Clinical trials: Hypercapnia
COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD
Remote Intervention Versus Routine Monitoring in COPD Patients With Chronic Hypercapnia Receiving Home Non-invasive Respiratory Support
This study is a randomized controlled trial designed to compare the effectiveness of active remote intervention versus passive monitoring alone in patients with Chronic Obstructive Pulmonary Disease (COPD) and chronic hypercapnic…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD, Hypercapnia
- Trial name
- NCT07751003
- Testing
- Remote Management, Remote Monitoring Only
- Where
- 4 sites in China
- Volunteers
- 236 people
- Sponsor
- Sir Run Run Shaw Hospital
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Airways Disease
Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation
Background: In chronic obstructive pulmonary disease, the prognosis for patients who have survived an episode of acute hypercapnic respiratory failure due to an exacerbation is poor.
- Conditions
- Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Airways Disease, Chronic Hypercapnic Respiratory Failure
- Trial name
- NCT01513655
- Testing
- LTNIV
- Where
- 4 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Chronic Obstructive Pulmonary Disease (COPD)
Respiratory Muscle Function in COPD Exacerbations
There is evidence that noninvasive mechanical ventilation (NIV) is effective in the treatment of severe exacerbations of COPD presenting respiratory acidosis.
- Trial name
- NCT01869387
- Testing
- Non-invasive ventilation
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Parc de Salut Mar
Pulmonary Disease, Chronic Obstructive, Hypercapnia
Adaptive Non-invasive Ventilation to Abolish Tidal Flow Limitation
This study aimed to evaluate the effects of a novel automatic non-invasive ventilation (NIV) mode that continuously adjusts expiratory positive airway pressure (EPAP) to the lowest value that abolishes tidal expiratory flow…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypercapnia, Ventilator Lung
- Trial name
- NCT04497090
- Testing
- fixed-EPAP, auto-EPAP
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Politecnico di Milano
Hypercapnia, Exercise
Hypercapnia: Cognitive Effects and Monitoring
The investigators will simulate the conditions of a working, helmeted diver by using exercising, "head out" immersed subjects to test the following hypotheses: 1.
- Conditions
- Hypercapnia, Exercise, Nitrogen Narcosis, Diving
- Trial name
- NCT01782625
- Testing
- NO exercise at depth, exercise at depth
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Duke University
Decreased Lung Compliance, Hypoxia
Alveolar Recruitment Maneuver During Cesarean Section Improves Lung Compliance
The investigators tested the hypothesis that alveolar recruitment maneuver during cesarean section and in women under general anesthesia improves lung compliance and gas exchange.
- Conditions
- Decreased Lung Compliance, Hypoxia, Hypercapnia, Atelectasis
- Trial name
- CSRecGHPyr (NCT01826968)
- Testing
- Alveolar Recruitment maneuver
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- General Hospital Of Pyrgos
Acute Respiratory Distress Syndrome
Open Lung Ventilation in ARDS: The PHARLAP Trial
Some people develop the condition called acute respiratory distress syndrome (ARDS). This is a condition where the lungs have become injured from one of a number of various causes, and do not work as they normally do to provide…
- Trial name
- PHARLAP (NCT01667146)
- Testing
- PHARLAP mechanical ventilation strategy, Control group mechanical ventilation strategy
- Where
- 27 sites in Australia, Ireland and 3 more
- Volunteers
- 115 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Endoscopy, Gastrointestinal, Procedural Sedation
The Efficacy of Laryngeal Mask Airway Gastro (LMA® Gastro™) in Preventing Hypercarbia in ERCP Patients
Endoscopic retrograde cholangiopancreatography (ERCP) has evolved into a primarily therapeutic procedure that often requires anesthetic support.
- Conditions
- Endoscopy, Gastrointestinal, Procedural Sedation, Anesthesia Airway Management, Anesthesia for Endoscopic Procedures
- Trial name
- NCT07182786
- Testing
- LMA Gastro
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Total Intravenous Anesthesia
The Effect of Mild Hypercapnia During Anesthetic Emergence on Recovery Time From TIVA
We hypothesized that patients with mild hypercapnia during anesthetic emergence after TIVA had a shorter recovery time than patients with normal blood carbonate levels.
