Clinical trials: Hyperoxia
Heart Valve Disease, Coronary (Artery) Disease
Effects of Hyperoxia on Open Heart Surgery
Patients undergoing Open Cardiac Surgery will be randomized into two groups. Group I will be ventilated with 40% Fio2 during induction, surgery and in Postoperative care unit.
- Trial name
- NCT03012997
- Testing
- Fraction of inspired oxygen 40%, Fraction of inspired oxygen 100%
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Hyperoxia, Perioperative Care
Perioperative Hyperoxia vs Normoxia Biomarker Trial
This single-center randomized interventional study evaluated the biological effects of two perioperative oxygen strategies in adults undergoing elective laparoscopic lower abdominal surgery under standardized general anesthesia.
- Conditions
- Hyperoxia, Perioperative Care, Oxidative Stress, Endothelial Glycocalyx Injury
- Trial name
- NCT07525661
- Testing
- Perioperative Oxygen Strategy - Normoxia, Perioperative Oxygen Strategy-Hyperoxia
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Istanbul University
Hyperoxia / High FiO₂ Exposure, Interval Training
Oxygen as a Metabolic Modulator: Divergent Physiological Adaptations to Hypoxic and Hyperoxic Tabata Training.
The purpose of this study is to examine how breathing air with different oxygen concentrations (higher or lower than normal) during high-intensity interval training affects: Aerobic capacity (VO₂max) Ventilatory thresholds Blood…
- Conditions
- Hyperoxia / High FiO₂ Exposure, Interval Training, HIIT, High Intensity Interval Training
- Trial name
- NCT07551869
- Testing
- FIO2 modulation during HIIT protocol on assault bike
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Haute Ecole Bruxelles-Brabant
Ventilatory Depression, Postoperative Respiratory Failure
Hyperoxia on Ventilation During Recovery From General Anesthesia
In this preliminary, crossover investigation the investigators will examine the effect of oxygen supplementation on the recovery of breathing in the immediate post-anesthesia period.
- Trial name
- NCT05922020
- Testing
- Oxygen gas
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Ventilatory Depression, Postoperative Respiratory Failure
The Effect of Hyperoxia on Ventilation During Recovery From General Anesthesia
In this randomized-controlled trial the investigators will examine the effect of oxygen supplementation on the recovery of breathing for 90 minutes in the immediate post-anesthesia period starting from extubation of the trachea.
- Trial name
- NCT05379673
- Testing
- Oxygen Gas for Inhalation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Oxygen Toxicity, Oxidative Stress
Optimized Oxygen Delivery During General Anesthesia in Newborn Infants
An open randomized control trial investigating the delivery of two levels of inspired oxygen to newborn infants during general anesthesia.
- Trial name
- ANOXneo (NCT02698020)
- Testing
- Room-air
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Uppsala University
Healthy
The Validity of Retinal Blood Flow Measurements During Hyperoxia in Humans Using Fourier Domain Color Doppler Optical Coherence Tomography (CDOCT)
Noninvasive monitoring of blood flow in retinal circulation may elucidate the progression and treatment of ocular disorders, including diabetic retinopathy, age-related macular degeneration and glaucoma.
- Trial name
- NCT00431600
- Testing
- 100% Oxygen
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hyperoxia
Retrospective Multicentre Observational Study on the Incidence of Hyperoxia in Non-intubated Patients in Intensive Care in Belgium Study OxSIZgen
Oxygen is the most widely prescribed therapy in the ICU (intensive care unit) and can save lives in critical patients. While the deleterious effects of hypoxia are apparent and must be actively avoided, hyperoxia also has adverse…
- Trial name
- OxSIZgen (NCT04291911)
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- SIZ Nursing
Coronary Artery Disease, Anesthesia
Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients undergoing non-cardiac vascular surgery.
- Trial name
- Promise-O2 (NCT04808401)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
COPD Exacerbation, Hypoxia
Oxygen Control and Weaning by O2matic to Patients Admitted With an Exacerbation of COPD
The aim of the study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen and better oxygen control than manually controlled oxygen therapy for patients admitted with an exacerbation of…
- Conditions
- COPD Exacerbation, Hypoxia, Hypoxemia, Hyperoxia
- Trial name
- O2MATIC-WEAN (NCT03661086)
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Hvidovre University Hospital
IVH- Intraventricular Hemorrhage, Extreme Prematurity
Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants
This study is being conducted to compare the incidence of preterm infants (up to 28+6 weeks GA) who achieve a peripheral oxygen saturation of 80 percent by 5 minutes of life (MOL) given mask CPAP/PPV with an FiO2 of 1.0 during…
- Conditions
- IVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, Hyperoxia
- Trial name
- DOXIE (NCT04413097)
- Testing
- Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sharp HealthCare
PaO2/FiO2 Ratio
The Effect of FiO2 on PaO2/FiO2 Ratio
The PaO2/FiO2 ratio is frequently used to determine the severity of lung injury in mechanically ventilated patients. However, several mathematical models have shown that PaO2/FiO2 ratio depends on FiO2.
- Trial name
- NCT03156218
- Testing
- Modulation of FiO2
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Decompression Sickness
Impact of Hyperoxia and Involvement of the Immune System in Diving Accident
The impact of oxygen therapy in many pathologies has been subject of recent work, arguing both favourable and harmful effects. Consequently, one can wonder about the influence of hyperoxic gas mixture during diving on the genesis…
- Trial name
- OXYDIVE (NCT04791488)
- Testing
- Hyperbaric oxygen therapy, Diving simulation
- Where
- France
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées