Clinical trials: Hydrocephalus, Normal Pressure, open to volunteers
Normal Pressure Hydrocephalus, Hydrocephalus
European Study of Prodromal iNPH
To investigate if progression from prodromal into symptomatic NPH can be predicted from advanced neuroimaging, biomarkers in cerebrospinal fluid (CSF) and plasma and investigate the unknown mechanisms causing deterioration by…
- Trial name
- STOP iNPH (NCT05910944)
- Testing
- Shunt surgery
- Where
- 7 sites in Finland, Italy and 1 more
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Johan Virhammar
Brain Pulsatility, Idiopathic Normal Pressure Hydrocephalus (INPH)
Transcranial Ultrasound Assessment of Cerebral Pulsatility in Shunt Decision-making for Suspected Idiopathic Normal Pressure Hydrocephalus: a Prospective Cohort Study
This will be a single-center, prospective, analytical cohort study. All included patients will undergo transcranial ultrasound (TPI) with measurement of cerebral pulsatility parameters prior to subtractive lumbar puncture during…
- Trial name
- HYDROPULSE (NCT07285928)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Tours
Normal Pressure Hydrocephalus Patients, Normal Pressure Hydrocephalus
Non-invasive Diagnostics of Shunt Obstruction in Adult Hydrocephalus
The goal of this RCT is to test whether volumetric assessment of magnetic resonance imaging (MRI) could diagnose shunt obstruction in Adult Hydrocephalus patients, and in addition to explore correlations of blood biomarkers…
- Trial name
- NCT07172841
- Testing
- Intervention group "Virtual OFF", Control group (no change in shunt setting)
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Normal Pressure Hydrocephalus
White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive condition of the elderly that results in severe disability. iNPH can dramatically respond to Cerebral spinal fluid(CSF)-shunting where excess ventricular fluid is…
- Trial name
- OWN-NPH (NCT07103681)
- Testing
- Ventriculoperitoneal Shunt (VP), Brain and Skin Biopsy, MRI Brain
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Idiopathic Normal Pressure Hydrocephalus (INPH), Gait Disorders, Neurologic
Unsteady Gait in Older People May be a Common and Treatable Neurological Disease Associated With Increased Mortality
We live in an aging population and a third of the older population has a gait disorder that may cause institutionalization, and increased mortality.
- Conditions
- Idiopathic Normal Pressure Hydrocephalus (INPH), Gait Disorders, Neurologic, Gait Disorders in Old Age
- Trial name
- VESPR2 (NCT07137403)
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Umeå University
Normal Pressure Hydrocephalus, Hakim Syndrome
Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland
The study aims to estimate Normal Pressure Hydrocephalus (NPH) prevalence and evaluate health equity gaps in Baltimore and Maryland based on zip codes and race, with a focus on the Black community.
- Trial name
- NPH (NCT06426004)
- Testing
- patients will receive NPH education, primary care physicians (PCPs) will receive professional NPH education, A community health worker will assist PCP
- Where
- 2 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Normal Pressure Hydrocephalus
Identifying Gait Changes From a CSF Tap Test Using a Smart Insole in iNPH
The goal of this clinical trial is to to evaluate various gait parameters by a sensor-embedded smart insole before and after the cerebrospinal fluid (CSF) tap test in idiopathic normal pressure hydrocephalus (iNPH) patients.
- Trial name
- NCT06722768
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Freezing of Gait, Parkinson's Disease
Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)
This study is a prospective, multicenter, observational cohort (patient registry) designed to better understand freezing of gait (FOG), a disabling walking problem that can occur in Parkinson's disease and other related…
- Conditions
- Freezing of Gait, Parkinson's Disease, Parkinsonism, Vascular Parkinsonism
- Trial name
- NCT07386015
- Testing
- Observational Data Collection
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Tianjin Huanhu Hospital
Alzheimer Disease, Frontotemporal Dementia
Proteinopathies Expression in Skin of Neurodegenerative Disorders
The goal of this observational study is to compare the aggregation pattern of proteinopathies (alpha-synuclein, amyloid-beta, phosphorylated tau and transactive response DNA -binding protein 43 [TDP43]) in skin biopsies of…
- Conditions
- Alzheimer Disease, Frontotemporal Dementia, Parkinson Disease, Atypical Parkinsonism
- Trial name
- NCT06528964
- Testing
- Immunohistochemistry and immunofluorescence
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Beta-amiloid and Phospho-tau Proteins in CSF, Ventricular Size After CSF Shunt
CSF Protein Markers as Prognostic Indicators of the Response to CSF Shunt in Normotensive Hydrocephalus
In all published series of adult chronic hydrocephalus, there is a percentage between twenty and twenty-five percent of patients who present poor results after implantation of a cerebrospinal fluid shunt,1-11 usually…
- Conditions
- Beta-amiloid and Phospho-tau Proteins in CSF, Ventricular Size After CSF Shunt, Cognitive Impairment and CSF Shunt, Motor Impairment Evolution After CSF Shunt
- Trial name
- NCT05915000
- Testing
- Lumbar CSF protein marker determination
- Where
- 2 sites in Spain
- Volunteers
- 150 people
- Sponsor
- University of Valencia
Normal Pressure Hydrocephalus, Sleep Apnea
Normal Pressure Hydrocephalus and Sleep Apnea
Normal-pressure hydrocephalus is associated with increases in the intracranial pressure during the night sleep. Sleep apnea also increases the intracranial pressure during the apneic spells.