- Trial name
- NCT05401266
- Testing
- mild hypercapnia
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dyspnea
Specificity of Dyspnoea Relief With Inhaled Furosemide
This study evaluates the effect of inhaled furosemide on different types of breathlessness relief in healthy volunteers. Each volunteer inhaled mists of either furosemide or a control substance on 3 occasions per day on 2…
- Trial name
- FurosAH (NCT02881866)
- Testing
- Furosemide, Saline
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Hypoxemic Without Hypercapnia Acute Respiratory Failure
Pronostic Value of Fluid Responsiveness Evaluated by Inferior Vena Cava Collapsibility Index in Patients Admitted in ICU With Acute Respiratory Failure
Acute respiratory failure represents a frequent cause of admission to intensive care units (ICUs). In the absence of tailored interventions, it poses an imminent threat to patients' lives.
- Trial name
- PRIVACY (NCT06286306)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Chronic Obstructive Pulmonary Disease, Hypercapnic
Effect of Noninvasive Ventilation on Physical Activity and Inflammation in COPD Patients
Parallel, randomized and controlled clinical trial to evaluate the effect of 12 months of noninvasive mechanical ventilation versus conventional treatment in hypercapnic patients with stable COPD.
- Trial name
- NCT01037387
- Testing
- Control, NIMV group
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario La Paz
Hypoxic Respiratory Failure, Hypercapnic Respiratory Failure
Snow Physical Properties and Human Ventilatory Response
Sufficient oxygenation is critical for completely buried avalanche victims to avoid life-threatening consequences during hypoxic exposure.
- Conditions
- Hypoxic Respiratory Failure, Hypercapnic Respiratory Failure, Avalanche Burial, Snow Physical Properties
- Trial name
- NCT03082105
- Testing
- Breathing in snow
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Hypercapnic Respiratory Failure, COPD, ARDS
Feasibility Study of the Hemolung Respiratory Assist System (Germany)
The purpose of this study is to evaluate the safety and efficacy of the Hemolung Respiratory Assist System (RAS) in patients with hypercapnic respiratory failure.
- Trial name
- NCT01021605
- Testing
- Hemolung Respiratory Assist System
- Where
- 7 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Alung Technologies
Pain, Hypoxia
Effects of Walking Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxia, Hypercapnia, Apnea
- Trial name
- NCT06158295
- Testing
- Voluntary apnoea
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Obstructive Sleep Apnoea
Morphine in Moderate Obstructive Sleep Apnoea
The aim of this study is to investigate the effects of morphine (a drug commonly used for the treatment of moderate to severe pain, particularly following surgery) on the number of pauses in breathing in patients with moderate…
- Trial name
- MIMOSA (NCT03127800)
- Testing
- Morphine sulphate
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Chronic Obstructive Pulmonary Disease (COPD)
High Intensity Non-Invasive Positive Pressure Ventilation (HINPPV)
The purpose of this pilot study is to evaluate the effect of high intensity non-invasive positive pressure ventilation (HINPPV) for stable, hypercapnic COPD patients.
- Trial name
- HINPPV (NCT01214200)
- Testing
- Bilevel positive airway pressure (BiPAP)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Philips Respironics
Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
Evaluation of Conventional Non-invasive Mechanical Ventilation (NIV) Versus an Automatic Ventilation Mode.
To evaluate the polysomnographic performance of an automatic ventilatory mode compared with the gold standard (manual polysomnographic titration) to adjust chronic non-invasive ventilation by means of a randomized cross-over…
- Trial name
- NCT03872167
- Testing
- BIPAP, Intelligent automatic mode defined by assured volume with pressure support, BIPAP, manual tritration.
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Hospital Clinic of Barcelona
Hypoxemia, Hypercapnia
Optimising Ventilatory Strategies by Using Positive Respiratory Integer Measurements
Background Intermittent Positive Pressure Ventilation is used during general anesthesia but can lead to serious complications. Respiratory parameter settings can be adjusted to minimize the detrimental effects of this…
- Conditions
- Hypoxemia, Hypercapnia, Ventilator Associated Pneumonia, Complication of Anesthesia
- Trial name
- OPTIMVSPRIME (NCT06298435)
- Testing
- Intermittent Positive pressure ventilation
- Where
- Netherlands
- Volunteers
- 20,000 people
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease
HomeVent ( Connect) Registry: EU COPD Home NIV Registry
The prevalence of chronic respiratory disease, including chronic obstructive pulmonary disease (COPD), is increasing in industrialized countries.
- Trial name
- HOmeVent (NCT02811588)
- Testing
- Non-invasive ventilation
- Where
- 4 sites in Germany
- Volunteers
- 169 people
- Sponsor
- ResMed