Clinical trials: Human Immunodeficiency Virus Transmission
COPD, HIV/AIDS
High-quality COPD Care for People With Immune Dysfunction Through Proactive E-consults
This study examines an intervention to promote effective, evidence-based care and de-implement inappropriate therapies for COPD in HIV-infected (HIV+) patients.
- Trial name
- ACHIEVE (NCT03856879)
- Testing
- Proactive E-consult
- Where
- 7 sites in United States
- Volunteers
- 270 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
HIV/AIDS
Pediatric Decentralization of ART in South Africa
The decentralization study will describe children taking antiretroviral therapy (ART) at a larger health facility in the Eastern Cape province of South Africa, between the years of 2004-2013.
- Trial name
- NCT03049891
- Testing
- Data abstraction, Tracing questionnaire, Tier.net
- Where
- 15 sites in South Africa
- Volunteers
- 1,583 people
- Sponsor
- Columbia University
Healthy
A Study to Evaluate Safety, Acceptability, Pharmacokinetics, and ex Vivo Pharmacodynamics of TMC278 Long Acting Formulation in HIV-1 Seronegative Participants
The purpose of this study is to evaluate the safety, acceptability, pharmacokinetics (what the body does to the medication), and ex vivo (tested outside the body) pharmacodynamics (what the medication does to the body) of TMC278…
- Trial name
- NCT01656018
- Testing
- TMC278, Long acting (LA)
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
HIV Infections
The Safety and Effectiveness of Two Forms of Saquinavir Combined With Other Anti-HIV Drugs in HIV-Infected Infants and Children
To determine the pharmacokinetic properties, tolerance and safety of 2 formulations of saquinavir, given in combination with 2 nucleoside antiretroviral drugs (part 1) or in combination with nelfinavir and nucleoside…
- Trial name
- NCT00002380
- Testing
- Nelfinavir mesylate, Saquinavir
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Hoffmann-La Roche
Hiv
Assessing Perceptions and Preferences Around Long-acting Injectables (APPLI)
The Ryan White HIV/AIDS Program is an essential platform for reducing health disparities among people with HIV and scaling up evidence-based strategies to strengthen the HIV care continuum.
- Trial name
- APPLI (NCT05833542)
- Testing
- Health education materials, Patient-provider decision tool
- Where
- 6 sites in United States
- Volunteers
- 243 people
- Sponsor
- City University of New York
HIV Infection
Characterization of the Adherence Threshold for HIV Suppression of a Kaletra-based Regimen
The hypothesis of this study is that the level of adherence necessary to achieve HIV virologic suppression with a ritonavir boosted protease inhibitor regimen (i.e.
- Trial name
- NCT00200369
- Testing
- MEMS cap
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Montefiore Medical Center
Multi Drug Resistant Tuberculosis, HIV Infections
An Adaptive Randomized Controlled Trial
This is a prospective, adaptive, randomized controlled trial comparing the effectiveness of 4 intervention arms on a combined endpoint in adults with confirmed MDR-TB HIV initiating Bedaquiline-containing MDR-TB treatment…
- Trial name
- ADAP-TIV (NCT05633056)
- Testing
- Adherence support intevention
- Where
- South Africa
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Columbia University
Infection, Human Immunodeficiency Virus
GSK706769 Repeat Dose Study
To determine safety, tolerability and Pharmacokinetics of GSK706769
- Trial name
- NCT00711386
- Testing
- GSK706769
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections, Sleep Disorder
Assessment of Sleep Disordersin People Living With HIV in the Era of New Antiretroviral Therapies in North of France
People living with HIV (PLHIV) appear to present with sleep-related complaints more frequently than the general population, with a prevalence of 50-70%. The latest French multi-center epidemiological data are dated.
- Trial name
- SANDMAN (NCT06441383)
- Testing
- Pittsburgh Sleep Quality Index
- Where
- France
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Tourcoing Hospital
HIV Infections
A Clinical Study of the HIV Drug CPT31 in Healthy Volunteers
This first-in-human study will evaluate the safety, tolerability, immunogenicity, and pharmacokinetics of the HIV entry inhibitor CPT31 (cholesterol-PIE12-2-trimer) in healthy adults.
- Trial name
- NCT04672083
- Testing
- CPT31
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Navigen, Inc.
HIV Infections
Switch to TAF+FTC+BIC in HIV-1-infected Patients Over 65 Years Old at Risk of Polymedication
Patients infected and living with HIV are getting older and have more and more non-HIV co-morbidities. These expose them to polypharmacy that increases the risk of pharmacological interaction.
- Trial name
- BICOLDER (NCT04222283)
- Testing
- BIKTARVY 50Mg-200Mg-25Mg Tablet
- Where
- 8 sites in France
- Volunteers
- 27 people
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Lung Inflammation, HIV Seropositivity
Effects of E-cigarettes (ECIGs) on Pulmonary Inflammation and Behavior in HIV Infected Smokers
The purpose of this study is to determine if using e-cigarettes (ECIG) rather than regular tobacco cigarettes alters lung inflammation in people with and without HIV.
- Trial name
- NCT02848586
- Testing
- ECIGS, mobile contingency management (mCM), Usual brand
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV Infections
ETE Interventions in the Dental Setting
The purpose of this study is to use information technology (IT) to support the delivery of HIV prevention and care best practices in the dental care setting to meet the Department of Health and Human Services (DHHS) Ending the…
- Trial name
- NCT05584501
- Testing
- Care Navigator, Health Information Supported Ending the HIV Epidemic (ETE) Activities in Dental Setting
- Where
- 2 sites in United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV/AIDS
Packaging PrEP to Prevent HIV Among WWID
Evidence suggests women who inject drugs (WWID) are disproportionately vulnerable to HIV. If HIV incidence continues unchecked, 1 in 23 WWID in the United States will acquire HIV.
- Trial name
- NCT03304912
- Testing
- PrEP Education and option to accept a PrEP prescription
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Drexel University
Methadone, HIV Infections
Recovery Management Intervention in China
The purpose of the study is to develop and pilot-test a Recovery Management Intervention (RMI) program for heroin addicts released from compulsory rehabilitation in China.
- Trial name
- NCT01270100
- Testing
- Recovery management
- Where
- China
- Sponsor
- University of California, Los Angeles
Infection, Human Immunodeficiency Virus
Effect of Carbamazepine on Dolutegravir Pharmacokinetics in Healthy Adult Subjects
This study will be a phase I, open label, three period, fixed sequence crossover study to evaluate the effect of Carbamazepine (CBZ) on the steady-state pharmacokinetics of Dolutegravir (DTG) and on the safety and tolerability of…
- Trial name
- NCT01967771
- Testing
- DTG, CBZ
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Infection, Hypercholesterolemia
Pravastatin and Protease Inhibitors in HIV-infected Patients
To assess the use of pravastatin in hypercholesterolemic HIV-infected patients treated with protease inhibitors in a randomised double blind study.
- Trial name
- NCT00221754
- Testing
- Pravastatin (drug)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Bordeaux
HIV Infections
Implementation of Long-acting Cabotegravir + Rilpivirine Administration Out of "HIV Units".
This is a clinical trial whose main purpose is to evaluate the acceptability of the administration of LA CAB + extended-release RPV as perceived by patients in month 12 in multipurpose day hospital units versus specialized care…
- Trial name
- IMAdART (NCT06159894)
- Testing
- DAY HOSPITAL ARM, Specialist-Care arm
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
HIV Infections
Safety and Effectiveness of Giving Adefovir Dipivoxil Plus Abacavir Plus Efavirenz Plus Amprenavir to HIV-Infected Patients Who Have Failed to Respond to Previous Protease Inhibitor Treatment
The purpose of this study is to see if it is safe and effective to give adefovir dipivoxil plus abacavir (ABC) plus efavirenz (EFV) plus amprenavir (APV) to HIV-infected patients who have failed to respond to previous treatment…
- Trial name
- NCT00002419
- Testing
- Abacavir sulfate, Amprenavir, Efavirenz
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Gilead Sciences
HIV Infections, HIV Wasting Syndrome
A Study to Evaluate the Effect of Nandrolone Decanoate in Women With HIV-Associated Weight Loss
The purpose of this study is to see if giving nandrolone decanoate (a hormonal drug) will cause weight gain in HIV-positive women who have HIV-associated weight loss (wasting). Wasting has become an AIDS-defining condition.
- Trial name
- NCT00000854
- Testing
- Nandrolone decanoate
- Where
- 22 sites in United States, Puerto Rico
- Volunteers
- 38 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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