Clinical trials: Hypercapnic Respiratory Failure
Hypercapnic Respiratory Failure, Sleep Disordered Breathing
Remote Monitoring to Improve Low Adherence in Non-invasive Ventilation
Patients are invited to participate in a trial to test a new way to optimise long-term use of non-invasive ventilation using remote monitoring.
- Conditions
- Hypercapnic Respiratory Failure, Sleep Disordered Breathing, COPD, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- READ-NIV (NCT04884165)
- Testing
- Remote monitoring of home mechanical ventilation (NIV) using SRETT, Home mechanical ventilation (NIV) without remote monitoring
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Mechanical Ventilatory Failure
Criteria Analysis for Ventilatory Support Adjustment of Mechanical Ventilation
The indications for mechanical ventilation (MV) include excessive work of breathing, with or without evidence of respiratory muscle fatigue.
- Trial name
- NCT02743624
- Testing
- Variation of the level of pressure support during the mechanical ventilation
- Where
- 2 sites in Brazil
- Volunteers
- 27 people
- Sponsor
- University of Sao Paulo General Hospital
Ventilatory Failure
Tele-monitoring of Patients With Home Mechanical Ventilation (HMV) Trough Telemedicine System (MyVENT)
The purpose of this study is to improve HMV treatment adherence using an integrated telemedicine platform (MyVENT system)
- Trial name
- MyVENT (NCT03971630)
- Testing
- Telemedicine
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Acute Viral Bronchitis, Hypoxemic Respiratory Failure
NHF vs. COT in Hypoxemic Pandemic Viral Illness
The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.
- Conditions
- Acute Viral Bronchitis, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
- Trial name
- HIVI (NCT04750408)
- Testing
- Standard oxygen, Nasal high-flow
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Jens Bräunlich
Nocturnal Hypoventilation, Neuromuscular Disease
Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Newly Diagnosed Patients
The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients with newly diagnosed nocturnal hypoventilation who have never experienced nocturnal…
- Conditions
- Nocturnal Hypoventilation, Neuromuscular Disease, Chest Wall Disorder
- Trial name
- NCT00901485
- Testing
- AutoVPAP, VPAPIIIST-A
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- ResMed
Anesthesia, Cardiac Disease
High Flow Nasal Oxygen During Sedation
The primary objective of this study is to test the hypothesis that using high flow nasal oxygen improves ventilation during cardiac implantable electronic device procedures performed with conscious sedation.
- Trial name
- NCT03858257
- Testing
- High flow nasal oxygen, Standard oxygenation
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- University Health Network, Toronto
Amyotrophic Lateral Sclerosis (ALS)
Developing New Ways to Detect Respiratory Impairment Early in ALS
The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
- Trial name
- NCT07844590
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Acute-on-chronic Respiratory Failure
Prospective Trial of the Bilevel Positive Airway Pressure (by Boussignac) in Emergency Department of Non-invasive Patients Presenting With Acute Hypercapnic Respiratory Failure
The purpose of this study is to determine whether the new Boussignac-system of non-invasive ventilation is as good as the conventional non-invasive System in patients presenting with acute hypercapnic respiratory failure.
- Trial name
- Boussignac (NCT01788345)
- Testing
- non- invasive ventilation
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Vygon GmbH & Co. KG
Intensive Care Unit Syndrome, Hypercapnia
Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study
Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg.
- Conditions
- Intensive Care Unit Syndrome, Hypercapnia, Acute Respiratory Failure
- Trial name
- YETI (NCT04304339)
- Testing
- Hypercapnic respiratory failure
- Where
- 3 sites in France
- Volunteers
- 862 people
- Sponsor
- French Society for Intensive Care
Cystic Fibrosis, Chronic Respiratory Failure
Effect of Non-Invasive Ventilation in Cystic Fibrosis Patient With Chronic Respiratory Failure.
There is no randomised controlled trials to determine the clinical effects of long term Non-Invasive Ventilation in Cystic Fibrosis patients.
