretinoin Cream on Post-phototherapy Hyperpigmentation
A randomized controlled split-face pilot study was planned to investigate the preventive effect of tretinoin 0.05% cream on hyperpigmentation during phototherapy in patients with vitiligo.
- Trial name
- NCT03933774
- Testing
- Tretinoin 0.05% cream
- Where
- South Korea
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Melasma
Inflammation in Melasma: Study of Its Infiltrate and the Expression of Acute and Chronic Mediators
Melasma is an acquired hyperpigmentary disorder that commonly affects women from Asia and Latin-America.There is evidence of subclinical inflammation supported by diffuse spectrometry and by prominent inflammatory cells in…
- Trial name
- NCT01952379
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Melasma, Periodontitis, Vitamin D Abnormalities, Anaemia
Prevalence of Serum-Vitamin D Abnormalities, Periodontitis and Anaemia in Patients With Melasma
Melasma is a commonly pigmention characterized by melanotic patches on the face. literature searched revealed that periodontitis and vitamin D deficiency have occurred along with anemia.
- Trial name
- NCT03241381
- Testing
- vitamin D serum assay study and control groups, Photometry, Russels periodontal index
- Volunteers
- 100 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Melasma
Study of Light Treatment and Laser Treatment for Melasma
The purpose of this study is to determine the efficacy of light treatment and laser treatment for melasma. These treatment options have not been thoroughly explored in the treatment of melasma.
- Trial name
- NCT00509977
- Testing
- Light Treatment, Laser Treatment
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwestern University
Hyperpigmentation, Varicosis
Brightening Cream and Lasers in Post-sclerotherapy Hyperpigmentation
The treatment of leg veins and varicosis with sclerotherapy is one of the most frequently performed medical intervention in the western world.
- Trial name
- NCT05165524
- Testing
- QS Nd:YAG laser, Triple cream
- Where
- Switzerland
- Volunteers
- 66 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern