Clinical trials: Hyaline Membrane Disease
Preterm Infants
NHFOV vs. NCPAP as a Primary Treatment to Neonatal Respiratory Distress Syndrome(NRDS)
The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -noninvasive high-frequency oscillatory ventilation (nHFOV) or nasal continuous positive airway pressure (nCPAP) -as a…
- Trial name
- NCT03099694
- Testing
- noninvasive high-frequency ventilation (nHFOV), nasal continuous positive airway pressure (nCPAP)
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Xingwang Zhu
Prematurity, Respiratory Distress Syndrome, Infant
Weaning of Nasal Continuous Positive Airway Pressure (CPAP) in Premature Infants
The aim of this study is to investigate two different strategies for the withdrawal of CPAP in preterm infants born before 32 weeks of gestation.
- Trial name
- NCT01721629
- Testing
- Sudden wean of nasal CPAP, Gradual wean of nasal CPAP
- Where
- 6 sites in Denmark
- Volunteers
- 380 people
- Sponsor
- Aarhus University Hospital
Respiratory Distress Syndrome, Newborn
Randomized Controlled Trial of Surfactant Administration by Laryngeal Mask Airway (LMA)
In this protocol we will conduct a randomized controlled trial where babies with respiratory distress syndrome (RDS) who have not yet reached criteria for intubation, will be randomized to receive surfactant by LMA or to continue…
- Trial name
- NCT00599651
- Testing
- Surfactant administered via Laryngeal Mask Airway (LMA), standard of care (nasal CPAP and supplemental oxygen)
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- University of Virginia
Neonatal Respiratory Distress Syndrome
Flow-cycled Ventilation in Preterm Infants
This short pilot study is to assess the tolerance of preterm infants, born below 32 weeks gestation with respiratory distress syndrome, to flow-cycle ventilation, and see if infants require less overall pressure from the…
- Trial name
- FLIPI (NCT02522455)
- Testing
- Flow-cycle ventilation, Time-cycle ventilation mode
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Manchester University NHS Foundation Trust
Acute Respiratory Distress Syndrome
Surfactant Versus Nasal Continuous Positive Airway Pressure (nCPAP) for Respiratory Distress Syndrome in the Newborn ≥ 35 Weeks of Gestation
Term and near term newborns can present acute respiratory distress syndrome (RDS). Surfactant treatment has been shown effective in reducing mechanical ventilation and oxygen treatment durations in the preterm newborn.
- Trial name
- ASPEN (NCT01306240)
- Testing
- Surfactant instillation, nCPAP
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Respiratory Disease, Respiratory Insufficiency
Evaluation Of The Efficacy Of Four Different Non-invasive Ventilation Modes Performed In The Delivery Room
Evaluation Of The Efficacy Of Four Different Non-invasive Ventilation Modes Performed In The Delivery Room In Late Preterm And Term Infants Wıth Respiratory Distress
- Trial name
- NCT04282369
- Testing
- HHHFNC, NCPAP, NIPPV
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Newborn Respiratory Distress, Preterm Infant
Short Term Effects of Synchronized vs. Non-synchronized NIPPV in Preterm Infants.
Comparing the cardio-respiratory adaptation and differences to non invasive ventilation techniques, nasal intermittent positive pressure ventilation (NIPPV) non synchronized vs synchronized (SNIPPV) in preterm newborns…
- Trial name
- SyncNIV (NCT03289936)
- Testing
- NIPPV, SNIPPV
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Prematurity, Respiratory Distress Neonatal
Effect of Automated Oxygen Control on Early-childhood Lung Mechanics
Preterm infants are at higher risk of long-term respiratory problems and abnormal lung function in childhood. Respiratory support including mechanical ventilation, that is the use of a machine to move air into and out of the…
- Conditions
- Prematurity, Respiratory Distress Neonatal, Oxygen Delivery
- Trial name
- NCT07866820
- Testing
- Forced oscillometry technique
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust
Respiratory Distress Neonatal, Noninvasive Ventilation
Comparison of the Silverman-Andersen Score and the Downes Score
This study aimed to compare the Silverman-Andersen score and the Downes score in predicting noninvasive ventilation (NIPPV) failure in preterm and term infants who received NIPPV support due to postnatal respiratory distress, as…
- Conditions
- Respiratory Distress Neonatal, Noninvasive Ventilation, Intubation, Scoring Systems
- Trial name
- CSASDS (NCT07183956)
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Muğla Sıtkı Koçman University
Newborn Rds, Transient Tachypnea of the Newborn
LUNG ULTRASONOGRAPHY DECREASES RADIATION EXPOSURE
We aimed to decrease in the number of chest X-rays in newborns with respiratory distress, with the use of lung ultrasonography. From January 2019 to June 2020, 104 newborn infants with respiratory distress enrolled in this study.
- Conditions
- Newborn Rds, Transient Tachypnea of the Newborn, Pneumonia
- Trial name
- LUDRE (NCT04722016)
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Hacettepe University
Respiratory Distress of Newborn, Preterm Birth
Antenatal Dexamethasone for Late Preterm Deliveries
The goal of this clinical trial is to compare dexamethasone in late preterm deliveries. The main questions it aims to answer are: Does antenatal dexamethasone reduce the need for respiratory support in late preterm infants? Does…
- Trial name
- NCT05841121
- Testing
- Dexamethasone
- Where
- Vietnam
- Volunteers
- 294 people
- Sponsor
- Chulalongkorn University
Preterm Infants, Neonatal Respiratory Distress Syndrome
Comparison of the Need Of Mechanical Ventilation Between Less Invasive Surfactant Administration (LISA) and Conventional INSURE (Intubation-Surfactant Administration-Extubation) Methods in Spontaneously Breathing Preterm Infants With Respiratory Distress Syndrome
Brief Summary of the Study This randomized controlled trial aims to compare the need for mechanical ventilation between Less Invasive Surfactant Administration (LISA) and the conventional INSURE (Intubation, Surfactant…
- Conditions
- Preterm Infants, Neonatal Respiratory Distress Syndrome, Need for Mechanical Ventilation
- Trial name
- NCT07910539
- Testing
- Intervention Name: Poractant alfa (surfactant) administered by the INSURE method
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Fatima Jinnah Medical University
Respiratory Distress Syndrome, Newborn
Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study
The primary objective of this study is to compare two methods of post-delivery stabilization and subsequent early respiratory care for reducing the need for MV and related secondary complications, such as BPD, in premature babies…
- Trial name
- Curpap (NCT00501982)
- Testing
- Poractant alfa (Curosurf®)
- Where
- 5 sites in Czechia, France and 3 more
- Volunteers
- 208 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Bronchopulmonary Dysplasia (BPD)
Combined Oscillation-Volume guarantEe Study
Respiratory Distress Syndrome (RDS) remains the most common respiratory complication in the early postnatal period among preterm infants born before 32 weeks' gestational age.
- Trial name
- NCT07377955
- Testing
- HFOV, HFOV+VG
- Volunteers
- 348 people
- Sponsor
- Xingwang Zhu
Bronchopulmonary Dysplasia, Hyaline Membrane Disease
Inhaled Beclomethasone to Prevent Chronic Lung Disease
To test if inhaled glucocorticoids, early in the course of respiratory failure in premature infants, permit normal lung growth and differentiation, thus preventing development of bronchopulmonary dysplasia.
- Conditions
- Bronchopulmonary Dysplasia, Hyaline Membrane Disease, Lung Diseases
- Trial name
- NCT00000576
- Testing
- beclomethasone
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Respiratory Distress Syndrome (RDS), Newborn
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm Neonates
The goal of this clinical trial is to learn if nasal high frequency oscillatory ventilation (nHFOV) works no worse than nasal intermittent mandatory ventilation (NIMV) as early breathing support.
- Conditions
- Respiratory Distress Syndrome (RDS), Newborn, Premature Birth
- Trial name
- NOV-RDS (NCT07837141)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 158 people
- Sponsor
- Aga Khan University
Neonatal Respiratory Distress Syndrome
To Investigate the Effect of Pulmonary Surfactant With Different Inspired Oxygen Concentrations on the Clinical Outcomes of Very Preterm Infants Under Non-invasive Assisted Ventilation
A prospective multicenter randomized controlled study was conducted. Eligible very preterm infants with a gestational age of <32 weeks were enrolled.
- Trial name
- NCT07235345
- Testing
- According to the FiO2 threshold of PS application corresponding to randomization, PS treatment was given when FiO2 reached the threshold
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xu Falin
Hyaline Membrane Disease (HMD)
Impact of Antenatal Corticosteroid Therapy on Postnatal Surfactant Use in Preterm Infants
No study has shown that two doses of corticosteroids are more effective than a single dose in lung maturation and prevention of hyaline membrane disease (HMD) The aim of this study is to assess the impact of the number of doses…
- Trial name
- CORISURF (NCT05455879)
- Testing
- Impact of antenatal corticosteroid therapy on surfactants use postnatal
- Where
- France
- Volunteers
- 145 people
- Sponsor
- Hôpital NOVO
Pregnant Women Receive Celesten
Betamethasone and Severity of Hyaline Membrane Disease
Primary purpose: to study the relationship between betamethasone placental transfer and the occurrence and severity of the Hyaline Membrane Disease.
- Trial name
- b-Mhyalines (NCT01854840)
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preterm Birth Complication, Neonatal Morbidity and Mortality
Delayed Versus Immediate Cord Clamping in Preterm Birth
The goal of this study is to evaluate whether delayed cord clamping improves early neonatal outcomes compared with immediate clamping in preterm birth.
- Conditions
- Preterm Birth Complication, Neonatal Morbidity and Mortality, Cord Clamping, Delayed Cord Clamping
- Trial name
- PREM-CORD (NCT07699666)
- Testing
- Delayed Umbilical Cord Clamping, Immediate Umbilical Cord Clamping
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Faculty of Medicine of Tunis