- Trial name
- NCT00208078
- Testing
- pressure support ventilator
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Cochin Hospital
Respiratory Insufficiency, Acute Respiratory Insufficiency
NIV-NAVA vs NIV-PS/PC in Respiratory Insufficiency
This study evaluates the difference between Non Invasive Ventilation with Neurally Adjusted Ventilatory Assist (NIV-NAVA) and Conventional Non Invasive Ventilation with Pressure Support (PS) or Pressure Control (PC).
- Trial name
- NCT02592512
- Testing
- NIV-NAVA, NIV-PS/PC
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis
Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis
The purpose of this study is to determine whether nasal high flow is non inferior to non invasive ventilation (NIV) in the early treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and…
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis, Respiratory Failure With Hypercapnia
- Trial name
- HiCOPD (NCT06114667)
- Testing
- Ventilatory support via nasal high flow, Ventilatory support via NIV
- Where
- 3 sites in France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Montpellier
Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome
Randomized Controlled Trial Between Auto-titration and Manual Titration of Non-invasive Ventilation in Obesity Hypoventilation Syndrome
Primary Objectives: To evaluate the effectiveness in the obesity hypoventilation syndrome (OHS) treatment with non-invasive ventilation (NIV) set manually by polysomnography compared to the same treatment with a respirator with…
- Trial name
- TITRATION (NCT04327336)
- Testing
- Manual Non invasive ventilation titration, Automatic Non invasive ventilation titration
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Acute Hypercapnic Respiratory Failure
Asymmetrical High Flow Oxygen Versus Noninvasive Ventilation in Acute Hypercapnic Respiratory Failure
NIV is a life-saving treatment for people with breathing failure and carbon dioxide (CO2) retention. It helps remove this waste gas from the lungs and reduces the effort needed to breathe.
- Trial name
- HIFOLD2 (NCT07157098)
- Testing
- asymmetrical high-flow nasal cannula, non-invasive ventilation with standard mask, non-invasive ventilation with a new mask
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Non-invasive Positive Pressure (NPPV ) for Severe Stable Chronic Obstructive Pulmonary Disease
Assessment of the effect and safety of noninvasive positive pressure ventilation for severe stable chronic obstructive pulmonary disease
- Trial name
- NCT02499718
- Testing
- BiPAP mode
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Lung, Hyperlucent, Positive-Pressure Respiration, Intrinsic
Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD
Objective: To analyze the additional benefits of exercise training application by the non-invasive home mechanical ventilation in patients with stable COPD and hypercapnic respiratory failure.
- Trial name
- COPD (NCT01377818)
- Testing
- ventilation, excecise training, Both
- Volunteers
- 45 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT)
High flow nasal oxygen therapy (HFNO) is an established modality in the supportive treatment of patients suffering from acute hypoxemic respiratory failure.
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure, Respiratory Depression, Respiratory Failure
- Trial name
- CLOUDHFOT (NCT06374589)
- Testing
- Closed-loop FiO2 controller, Conventional
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Respiratory Failure With Hypercapnia, Therapeutic Bronchofiberoscopy
To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated Respiratory Acidosis (Complete Respiratory Failure).
Background: Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes.
- Trial name
- NCT06970041
- Testing
- Use of NIV during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure, Use of HFNC during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure
- Volunteers
- 315 people
- Sponsor
- Medical University of Silesia
ARDS, Hypercapnic Respiratory Failure
Low-flow Extracorporeal Carbon Dioxide Removal in COVID-19-associated Acute Respiratory Distress Syndrome
The study aims to investigate the efficacy of extracorporeal CO2 removal for correction of hypercapnia in coronavirus disease 19 (COVID-19)-associated acute respiratory distress syndrome
- Conditions
- ARDS, Hypercapnic Respiratory Failure, AKI
- Trial name
- NCT04351906
- Testing
- ECCO2R
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Giessen
Acute Respiratory Distress Syndrome
Effects of End-inspiratory Pause on Ventilation
This study aims to evaluate the effect of reducing tidal volume and respiratory rate together with an end-inspiratory pause setting on ventilatory efficiency and the distribution of inspired gas within the lungs in ARDS patients.
- Trial name
- NCT06692634
- Testing
- mechanical ventilation setting
- Where
- 2 sites in Chile
- Volunteers
- 20 people
- Sponsor
- Clinica las Condes, Chile