- Conditions
- Normal Pressure Hydrocephalus, Sleep Apnea, Cerebrospinal Fluid Shunt Occlusion
- Trial name
- NPH/OSA (NCT04471740)
- Testing
- CSF shunt diversion
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- University of Valencia
Idiopathic Normal Pressure Hydrocephalus (INPH)
Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST)
The aim of this single-center, two-arm, open-labeled, randomized controlled clinical study is to compare two surgical interventions, endoscopic third ventriculostomy and ventriculoperitoneal shunt, in treating idiopathic normal…
- Trial name
- NCT06488248
- Testing
- Endoscopic third ventriculostomy (ETV), Ventriculoperitoneal shunt (VPS)
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Basel, Switzerland
Hydrocephalus, Normal Pressure
Assessment of ShuntCheck Performance Characteristics in Asymptomatic Patients With Normal Pressure Hydrocephalus
The purpose of the study is to determine if the ShuntCheck test can correctly identify flow or no flow in a ventriculoperitoneal shunt in patients with asymptomatic normal pressure hydrocephalus.
- Trial name
- NCT04011566
- Testing
- ShuntCheck
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of South Florida
Idiopathic Normal Pressure Hydrocephalus
Integrated Multimodal Assessment to Optimize Diagnosis and Surgical Selection in Idiopathic Normal Pressure Hydrocephalus
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological condition that can cause walking difficulties, cognitive impairment, and urinary incontinence.
- Trial name
- NPH-OPTIMIZE (NCT07427836)
- Where
- 2 sites in Italy
- Volunteers
- 116 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Normal Pressure Hydrocephalus
Analysis of Cerebrospinal Fluid Dynamics in Normal Pressure Hydrocephalus
This study aims to evaluate whether phase-contrast magnetic resonance imaging (MRI)-based cerebrospinal fluid (CSF) flow dynamics can improve the diagnosis and prognostic assessment of normal pressure hydrocephalus (NPH).
- Trial name
- NCT07831044
- Testing
- Cerebrospinal fluid drainge
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Chungnam National University Hospital
Idiopathic Normal Pressure Hydrocephalus
Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH)
The research is designed to study the prognostic factors of ventriculoperitoneal (VP) shunt for iNPH by multi-omics research
- Trial name
- NCT04998175
- Testing
- ventriculo-peritoneal shunt
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
NPH (Normal Pressure Hydrocephalus)
Examining the Feasibility of Using Pressure Gradient Regulated Automated Cerebral Spinal Fluid Drainage During External Lumbar Drain Trials
The intellidrop device is an FDA-approved system that automates safe, small volume of cerebral spinal fluid drainage with continuous pressure monitoring, reducing nursing workload and human error while improving patient mobility…
- Trial name
- UPGRADE (NCT07494812)
- Testing
- Intellidrop Automated CSF Drainage System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
Hydrocephalus, Idiopathic Normal Pressure Hydrocephalus
Clinical Outcome in Patients With INPH
The aim of this study is to determine the clinical spectrum and natural progression of idiopathic normal pressure hydrocephalus （iNPH ) and related disorders in a prospective single center study, identify digital, imaging and…
- Conditions
- Hydrocephalus, Idiopathic Normal Pressure Hydrocephalus, CSF, Glympathic System
- Trial name
- NCT06428734
- Testing
- hydrocephalus group, normal group
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Idiopathic Normal Pressure Hydrocephalus, Normal Pressure Hydrocephalus
Prediction of Response to Shunt Surgery in Normal Pressure Hydrocephalus Using Radscale and Lumbar Puncture
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder in older adults characterized by walking difficulties, cognitive decline, and urinary dysfunction.
- Trial name
- NCT07832877
- Volunteers
- 40 people
- Sponsor
- Assiut University