Clinical trials: Hyaluronic Acid
Osteoarthritis, Hip
MONOVISC for Hip Joint Pain Relief Due to Osteoarthritis
Obtain real world, post market data to confirm the clinical improvement and safety in patients treated with a single injection of MONOVISC for the symptomatic relief of osteoarthritis in the hip joint.
- Trial name
- NCT04204083
- Testing
- Monovisc
- Where
- 4 sites in Czechia, Poland
- Volunteers
- 25 people
- Sponsor
- Anika Therapeutics, Inc.
Interstitial Cystitis and Bladder Pain Syndrome
Real-world Evidence Study on Cystistat
This study will be conducted with the aim of ensuring the continued acceptability of the benefit-risk ratio and confirming the safety and performance of the device throughout its expected lifetime.
- Trial name
- IC/BPS (NCT05544695)
- Testing
- intravesical sodium hyaluronate (Cystistat®)
- Where
- Austria
- Volunteers
- 74 people
- Sponsor
- MEDA Pharma GmbH & Co. KG
Dry Eye Syndromes, Lubricant Allergy
Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects
Phase I clinical study, to evaluate the safety and tolerability of the preservative-free ophthalmic solution PRO-087 versus Xyel Ofteno® and Systane Ultra®, on the ocular surface of ophthalmological and clinically healthy…
- Conditions
- Dry Eye Syndromes, Lubricant Allergy, Tear Disorder
- Trial name
- PRO-087/I (NCT03524157)
- Testing
- PRO-087, Systane Ultra, Xyel Ofteno
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Dry Eye Syndromes
Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel
Objective: To assess the safety and tolerability of the PRO-165 formulation on the ocular surface of ophthalmologically and clinically healthy subjects.
- Trial name
- PRO-165 (NCT03697876)
- Testing
- PRO-165, Artelac
- Where
- Mexico
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Infra-orbital Hollows, Tear-trough Deformity
RHA® Redensity Eye Versus No-treatment for the Infra-Orbital Hollows
This is a multicenter, blinded evaluator, randomized, prospective, no treatment control clinical study to identify whether RHA® Redensity Eye (*) is superior to no treatment for the correction of moderate to severe tissue volume…
- Conditions
- Infra-orbital Hollows, Tear-trough Deformity, Wrinkle
- Trial name
- NCT04577898
- Testing
- RHA® Redensity Eye
- Where
- 4 sites in United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Dehydration
Study of In-line Pressure Using Various Techniques of Subcutaneous Administration of Fluids Enabled by Human Recombinant Hyaluronidase (INFUSE-AT1A)
The purpose is to characterize the in-line pressure profiles associated with several infusion technique factors during subcutaneous (SC) infusion of Lactated Ringer's solution, preceded by recombinant human hyaluronidase…
- Trial name
- INFUSE-AT1A (NCT01116102)
- Testing
- Subcutaneous HYLENEX (recombinant human hyaluronidase) and Lactated Ringer's solution
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Cataracts
Clinical Investigation of Healon EndoCoat Ophthalmic Viscosurgical Device (OVD)
Prospective, multicenter, paired-eye, randomized, subject/evaluator-masked clinical investigation of the experimental EndoCoat OVD versus the control EndoCoat OVD.
- Trial name
- NCT05575063
- Testing
- Investigational Healon Endocoat, Control Healon EndoCoat
- Where
- 8 sites in United States
- Volunteers
- 165 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Facial Wrinkles
Global Management of Facial Rejuvenation With a New Range of Hyaluronic Acid Dermal Fillers
The aim of this study is to assess performance and tolerance as well as investigator and subject satisfaction linked to the global management of facial rejuvenation with a new range of hyaluronic acid dermal fillers.
- Trial name
- FRESH (NCT01151436)
- Testing
- hyaluronic acid dermal fillers
- Where
- 5 sites in France, Germany
- Volunteers
- 77 people
- Sponsor
- Galderma R&D
Wrinkles
Safety Study of Cosmetic Tissue Augmentation in People of Color
Elevess is intended for all skin types. However, further study of all soft tissue fillers is needed in people of color because of the increasing use of cosmetic dermal filler products.
- Trial name
- NCT01147172
- Testing
- Elevess
- Where
- 9 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Anika Therapeutics, Inc.
Osteoarthritis, Knee
nSTRIDE APS Versus Hyaluronic Acid for Knee Osteoarthritis
This is a two-phase multicenter, double-blind, randomized, prospective evaluation of intra-articular injection(s) comparing APS to intra-articular HA injection(s).
- Trial name
- NCT03182374
- Testing
- nSTRIDE APS, Synvisc-One
- Where
- 14 sites in Belgium, Denmark and 8 more
- Volunteers
- 252 people
- Sponsor
- Zimmer Biomet
Glenohumeral Osteoarthritis
ORTHOVISC Shoulder Osteoarthritis Study
A comparison of Orthovisc to corticosteroid injections in the shoulder for pain due to osteoarthritis.
- Trial name
- NCT00436969
- Testing
- Orthovisc, Control
- Where
- 13 sites in United States
- Volunteers
- 274 people
- Sponsor
- DePuy Mitek
Osteoarthritis of the Knee
Efficacy and Safety of Repeated Intraarticular Injections of Hyaluronic Acid in Patients With OA of the Knee
The main objective is the long-term comparison (3 years and 4 months) of the efficacy and safety of repeated intra-articular administration of hyaluronic acid in the treatment of osteoarthritis of the knee.
- Trial name
- NCT00669032
- Testing
- Hyaluronic acid
- Volunteers
- 446 people
- Sponsor
- Tedec-Meiji Farma, S.A.
Age-related Cataract, Phacoemulsification
Study to Evaluate the Safety of the Viscoelastic Substance PRO-149, Compared to Healon® EndoCoat.
Pilot, controlled, parallel group, open, randomized clinical trial to evaluate the safety of the viscoelastic substance PRO-149 (sodium hyaluronate 3%) after trans-surgical administration as a device in performing…
- Trial name
- PRO-149 (NCT04702802)
- Testing
- Sodium hyaluronate 3%
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Cataract
Clinical Investigation of the Bacterially-Derived Healon5 Ophthalmic Viscosurgical Device (OVD)
Prospective, multicenter, paired-eye, randomized, masked, clinical trial of the bacterially-derived Healon5 OVD versus the currently available Healon5 OVD control.
- Trial name
- NCT02782676
- Testing
- Investigational Healon5 OVD, Healon5 OVD
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Midface Volume Deficit
Restylane Volyme for Correction of Midface Volume Deficit and/or Midface Contour Deficiency
This is a randomized, evaluator-blinded, no-treatment controlled study in subjects with Midface Volume Deficit and/or Midface Contour Deficiency.
- Trial name
- NCT03289052
- Testing
- Restylane Volyme
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Galderma R&D
Knee Osteoarthritis
Durolane Versus Phosphate Buffered Saline (PBS) in Knee Osteoarthritis
The purpose of the study is to determine whether a single intra-articular injection of Durolane 4.5 mL is superior to a single injection of PBS 4.5 mL for the relief of joint pain in patients with osteoarthritis of the knee.
- Trial name
- NCT01753830
- Testing
- Durolane, PBS
- Where
- 25 sites in United States
- Volunteers
- 75 people
- Sponsor
- Galderma R&D
Osteoarthritis, Hip
Study of Cingal® for Symptomatic Relief of Osteoarthritis of Hip Joint
This Trial will obtain clinical data to support an expanded indication for a single injection of Cingal used for the symptomatic relief of osteoarthritis in the hip joint.
- Trial name
- NCT04640298
- Testing
- Cingal
- Where
- 4 sites in Czechia, Poland
- Volunteers
- 25 people
- Sponsor
- Anika Therapeutics, Inc.
Nasolabial Folds, Wrinkles
TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines, and Juvéderm® Ultra XC for the Correction of Nasolabial Folds
The purpose of this study is 1) to compare the effectiveness and safety of TEOSYAL® RHA Global Action versus Juvéderm® Ultra XC, and 2) to compare the effectiveness and safety of TEOSYAL® RHA Deep Lines versus Juvéderm® Ultra XC…
- Trial name
- NCT02195427
- Testing
- TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines
- Where
- 5 sites in United States
- Volunteers
- 148 people
- Sponsor
- Teoxane SA
Wrinkle, Nasolabial Fold
RHA® 4 NLF Cannula
This is a randomized, controlled, single-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA®4 injected in NLFs with a cannula is non-inferior to RHA®4 injected in NLFs with a sharp…
- Conditions
- Wrinkle, Nasolabial Fold, Aging
- Trial name
- NCT04754646
- Testing
- Split-face injection of RHA® 4 with a cannula into a single NLF., Split-face injection of RHA® 4 with a needle (TSK 27G x ½") into the contralateral NLF.
- Where
- 4 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Persistent Corneal Epithelial Defect
A Study of the KIO-201 (Ocular Bandage Gel) for Improving Persistent Corneal Epithelial Defects
The objective of this study is to evaluate the safety and effectiveness of topical KIO-201 in patients with persistent corneal epithelial defects (PED). KIO-201 will be administered six (6) times per day while awake for 4 weeks.
- Trial name
- NCT05436288
- Testing
- KIO-201, a Crosslinked Thiolated Carboxymethyl Hyaluronic Acid 0.75% (CMHA-S)
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Kiora Pharmaceuticals, Inc.