Clinical trials: Hyperalgesia
Pain, Hyperalgesia
Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia
The aim of this study was to determine if the addition of ketamine reduces remifentanil-induced hyperalgesia, improves its analgesic effect, inhibits IL(interleukin)-6 and IL-8 (inflammatory cytokines), and stimulates IL-10 (an…
- Conditions
- Pain, Hyperalgesia, Inflammatory Response
- Trial name
- NCT01301079
- Testing
- Ketamine, Saline
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Chronic Pain
Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance
Dual medication (guanfacine and morphine) as a standard treatment for chronic pain.
- Trial name
- NCT01681264
- Testing
- Morphine, Guanfacine 1mg, Guanfacine 2mg
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Massachusetts General Hospital
Pain
The Effect of Intravenous Lidocaine on Allodynia
The purpose of this study is to study if lidocaine, given intravenously, reduces pain.
- Trial name
- NCT00659633
- Testing
- lidocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Central Neuropathic Pain, Allodynia
Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial
This randomized, placebo-controlled, double-blind 4x4 crossover clinical trial was part of a larger NIH-funded study to evaluate the analgesic efficacy of three doses of chronic oral (PO) dextromethorphan compared to placebo in…
- Conditions
- Central Neuropathic Pain, Allodynia, Spinal Cord Injury
- Trial name
- NCT01435798
- Testing
- Dextromethorphan
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Brigham and Women's Hospital
Hyperalgesia, Secondary
Transversus Abdominis Plane (TAP) Block for Cesarean Section
The purpose of this study is to determine whether a transversus abdominis plane (TAP) block with Clonidine added to the injectate (Clo-TAP) performed approximately 2hrs after the cesarean section (CS) will decrease the amount of…
- Trial name
- CLOTAP (NCT01015807)
- Testing
- Bupivacaine, Clonidine
- Where
- 2 sites in United States, Brazil
- Volunteers
- 90 people
- Sponsor
- University of Washington
Central Neuropathic Pain, Allodynia
Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial
This randomized, placebo-controlled, double-blind 4x4 crossover clinical trial was part of a larger NIH-funded study to evaluate the analgesic efficacy of multiple dose-combinations of chronic oral (PO) dextromethorphan and…
- Conditions
- Central Neuropathic Pain, Allodynia, Spinal Cord Injury
- Trial name
- NCT02218203
- Testing
- Dextromethorphan, Lidocaine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Brigham and Women's Hospital
Acute Pain, Hyperalgesia
IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery
Patients undergoing cardiac surgery experience significant postoperative pain, which may impact postoperative outcomes. The aim of this single center, double-blind, randomized, placebo controlled trial is to determine if…
- Trial name
- CarDolMev (NCT01544062)
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Washington
Pain
The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers
The purpose of this study is to study if lidocaine, given intravenously, reduces pain.
- Trial name
- NCT00657358
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Neuropathy, Paraneoplastic
MC-5A for Chemotherapy Induced Peripheral Neuropathy
Painful chemotherapy induced peripheral neuropathy (CIPN) is a common complication of cancer therapy with few treatment options.
- Trial name
- NCT01261780
- Testing
- MC-5A
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Wisconsin, Madison
Post Operative Pain, Hyperalgesia
Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery.
- Trial name
- NCT01594047
- Testing
- ketamine infusion, Methadone PCA
- Where
- Italy
- Volunteers
- 113 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Pain, Anesthesia
Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia
To explore and compare antihyperalgesic effects of Dexmedetomidine,Nalmefene,and a combination of both received before anesthesia induction.
- Trial name
- NCT03096730
- Testing
- Normal saline, Remifentanil, Sufentanil
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tianjin Medical University General Hospital
Cannabis, Pain
Repeated Cannabis Administration on Experimental Pain and Abuse Liability
Chronic pain is a significant public health concern in the U.S., for which prescription opioids have historically been the standard treatment. This has resulted in striking rates of opioid use disorders and fatal overdoses.
- Conditions
- Cannabis, Pain, Tolerance, Hyperalgesia
- Trial name
- NCT04576507
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Pain, Anesthesia
Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients
Purpose: To explore and compare antihyperalgesic effects of butorphanol, flurbiprofen axetil, and a combination of both received before anesthesia induction.
- Trial name
- NCT02043366
- Testing
- Normal Saline, Butorphanol, Flurbiprofen axetil
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Tianjin Medical University General Hospital
Opioid-Induced Hyperalgesia
Hyperalgesia in Methadone-Maintained Patients: Can it be Treated?
Utilizing a double-blind, placebo-controlled design, the proposed work will evaluate the ability of an adjuvant anticonvulsant analgesic to diminish or reverse the opioid-induced hyperalgesia complicating the pain states suffered…
- Trial name
- NCT01210079
- Testing
- Gabapentin;
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, Los Angeles
Pain, Peripheral Neuropathy
A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia
The purpose of this study is to evaluate the efficacy of Sativex® compared with placebo in relieving peripheral neuropathic pain associated with allodynia.
- Trial name
- NCT00710554
- Testing
- Sativex
- Where
- United Kingdom
- Volunteers
- 246 people
- Sponsor
- Jazz Pharmaceuticals
Hyperalgesia
Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia
The purpose of this study is to evaluate whether using ultra-low dose naloxone, an opioid antagonist, has the potential to block remifentanil-induced hyperalgesia and tolerance following surgery.
- Trial name
- NCT03066739
- Testing
- Remifentanil, Remifentanil +ultra-low dose naloxone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, Irvine
Chronic Pain
Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment
Peroperative opioids are known to induce N-Methyl-D-Aspartate dependent enhancement of postoperative hyperalgesia. For patients with current opioid treatment, these phenomena could be exagerated and could produce greater…
- Trial name
- PROTOX (NCT00210158)
- Testing
- Air, Protox
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Institut Bergonié
Idiopathic Scoliosis, Spondylolisthesis
Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia
The purpose of this study is to: 1. Establish whether ketamine can decrease opioid consumption and modulate the onset of opioid tolerance and prevent opioid-induced hyperalgesia in pediatric subjects, ages 10 years to 18 years…
- Trial name
- KPSF (NCT01325493)
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Julia Finkel
Wound Care, Pain Intensity
Pain Medicine for Wound Care Procedures
This is a randomized double-blind study to determine if the administration of a small-dose of ketamine (an anesthetic)added to morphine (an opioid) contributes to reducing pain intensity during open wound care procedure (WCP)in…
- Conditions
- Wound Care, Pain Intensity, Hyperalgesia, Nausea
- Trial name
- NCT00701909
- Testing
- Morphine plus Ketamine
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Chronic Pain
Effect of Guanfacine on the Reversal of Opioid-induced Hyperalgesia (OIH)
Combination of guanfacine with opioid medication as a standard treatment for chronic pain.
- Trial name
- NCT02192398
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital