Clinical trials: Hyperoxia
Cardiac Surgery, Delirium - Postoperative
Effect of Hyperoxia or Hypoxemia on the Incidence of Delirium in Patients After Cardiac Surgery
Our goal was to study the effect of hyperoxia or hypoxemia on the incidence of delirium in patients after cardiac surgery.
- Conditions
- Cardiac Surgery, Delirium - Postoperative, Hyperoxia, Hypoxemia
- Trial name
- NCT07548905
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Southeast University, China
Cerebrovascular Disorders
HYPEROXIA Responses and ROS
30 participants (15 males and 15 females) who are ≥18 - ≤ 40 years old and considered healthy will be enrolled into this study to test the role of reactive oxygen species (ROS) in regulating cerebral blood flow (CBF).
- Trial name
- NCT05958303
- Testing
- Antioxidant Cocktail
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Chronic Obstructive Pulmonary Disease (COPD)
Hyperoxia During Outpatient Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter?
Chronic obstructive pulmonary disease (COPD) is a global burden. Treatment options have improved in recent years, pulmonary rehabilitation plays a key role.
- Trial name
- NCT06776731
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
Oxygen Reserve Index
Oxygen Reserve Index in Different Fresh Gas Flow
Our primary objective is to determine whether oxygen reserve index ORI can be a reliable and sensitive indicator of hypoxia and hyperoxia in low-flow anesthesia settings.
- Trial name
- NCT06649279
- Testing
- Oxygen reserve index
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Sakarya University
Obesity, Hyperoxia
Evaluation of the Risk of Hyperoxia-induced Hypercapnia in Obese Cardiac Surgery Patients
This study aims to evaluate the risk of hyperoxia-induced hypercapnia in post-op obese cardiac surgery patients. It will compare two oxygenation modes in terms of their effect on the arterial partial pressure of carbon dioxide…
- Conditions
- Obesity, Hyperoxia, Hypercapnia
- Trial name
- NCT02917668
- Testing
- FreeO2, Usual care
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Intraocular Pressure
The Response of Intraocular Pressure to Systemic Hypercapnia and Hyperoxia
The purpose of this study is to determine how intraocular pressure responds to changes in the levels of carbon dioxide or oxygen that a healthy individual inspires.
- Trial name
- NCT01325285
- Testing
- RespirAct
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Chronic Obstructive Pulmonary Disease
Effect of Supplemental Oxygen on Maximal Oxygen Consumption in Patients With Chronic Obstructive Pulmonary Disease
Maximal consumption of oxygen (VO2max) during exercise is used in patients with chronic obstructive pulmonary disease (COPD) to stratify perioperative risk.
- Trial name
- NCT01294033
- Testing
- Fractional inspired oxygen (FiO2) 0.21, Fractional inspired oxygen 0.28
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cardiac Failure, Critical Illness
Blend to Limit Oxygen in ECMO: A Randomised Controlled Registry Trial
To determine in patients requiring venoarterial (V-A) ECMO, whether the use of a conservative as compared with liberal oxygen strategy, results in a greater number of ICU-free days at day 28.
- Trial name
- BLENDER (NCT03841084)
- Testing
- Oxygen
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Stroke Acute
Adjuvant Cerebroprotection Using Normobaric Hyperoxia in Pre-hospital Patients with Suspected Stroke
The primary objective of this study is to determine the efficacy and safety of inhaled normobaric hyperoxia therapy (NBO) beginning in the pre-hospital setting in patients with suspected acute cerebral ischemia (ACI) due to large…
- Trial name
- AN-O2-EMS (NCT06801457)
- Testing
- NBO, Control
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Capital Medical University
Trauma, Critical Illness
Pilot Study of Targeted Normoxia in Critically Ill Trauma Patients
The objective of this study is to conduct an observational pre/post study to evaluate the clinical impact oxygen guideline implementation on oxygen utilization and oxygenation in critically ill trauma patients.
- Conditions
- Trauma, Critical Illness, Oxygen Toxicity
- Trial name
- NCT03789396
- Testing
- Targeted Normoxia (oxygen saturation 90-96%), Usual Care Oxygenation
- Where
- United States
- Volunteers
- 572 people
- Sponsor
- University of Colorado, Denver
Hypoxia, Brain, Hyperoxia
The Effect of Respiratory Challenge on the BOLD Signal
The purpose of this research study is to better understand how blood flow and metabolism are different between normal controls and patients with disease.
- Conditions
- Hypoxia, Brain, Hyperoxia, Hypercapnia, Hypocapnia
- Trial name
- NCT04258774
- Testing
- Carbon Dioxide
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Psychosis, Schizophrenia
Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis
Single-blind, randomized controlled trial of normobaric oxygen therapy among individuals with first-episode psychosis: Effects on symptomatology and cognition.
- Conditions
- Psychosis, Schizophrenia, First-episode Psychosis
- Trial name
- NCT04368039
- Testing
- Normobaric Oxygen
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Nicholas Breitborde
Acute Ischemic Stroke
Normobaric Hyperoxia Combined With Intravenous Thrombolysis for Acute Ischemic Stroke：Longterm Outcome (OPENS-3L)
The purpose of this study is to determine the long-term efficacy and safety of Normobaric Hyperoxia combined with intravenous thrombolysis for acute ischemic stroke.
- Trial name
- NCT05965193
- Testing
- Normobaric Hyperoxia, Nasal oxygen, Intravenous thrombolysis(rt-PA)
- Where
- China
- Volunteers
- 1,230 people
- Sponsor
- Ji Xunming,MD,PhD
Heart Valve Disease, Coronary (Artery) Disease
Effects of Hyperoxia on Open Heart Surgery
Patients undergoing Open Cardiac Surgery will be randomized into two groups. Group I will be ventilated with 40% Fio2 during induction, surgery and in Postoperative care unit.
- Trial name
- NCT03012997
- Testing
- Fraction of inspired oxygen 40%, Fraction of inspired oxygen 100%
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Hyperoxia, Normoxic
Intraoperative Oxygen Concentration and Neurocognition After Cardiac Surgery
This is a randomized, prospective controlled trial in patients undergoing cardiac surgery, specifically on-pump coronary artery bypass grafting, comparing level of administered oxygen and partial pressure of arterial oxygen in…
- Conditions
- Hyperoxia, Normoxic, Delirium
- Trial name
- NCT02591589
- Testing
- Normoxic oxygenation, Hyperoxic oxygenation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Ischemic Stroke
Normobaric Hyperoxia Stabilizing Ischemic Penumbra
To investigate the safety and efficacy of normobaric hyperoxia (NBO) stabilizing penumbra in acute ischemic stroke patients.
- Trial name
- NCT05781880
- Testing
- Oxygen 100%
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Ji Xunming,MD,PhD
Infant, Newborn, Diseases, Mechanical Ventilation Complication
Optimising Neonatal Ventilation with Closed-loop Oxygen Control
Ventilated newborns frequently need supplemental oxygen but its use must be monitored carefully as both giving too much or too little oxygen can have harmful effects.
- Trial name
- NCT05657795
- Testing
- Closed-loop automated oxygen control (Oxygenie, SLE6000)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College Hospital NHS Trust
Atelectasis
Effect of Hyperoxia and Hypergravity on Lung Ventilation and Perfusion
The primary aim of this project is to get further knowledge on the effects of + Gz accelerations and hyperoxia on lung ventilation in humans.
- Trial name
- NCT01993394
- Testing
- hypergravity, gas mixture
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Premature Infant, Respiratory Insufficiency
Comparison of Oxygen Controllers in Preterm InfanTs
Premature infants often receive respiratory support and supplemental oxygen for a prolonged period of time during their admission in the NICU.
- Conditions
- Premature Infant, Respiratory Insufficiency, Hypoxia, Hyperoxia
- Trial name
- COCkPIT (NCT03877198)
- Testing
- Automated oxygen control by the CLiO2 algorithm, Automated oxygen control by the Oxygenie algorithm
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Leiden University Medical Center
Older Adults, Cardiovascular Health
Acute Effects of Intermittent Hypoxia-Hyperoxia in Older Adults
The supply of oxygen is essential for energy production, recovery from efforts, and human life. Intermittent Hypoxia-Hyperoxia Exposure (IHHE) is a novel technique in which the subject is exposed to a respiratory environment with…
- Conditions
- Older Adults, Cardiovascular Health, Blood Pressure, Sedentary
- Trial name
- NCT06686238
- Testing
- MITOVIT® Hypoxic Training System
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Sierra Varona SL